The Different Effects of IFN-β and IFN-γ on the Tumor-Suppressive Activity of Human Amniotic Fluid-Derived Mesenchymal Stem Cells by Jingchun Du, Anqi Liu, Rui Zhu, Chengbo Zhou, Heng Su, Guie Xie, Yingshan Deng, Xia Xu

“…Current studies have shown that type I or II interferon-modified mesenchymal stem cells have great potential for the application of tumor-targeted therapy, but the underlying mechanism remains largely elusive. …”
Get full text

Effects of Lactobacillus plantarum on Physicochemical Properties and Volatile Flavor Substances of Blueberry Juice during Fermentation and Storage by Maowen LIAO, Chen HAN, Wei LIU, Yanlin LI, Changlin CHEN, Huaiyu YUAN, Yan ZHOU, Ke LI, Huajia LI

“…Furthermore, the physicochemical properties of the blueberry juice had a great change during the fermentation, for example, the content of the total acid gradually increased during the fermentation process, while the pH value showed a significant decreasing trend (P<0.05). …”
Get full text

Mutation in CDC42 Gene Set as a Response Biomarker for Immune Checkpoint Inhibitor Therapy by Kun Wang, Yingying Zhang, Zhaoming Su, Bei Wang, Yuanyang Zhou, Xiaochu Tong, Chengying Xie, Xiaomin Luo, Sulin Zhang, Mingyue Zheng

“…ABSTRACT Background Immune checkpoint inhibitors (ICIs) have achieved great success; however, a subset of patients exhibits no response. …”
Get full text

Phasor-FSTM: a new paradigm for multicolor super-resolution imaging of living cells based on fluorescence modulation and lifetime multiplexing by Luwei Wang, Yue Chen, Jiaqing Guo, Xiaoyu Weng, Wei Yan, Jun Song, Tong Ye, Junle Qu

“…Abstract Multicolor microscopy and super-resolution optical microscopy are two widely used techniques that greatly enhance the ability to distinguish and resolve structures in cellular imaging. …”
Get full text

UTE MRI technical developments and applications in osteoporosis: a review by Soo Hyun Shin, Hee Dong Chae, Hee Dong Chae, Arya Suprana, Arya Suprana, Saeed Jerban, Eric Y. Chang, Eric Y. Chang, Lingyan Shi, Robert L. Sah, Jeremy H. Pettus, Gina N. Woods, Jiang Du, Jiang Du, Jiang Du

“…These UTE-MRI advancements hold great potential for improving the diagnosis and management of osteoporosis and other metabolic bone diseases by providing a more comprehensive assessment of bone quantity and quality.…”
Get full text

Circ_0044516 Regulates miR-136/MAT2A Pathway to Facilitate Lung Cancer Development by Yue-Wei Chen, Qiu-Rong Du, Yu-Juan He, Wen-Shu Chen, Wen-Yang Jiang, Qi Gui, Cheng-Cheng Xu, Wei Wang, Hong-Yun Cheng

“…Moreover, A549 and SPCA1 cell migration and invasion abilities were greatly repressed by circ_0044516 siRNA. Due to accumulating evidence demonstrating the vital role of cancer stem cells, their mechanism of involvement has drawn increasing attention in tumor progression and metastasis research. …”
Get full text

Effect of Drying and Broccoli Leaves Incorporation on the Nutritional Quality of Durum Wheat Pasta by Natalia Drabińska, Mariana Nogueira, Ewa Ciska, Henryk Hubert Jeleń

“…Pasta is a great vehicle for the incorporation of vegetable-derived ingredients to increase the consumption of the health-beneficial components originating from vegetables. …”
Get full text

Daedalus Mega-ichnosites: The Armorican Quartzite Bridge between Villuercas-Ibores-Jara and Naturtejo UNESCO Global Geoparks by Carlos Neto de Carvalho, Andrea Baucon, Ivan Cortijo, Soren Jensen, Jose Maria Barrera, Javier Lopez Caballero

“…The Early Paleozoic oceans were generally characterized by short trophic chains and simple ecological tiering dominated by suspension-feeding organisms. However, the Great Ordovician Biodiversification Event (GOBE) was responsible for the complexification of food webs, increasing depth and diversity of substrate ecospace utilization and increasing benthic competition for resources near the water-substrate interface. …”
Get full text

Key regions aberrantly connected within cerebello-thalamo-cortical circuit and their genetic mechanism in schizophrenia: an fMRI meta-analysis and transcriptome study by Yarui Wei, Ziyu Wang, Kangkang Xue, Xiaoyu Niu, Longyao Ma, Shaoqiang Han, Baohong Wen, Yong Zhang, Huafu Chen, Jingliang Cheng

“…However, these individual studies vary greatly in their methods and findings, and important areas within CTCC and related genetic mechanism are unclear. …”
Get full text

Intracardiac Echocardiography as a Guide for Transcatheter Closure of Patent Ductus Arteriosus by Hironaga Yoshimoto, Maeda Yasuto, Tadashi Inoue, Yoshiyuki Kagiyama, Yozo Teramachi, Ryuta Takase, Yusuke Koteda, Yoshihiro Fukumoto, Motofumi Iemura, Kenji Suda

“…Results. In phase 1, we found great correlation and agreement between ICE and AoG/CCT in PA-D (r = 0.985, bias −0.077 to 0.224), but moderate to poor correlation and agreement in length (r = 0.653, bias −0.491 to 3.065) and Ao-D (r = 0.704, bias 0.738 to 4.732), respectively. …”
Get full text

Questionnaire to Survey Cosmetic Outcomes in Laparoscopic Surgery for Colorectal Cancer by Masaaki Miyo, MD, PhD, Ichiro Takemasa, MD, PhD, Koichi Okuya, MD, PhD, Tatsuya Ito, MD, PhD, Emi Akizuki, MD, PhD, Tadashi Ogawa, MD, PhD, Ai Noda, MD, Masayuki Ishii, MD, PhD, Ryo Miura, MD, Momoko Ichihara, MD, Maho Toyota, MD, Akina Kimura, MD, Mitsugu Sekimoto, MD, PhD

“…Participants who were female, younger, and in the nonmedical group placed great importance on cosmetic outcomes. For all questions regarding body image and cosmesis, SLS had superior scores compared with MLS. …”
Get full text

The influence of prosthetic treatments and implant-supported prostheses on posterior mandibular ridge atrophy: a retrospective cohort study by Alwin Sokolowski, Sandra Huber, Behrouz Arefnia, Anke Pichler, Martin Lorenzoni, Armin Sokolowski

“…Conclusion Bone atrophy in the posterior mandible should be expected to vary greatly with prosthetic designs. Long-term stability is possible with fixed partial prostheses, RPDs are less favorable in the absence of a distal support and bar-retained overdentures on four or more implants exhibited the lowest bone atrophy in fully edentulous mandibles. …”
Get full text

Nociceptor-localized KCC2 suppresses brachial plexus avulsion-induced neuropathic pain and related central sensitization by Hang Xian, Huan Guo, Yuan-Ying Liu, Sui-Bin Ma, Rui Zhao, Jian-Lei Zhang, Hang Zhang, Rou-Gang Xie, Xu-Cheng Guo, Jie Ren, Sheng-Xi Wu, Ceng Luo, Rui Cong

“…The consistent results in both humanity and rodents endow great potential to future transformation of clinical practice.…”
Get full text

Thymosin alpha 1 in the prevention of infected pancreatic necrosis following acute necrotising pancreatitis (TRACE trial): protocol of a multicentre, randomised, double-blind, plac... by Tao Chen, Jing Zhou, Jianfeng Tu, Weiqin Li, XinTing Pan, Wenjian Mao, Lu Ke, Wenhua He, Miao Chen, Chengjian He, Weili Gu, Jingyi Wu, Jingchun Song, Haibin Ni, Junli Sun, Guoxiu Zhang, Weiwei Chen, Bing Xue, Xiangyang Zhao, Min Shao, Yuxiu Liu, Zhihui Tong

“…Therefore, the prevention of IPN is of great clinical value, and immunomodulatory therapy with thymosin alpha 1 may be beneficial. …”
Get full text

Improving the accUracy of Referrals to the emerGency departmEnt of patieNts with chesT pain using the modified HEART score in Emergency Medical Transport (URGENT 2.0): protocol for... by Joan G Meeder, Frits H M Van Osch, Robert T A Willemsen, Braim M Rahel, Lisa D S Frenk, Cees B de Vos, Fabiana G Prestigiacomo, Marcel J W Janssen, Arnoud W van 't Hof

“…Less than 20% of patients with chest pain, transferred to the emergency department (ED), have an acute coronary syndrome (ACS) and the transportation and analysis at the ED of non-ACS patients result in substantial healthcare costs and a great patient burden. Advanced risk stratification, with the help of cardiac troponin measurements, seems crucial to improve prehospital diagnostic accuracy.Methods and analysis The URGENT 2.0 trial is a randomised controlled trial in which the primary objective is to reduce the referral of non-cardiac chest pain (NCCP) patients, using a modified HEART score including a high-sensitivity capillary point-of-care high-sensitivity cardiac troponin I measurement. …”
Get full text

Ginsenosides 20R-Rg3 and Rg5 enriched black ginseng inhibits colorectal cancer tumor growth by activating the Akt/Bax/caspase-3 pathway and modulating gut microbiota in mice by Peng Yu, Weiyin Xu, Yanqi Li, Zhaoyang Xie, Simeng Shao, Jianing Liu, Ying Wang, Long Wang, Hongmei Yang

“…Black ginseng (BG) is of great interest for its anti-cancer property. Its detailed mechanism, however, is still lacking. …”
Get full text

Enhancing environmental models with a new downscaling method for global radiation in complex terrain by A. Druel, J. Ruffault, H. Davi, A. Chanzy, O. Marloie, M. De Cáceres, A. Olioso, F. Mouillot, C. François, K. Soudani, N. K. Martin-StPaul

“…Finally, by using two different PBMs (CASTANEA, a PBM simulating tree growth, and SurEau, a plant hydraulic model simulating hydraulic failure risk), we showed that accounting for fine-resolution radiation can have a great impact on predictions of forest functions.</p>…”
Get full text

Tumor characteristics and survival rate of axillary metastatic breast cancer patients: a three decades retrospective cohort study by Seyed Mohamad Sadegh Mousavi-kiasary, Mahdis Bayat, Fereshteh Abbasvandi, Batoul Khoundabi, Fatemeh Mousavi, Atieh Akbari, Maryam Bagherian, Afsoon Zandi, Behnam Honarvar, Mohammad Esmaeil Akbari

“…Abstract Background: Lymph node (LN) involvement, as an important prognostic factor in breast cancer (BC) patients, has a crucial role in their therapeutic approach. Consequently, a great desire is to thoroughly assess the patients based on their axillary LN status. …”
Get full text

Ecotoxicity of lanthanides to Daphnia magna: insights from elemental behavior and speciation in a standardized test medium by Vignati, Davide A.L., Martin, Loïc A., Poirier, Laurence, Zalouk-Vergnoux, Aurore, Fouque, Chantal, Bojic, Clément, Hissler, Christophe, Cossu-Leguille, Carole

“…Although knowledge on LN ecotoxicology has greatly improved over the last decade, uncertainty persists with regard to their actual hazard and risk in freshwater environments. …”
Get full text

The Influence of Reservoir Composition on the Pore Structure of Continental Shale: A Case Study from the Qingshankou Formation in the Sanzhao Sag of Northern Songliao Basin, NE Chi... by Jianguo Yang, Liu Wang, Shichao Li, Cheng Zuo, Fei Xiao, Yuchu Chen, Yulai Yao, Longhui Bai

“…Determining the pore structure characteristics and influencing factors of continental shale reservoir in the oil generation stage is of great significance for evaluating the shale oil reservoir space and analyzing shale oil enrichment mechanism. …”
Get full text