Selecting habitats to reintroduce the endangered species Ardisia gigantifolia (Primulaceae) based on growth and physiological traits by Rong Liu, Dan Xie, Mengling Li, Yanmei Ping, Dongmei Li, Shupeng Dong, Yongjie Yu, Jinguo Zhang, Zulin Ning

“…Compared to NX, severe shading at GLQ and HK resulted in the decrease of light energy utilization efficiency and growth parameters. …”
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Paeoniflorin alleviates sepsis-associated acute kidney injury in mice by inhibiting aerobic glycolysis through the β-catenin/c-Myc pathway by GONG Yu, LEI Jiao, ZHANG Ming

“…ELISA was used to determine the contents of serum creatinine （Scr）， neutrophil gelatinase-associated lipocalin （NGAL） and lactate， and renal contents of hexokinase 2 （HK2）， lactate dehydrogenase A （LDHA）， IL-1β and IL-18. …”
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eSports Participation among Hong Kong Middle-Aged and Older Adults: A Qualitative Study by Ka-Man Leung, William Chu

“…The HK Special Administrative Region Government has been making efforts to promote active aging among older adults. …”
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Investigating the antioxidant and anti-inflammatory potential of Nypa fruticans: a multifaceted approach to skin protection and aging by Seul Ki Kim, Sang-Back Kim, Seul Bi Lee, Kang sub Kim, So-Ri Son, En Jin Choi, Byung Chul Park, Eunyoung Hong, You Ah Kim, Byoung Seok Moon, Sullim Lee

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DKK3 promotes renal fibrosis by increasing MFF-mediated mitochondrial dysfunction in Wnt/β-catenin pathway-dependent manner by Jianling Song, Yanxia Chen, Yan Chen, Minzi Qiu, Wenliu Xiang, Ben Ke, Xiangdong Fang

“…However, the underlying mechanisms of DKK3 in CKD are not fully understood.Methods H2O2-treated HK-2 cells and ureteric obstruction (UUO) mice were used as RF models. …”
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Inhibition of complement system-related gene ITGB2 attenuates epithelial–mesenchymal transition and inflammation in diabetic nephropathy by Jun Peng, Wenqi Zhao, Lu Zhou, Kun Ding

“…Besides, mRNA and protein expression levels of ITGB2 in HG-treated HK-2 cells were remarkably elevated. Moreover, the viability of HK-2 cells, expression of TNF-α, IL-6, IL-12, α-SMA, E-cadherin and vimentin in HK-2 cells changed by HG administration were reversed by ITGB2-silence. …”
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SPDEF ameliorates UUO-induced renal fibrosis by transcriptional activation of NR4A1 by Hongshuang Wang, Ziheng Wei, Chang Xu, Fang Fang, Zheng Wang, Yan Zhong, Xiangting Wang

“…Our results showed that the knockdown of NR4A1 can accelerate unilateral ureteral obstruction (UUO)-induced renal fibrosis in mice, and overexpression of NR4A1 can significantly reduce transforming growth factor-β1-induced (TGF-β1) fibrosis in HK-2 cells. Additionally, we found that overexpression of SPDEF can improve UUO-induced renal fibrosis in mice and TGF-β1-induced fibrosis in HK-2 by transcriptionally activating NR4A1. …”
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Blocking REDD1/TXNIP Complex Ameliorates HG-Induced Renal Tubular Epithelial Cell Apoptosis and EMT through Repressing Oxidative Stress by Lin Mu, Nan Chen, Yakun Chen, Zhifen Yang, Huandi Zhou, Shan Song, Yonghong Shi

“…In vitro experiments showed that REDD1 generation was induced by high glucose (HG) in HK-2 cells. Similarly, the transfection of REDD1 siRNA plasmid also suppressed HG-induced apoptosis and EMT. …”
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RETRACTED ARTICLE: P16INK4a Deletion Ameliorated Renal Tubulointerstitial Injury in a Stress-induced Premature Senescence Model of Bmi-1 Deficiency by Jianliang Jin, Jianguo Tao, Xin Gu, Zhenzhen Yu, Rong Wang, Guoping Zuo, Qing Li, Xianhui Lv, Dengshun Miao

“…P16INK4a deletion also promoted proliferation, reduced senescence and SASP of RIFs and subsequently inhibited EMT of Bmi-1-knockdown HK2 cells. TGF-β1 further induced the EMT of Bmi-1-knockdown HK2 cells. …”
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Prooxidant-Antioxidant Balance in Umbilical Cord Blood of Infants with Meconium Stained of Amniotic Fluid by Mohammad Hassan Arjmand, Farhat Ahmad Shah, Masoud Saleh Moghadam, Fatemeh Tara, Amin Jalili, Mojtaba Mosavi Bazaz, Daryoush Hamidi Alamdari

“…There was a significant increase of PAB value (32.8±15.9 HK) in umbilical cord blood of infants with MSAF in comparison to HI (24.5±12.6 HK) (P<0.05). …”
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Merging metabolic modeling and imaging for screening therapeutic targets in colorectal cancer by Niki Tavakoli, Emma J. Fong, Abigail Coleman, Yu-Kai Huang, Mathias Bigger, Michael E. Doche, Seungil Kim, Heinz-Josef Lenz, Nicholas A. Graham, Paul Macklin, Stacey D. Finley, Shannon M. Mumenthaler

“…Our results highlighted hexokinase (HK) as a crucial target, which subsequently became our focus for experimental validation using patient-derived tumor organoids (PDTOs). …”
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New Stability Conditions for Linear Differential Equations with Several Delays by Leonid Berezansky, Elena Braverman

“…New explicit conditions of asymptotic and exponential stability are obtained for the scalar nonautonomous linear delay differential equation x˙(t)+∑k=1mak(t)x(hk(t))=0 with measurable delays and coefficients. …”
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The Extropy of Concomitants of Generalized Order Statistics from Huang–Kotz–Morgenstern Bivariate Distribution by I. A. Husseiny, A. H. Syam

“…In this paper, we study the extropy for concomitants of m−generalized order statistics (m−GOSs) from Huang–Kotz–Farlie–Gumbel–Morgenstern (HK-FGM) bivariate distribution. Moreover, the cumulative residual extropy (CREX) and negative cumulative extropy (NCEX) are depicted. …”
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Stem Cells from Human Exfoliated Deciduous Teeth Ameliorate Diabetic Nephropathy In Vivo and In Vitro by Inhibiting Advanced Glycation End Product-Activated Epithelial-Mesenchymal... by Nanquan Rao, Xiaotong Wang, Jing Xie, Jingzhi Li, Yue Zhai, Xiaoxia Li, Tengjiaozi Fang, Yuanyuan Wang, Yuming Zhao, Lihong Ge

“…This study is the first to apply a transwell system for coculture to explore the effects of MSCs on the EMT of human proximal tubular epithelial (HK-2) cells. The effects of SHED on advanced glycation end product- (AGE-) activated EMT in HK-2 cells were explored by real-time PCR and western blot. …”
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Relationships between the allozyme and phenotypic diversities of Picea ajanensis populations by V. P. Vetrova, A. K. Ekart, A. N. Kravchenko, A. Ya. Larionova

“…Genetic differences between the morphotypes with regard to nine polymorphic loci (Got-2, Skdh-1, Idh-2, Pgm-2, Mdh-1, Mdh-3, Pgm- 1, Pgi-2, and Hk) were not significant. Statistically significant differences between the morphotypes were revealed for two loci: Pgm-2 and Mdh-1. …”
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On Harmonic Functions Defined by Differential Operator with Respect to k-Symmetric Points by Afaf A. Ali Abubaker, Maslina Darus

“…We introduce new classes MHkσ,s(λ,δ,α) and M¯Hkσ,s(λ,δ,α) of harmonic univalent functions with respect to k-symmetric points defined by differential operator. …”
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Fixed point theorems for generalized Lipschitzian semigroups in Banach spaces by Balwant Singh Thakur, Jong Soo Jung

“…As applications, its corollaries are given in a Hilbert space, in Lp spaces, in Hardy space Hp, and in Sobolev spaces Hk,p, for 1<p<∞ and k≥0.…”
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Personal glucose meter-based portable method for creatine kinase assay by Jinhwan Lee, Yejin Oh, Hyoyong Kim, Sangmo Lee, Hyun Gyu Park

“…HK then phosphorylates glucose into glucose-6-phosphate by converting the produced ATP back to ADP, which could enter another cycle of the CER to further phosphorylate glucose in a sample. …”
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Magnesium hydride protects against acetaminophen-induced acute kidney injury by inhibiting TXNIP/NLRP3/nf-κb pathway by Yachen Si, Lulu Liu, Yinyin Zhang, Hongxia Li, Tingting Zhao, Su Liu, Xuejun Sun, Jin Cheng, Hongtao Lu

“…Furthermore, the expressions of molecules related to TXNIP/NLRP3/NF-κB pathway (TXNIP, NLRP3, NF-κB p65 and p-NF-κB p65) in renal tissues and HK-2 cells were enhanced by APAP overdose, which were reduced by MgH2 administration. …”
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Astragaloside IV attenuates cadmium induced nephrotoxicity in rats by activating Nrf2 by Yuchen Li, Jiayi Zhou, Tianxin Zhang, Xiaocong Li, Cheng Wu, Ziyi Zhao, Jianyuan Tang, Xiaoyu Tan, Qiongying Hu, Wenhao Liao

“…Astragaloside IV (AS-IV) is a saponin isolated from Astragalus membranaceus with good antioxidant, anti-inflammatory and anti-tumor properties. In this study, HK2 cells and rat model were utilized to explore the protective effect of AS-IV against cadmium chloride-induced oxidative stress-induced apoptosis. …”
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