CD154 Induces Interleukin-6 Secretion by Kidney Tubular Epithelial Cells under Hypoxic Conditions: Inhibition by Chloroquine by Antoine Dewitte, Julien Villeneuve, Sébastien Lepreux, Marion Bouchecareilh, Xavier Gauthereau, Claire Rigothier, Christian Combe, Alexandre Ouattara, Jean Ripoche

“…Here, we studied the control by CD154 of the proinflammatory cytokine interleukin- (IL-) 6 secretion in short-term oxygen (O2) deprivation conditions, using the HK-2 cell line as a kidney tubular epithelial cell (TEC) model. …”
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Beta-Hydroxybutyric Acid Inhibits Renal Tubular Reabsorption via the AKT/DAB2/Megalin Signalling Pathway by Minxia Zuo, Cheng Meng, Qian Song, Zhongai Gao, Xiao Cui, Jingyu Wang, Yongmei Li, Xiaochen Li, Chunyan Shan, Juhong Yang, Baocheng Chang

“…After controlling ketosis, urinary microalbumin, TF, IgG, β2-MG, and RBP decreased significantly. In HK-2 cells, albumin endocytosis and megalin expression decreased with increasing BOHB concentration. …”
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EZH2 Mediates miR-146a-5p/HIF-1α to Alleviate Inflammation and Glycolysis after Acute Spinal Cord Injury by Shuangfei Ni, Bo Yang, Lei Xia, Huafeng Zhang

“…We used lipopolysaccharide (LPS) to induce inflammation of microglia, and we constructed the ASCI animal model. qRT-PCR detected the relative expression levels of EZH2, HIF-1α, miR-146a-5p, IL-6, TNF-α, IL-17, PKM2, GLUT1, and HK2 in cells and tissues. Western blot was performed to detect the expression levels of EZH2, HIF-1α, H3K27me3, IL-6, TNF-α, IL-17, PKM2, GLUT1, and HK2. …”
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Permanents of Hexagonal and Armchair Chains by O. Nekooei, H. Barzegar, A. R. Ashrafi

“…As a consequence of our work, it is proved that if Gk and Hk denote the hexagonal and armchair chains, respectively, then permAG1=4, permAGk=k+12, k≥2, and permAHk=4k with k≥1. …”
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Forging ahead with enterprise and fortitude, endeavoring to write a new chapter of scholarly communication in integrative nursing (踔厉奋发、勇毅前行, 谱写中西医结合护理学术传播体系新篇章)... by TANG Ling (唐玲), YE Zhenhua (叶振华)

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Focusing on the multi-disciplinary treatment and integrative nursing model, inheriting and innovating characteristic external therapy of Traditional Chinese Medicine, and construct... by LIU Dong (刘东)

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Dapagliflozin improves diabetic kidney disease by inhibiting ferroptosis through β-hydroxybutyrate production by Yan Tian, Chenxia Zhou, Qun Yan, Ziyi Li, Da Chen, Bo Feng, Jun Song

“…Human proximal tubule cells (HK2 cells) were exposed to high glucose alone or in combination with dapagliflozin. …”
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PTEN suppresses renal cell carcinoma proliferation and migration via inhibition of the PI3K/AKT pathway by Xu Xu, Yuan-Yue Tang, Xiaohong Liang, Wen Luo, Dong-Mei Jiang, Jie Chen

“…Methods This study collected renal cancer and adjacent non-cancerous tissue samples from our hospital. HK-2 and 786-O cells were used, with 786-O cells divided into control, vector, and oe-PTEN groups. …”
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Nonlinear Integrodifferential Equations of Mixed Type in Banach Spaces by Aneta Sikorska-Nowak, Grzegorz Nowak

“…We prove two existence theorems for the integrodifferential equation of mixed type: x'(t)=f(t,x(t),∫0tk1(t,s)g(s,x(s))ds,∫0ak2(t,s)h(s,x(s))ds), x(0)=x0, where in the first part of this paper f, g, h, x are functions with values in a Banach space E and integrals are taken in the sense of Henstock-Kurzweil (HK). In the second part f, g, h, x are weakly-weakly sequentially continuous functions and integrals are taken in the sense of Henstock-Kurzweil-Pettis (HKP) integral. …”
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Emotional relief for patients and nurses in Traditional Chinese Medicine clinics (中医护理门诊工作中缓解患者及护士焦虑情绪的方法) by CHU Yina (初伊娜), TIAN Jing (田婧)

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The design and application of the mask for preventing glasses from fogging (一种防眼镜片起雾口罩的设计与应用) by HE Mengjia (贺梦佳), HUANG Juan (黄娟)

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Research progress on hand hygiene of nursing students (护理实习生手卫生研究进展) by PENG Ling (彭琳), LEI Sai (雷赛), YANG Weiwei (杨微微), YU Lili (余丽丽)

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乳酸脱氢酶A在肾细胞癌中的表达及意义 by 邱文瀚, 廖定准, 盛义雨, 熊海云, 李骏

“…qRT-PCR和Western blot结果可见，<italic>LDHA</italic>在各肾细胞癌细胞系中的表达均较HK-2有明显升高（<italic>P</italic>&lt;0.05）。在786-O敲低<italic>LDHA</italic>表达后，细胞增殖活性及糖酵解能力均显著下调（<italic>P</italic>&lt;0.05）。…”
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Ursodeoxycholic acid protects against sepsis-induced acute kidney injury by activating Nrf2/HO-1 and inhibiting NF-κB pathway by Yunpeng Lou, Hongguang Shi, Ning Sha, Feifei Li, Xiaofeng Gu, Huiyan Lin

“…In vitro, UDCA reduced LPS-induced cell injury and apoptosis in HK-2 cells, with these protective effects being blocked by the Nrf2 inhibitor ML385. …”
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Danshen injection ameliorates unilateral ureteral obstruction-induced renal fibrosis by inhibiting ferroptosis via activating SIRT1/GPX4 pathway by Yiwen Cao, Huan Zhao, Shuyin Lin, Junqi Chen, Jingli Xiong, Zhijun Zeng, Ziyu Long, Yingru Su, Yingqi Zhong, Lingru Zhao, Mingshan Zhang, Junbiao Wu, Yuan Zhou, Jiuyao Zhou

“…Besides, DSI or Fer-1 inhibited renal fibrosis in vivo and in TGF-β-induced HK-2 cells. Furthermore, ferroptosis was lessened under DSI or Fer-1 treatment. …”
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Oridonin ameliorates renal fibrosis in diabetic nephropathy by inhibiting the Wnt/β-catenin signaling pathway by Jushuang Li, Lan Shu, Qianqian Jiang, Baohong Feng, Zhimin Bi, Geli Zhu, Yanxia Zhang, Xiangyou Li, Jun Wu

“…In vitro, HG treatment increased the migration of HK-2 cells while reducing their viability and proliferation rate, and treatment with Ori reversed these changes. …”
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Thinking way and method of diagnosis and treatment in Traditional Chinese Medicine and its implications for narrative nursing (中医诊疗思维对叙事护理的启示) by WANG Zixu (王子旭)

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An innovative mode of whole-process non-contact single-person sample collection of nucleic acid testing (一种全程无接触式单人核酸检测样本采集创新模式) by ZHANG Lijun (张丽君), TANG Ling (唐玲)

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Progress of nursing interventions on medication adherence in patients with hypertension (高血压患者服药依从性的护理进展) by LI Fang (李芳)

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Research progress on interventions of aged frailty syndrome (老年衰弱综合征干预的研究进展) by WANG Yuan (王媛)

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