激活TGR5缓解肾缺血再灌注后肾脏纤维化损伤 by 李蒙, 隆罗莎, 梁柏恩, 徐龙, 赵晓朵, 王蔚东, 李春凌

“…方法体内实验：将C57BL/6J小鼠随机分成假手术（Sham）组、uIRIx组及uIRIx+石胆酸（LCA）组，每组6只，使用uIRIx模型诱导肾脏纤维化，通过血和尿生化指标评估肾脏功能，利用HE染色评估肾脏损伤程度，使用Masson染色及免疫组化对肾脏纤维化程度进行评估，并用Western Blotting检测肾脏皮质纤维化相关指标蛋白表达；分别在<italic>TGR5</italic>^+/+小鼠及<italic>TGR5</italic>^-/-小鼠中设置Sham组及uIRIx组，每组6只，利用Western Blotting检测各组肾脏纤维化程度。体外实验：在人源肾上皮细胞系HK2细胞中给予TGF-β1诱导促纤维化反应，给予LCA进行药物干预，利用鬼笔环肽染色标记细胞骨架，使用Western Blotting检测HK2细胞内纤维化相关指标蛋白表达。…”
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eSports Participation among Hong Kong Middle-Aged and Older Adults: A Qualitative Study by Ka-Man Leung, William Chu

“…The HK Special Administrative Region Government has been making efforts to promote active aging among older adults. …”
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Investigating the antioxidant and anti-inflammatory potential of Nypa fruticans: a multifaceted approach to skin protection and aging by Seul Ki Kim, Sang-Back Kim, Seul Bi Lee, Kang sub Kim, So-Ri Son, En Jin Choi, Byung Chul Park, Eunyoung Hong, You Ah Kim, Byoung Seok Moon, Sullim Lee

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Curcumin nanocrystals ameliorate ferroptosis of diabetic nephropathy through glutathione peroxidase 4 by Mengjiao Xue, Mengjiao Xue, Yiwei Tian, Hua Zhang, Hua Zhang, Shijie Dai, Yangsheng Wu, Juan Jin, Juan Jin, Jian Chen

“…ObjectiveThe aim of this study was to investigate the effect of curcumin nanocrystals (Cur-NCs) on ferroptosis in high-glucose (HG)-induced HK-2 cells and streptozotocin (STZ)-induced diabetic nephropathy model (DN) rats. …”
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DKK3 promotes renal fibrosis by increasing MFF-mediated mitochondrial dysfunction in Wnt/β-catenin pathway-dependent manner by Jianling Song, Yanxia Chen, Yan Chen, Minzi Qiu, Wenliu Xiang, Ben Ke, Xiangdong Fang

“…However, the underlying mechanisms of DKK3 in CKD are not fully understood.Methods H2O2-treated HK-2 cells and ureteric obstruction (UUO) mice were used as RF models. …”
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Inhibition of complement system-related gene ITGB2 attenuates epithelial–mesenchymal transition and inflammation in diabetic nephropathy by Jun Peng, Wenqi Zhao, Lu Zhou, Kun Ding

“…Besides, mRNA and protein expression levels of ITGB2 in HG-treated HK-2 cells were remarkably elevated. Moreover, the viability of HK-2 cells, expression of TNF-α, IL-6, IL-12, α-SMA, E-cadherin and vimentin in HK-2 cells changed by HG administration were reversed by ITGB2-silence. …”
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Effect of Scapular Intensive Training on Functional Recovery of Upper Extremities in Early Stroke by Min JIANG, Lun LUO, Fan BAI, Wenyuan SU, Chaomou HE, Tao XIANG

“…Fugl-Meyer upper eExtremity motor function rating scale, Hong Kong version of hemiplegic upper extremity functional test (FTHUE-HK) scale and modified Barthel index (MBI) score were used to evaluate upper limb function and activities of daily living in patients with stroke.Results:After 4 weeks of treatment, Fugl-Meyer upper limb motor function scores, FTHUE-HK scale scores, and MBI index scores were significantly higher than those before treatment in both groups, with statistically significant differences (<italic>P</italic>&lt;0.05);and the scores of the evaluation scores of the scapular augmentation group were higher than those of the control group, with statistically significant differences (<italic>P</italic>&lt;0.05).Conclusion:The scapula reinforcement group can improve the upper extremity motor function and the activities of daily living in stroke patients.…”
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SPDEF ameliorates UUO-induced renal fibrosis by transcriptional activation of NR4A1 by Hongshuang Wang, Ziheng Wei, Chang Xu, Fang Fang, Zheng Wang, Yan Zhong, Xiangting Wang

“…Our results showed that the knockdown of NR4A1 can accelerate unilateral ureteral obstruction (UUO)-induced renal fibrosis in mice, and overexpression of NR4A1 can significantly reduce transforming growth factor-β1-induced (TGF-β1) fibrosis in HK-2 cells. Additionally, we found that overexpression of SPDEF can improve UUO-induced renal fibrosis in mice and TGF-β1-induced fibrosis in HK-2 by transcriptionally activating NR4A1. …”
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Blocking REDD1/TXNIP Complex Ameliorates HG-Induced Renal Tubular Epithelial Cell Apoptosis and EMT through Repressing Oxidative Stress by Lin Mu, Nan Chen, Yakun Chen, Zhifen Yang, Huandi Zhou, Shan Song, Yonghong Shi

“…In vitro experiments showed that REDD1 generation was induced by high glucose (HG) in HK-2 cells. Similarly, the transfection of REDD1 siRNA plasmid also suppressed HG-induced apoptosis and EMT. …”
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RETRACTED ARTICLE: P16INK4a Deletion Ameliorated Renal Tubulointerstitial Injury in a Stress-induced Premature Senescence Model of Bmi-1 Deficiency by Jianliang Jin, Jianguo Tao, Xin Gu, Zhenzhen Yu, Rong Wang, Guoping Zuo, Qing Li, Xianhui Lv, Dengshun Miao

“…P16INK4a deletion also promoted proliferation, reduced senescence and SASP of RIFs and subsequently inhibited EMT of Bmi-1-knockdown HK2 cells. TGF-β1 further induced the EMT of Bmi-1-knockdown HK2 cells. …”
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Prooxidant-Antioxidant Balance in Umbilical Cord Blood of Infants with Meconium Stained of Amniotic Fluid by Mohammad Hassan Arjmand, Farhat Ahmad Shah, Masoud Saleh Moghadam, Fatemeh Tara, Amin Jalili, Mojtaba Mosavi Bazaz, Daryoush Hamidi Alamdari

“…There was a significant increase of PAB value (32.8±15.9 HK) in umbilical cord blood of infants with MSAF in comparison to HI (24.5±12.6 HK) (P<0.05). …”
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IGFBP2 and IGFBP4 interact to activate complement pathway in diabetic kidney disease by Jieling Liang, Yangxiao Huang, Daping Peng, Yali Xie, Yifei Liu, Xiuxia Lu, Junfa Xu

“…High glucose and serum from DKD mice stimulated an increase in the levels of IGFBP2 and IGFBP4 in HK-2 cells. The supernatant from HK-2 cells was used to culture THP-1 cells, resulted in an increase in the M1 type of THP-1 cells, a decrease in the M2 type, and activation of the complement pathway. …”
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Merging metabolic modeling and imaging for screening therapeutic targets in colorectal cancer by Niki Tavakoli, Emma J. Fong, Abigail Coleman, Yu-Kai Huang, Mathias Bigger, Michael E. Doche, Seungil Kim, Heinz-Josef Lenz, Nicholas A. Graham, Paul Macklin, Stacey D. Finley, Shannon M. Mumenthaler

“…Our results highlighted hexokinase (HK) as a crucial target, which subsequently became our focus for experimental validation using patient-derived tumor organoids (PDTOs). …”
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Promoting high quality development of Longfu Humanistic Care column (高起点高品质发展“隆福·护理人文关怀”专栏) by PENG Kun (彭堃)

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New Stability Conditions for Linear Differential Equations with Several Delays by Leonid Berezansky, Elena Braverman

“…New explicit conditions of asymptotic and exponential stability are obtained for the scalar nonautonomous linear delay differential equation x˙(t)+∑k=1mak(t)x(hk(t))=0 with measurable delays and coefficients. …”
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Promoting the high-quality development of care in angiology and peripheral vascular surgery (以强烈的责任感推动周围血管专科护理事业高质量发展——“周围血管疾病护理及质量管理”专栏导读)...

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The Extropy of Concomitants of Generalized Order Statistics from Huang–Kotz–Morgenstern Bivariate Distribution by I. A. Husseiny, A. H. Syam

“…In this paper, we study the extropy for concomitants of m−generalized order statistics (m−GOSs) from Huang–Kotz–Farlie–Gumbel–Morgenstern (HK-FGM) bivariate distribution. Moreover, the cumulative residual extropy (CREX) and negative cumulative extropy (NCEX) are depicted. …”
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Focusing on enteral nutrition, improving population health and prompting the development of Healthy China (关注肠内营养, 关心人民健康, 助力健康中国建设) by LIU Guiying (刘桂英)

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The promising future of rehabilitation nursing (康复护理 未来可期) by ZHOU Yuzhen (周玉贞)

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Stem Cells from Human Exfoliated Deciduous Teeth Ameliorate Diabetic Nephropathy In Vivo and In Vitro by Inhibiting Advanced Glycation End Product-Activated Epithelial-Mesenchymal... by Nanquan Rao, Xiaotong Wang, Jing Xie, Jingzhi Li, Yue Zhai, Xiaoxia Li, Tengjiaozi Fang, Yuanyuan Wang, Yuming Zhao, Lihong Ge

“…This study is the first to apply a transwell system for coculture to explore the effects of MSCs on the EMT of human proximal tubular epithelial (HK-2) cells. The effects of SHED on advanced glycation end product- (AGE-) activated EMT in HK-2 cells were explored by real-time PCR and western blot. …”
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