Succinate Supplement Elicited “Pseudohypoxia” Condition to Promote Proliferation, Migration, and Osteogenesis of Periodontal Ligament Cells by Huimin Mao, Andi Yang, Yunhe Zhao, Lang Lei, Houxuan Li

“…The succinate supplement enhanced hPDLC proliferation, migration, and osteogenesis with decreased succinate dehydrogenase (SDH) expression and activity, as well as increased hexokinase 2 (HK2) and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), suggesting metabolic reprogramming from oxidative phosphorylation to glycolysis in a normal oxygen condition. …”
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Design and application of a disposable insulin dosing container and emergency injection module (一种一次性胰岛素定量容器瓶及紧急注射组件的设计与应用) by WU Xueqiong (邬雪琼), XIONG Li (熊丽), AI Shanmu (艾山木), PANG Cuihua (庞翠华)

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Synthesis of Some Metal Complexes with New Heterocyclic Ligand (5-(((2-(3-(1<i>H</i>-indol-3-yl)acryloyl)phenyl)amino)methylene)-2-thiooxodihydropyrimidine-4,6(1<i>H</i>,5<i>H</i>)... by Thanaa Abdul Ameer Hilal, Ibtihal Kadhim Kareem

“…This indicates that the [Au(L1)Cl]Cl2 complex has a strong affinity for the protein kinase (1HK7). Significant antiproliferative activity was seen in it against human breast cancer (MCF-7) and normal cell lines (MCF-10), as evidenced by the IC50 and selective indices (SI) values. …”
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Advanced Glycation End-Product-Modified Heat Shock Protein 90 May Be Associated with Urinary Stones by Takanobu Takata, Shinya Inoue, Kenshiro Kunii, Togen Masauji, Junji Moriya, Yoshiharu Motoo, Katsuhito Miyazawa

“…Recently, heat shock protein 90 (HSP90) on the membrane of HK-2 human proximal tubular epithelium cells has been associated with the adhesion of urinary stones and cytotoxicity. …”
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Mechanism of sensor kinase CitA transmembrane signaling by Xizhou Cecily Zhang, Kai Xue, Michele Salvi, Benjamin Schomburg, Jonas Mehrens, Karin Giller, Marius Stopp, Siegfried Weisenburger, Daniel Böning, Vahid Sandoghdar, Gottfried Unden, Stefan Becker, Loren B. Andreas, Christian Griesinger

“…Here, we used solid-state NMR in conjunction with crystallography, solution NMR and distance measurements to investigate the transmembrane signaling mechanism of a paradigmatic citrate sensing membrane embedded HK, CitA. Citrate binding in the sensory extracytoplasmic PAS domain (PASp) causes the linker to transmembrane helix 2 (TM2) to adopt a helical conformation. …”
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Quercetin improves diabetic kidney disease by inhibiting ferroptosis and regulating the Nrf2 in streptozotocin-induced diabetic rats by Lei Zhang, Xingzhi Wang, Liang Chang, Yiqun Ren, Manshu Sui, Yuting Fu, Lei Zhang, Lirong Hao

“…However, quercetin counteracted this by inhibiting ferroptosis and activating NFE2-related factor 2 (Nrf2) expression in both DKD rats and HG-treated HK-2 cells, indicating its renal protective role. …”
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Design and application of a breathing circuit joint for preventing condensation water from gathering (一种用于防冷凝水聚集的呼吸回路接头的设计与应用) by TIAN Suai (田素爱), YANG Fangfang (杨方方), ZHANG Xinna (张新娜)

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UHRF1 promotes epithelial-mesenchymal transition mediating renal fibrosis by activating the TGF-β/SMAD signaling pathway by Lijie Yang, Penghui Si, Tuoheti Kuerban, Linfa Guo, Shanzhi Zhan, Yisha Zuhaer, Yingtong Zuo, Peixiang Lu, Xiaojie Bai, Tongzu Liu

“…By establishing a TGF-β1-stimulated HK2 cell model and animal models of renal fibrosis induced by UUO and folic acid, we confirmed that UHRF1 was highly expressed in both in vitro and in vivo models of renal fibrosis. …”
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Design and application of a pressure relief pad for preventing pressure injuries (一种防压力性损伤减压垫的设计与应用) by ZHANG Yitian (张怡天), SUN Xiumei (孙秀梅), LI Jingwen (李静文)

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Histological, physiological and transcriptomic analysis in hepatopancreas of Procambarus clarkii under heat stress by Yongfeng Zou, Panhui Cao, Zhiming Bao, Yu Xu, Zhiqiang Xu, Hui Guo

“…Significant fluctuations were observed in the malondialdehyde (MDA) content, reactive oxygen species (ROS) production, total antioxidant capacity (T-AOC), and activities of pyruvate kinase (PK), hexokinase (HK), alkaline phosphatase (ALP), lysozyme (LYS), acid phosphatase (ACP), fatty acid synthase (FAS), as well as lipoprotein lipase (LPL) in response to different stress conditions (P < 0.05). …”
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Research status quo of Traditional Chinese Medicine hot ironing therapy in the treatment of spleen and stomach diseases (中医热熨疗法治疗脾胃疾病的研究现状分析) by TIAN Xiaodong (田小冬), HUANG Yanping (黄砚萍), WANG Wenqing (王文清), WANG Ting (王婷)

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<i>Lin28b-let-7</i> Modulates mRNA Expression of <i>GnRH1</i> Through Multiple Signaling Pathways Related to Glycolysis in GT1-7 Cells by Yujing Xie, Xin Li, Meng Wang, Mingxing Chu, Guiling Cao

“…The pyruvate content and the expression of <i>Hif1a</i> and <i>Hk2</i>, which were related to glycolysis, were also promoted by <i>Lin28b</i> overexpression. …”
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Application of Internet Plus nursing services in the management of chronic diseases among the elderly (“互联网+护理服务”在老年慢性病患者管理中的应用) by LI Jiao (李娇), CAI Miaomiao (蔡苗苗)

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Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology by Arthur D. Stem, Cole R. Michel, Peter S. Harris, Keegan L. Rogers, Matthew Gibb, Carlos A. Roncal-Jimenez, Richard Reisdorph, Richard J. Johnson, James R. Roede, Kristofer S. Fritz, Jared M. Brown

“…Methods In order to characterize the impact of sugarcane ash derived (SAD) SiNPs on human kidney proximal convoluted tubule (PCT) cells and identify potential mechanisms of toxicity, HK-2 cells were exposed to treatments of either pristine, manufactured, 200 nm SiNPs or SAD SiNPs and changes to cellular energy metabolism and redox state were determined. …”
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RECK as a Potential Crucial Molecule for the Targeted Treatment of Sepsis by Qin Y, Liao S, Sun J, Ye H, Li J, Pan J, He J, Xia Z, Shao Y

“…Yuting Qin,1,&ast; Shuanglin Liao,1,&ast; Jianbo Sun,2 Huiyun Ye,1 Jiafu Li,1 Jiahui Pan,1 Junbing He,3 Zhengyuan Xia,4,5 Yiming Shao1,6 1Dongguan Key Laboratory of Sepsis Translational Medicine, The Intensive Care Unit, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, Guangdong, People’s Republic of China; 2Dongguan Key Laboratory of Chronic Inflammatory Diseases, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, Guangdong, People’s Republic of China; 3The Key Laboratory of Organ Dysfunction and Protection Translational Medicine, Jieyang Medical Research Center, Jieyang People’s Hospital, Jieyang, Guangdong, People’s Republic of China; 4Department of Anesthesiology and Perioperative Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, People’s Republic of China; 5State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, People’s Republic of China; 6The Key Laboratory of Sepsis Translational Medicine, Guangdong Medical University, Zhanjiang, Guangdong, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yiming Shao, Dongguan Key Laboratory of Sepsis Translational Medicine, the Intensive Care Unit,The First Dongguan Affiliated Hospital, Guangdong Medical University, Jiaoping Road 42, Tangxia Town, Dongguan, Guangdong Province, 523710, People’s Republic of China, Tel +86 18826690188, Email sym@gdmu.edu.cn Zhengyuan Xia, Department of Anesthesiology and Perioperative Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, People’s Republic of China, Tel +852-68798794, Email zyxia@hku.hkAbstract: Reversion inducing cysteine rich protein with kazal motifs (RECK), a Kazal motif-containing protein, regulates pro-inflammatory cytokines production, migration of inflammatory cells, vascular endothelial growth factor (VEGF) and Wnt pathways and plays critical roles in septic inflammatory storms and vascular endothelial dysfunction. …”
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Research on comprehensive quality training strategies for nursing staff in the rotating nursing department (轮转护理部护理人员综合素质培养策略研究) by ZHENG Xiaoyan (郑晓艳), LI Jiayue (李佳玥), LIU Yan (刘焱), TIAN Runxi (田润溪)

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Hufu Tongbian Guasha in the treatment of bloating and constipation in a patient with cholestatic jaundice (虎符铜砭刮痧改善1例胆汁淤积性黄疸患者腹胀和便秘的护理)... by WANG Rui (王蕊), HU Jinrui (胡金瑞)

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Effects of holistic nursing interventions in newborns with hypoxic-ischemic encephalopathy (缺氧缺血性脑病新生儿整体护理效果观察) by HE Xuelian (何雪莲), WANG Jing (王京), LIU Li (刘丽)

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Nursing interventions based on the knowledge-attitude-practice model on anxiety and treatment compliance in an elderly patient with Ramsay-Hunt Syndrome and vestibular neuritis (知信... by CAO Haiyan (曹海燕), XU Ling (徐玲), YANG Hui (杨惠), LI Qingqing (李青青)

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Nursing of a patient with gout of damp-heat stagnation syndrome combined with erosive gastritis treated with auricular acupoint therapy combine with pricking and cupping therapy (耳... by ZHU Jianmei (朱建妹), CHEN Hui (陈慧), ZHANG Xiaolin (张小林), LIAO Xuefeng (廖雪锋)

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