Preclinical development of a standardized extract of Ilex paraguariensis A.St.-Hil for the treatment of obesity and metabolic syndrome by Sara E.L. Tolouei, Rodrigo Marcon, Fabiana Cardoso Vilela, Cristina Setim Freitas, Melina Heller, Edineia Lemos de Andrade, Sergio José Macedo Júnior, Adara Áurea dos Santos, Ruth Fernandes Rocha, Guilherme Pasetto Fadanni, Naiani Ferreira Marques, Jarbas Mota Siqueira Júnior, João B. Calixto

“…These findings strongly suggest that TI-076 holds great potential for clinical trials aimed at developing a safe phytomedicine for treating obesity and related metabolic diseases.…”
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Study of subterranean biodiversity of the upper Neretva River catchment in Bosnia and Herzegovina by Maja Zagmajster, Ester Premate, Špela Borko, Behare Rexhepi, Vojo Milanović, Anton Brancelj, Michaela Brojer, Christophe Douady, Josef Grego, Milica Jovanović, Florian Malard, Nataša Mori, Vladimir Pešić

“…Further studies are needed to properly highlight the great diversity of the subterranean habitats of the Neretva River catchment and its wider region, and to include this knowledge in conservation strategies. …”
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Chemical profiles of venom glands in queens, foundresses, pre-wintering gynes, and workers in the hornet Vespa velutina nigrithorax by Berville, Laurence, Lucas, Christophe, Haouzi, Mélissa, Khalil, Ali, Gévar, Jérémy, Bagnères, Anne-Geneviève, Darrouzet, Eric

“…Due to its marked invasiveness, this yellow-legged hornet is of great economic and ecological concern, mainly because of the damage it causes to insects in general and bees in particular. …”
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The GWAS-MAP|ovis platform for aggregation and analysis of genome-wide association study results in sheep by A. V. Kirichenko, A. S. Zlobin, T. I. Shashkova, N. A. Volkova, B. S. Iolchiev, V. A. Bagirov, P. M. Borodin, L. С. Karssen, Y. A. Tsepilov, Y. S. Aulchenko

“…In contrast to research in human genetics, GWAS on farm animals often does not meet generally accepted standards (availability of information about effect and reference alleles, the size and direction of the effect, etc.). This greatly complicates the use of GWAS results for breeding needs. …”
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The formation mechanism of geological disasters on loess fill slopes revealed by the deformation characteristics of remolded loess under different stress paths by Shuran Meng, Shuran Meng, Dunyu Lv, Dunyu Lv, Ru Liu, Mancang Yu, Mancang Yu, Jianyu Zhang, Jianyu Zhang

“…When the lateral constraint is reduced to a critical state, the structure is completely unstable, and the deformation develops rapidly in a short time until it is destroyed. This study is of great significance for reducing the occurrence of geological disasters on fill slopes in loess areas.…”
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A novel agricultural drought index based on multi-source remote sensing data and interpretable machine learning by Hao Chen, Ni Yang, Xuanhua Song, Chunhua Lu, Menglan Lu, Tan Chen, Shulin Deng

“…Besides, IMLDI-based agricultural drought risk analysis shows that the Huang-Hai Region and Yunnan, Guizhou, and Guangxi Provinces have a high risk to suffer from severe agricultural droughts. Overall, IMLDI has a great potential to use as a new integrated remote sensing drought index for agricultural drought monitoring.…”
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Emerging Trends and New Developments in Transient Elastography: A Bibliometric and Cocitation Analysis from 1999 to 2017 by Jingjing Gu, Weimian Wang, Ziyuan Zou, Fangze Huang, Chihua Fang, Xun Li, Xiaolong Qi

“…For transient elastography, as a noninvasive assessment of liver fibrosis, its use in the evaluation of liver fibrosis is gradually mature and shows great advantages. Moreover, the field of transient elastography is in a stage of rapid development.…”
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Associations of plasma biomarkers with cerebral perfusion and structure in Alzheimer’s disease by Yong He, Xiaojiao Liu, Fang Liu, Ping Che, Yanxin Zhang, Ruxue Fan, Yuan Li, Wen Qin, Nan Zhang

“…Abstract Plasma biomarkers have great potential in the screening, diagnosis, and monitoring of Alzheimer’s disease (AD). …”
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Successful Use of Negative Pressure Wound Therapy for Abdominal Wall Necrosis Caused by a Perforated Ascending Colon Using the ABThera System by Kouki Imaoka, Takuya Yano, Yasuhiro Choda, Ko Oshita, Yuma Tani, Tetsushi Kubota, Michihiro Ishida, Daisuke Satoh, Masanori Yoshimitsu, Kanyu Nakano, Masao Harano, Hiroyoshi Matsukawa, Hitoshi Idani, Shigehiro Shiozaki, Masazumi Okajima

“…In the management of a case of a massive wound with infection, it can be of great benefit to treat the wound with NPWT initially to decrease its size. …”
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Design of a novel Cu-Cr-X alloy with high strength and high electrical conductivity based on mechanical learning by Yunqing Zhu, Yicheng Cao, Lijun Peng, Qian Yu, Zhen Yang, Zengde Li, Junsheng Wu, Haofeng Xie

“…The outstanding performance enhancement and rapid prediction of process scopes leads us to recognise that the great potential of multi-objective machine-learning-aid design in the complex composition and process problems.…”
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The Influences of Key Strata Compound Breakage on the Overlying Strata Movement and Strata Pressure Behavior in Fully Mechanized Caving Mining of Shallow and Extremely Thick Seams:... by Junmeng Li, Yanli Huang, Jixiong Zhang, Meng Li, Ming Qiao, Fengwan Wang

“…The actual measurement results of ground pressure in the working face showed that, in the working process, the first weighting interval of the inferior key strata was about 51 m and its average periodic weighting interval was about 12.6 m, both of which were basically consistent with the results of numerical simulation. The research has great significance in providing theoretical guidance and practical experience for predicting and controlling the ground pressure under the similar mining and geological conditions.…”
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Phycospheric Bacteria Alleviate the Stress of Erythromycin on <i>Auxenochlorella pyrenoidosa</i> by Regulating Nitrogen Metabolism by Jiping Li, Ying Wang, Yuan Fang, Xingsheng Lyu, Zixin Zhu, Chenyang Wu, Zijie Xu, Wei Li, Naisen Liu, Chenggong Du, Yan Wang

“…Macrolide pollution has attracted a great deal of attention because of its ecotoxic effects on microalgae, but the role of phycospheric bacteria under antibiotic stress remains unclear. …”
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The Influence of Negative Pressure and of the Harvesting Site on the Characteristics of Human Adipose Tissue-Derived Stromal Cells from Lipoaspirates by Martina Travnickova, Julia Pajorova, Jana Zarubova, Nikola Krocilova, Martin Molitor, Lucie Bacakova

“…Adipose tissue-derived stromal cells (ADSCs) have great potential for cell-based therapies, including tissue engineering. …”
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Research Review and Prospect of Litchi Fruit Cracking by Xiwen LI, Haoshuang SUN, Xuequn PANG, Zhaoqi ZHANG

“…The review points out that although there are great differences in the susceptibility of fruit cracking among different litchi varieties, so far, we have not been able to identify the key enzymes or major genes related to fruit cracking; compared with other fruits, litchi fruit cracking has a certain degree of specificity, which is manifested in that litchi fruit cracking peaks at the stage from the green fruit stage to the color turning stage, and that the fruits always crack along the suture line with the pulp remaining intact. …”
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Spatiotemporal Variability of Channel Roughness and its Substantial Impacts on Flood Modeling Errors by Md Abdullah Al Mehedi, Shah Saki, Krutikkumar Patel, Chaopeng Shen, Sagy Cohen, Virginia Smith, Adnan Rajib, Emmanouil Anagnostou, Tadd Bindas, Kathryn Lawson

“…We therefore offer a model of great practical utility.…”
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Multielement Principal Component Analysis and Origin Traceability of Rice Based on ICP-MS/MS by Yan Wang, Xiaoxuan Yuan, Linan Liu, Junmei Ma, Sufang Fan, Yan Zhang, Qiang Li

“…The detection limit of each element was 0.0000662–0.144 mg/kg, and the limit of quantification was in the range of 0.000221–0.479 mg/kg, the linear correlation coefficient was greater or equal to 0.9987 (R2 ≥ 0.9987), and the detection results had low detection limit and great linear regression. Recovery of the method was in the range of 80.6% to 110.5% with spike levels of 0.10–100.00 mg/kg, and relative standard deviations were lower than 10%. …”
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Optimal configuration of a solar-powered Organic Rankine Cycle power plant utilizing thermochemical energy storage by Sofiene Mellouli, Talal Alqahtani, Salem Algarni, Abdullah A. Faqihi, Badr M. Alshammari, Lioua Kolsi

“…The thermal energy storage system greatly influences the efficiency and design of the Organic Rankine Cycle (ORC) power plant. …”
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Digital twin-based modeling of natural gas leakage and dispersion in urban utility tunnels [version 2; peer review: 2 approved] by Jiansong Wu, Jitao Cai, Ziqi Han, Yanzhu Hu, Ming Fu, Yuefei Li, Xin Wang, Xiaofu Zou

“…Background Unexpected leakage accidents of the natural gas pipeline inside urban utility tunnels can pose great threats to public safety, property, and the environment. …”
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Proximal bronchiolar adenoma with malignant transformation to invasive mucinous adenocarcinoma with 4 years follow-up: a case report and literature review by Yuan-Hui Yang, Ke Yin, Jia-Qi Xu, Xiao-Ying Xu, Jun-Lei Zhang, Ji-Xuan Liu, Xin-Zhi Feng, Xiao-Yan Lin, Xiao-Yan Lin

“…In frozen sections, basal cells are difficult to identify under the microscope, which makes it difficult to distinguish from mucinous adenocarcinoma, especially when BA malignancies transform into invasive mucinous adenocarcinoma (IMA), which can only be distinguished by histomorphological criteria, greatly increasing the difficulty of diagnosis.Case summaryIn this paper, we present a case study of a 59-year-old man whose chest computed tomography (CT) revealed a progressively enlarging, high-density nodule over a four-year period in the outer basal segment of the right lower lobe. …”
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Hydrothermal Pre-Carbonization Triggers Structural Reforming Enabling Pore-Tunable Hierarchical Porous Carbon for High-Performance Supercapacitors by Cuihua Kang, Mingyuan Zuo, Chang Qiu, Fanda Zeng, Yuehui Wang, Zhuo Chen, Tingting Liang, Daping Qiu

“…The engineering of pore structures has great significance in the development of high-performance carbon-based supercapacitor electrode materials. …”
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