Delivery of dendritic cells targeting 3M2e-HA2 nanoparticles with a CpG adjuvant via lysosomal escape of Salmonella enhances protection against H9N2 avian influenza virus by Futing Jia, Wenfeng Wang, Yawen Tian, Ainul Zahra, Yingkai He, Chongbo Ge, Tongyu Zhang, Mingyue Wang, Jingshuo Gong, Gerui Zhang, Guilian Yang, Wentao Yang, Chunwei Shi, Jianzhong Wang, Haibin Huang, Xin Cao, Yang Zeng, Nan Wang, Zhannan Wang, Chunfeng Wang, Yanlong Jiang

“…Avian influenza virus (AIV) subtype H9N2 still poses a great threat to the poultry farming industry and public health worldwide, and the development of a new influenza vaccine that is safe and conservative and able to address influenza virus mutations is highly promising for application. …”
Get full text

Systematic identification of secondary bile acid production genes in global microbiome by Yuwei Yang, Wenxing Gao, Ruixin Zhu, Liwen Tao, Wanning Chen, Xinyue Zhu, Mengping Shen, Tingjun Xu, Tingting Zhao, Xiaobai Zhang, Lixin Zhu, Na Jiao

“…To bridge this gap, we employed hidden Markov models to systematically search in a large-scale and high-quality search library comprising 28,813 RefSeq multi-kingdom microbial complete genomes, enabling us to construct a secondary bile acid production gene catalog. This catalog greatly expanded the distribution of secondary bile acid production genes across 11 phyla, encompassing bacteria, archaea, and fungi, and extended to 14 habitats spanning hosts and environmental contexts. …”
Get full text

Changes in laboratory value improvement and mortality rates over the course of the pandemic: an international retrospective cohort study of hospitalised patients infected with SARS... by Ramakanth Kavuluru, Xuan Wang, Paul Avillach, Florence Bourgeois, Kee Yuan Ngiam, Gabriel A Brat, Isaac Kohane, Tianxi Cai, Yuk-Lam Ho, Yuan Luo, Harrison G Zhang, Kelly Cho, Vincent Benoit, Antoine Neuraz, Chuan Hong, Sehi L'Yi, Griffin Weber, Bryce W Q Tan, Alba Gutiérrez-Sacristán, Clara-Lea Bonzel, Nathan P Palmer, Alberto Malovini, Valentina Tibollo, Meghan R Hutch, Molei Liu, Riccardo Bellazzi, Luca Chiovato, Fernando J Sanz Vidorreta, Trang T Le, William Yuan, Bertrand Moal, Michele Morris, David A Hanauer, Sarah Maidlow, Kavishwar Wagholikar, Shawn Murphy, Hossein Estiri, Adeline Makoudjou, Patric Tippmann, Jeffery Klann, Robert W Follett, Nils Gehlenborg, Gilbert S Omenn, Zongqi Xia, Arianna Dagliati, Shyam Visweswaran, Lav P Patel, Danielle L Mowery, Emily R Schriver, Malarkodi Jebathilagam Samayamuthu, Sara Lozano-Zahonero, Daniela Zöller, Amelia L M Tan, Byorn W L Tan, John H Holmes, Petra Schubert, Brett K. Beaulieu-Jones, Miguel Pedrera-Jiménez, Noelia García-Barrio, Pablo Serrano-Balazote, Andrew South

“…The mortality rates within each risk category significantly decreased over time, with the most substantial decrease in the high-risk group (47.1% in March–April 2020 vs 30.8% in November 2020 to January 2021, p<0.001) and a moderate decrease in the intermediate-risk group (21.5% in March–April 2020 vs 14.3% in November 2020 to January 2021, p<0.001).Conclusions Admission profiles of patients hospitalised with SARS-CoV-2 infection did not differ greatly between the first and second waves of the pandemic, but there were notable differences in laboratory improvement rates during hospitalisation. …”
Get full text

Group Psychological Therapy Program in Adult Patients with Congenital Heart Disease and Anxious–Depressive Symptoms by Efrén Martínez-Quintana, Karen Codana-Alcántara, Hector M. Montesdeoca-Naranjo, Marta Isabel García-Suárez, María Pino Fleitas-Álvarez, María Alcántara-Castellano, Alejandro Ruiz-Castellano, Ana González-Isasi, Fayna Rodríguez-González, Esperanza Bosch-Casañas

“…According to CHD complexity, five (28%) patients had mild, six (33%) moderate, and seven (38%) great defects. Patients with CHD scored significantly higher in the Euro quality of life visual analogue scale (7.83 ± 1.4 vs. 7.14 ± 1.6, <i>p</i> = 0.012) and lower in the Beck Depression Inventory-II (12.3 ± 10.9 vs. 18.1 ± 12.1, <i>p</i> = 0.003) post-program than pre-intervention. …”
Get full text

Relevance of the synergy of surveillance and populational networks in understanding the Usutu virus outbreak within common blackbirds (Turdus merula) in Metropolitan France, 2018 by Bouchez-Zacria, Malika, Calenge, Clément, Villers, Alexandre, Lecollinet, Sylvie, Gonzalez, Gaelle, Quintard, Benoit, Leclerc, Antoine, Baurier, Florence, Paty, Marie-Claire, Faure, Éva, Eraud, Cyril, Decors, Anouk

“…In France, it was first detected in birds in 2015, but during summer 2018 the spread of USUV was particularly significant throughout the country, killing mainly common blackbirds (Turdus merula) and to a lesser extent great grey owls (Strix nebulosa), among other captive and non-captive wild bird species. …”
Get full text

Advanced delivery systems for gene editing: A comprehensive review from the GenE-HumDi COST Action Working Group by Alessia Cavazza, Francisco J. Molina-Estévez, Álvaro Plaza Reyes, Victor Ronco, Asma Naseem, Špela Malenšek, Peter Pečan, Annalisa Santini, Paula Heredia, Araceli Aguilar-González, Houria Boulaiz, Qianqian Ni, Marina Cortijo-Gutierrez, Kristina Pavlovic, Inmaculada Herrera, Berta de la Cerda, Emilio M. Garcia-Tenorio, Eva Richard, Sergio Granados-Principal, Arístides López-Márquez, Mariana Köber, Marijana Stojanovic, Melita Vidaković, Irene Santos-Garcia, Lorea Blázquez, Emily Haughton, Dongnan Yan, Rosario María Sánchez-Martín, Loubna Mazini, Gloria Gonzalez Aseguinolaza, Annarita Miccio, Paula Rio, Lourdes R. Desviat, Manuel A.F.V. Gonçalves, Ling Peng, Cecilia Jiménez-Mallebrera, Francisco Martin Molina, Dhanu Gupta, Duško Lainšček, Yonglun Luo, Karim Benabdellah

Get full text

Scandinavia in Lithuanian Diplomacy in 1915-1917 by Sandra Grigaravičiūtė

“…Scandinavia in 1917 meant to Lithuania the possibility to choose between the West-East and North-South geopolitical axis, and the orientation of Lithuania to Scandinavia could be interpreted in two ways: to Germany as orientation to Germany, and to Great Britain - as orientation to Scandinavia and the states of the Entente. …”
Get full text

Design of an improved model using federated learning and LSTM autoencoders for secure and transparent blockchain network transactions by R. Vijay Anand, G. Magesh, I. Alagiri, Madala Guru Brahmam, Balamurugan Balusamy, Chithirai Pon Selvan, Haya Mesfer Alshahrani, Masresha Getahun, Ben Othman Soufiene

“…The work presented here provides a great boost to send secure and very easily transparent transactions across the network, and thus resulted in enhanced network trust and decentralization.…”
Get full text

Rainwater and fog harvesting from solar panels by I. Alazzam, K. Shatanawi, R. Al-Weshah

“…The viability of implementing the method of rainwater and fog harvesting from solar panels will be examined in terms of economic and environmental factors.CONCLUSIONS: The quantity of rainwater gathered in this research with just two solar panels shows great potential for widespread use as a supplementary water supply. …”
Get full text

Home-Based Intervention Tool for Cardiac Telerehabilitation: Protocol for a Controlled Trial by Francesca Mastorci, Maria Francesca Lodovica Lazzeri, Lamia Ait-Ali, Paolo Marcheschi, Paola Quadrelli, Massimiliano Mariani, Rafik Margaryan, Wanda Pennè, Marco Savino, Giuseppe Prencipe, Alina Sirbu, Paolo Ferragina, Corrado Priami, Alessandro Tommasi, Cesare Zavattari, Pierluigi Festa, Stefano Dalmiani, Alessandro Pingitore

“…The increase of mobile health care devices and software has greatly extended self-care capabilities across the spectrum of health care activities. …”
Get full text

Genetic polymorphism of high-molecular-weight glutenin subunit loci in bread wheat varieties in the Pre-Ural steppe zone by A. A. Galimova, A. R. Kuluev, K. R. Ismagilov, B. R. Kuluev

“…However, breeding bread wheat for this trait is very laborious and, therefore, the genotyping of variety samples according to the allelic composition of high-molecular-weight glutenin genes is of great interest. The aim of the study was to determine the composition of high-molecular-weight glutenin subunits based on the identification of the allelic composition of the Glu-1 genes, as well as to identify the frequency of the Glu-1 alleles in bread wheat cultivars that are in breeding work under the conditions of the Pre-Ural steppe zone (PSZ). …”
Get full text

Digital Exclusion and Depressive Symptoms among Older People: Findings from Five Aging Cohort Studies across 24 Countries by Jingjing Wang, Xinran Lu, Sing Bik Cindy Ngai, Lili Xie, Xiaoyun Liu, Yao Yao, Yinzi Jin

“…Digital exclusion varied greatly across countries, ranging from 21.1% in Denmark to 96.9% in China. …”
Get full text

The relationship between self-efficacy, learning burnout, willingness to fulfill the contract and empathy of rural-oriented tuition-waived medical students of China: a cross-sectio... by Xuewen Zhang, Guanqi Han, Chen Feng, Yuxuan Xu, Leyan Gao, Zhen Tan

“…This provides positive suggestions for medical colleges to improve the empathy of students, which is of great practical significance for continuously improving the service quality of general practitioners and ultimately realizing the development of high-quality rural medical and health undertakings. …”
Get full text

A method for evaluating the accessibility of underground auxiliary transportation vehicles in coal mines based on multi feature fusion by Fan JIANG, Yifan LIU, Zhencai ZHU, Chaofan ZHANG, Gongbo ZHOU, Yuxing PENG

“…With the continuous promotion of the construction of smart mines in China, improving the safety and intelligence of auxiliary transportation vehicles is of great practical significance for achieving less manned and unmanned coal mines. …”
Get full text

Environmental, socioeconomic, and sociocultural drivers of monkeypox transmission in the Democratic Republic of the Congo: a One Health perspective by Guangyu Lu, Zeyin Chong, Enyu Xu, Ce Na, Kaixuan Liu, Liying Chai, Pengpeng Xia, Kai Yang, Guoqiang Zhu, Jinkou Zhao, Olaf Müller

“…Understanding the risk factors for disease transmission from a One Health perspective is of great importance in the risk assessment, prevention, and control of zoonotic diseases. …”
Get full text

Comparison of the efficacy of LTCBDE and LCBDE for common bile duct stones: a systematic review and meta-analysis by Bin Zheng, Yixin Lu, Erqi Li, Ziyu Bai, Kaiqian Zhang, Jian Li, Jian Li

“…P = 0.86; I2 = 0%, P = 0.98) and biliary stricture(OR: 0.30, 95% CI: 0.08, 1.09, P = 0.07; I2 = 0%, P = 0.57).ConclusionsLTCBDE is safe, efficient, and of great clinical significance, and is worth promoting to some patients.…”
Get full text

Microfluidic Synthesis of miR-200c-3p Lipid Nanoparticles: Targeting ZEB2 to Alleviate Chondrocyte Damage in Osteoarthritis by Zheng D, Chen T, Yang K, Yin G, Chen Y, Gui J, Xu C, Lv S

“…The ZEB2 expression was greatly elevated following LPS stimulation and dramatically decreased following transfection of miR-200c-3p. …”
Get full text

ANALISIS KEMAMPUAN PENGUASAAN KONSEP IPA TERPADU DAN KEPEDULIAN LINGKUNGAN MAHASISWA MELALUI PENGGUNAAN BAHAN AJAR PENGOLAHAN TEBU SEBAGAI ENERGI TERBARUKAN by Lailatul Nuraini, Supeno Supeno, Sudarti Sudarti, Sri Astutik, Shinta Nuriyah Mahbubiyah Royani

“…Kata Kunci: IPA Terpadu, Penguasaan Konsep, Kesadaran Lingkungan, Tanaman Tebu ABSTRACT   Jember is a regency which has a great potential of sugar cane. Meanwhile, the potential of the processing of sugar cane was not yet to be developed as a learning resource and hence was not able to grow the environment awareness which was caused by the waste of sugar cane factory. …”
Get full text