Combined Transplantation of Adipose Tissue-Derived Stem Cells and Endothelial Progenitor Cells Improve Diabetic Erectile Dysfunction in a Rat Model by Qiyun Yang, Wanmei Chen, Chi Zhang, Yun Xie, Yong Gao, Cuncan Deng, Xiangzhou Sun, Guihua Liu, Chunhua Deng

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Experiences and opinions of adults with type 1 diabetes on the android-based open-source closed-loop system in China: a qualitative study by Chaofan Wang, Daizhi Yang, Jinhua Yan, Ping Ling, Mengyun Lei, Ying Ni, Xiaodi Guo, Qingying Huang

“…The scores of the questionnaire on AAPS satisfaction were calculated, and the Mann-Whitney U test was used to compare the results of different sections of the questionnaire.Setting Guangdong Province in China.Participants This study recruited patients with T1D from the Guangdong T1D translational medicine study and the ‘Tang Tang Quan’ T1D online community in China, who participated in a clinical trial on the efficacy and safety of AAPS.Results The study interviewed 20 adults with T1D aged 32±9.94 years. …”
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Anti-diabetic potential of apigenin, luteolin, and baicalein via partially activating PI3K/Akt/Glut-4 signaling pathways in insulin-resistant HepG2 cells by Lingchao Miao, Haolin Zhang, Meng Sam Cheong, Ruting Zhong, Paula Garcia-Oliveira, Miguel A. Prieto, Ka-Wing Cheng, Mingfu Wang, Hui Cao, Shaoping Nie, Jesus Simal-Gandara, Wai San Cheang, Jianbo Xiao

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Predicting risk factors for Epstein-Barr virus reactivation using Bayesian network analysis: a population-based study of high-risk areas for nasopharyngeal cancer by Zhiwen Zeng, Kena Lin, Xueqi Li, Xueqi Li, Tong Li, Xiaoman Li, Jiayi Li, Zule Ning, Qinxian Liu, Shanghang Xie, Sumei Cao, Sumei Cao, Jinlin Du

“…This study aimed to investigate the risk factors for EBV reactivation associated with NPC in high-prevalence areas in China using a Bayesian network (BN) model combined with structural equation modeling tools.MethodsThe baseline information for this study was derived from NPC screening data from a population-based prospective cohort in Sihui City, Guangdong Province, China. We divided the data into a training dataset and a test dataset. …”
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Asiaticoside Attenuates Chronic Restraint Stress-Induced Hippocampal CA1 Neuronal Ferroptosis via Activating BDNF/Nrf2/GPX4 Signaling Pathway by Zhou A, Feng HY, Fan CN, Wang J, Yuan ZY, Xu GH, Li CF, Huang WF, Yi LT

“…An Zhou,1– 3 Hao-Yinghua Feng,4 Chu-Ning Fan,3 Jun Wang,3 Zhong-Yu Yuan,3 Guang-Hui Xu,5 Cheng-Fu Li,6 Wei-Feng Huang,1 Li-Tao Yi3,7,8 1Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian Province, 361003, People’s Republic of China; 2School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen, Fujian Province, 361102, People’s Republic of China; 3Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, Fujian Province, 361021, People’s Republic of China; 4College of Pharmacy, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong province, 510006, People’s Republic of China; 5Xiamen Medicine Research Institute, Xiamen, Fujian Province, 361008, People’s Republic of China; 6Xiamen Hospital of Traditional Chinese Medicine, Xiamen, Fujian Province, 361009, People’s Republic of China; 7Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen, Fujian Province, 361021, People’s Republic of China; 8Fujian Provincial Key Laboratory of Biochemical Technology, Huaqiao University, Xiamen, Fujian Province, 361021, People’s Republic of ChinaCorrespondence: Li-Tao Yi, Department of Chemical and Pharmaceutical Engineering, Huaqiao University, 668 Jimei Avenue, Xiamen, Fujian Province, 361021, People’s Republic of China, Email litaoyi@hqu.edu.cn Wei-Feng Huang, Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, 55 Zhenhai Road, Xiamen, Fujian Province, 361003, People’s Republic of China, Email hwf0625@xmu.edu.cnPurpose: Ferroptosis, characterized by iron-dependent lipid reactive oxygen species accumulation, plays a critical role in the pathophysiology of depression. …”
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Nutrient dynamics and discharge in a coastal sandy beach aquifer by Xuejing WANG, Yifan GUO, Shengchao YU, Qianqian WANG, Hailong LI, Chunmiao ZHENG

“…This study focuses on the coastal sandy beach of Beijin Bay, Guangdong Province. Based on the stratified sampling and analysis of the hydrochemical composition of coastal groundwater, this study investigated the distribution characteristics, migration, and transformation of nutrients in coastal groundwater.The submarine groundwater discharge (SGD) and associated nutrient flux into the sea were also evaluated, exploring the potential environmental impacts on coastal water. …”
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Improved Efficacy of a Predictive Model for Swallowing-Induced Breakthrough Pain Based on a Redefined Delineation Method in Locally Advanced Nasopharyngeal Carcinoma by Jian-Da Sun, MD, Ze-Kai Chen, MM, Shu-Peng Liu, PhD, Feng Ye, MD, Ting-Xi Tang, MD, Zhen-Hua Zhou, MD, Han-Bin Zhang, MM, Long-Shan Zhang, MD, Ting Xiao, BS, Lin-Lin Xiao, MM, Xiao-Qing Wang, MD, Jian Guan, MD

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Bedrock modulates the elevational patterns of soil microbial communities by Xianjin He, Ruiqi Wang, Daniel S. Goll, Laurent Augusto, Naoise Nunan, M.D. Farnon Ellwood, Quanzhou Gao, Junlong Huang, Shenhua Qian, Yonghua Zhang, Zufei Shu, Buhang Li, Chengjin Chu

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Biochanin A Reduces Inflammatory Injury and Neuronal Apoptosis following Subarachnoid Hemorrhage via Suppression of the TLRs/TIRAP/MyD88/NF-κB Pathway by Ling-yun Wu, Zhen-nan Ye, Zong Zhuang, Yongyue Gao, Chao Tang, Chen-hui Zhou, Chun-xi Wang, Xiang-sheng Zhang, Guang-bin Xie, Jing-peng Liu, Meng-liang Zhou, Chun-hua Hang, Ji-xin Shi

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Revisiting the Flaring Activity in Early 2015 of BL Lacertae Object S5 0716+714 by Zhihao Ouyang, Hubing Xiao, Marina Manganaro, Shangchun Xie, Jingyu Wu, Jianzhen Chen, Rui Xue, Gege Wang, Shaohua Zhang, Junhui Fan

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A comparative study of hospitalization costs of TKA inpatients before and after National Volume-based Procurement in Guangdong, China: an interrupted time-series analysis by Anqi Li, Gongduan Li, Dong Han, Manru Fu, Jinghui Chang, Jinghui Chang

“…BackgroundThis study aims to explore the impact of the National Volume-based Procurement Policy in Guangdong Province on hospitalization costs for total knee arthroplasty inpatients.MethodsInterrupted time-series analysis were used to examine the expenses associated with total knee arthroplasty for inpatients at a hospital in Guangzhou between May 10, 2021, and December 26, 2023. …”
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Interleukin-1 Receptor-Associated Kinase-3 Aggravates Neuroinflammatory Injury After Intracerebral Hemorrhage via Activation NF-κB/IL-17A Pathway in Mice by Wang J, Li Y, Tan C, Shao J, Tang W, Kong Q, Sheng W, Ding Z, Li F, Piao J, Lv D, Hu L, Wang Q, Jiang X

“…Jun Wang,1,* Yulong Li,1,* Chunyu Tan,1,* Jinlian Shao,1 Weitai Tang,2 Quan Kong,3 Wenqianjun Sheng,1 Zhiquan Ding,1 Feng Li,1 Jifeng Piao,1 Dingyi Lv,1 Libin Hu,1 Qinghua Wang,1 Xiaodan Jiang1 1Neuromedicine Center, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, People’s Republic of China; 2Department of Neurosurgery, The People’s Hospital of Luoding & Affiliated Luoding Hospital of Guangdong Medical University, Luoding, 527200, People’s Republic of China; 3Neurosurgery Department of Zengcheng Campus, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qinghua Wang; Xiaodan Jiang, Email wqh1123@126.com; jiangxiao_dan@163.comBackground: Neuroinflammatory reactions are crucial factors in secondary brain damage following intracerebral hemorrhage (ICH). …”
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Effectiveness of using implementation frameworks to facilitate the implementation of a stroke management guideline in the traditional Chinese medicine hospitals in China: protocol... by Zhuo Chen, Yefeng Cai, Wenjun He, Yiyuan Cai, Lingrui Liu, Qing Zhao, Sensen lv, Dong (Roman) Xu, Chun Hao, Lanping Zhang, Pengfei Guo, Yuning Shi

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Impact of zero-markup consumable policy and national procurement of coronary stents on hospitalization expenses: an interrupted time series analysis by Shao-long Wu, Shao-long Wu, Kun Wang, Xin Yang, Ning Liu, Ning Liu, Wen-xin Zou, Xiao-wei Li, Dan-hua Huang, Tian-hao Yu

“…The public hospitals in Guangdong province had implemented the zero-markup policy and national procurement policy for coronary stents. …”
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Systemic Immune-Inflammation Index (SII) and Neutrophil-to-Lymphocyte Ratio (NLR): A Strong Predictor of Disease Severity in Large-Artery Atherosclerosis (LAA) Stroke Patients by Liu K, Yang L, Liu Y, Zhang Y, Zhu J, Zhang H, He Z

“…Keting Liu,1,2,* Li Yang,1,* Yang Liu,3 Yun Zhang,1 Juncheng Zhu,4 Haofeng Zhang,5 Zemin He6 1Department of Neurology, Chengdu Seventh People’s Hospital (Affiliated Cancer Hospital of Chengdu Medical College), Chengdu, Sichuan Province, 610213, People’s Republic of China; 2Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, 510515, People’s Republic of China; 3Department of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, 610075, People’s Republic of China; 4Department of Radiology, Chengdu Seventh People’s Hospital (Affiliated Cancer Hospital of Chengdu Medical College), Chengdu, Sichuan Province, 610213, People’s Republic of China; 5Department of Information, Chengdu Seventh People’s Hospital (Affiliated Cancer Hospital of Chengdu Medical College), Chengdu, Sichuan Province, 610213, People’s Republic of China; 6Department of Thoracic Surgery, The First People’s Hospital of Shuangliu District (West China Airport Hospital of Sichuan University), Chendu, Sichuan Province, 610200, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zemin He, Email 993092572@qq.comBackground: Systemic immune-inflammation index (SII) and neutrophil-to-lymphocyte ratio (NLR) are novel inflammatory markers based on neutrophil, platelet and lymphocyte counts. …”
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The contextual adaptation and educational impacts of the mhGAP-IG to address child mental and behavioral disorder treatment gap in China: A mixed-method study by Meng Zheng, Yi Zhang, Feng Chen, Ang Chen, Di Kong, Kun Xie, Jie Li, Brian James Hall, Andre M.N. Renzaho, Jian-hui Gao, Dao-meng Cheng, Qing Zou, Xin-yuan Zhong, Qi-mei Yu, Wen Chen

“…This study sought to adapt the CMBDs-related components of the mhGAP-IG to the local context and assess the educational impacts of the adapted CMBDs-mhGAP-IG in non-specialized settings in Guangdong Province, China. Contextual adaptation was conducted through a four-step process guided by the Consolidated Framework for Implementation Research (CFIR) and the Ecological Validity Model (EVM). …”
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Artificial intelligence-based prediction of second stage duration in labor: a multicenter retrospective cohort analysisResearch in context by Xiaoqing Huang, Xiaodan Di, Suiwen Lin, Minrong Yao, Suijin Zheng, Shuyi Liu, Wayan Lau, Zhixin Ye, Zilian Wang, Bin Liu

“…Data from three hospitals in Guangdong Province was selected as derivation set, and a geographically independent dataset from Fujian Province as the external validation set. …”
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Morphological Characteristics, Mitochondrial Genome, and Evolutionary Insights Into a New Sea Squirt From the Beibu Gulf by Yichuan Zhang, Yuting Qin, Yueying Wu, Liping Liu, Wenguang Zhang, Ling Ding, Xiangpei Ya, Zhiting Wen, Kuaili Feng, Hong Wang, Yujun Wang

“…ABSTRACT A new species of the genus Microcosmus was described in this study based on specimens collected from the coast of Xilian Town, Xuwen County, Zhanjiang, Guangdong Province, China. The morphological and molecular characteristics of this new species, Microcosmus sp. z YZ‐2024 (YZ‐2024), distinguish it from other sea squirts. …”
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Associations of dietary choline intake and kidney function with hyperuricemia in Chinese children and adolescents: a cross-sectional studyResearch in context by Chengping Li, Jing Li, Zhiquan Diao, Lianhong Chen, Siwen Yu, Lianlong Yu, Qianrang Zhu, Xiaomei Dong, Yiya Liu, Tao Liu, Dan Liu

“…Funding: This work was supported by the National Natural Science Foundation of China (82003443, 42375180), the Natural Science Foundation of Guangdong Province of China (2024A1515012088), and the Construction of High-level University of Guangdong (G624330422).…”
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Risk of All-Cause Mortality in Mild Chronic Obstructive Pulmonary Disease: Evidence From the NHANES III and 2007–2012 by Zou W, Ou J, Wu F, Xiao S, Deng Z, Li H, Wang Z, Tang G, Liu S, Ye D, Zhu D, Hu J, Ran P

“…Weifeng Zou,1,2,* Jie Ou,1,2,* Fan Wu,3,4,* Shan Xiao,5 Zhishan Deng,3 Haiqing Li,3 Zihui Wang,3 Gaoying Tang,3 Shuling Liu,1 Dong Ye,6 Dongshuang Zhu,2 Jinxing Hu,1 Pixin Ran3,4 1State Key Laboratory of Respiratory Disease, Guangzhou Chest Hospital, Guangzhou, People’s Republic of China; 2Department of Pulmonary and Critical Care Medicine, Shufu County People’s Hospital, Kashgar region, Xinjiang, People’s Republic of China; 3State Key Laboratory of Respiratory Disease & Guangzhou Institute of Respiratory Health & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China; 4Guangzhou National Laboratory, Guangzhou, People’s Republic of China; 5Department of Pulmonary and Critical Care Medicine, Shenzhen Longgang District Central Hospital, Shenzhen, People’s Republic of China; 6Department of Internal Medicine, Guangdong Province Second People’s Hospital, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fan Wu; Pixin Ran, State Key Laboratory of Respiratory Disease & Guangzhou Institute of Respiratory Health & National Center for Respiratory Medicine & National Clinical Research Center for Respiratory Disease & The First Affiliated Hospital of Guangzhou Medical University, 195 Dongfeng Xi Road, Guangzhou, 510120, People’s Republic of China, Email wu.fan@vip.163.com; pxran@gzhmu.edu.cnBackground: It is unclear whether patients with Global Initiative for Chronic Obstructive Lung Disease stage 1 (mild) chronic obstructive pulmonary disease (COPD) have a higher risk of all-cause mortality than participants with normal spirometry results.Methods: We used the data from the National Health and Nutrition Examination Survey (NHANES) III and 2007– 2012, which included participants aged 20– 79 years, to investigate whether patients with mild COPD (whole population and subgroups) have a higher risk of all-cause mortality than participants with normal spirometry. …”
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