宁夏陆生野生动物疫源疫病监测工作现状及对策 by 何鑫, 王卫东

“…宁夏地处"中亚"和"东亚-澳大利亚"两大国际候鸟迁徙通道的重叠覆盖区,是候鸟迁徙过程中重要的停歇地、取食地、栖息地,野生动物资源特别是鸟类资源十分丰富。2005～2012年,宁夏境内连续发生4起H5N1高致病性禽流感疫情,也是野生鸟类感染、传播疫病的高发地区,因此,宁夏以禽流感为主的陆生野生动物疫源疫病监测工作十分重要。…”
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Convalescent plasma therapy in severe coronavirus disease-2019: A narrative review by Rasmi Ranjan Sahoo, Kasturi Hazarika, Prashant Bafna, Manesh Manoj, Anupam Wakhlu

“…It was also effective in reducing the mortality and viral load in severe acute respiratory syndrome, H5N1, H1N1, and Middle East Respiratory Syndrome. …”
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Epidemic spread of influenza viruses: The impact of transient populations on disease dynamics by Karen R. Ríos-Soto, Baojun Song, Carlos Castillo-Chavez

“…The recent H1N1 ('swine flu') pandemic and recent H5N1 ('avian flu') outbreaks have brought increased attention to the study of the role of animal populations as reservoirs for pathogens that could invade human populations. …”
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HDAC1 and HDAC2 Are Involved in Influenza A Virus-Induced Nuclear Translocation of Ectopically Expressed STAT3-GFP by Jessica Leong, Matloob Husain

“…Particularly, the evolution and increased interspecies and intercontinental transmission of avian IAV H5N1 subtype highlight the importance of continuously studying the IAV and identifying the determinants of its pathogenesis. …”
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HISTORY OF HIGHLY PATHOGENIC AVIAN INFLUENZA ERADICATION IN RUSSIAN FEDERATION IN 2016–2017 by M. S. Volkov, V. N. Irza, A. V. Varkentin

“…Specific properties of H5N8 disease progression and clinical manifestation are demonstrated against H5N1 disease. Data of epidemic investigations of the virus introduction to the closed-type farms are integrated. …”
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Short-term health system responses to epidemics across hard to reach areas in sub-Saharan Africa: A scoping review protocol. by Annette A Murunga, Ben Ngoye, Francis P Wafula, Gilbert O Kokwaro

“…In the past 20 years, the sub-Saharan region has witnessed a marked increase in the number of outbreaks in pandemics, such as cholera, dengue, A/H5N 1 influenza among others. While efforts toward containment have been individually studied, we have no recent studies that examine them collectively in order to draw appropriate comparisons, no recent studies that have especially focused on hard-to-reach areas, and none that have applied a health systems lens. …”
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Research Note: Novel reassortant avian influenza A(H9N2) Viruses in Wild Birds in Shanghai, China, 2020–2023 by Jie Hu, Yuting Xu, Min Ma, Chenyao Zhao, Yue Yuan, Guimei He

“…The nine H9N2 viruses were classified into seven genotypes, and some of them could contribute internal genes to recently circulating HPAI A(H5N8) and A(H5N1) viruses of clade 2.3.4.4b. These results highlight the importance of active surveillance of AIVs in wild birds to comprehend viral ecology and evaluate potential transmission risk in poultry and humans.…”
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流感病毒样颗粒疫苗研究进展

“…VLP不含有病毒核酸,不能自主复制,因此无致病性,在疫苗研发中具有广泛的应用前景。现已有H1N1、H3N2、H5N1、H7N1、H5N3及H9N2型流感VLP合成的报道,动物实验证明这些VLP可诱导产生保护性免疫应答?…”
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Emergence of a novel reassortant highly pathogenic avian influenza clade 2.3.4.4b A(H5N2) Virus, 2024 by Rabeh El-Shesheny, Mokhtar Gomaa, Mohamed El Sayes, Mina Nabil Kamel, Ahmed El Taweel, Omnia Kutkat, Mohamed GabAllah, Amany Elkhrsawy, Hager Emam, Yassmin Moatasim, Ahmed Kandeil, Pamela P. McKenzie, Richard J. Webby, Mohamed Ahmed Ali, Ghazi Kayali

“…Genomic and phylogenetic analyses revealed a novel genotype produced by the reassortment of an A(H5N1) clade 2.3.3.4b virus with an A(H9N2) G1-like virus. …”
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Global avian influenza situation (2019–2022). Host range expansion asevidence of high pathogenicity avian influenza virus evolution by M. V. Zhiltsova, T. P. Akimova, A. V. Varkentin, M. N. Mitrofanova, A. V. Mazneva, V. P. Semakina, E. S. Vystavkina

“…The change in the ratio between the virus types starting from 2020, when H5N8 subtype was responsible for the overwhelming number of the disease outbreaks reported, until 2022, when an obvious predominance of H5N1 subtype was detected is demonstrated. A noticeable expansion of the disease-affected areas in Central and South America, the influence of migration, anthropogenic and other factors on influenza spread are highlighted. …”
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Development of real-time RT-PCR for N2 subtype avian influenza RNA-virus detection by P. B. Akshalova, A. V. Andriyasov, L. O. Scherbakova, S. N. Kolosov, N. G. Zinyakov, I. A. Chvala, D. B. Andreychuk

“…The real-time RT-PCR assay was tested for its specificity using AI virus isolates of different neuraminidase subtypes (H5N8, H3N6, H4N6, H5N1, H10N7) as well as samples containing other RNA-viruses: Newcastle disease virus, infectious bronchitis virus and infectious bursal disease virus. …”
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Вірусні пневмонії в дітей: сьогодення і майбутнє by L.I. Chernyshova, A.V. Chernyshov

“…Після появи тяжкого гострого респіраторного синдрому (SARS), вірусу пташиного грипу A (H5N1) та вірусу пандемічного грипу A (H1N1) у 2009 р. особлива увага була привернута до важливої ролі респіраторних вірусів як причин тяжкої пневмонії. …”
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Evaluation of NxTAG Respiratory Pathogen Panel and Comparison with xTAG Respiratory Viral Panel Fast v2 and Film Array Respiratory Panel for Detecting Respiratory Pathogens in Naso... by K. H. Chan, K. K. W. To, P. T. W. Li, T. L. Wong, R. Zhang, K. K. H. Chik, G. Chan, C. C. Y. Yip, H. L. Chen, I. F. N. Hung, J. F. W. Chan, K. Y. Yuen

“…This study evaluated a new multiplex kit, Luminex NxTAG Respiratory Pathogen Panel, for respiratory pathogens and compared it with xTAG RVP Fast v2 and FilmArray Respiratory Panel using nasopharyngeal aspirate specimens and culture isolates of different swine/avian-origin influenza A subtypes (H2N2, H5N1, H7N9, H5N6, and H9N2). NxTAG RPP gave sensitivity of 95.2%, specificity of 99.6%, PPV of 93.5%, and NPV of 99.7%. …”
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The Development of a Novel Broad-Spectrum Influenza Polypeptide Vaccine Based on Multi-Epitope Tandem Sequences by Song Zhao, Junhao Luo, Wenhui Guo, Li Li, Siyu Pu, Libo Dong, Wenfei Zhu, Rongbao Gao

“…Methods: Immunoinformatics tools were used to screen conserved epitopes from different influenza virus subtypes (H1N1, H3N2, H5N1, H7N9, H9N2, and IBV). A polypeptide vaccine, P125-H, was constructed by linking multiple epitopes using Ii-Key technology. …”
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Preparedness, prevention and control related to zoonotic avian influenza by EFSA Panel on Animal Health and Animal Welfare (AHAW), ECDC, Julio Alvarez, Anette Boklund, Sabine Dippel, Fernanda Dórea, Jordi Figuerola, Mette S. Herskin, Virginie Michel, Miguel Ángel Miranda Chueca, Eleonora Nannoni, Søren Saxmose Nielsen, Romolo Nonno, Anja B. Riber, Jan Arend Stegeman, Karl Ståhl, Hans‐Hermann Thulke, Frank Tuyttens, Christoph Winckler, Claire Brugerolles, Thorsten Wolff, Anna Parys, Erika Lindh, Neus Latorre‐Margalef, Marie‐Anne Rameix Welti, Ralf Dürrwald, Ramona Trebbien, Sylvie Van der Werf, Magnus Gisslén, Isabella Monne, Alice Fusaro, Claire Guinat, Alessio Bortolami, Leonidas Alexakis, Theresa Enkirch, Olov Svartstrom, Katriina Willgert, Francesca Baldinelli, Ludovica Preite, Malin Grant, Alessandro Broglia, Angeliki Melidou

“…Globally, human cases remain rare, with the majority overall due to A(H5N1), A(H5N6), A(H7N9) and A(H9N2) that are among the subtypes that tend to have a higher number of adaptive traits. …”
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Delivery of dendritic cells targeting 3M2e-HA2 nanoparticles with a CpG adjuvant via lysosomal escape of Salmonella enhances protection against H9N2 avian influenza virus by Futing Jia, Wenfeng Wang, Yawen Tian, Ainul Zahra, Yingkai He, Chongbo Ge, Tongyu Zhang, Mingyue Wang, Jingshuo Gong, Gerui Zhang, Guilian Yang, Wentao Yang, Chunwei Shi, Jianzhong Wang, Haibin Huang, Xin Cao, Yang Zeng, Nan Wang, Zhannan Wang, Chunfeng Wang, Yanlong Jiang

“…HA2, the neck of the HA protein, and M2e, the extracellular N-terminal structural domain of the M2 protein, are conserved and effective protective antigens.In this study, the HA2 sequences were fused with three M2e copies (H9N2, H1N1 and H5N1) to the norovirus VP1 protein via the SpyTag-SpyCatcher platform to form self-assembled nanoparticles and display antigenic proteins on its surface, yielding pYL262. …”
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