Intradermal DNA Electroporation Induces Cellular and Humoral Immune Response and Confers Protection against HER2/neu Tumor by Alessia Lamolinara, Lorenzo Stramucci, Albana Hysi, Manuela Iezzi, Cristina Marchini, Marianna Mariotti, Augusto Amici, Claudia Curcio

“…Moreover, we tested the efficacy of intradermal vaccination against Her2/neu antigen in cellular and humoral response induction and consequent protection from a Her2/neu tumor challenge in Her2/neu nontolerant and tolerant mice. …”
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HER-2/neu Amplification Testing in Breast Cancer by Multiplex Ligation-Dependent Probe Amplification in Comparison with Immunohistochemistry and In Situ Hybridization by Cathy B. Moelans, Roel A. de Weger, Marja T.M. van Blokland, Chantal Ezendam, Sabrina Elshof, Marcel G. J. Tilanus, Paul J. van Diest

“…Background: Assessment of HER-2/neu status in invasive breast cancer is crucial to establish eligibility for trastuzumab and taxane based chemotherapy. …”
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Stromal Expression of CD10 in Invasive Breast Carcinoma and Its Correlation with ER, PR, HER2-neu, and Ki67 by Vandana Puri, Manjula Jain, Shaji Thomas

“…Stromal CD10 showed positive correlation with tumour grade, HER2-neu (P=.000), and ki67 (P=.027), negative correlation with ER and PR. …”
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A New Monoclonal Antibody Demonstrates That Muc4, the Intramembrane Ligand for Erbb2/Her2/Neu, Is Overexpressed in Multiple Carcinomas by Jin Zhang, Kermit L. Carraway

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LEAPS Vaccine Incorporating HER-2/neu Epitope Elicits Protection That Prevents and Limits Tumor Growth and Spread of Breast Cancer in a Mouse Model by Ken S. Rosenthal, Sarah Stone, Gary Koski, Daniel H. Zimmerman

“…The prototype J-LEAPS T cell vaccine for HER-2/neu breast cancer (J-HER) consists of the murine HER-2/neu66–74 H-2d CD8 T cell epitope covalently attached through a triglycine linker to the J-immune cell binding ligand (ICBL) (human β2 microglobulin38–50 peptide). …”
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Ribociclib-induced vitiligo in a case of metastatic carcinoma of the breast by Abhira Deb, Manthan Dhingra, Srutee Barman, Thinakaran Raja, Abhra Ghosh

“…This report presents a case of HR+ and HER2/neu− metastatic breast carcinoma treated with CDK4/6 inhibitor plus endocrine therapy with the development of vitiligo during the treatment.…”
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Assessment of Tissue Eosinophilic Infiltration in Invasive Mammary Carcinoma by Farah Falah Hasan, Mohammed Haider Fadhil, Zainab Khalid Almukhtar

“…The presence of tissue eosinophilic infiltration can predict HER2/NEU negativity in breast cancer.…”
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Biomarker panel for early detection of uterine cancer by Nemali Deepthi Deepthi Priya, NANDA KUMAR K V, DEVARAJAPPAGARI BINDU, KASIREDDY LIKHITHA, MEKALA SIVA CHARANI

“…Several biomarkers, including P53, K-RAS, CA-125, HER2/neu, HE4, PTEN, MSI are used for early detection, treatment, and prevention of uterine cancer. …”
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Papillary Carcinoma of Breast: Clinicopathological Characteristics, Management, and Survival by Bushra Rehman, Anam Mumtaz, Barka Sajjad, Namra Urooj, Sameen Mohtasham Khan, M. Toqeer Zahid, Huma Mannan, M. Zulqarnain Chaudhary, Amina Khan, M. Asad Parvaiz

“…Only two patients were ER negative (both IPC). HER-2 Neu was positive in 3 patients only, out of which 2 died of progressive disease (one EPC and one IPC). …”
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Comparing the Prognostic Value of PTEN and Akt Expression with the Mitotic Activity Index in Adjuvant Chemotherapy-Treated Node-Negative Breast Cancer patients aged <55 years by Emiel A. M. Janssen, Håvard Søiland, Ivar Skaland, Einar Gudlaugson, Kjell H. Kjellevold, Arne Nysted, Jon-Arne Søreide, Jan P. A. Baak

“…The MAI was the strongest prognosticator (Hazard Ratio = HR = 2.9, p = 0.01). Her2Neu/p110α/Akt/mTOR features have no additional prognostic value to the MAI. …”
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A Rare Case Report: Primary Vulvar Adenocarcinoma of Mammary Gland Type by Dai X, Lei H, Jie R

“…The tumor cells were positive for SOX10, TRPS1, and E-cadherin, and negative for ER, PR, and HER-2/neu, ruling out metastatic breast carcinoma. …”
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Contrast-Enhanced Mammography in the Diagnosis of Breast Angiosarcoma by Maya Grisaru Kacen, Nikhil Sangle, Anat Kornecki

“…She had a history of a stage I (T1bN0M0) right breast invasive mammary carcinoma, grade 2 (score 7/9) with receptors ER/PR-negative, HER2/neu-positive, diagnosed four years prior to her current presentation. …”
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Metaplastic Carcinoma Breast in Polycythemic Octogenarian – Lessons Learnt: Case Report by Swarup Prabhu, Munish Malhotra, Naresh Saidha, Ritu Mehta, Surjeet Dwivedi, Tarun Mohan Gupta

“…Clinically was aT4b lesion, sonomammogram showed BIRADS V lesion and core needle breast biopsy features were suggestive of metaplastic carcinoma breast of adenosquamous type, ER, PR-Positive, Her2Neu-Negative. Patient received preoperative hormonal therapy followed by modified radical mastectomy and postoperative adjuvant chemotherapy and hormonal therapy. …”
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Molecular Subtypes of Breast Carcinoma and Their Association with Clinicopathological Features by Ambreen Bari, Sumayyah Shawana

“…Immunohistochemical analysis was done for ER, PR, HER 2 Neu, and Ki-67 and the findings were statistically analyzed for association with clinicopathological parameters. …”
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Metastatic Extramammary Paget’s Disease of Scrotum Responds Completely to Single Agent Trastuzumab in a Hemodialysis Patient: Case Report, Molecular Profiling and Brief Review of t... by Peter Barth, Essel Dulaimi Al-Saleem, Kristin W. Edwards, Sherri Z. Millis, Yu-Ning Wong, Daniel M. Geynisman

“…We report a case of a complete response to single agent trastuzumab in a hemodialysis patient with metastatic Her2/neu overexpressed EMPD of the scrotum. Molecular profiling of his case as well as 12 other EMPD and 8 mammary Paget disease (MPD) cases was completed and revealed multiple biomarker aberrations. …”
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Lymphoepithelioma-Like Carcinoma of the Breast: A Case Report Unveiling Several Clinical and Histopathological Challenges by Tarek Aridi, Mohamad Fawwaz, Ahmad Kassab, Marwan Bahmad, Faisal Houcheimi, Mohamad Mshiek, Fouad Boulos, Ali Kanj, Ghassan Ramadan, Hisham F. Bahmad, Najla Fakhruddin

“…The tumor is negative for estrogen and progesterone receptors and did not overexpress HER2/neu. Routine tests for clearance before surgery were performed, and patient was managed by a modified radical mastectomy with axillary lymph node dissection showing no residual tumor. …”
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Canine Mammary Tumors as a Potential Model for Human Breast Cancer in Comparative Oncology by Amirhossein Razavirad, Sanaz Rismanchi, Pejman Mortazavi, Ahad Muhammadnejad

“…In total, 64 canine mammary tumors were selected to study the most common markers, which are applicable for human breast cancer treatment, including estrogen and progesterone receptors (ER and PR), human epidermal growth factor (HER2/neu), Ki67, and cyclooxygenase 2 (Cox2). Immunohistochemistry (IHC) was used to assess the protein expression. …”
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Genetics of Endometrial Cancers by Tsuyoshi Okuda, Akihiko Sekizawa, Yuditiya Purwosunu, Masaaki Nagatsuka, Miki Morioka, Masaki Hayashi, Takashi Okai

“…In contrast, p53 mutations or Her2/neu overexpression are more frequent in non-endometrioid tumors. …”
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Practical Consequences Resulting from the Analysis of a 21-Multigene Array in the Interdisciplinary Conference of a Breast Cancer Center by Hans-Ullrich Voelker, Lea Frey, Annette Strehl, Michael Weigel

“…In 50 hormone- receptor-positive, Her2neu-negative carcinomas of the breast with no or only minimal lymph node involvement (max. pT1a) we initiated an Oncotype DX® multigene assay in addition to the evaluation of usual parameters. …”
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Paget’s disease of the breast: a contemporary perspective by O. O. Yemelyanova, A. D. Zikiryakhodzhaev, N. N. Volchenko, V. V. Efanov

“…Significant prognostic factors, e.g. the invasive component of Paget’s cancer, the involvement status of regional lymph nodes, morphological criteria, the grade of malignancy, overexpression of epidermal growth factor Her2/neu, the presence of BRCA 1/2 and CHEK2 gene mutations, as well as age, affect the prognosis of Paget’s disease. …”
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