Revisiting the Flaring Activity in Early 2015 of BL Lacertae Object S5 0716+714 by Zhihao Ouyang, Hubing Xiao, Marina Manganaro, Shangchun Xie, Jingyu Wu, Jianzhen Chen, Rui Xue, Gege Wang, Shaohua Zhang, Junhui Fan

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Legal Disputes of Emigrant Periodical Publishers from the End of the 19th Century to 1904 by Remigijus Misiūnas

“…Conversely, the press opposing “Saulė” presented the case as a matter of great significance, serving Lithuanian interests, and depicted the initiator of the case almost as a hero sacrificing for the good of the emigrant community, using colourful epithets and emotional expressions (similar to “Saulė”). …”
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Clinical features of early multiple sclerosis by I. Čelpačenko, R. Stankevičiūtė, M. Malciūtė, R. Balnytė

“…Its heterogeneous presentation in combination with various conditions mimicking MS presents great diagnostic difficulties. Delayed treatment increases the risk of disability, therefore, establishing a clear phenotype of early MS can help in a more efficient diagnostic process. …”
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Challenges and Opportunities for Data Sharing Related to Artificial Intelligence Tools in Health Care in Low- and Middle-Income Countries: Systematic Review and Case Study From Tha... by Aprajita Kaushik, Capucine Barcellona, Nikita Kanumoory Mandyam, Si Ying Tan, Jasper Tromp

“… BackgroundHealth care systems in low- and middle-income countries (LMICs) can greatly benefit from artificial intelligence (AI) interventions in various use cases such as diagnostics, treatment, and public health monitoring but face significant challenges in sharing data for developing and deploying AI in health care. …”
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Modeling the quality of tax audit based on the acceptance of legal taxpayers in business by Mohsen Hajibabaei, Sina Kheradyar, Mojtaba Malekichoobari

“…Tax audit criteria have a great impact on audit quality (Brezina et al, 2022). …”
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Identifying factors affecting the distribution strategy in the food industry with the attitude of marketing and online sales by solmaz seyedghafouri, Vahid nasehifar, Farid askari

“…In order to apply these methods correctly, strategic marketing planning must be done in businesses, and this has a great impact on pricing and sales (Chen et al, 2021). …”
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Magnitude and dynamics of the T-cell response to SARS-CoV-2 infection at both individual and population levels by Thomas M. Snyder, Rachel M. Gittelman, Mark Klinger, Damon H. May, Edward J. Osborne, Ruth Taniguchi, H. Jabran Zahid, Ian M. Kaplan, Jennifer N. Dines, Matthew T. Noakes, Ravi Pandya, Xiaoyu Chen, Summer Elasady, Emily Svejnoha, Peter Ebert, Mitchell W. Pesesky, Patricia De Almeida, Hope O’Donnell, Quinn DeGottardi, Gladys Keitany, Jennifer Lu, Allen Vong, Rebecca Elyanow, Paul Fields, Hussein Al-Asadi, Julia Greissl, Lance Baldo, Simona Semprini, Claudio Cerchione, Fabio Nicolini, Massimiliano Mazza, Ottavia M. Delmonte, Kerry Dobbs, Rocio Laguna-Goya, Gonzalo Carreño-Tarragona, Santiago Barrio, Luisa Imberti, Alessandra Sottini, Eugenia Quiros-Roldan, Camillo Rossi, Andrea Biondi, Laura Rachele Bettini, Mariella D’Angio, Paolo Bonfanti, Miranda F. Tompkins, Camille Alba, Clifton Dalgard, Vittorio Sambri, Giovanni Martinelli, Jason D. Goldman, Jason D. Goldman, James R. Heath, Helen C. Su, Luigi D. Notarangelo, Estela Paz-Artal, Joaquin Martinez-Lopez, Bryan Howie, Jonathan M. Carlson, Harlan S. Robins

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Bryostatin-1 enhances the proliferation and functionality of exhausted CD8+ T cells by upregulating MAP Kinase 11 by Ling Li, Manzhi Zhao, Marjan van Meurs, Inge Brouwers-Haspels, Renske J. H. den Dekker, Merel E. P. Wilmsen, Dwin G. B. Grashof, Harmen J. G. van de Werken, Shringar Rao, Casper Rokx, Yvonne M. Mueller, Peter D. Katsikis

“…RNA-seq revealed that mitogen-activated protein kinases (MAPK) 11 was significantly downregulated in exhausted CD8+ T cells, however, it greatly upregulated after bryostatin-1 treatment. …”
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Targeting deubiquitinase USP7-mediated stabilization of XPO1 contributes to the anti-myeloma effects of selinexor by Junying Wang, Mengping Chen, Jinxing Jiang, Yike Wan, Xin Li, Minyue Zhang, Fei Xiao, Lu Zhong, Hua Zhong, Zhaoyu Qin, Jian Hou

“…However, intrinsic and acquired drug resistance constitute great challenges. SEL has been reported to promote the degradation of XPO1 protein in tumor cells. …”
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Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery by Arda Halu, Sarvesh Chelvanambi, Julius L. Decano, Joan T. Matamalas, Mary Whelan, Takaharu Asano, Namitra Kalicharran, Sasha A. Singh, Joseph Loscalzo, Masanori Aikawa

“…Abstract Background Large-scale pharmacogenomic resources, such as the Connectivity Map (CMap), have greatly assisted computational drug discovery. However, despite their widespread use, CMap-based methods have thus far been agnostic to the biological activity of drugs as well as to the genomic effects of drugs in multiple disease contexts. …”
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Differential Role of NKG2A/HLA-E Interaction in the Outcomes of Bladder Cancer Patients Treated with <i>M. bovis</i> BCG or Other Therapies by Inmaculada Ruiz-Lorente, Lourdes Gimeno, Alicia López-Abad, Pedro López Cubillana, Tomás Fernández Aparicio, Lucas Jesús Asensio Egea, Juan Moreno Avilés, Gloria Doñate Iñiguez, Pablo Luis Guzmán Martínez-Valls, Gerardo Server, Belén Ferri, José Antonio Campillo, María Victoria Martínez-Sánchez, Alfredo Minguela

“…<b>Background</b>: Immunotherapy is gaining great relevance in both non-muscle-invasive bladder cancer (NMIBC), with the use of bacille Calmette–Guerin (BCG), and in muscle-invasive BC (MIBC) with anti-checkpoint therapies blocking PD-1/PD-L1, CTLA-4/CD80-CD86, and, more recently, NKG2A/HLA-E interactions. …”
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Phenotypic diversity of CTCs and tdEVs in liquid biopsies of tumour-draining veins is linked to poor prognosis in colorectal cancer by Stefan A. Cieslik, Andrés G. Zafra, Christiane Driemel, Monica Sudarsanam, Jan-Philipp Cieslik, Georg Flügen, Levent Dizdar, Andreas Krieg, Sascha Vaghiri, Hany Ashmawy, Stephen Fung, Miriam Wilms, Leon W. M. M. Terstappen, Afroditi Nanou, Hans Neubauer, Nuh N. Rahbari, Wolfram T. Knoefel, Nikolas H. Stoecklein, Rui P. L. Neves

“…Abstract Background Circulating tumour cells (CTCs) and tumour-derived extracellular vesicles (tdEVs) have great potential for monitoring therapy response and early detection of tumour relapse, facilitating personalized adjuvant therapeutic strategies. …”
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Implementing and evaluating the comprehensive integration of physical activity into a major health system: study design and protocol by Alex Ewing, Mark Stoutenberg, Jennifer L Trilk, Christopher Wichman, Paul A Estabrooks, John M Brooks, Meenu Jindal, James Rosemeyer, Leah M Schumacher, Lia K McNulty, Stephanie Eskuri, Frankie Bennett

“…Introduction The healthcare sector has great potential for promoting physical activity (PA) for chronic disease prevention, treatment and management; however, multiple adoption and implementation barriers exist, ranging from practice integration to information flow. …”
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Cucumeropsis mannii seed oil shields against cyclophosphamide-induced hepatorenal toxicity by modulating redox imbalance and iNOS/IL-β1 signalling in rats by Amaka Cecilia Agbara, Ejike Daniel Eze, Christian Emeka Offor, Adam Moyosore Afodun, Ezebuilo Ugbala Ekpono, Peter Chinedu Agu, Chinyere Aloke, Nkeiru Nwaamaka Ezeani, Emmanuel Orire Ikuomola, Ekom Monday Etukudo, Ilemobayo Victor Fasogbon, Angela Mumbua Musyoka, Patrick Maduabuchi Aja

“…When cyclophosphamide was given to Wistar albino rats, it greatly decreased the activities of catalase (CAT) and superoxide dismutase (SOD), but it increased the activities of iNOS and the levels of MDA and IL-1β. …”
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Effects of group communication norms on daily steps in a team-based financial incentive mobile phone intervention in Shanghai, China by Yingnan Jia, Yingcheng Xiao, Hao Chen, Klaus Gebel, Chengshu Li, Shuangyuan Sun, Qinping Yang, Siyuan Wang, Li Zhang, Jing Wang, Minna Cheng, Dantong Gu, Yan Shi, Ding Ding

“…Abstract Background Mobile technology offers great potential for physical activity promotion, especially by facilitating online communication, however, the impact of group communication norms on intervention effectiveness remains unclear. …”
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Phase II clinical trial assessing the addition of hyperthermia to salvage concurrent chemoradiotherapy for unresectable recurrent head and neck cancer in previously irradiated pati... by Kai-Lin Yang, Mau-Shin Chi, Chung-Yu Hao, Hui-Ling Ko, Yi-Ying Huang, Ren-Hong Wu, Hung-Chih Lai, Ying-Chu Lin, Sheng-Po Hao, Kwan-Hwa Chi

“…Conclusions Adding hyperthermia to salvage CCRT greatly enhances tumor response and survival rates compared to historical re-irradiation outcomes for previously irradiated unresectable recurrent head and neck cancer, with manageable toxicities. …”
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Optimization of osmotic pressure swelling method in the process of hemoglobin extraction from red blood cells by ZHANG Honghui, ZHOU Wentao, HAO Shasha, WANG Hong, LIU Jiaxin, YANG Chengmin, LI Shen, LI Fengjuan

“…[Conclusion] Compared with the original preparation process, the hemoglobin extraction process which optimized through orthogonal experiments greatly reduces the cell membrane fragmentation rate and minimizes the entry of cell membrane matrix into the target solution, ensuring a slightly higher hemoglobin dissolution rate, and reducing the preparation difficulty for the subsequent cell membrane separation and further purification.…”
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Practice and experience of pre-examination triage mode in the emergency department during COVID-19 epidemic (新型冠状病毒感染流行期间急诊科预检分诊模式的实践及体会)... by HOU Pengxiao (候朋晓), LI Ying (李影), LIU Fusheng (刘福生), REN Yaxing (任亚星), QIN Shasha (秦沙沙), HAN Jianping (韩建萍)

“…Nurses in the Emergency departments of hospitals had faced great medical pressure and risks during COVID-19 epidemic. …”
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First-in-human dose escalation trial to evaluate the clinical safety and efficacy of an anti-MAGEA1 autologous TCR-transgenic T cell therapy in relapsed and refractory solid tumors by Ignacio I Wistuba, Mamta Kalra, Linus Backert, Martin Wermke, Edwin R Parra, Jason John Luke, Apostolia M Tsimberidou, Sebastian Bunk, Mohammad B Hossain, Andrea Mayer-Mokler, Arun Satelli, Norbert Hilf, Steffen Walter, Cedrik M Britten, Van K Morris, Tobias A W Holderried, Winfried H Alsdorf, Katrin Wetzko, Borje S Andersson, Sandra Grund-Gröschke, Katrin Aslan, Anantha Marisetty, Swapna Satam, Jens Hukelmann, M Alper Kursunel, Karine Pozo, Andreas Acs, Melissa Baumeister, Claudia Wagner, Oliver Schoor, Ali S Mohamed, Delfi Krishna

“…Rationale of the trial Although the use of engineered T cells in cancer immunotherapy has greatly advanced the treatment of hematological malignancies, reaching meaningful clinical responses in the treatment of solid tumors is still challenging. …”
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Dog demography and ecology with reference to rabies in the Amhara region, Ethiopia by Liuel Yizengaw Adnie, Wudu Temesgen Jemberu, Adane Bahiru Woreta, Adugna Berju, Araya Mengistu, Zeleke Tesema Wondie, Wassie Molla, Sefinew Alemu Mekonnen

“…However, as the study did not include stray dogs, which have great contributions to the spread of rabies, the information should be used with this caveat into consideration.…”
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