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7621
Curcumin Improves Epithelial Barrier Integrity of Caco-2 Monolayers by Inhibiting Endoplasmic Reticulum Stress and Subsequent Apoptosis
Published 2021-01-01“…Furthermore, curcumin administration greatly blocked the protein kinase-like endoplasmic reticulum kinase- (PERK-) eukaryotic translation initiation factor 2α- (eIF2α-) activating transcription factor 4- (ATF4-) CHOP signaling pathway. …”
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7622
Left Coronary Artery—Right Ventricle Fistula Case Report: Optimal Treatment Decision
Published 2025-01-01“…Coronary artery fistulas (CAFs) are rare congenital anomalies, presenting in 0.05–0.9% of cases, characterized by an aberrant connection between a coronary artery and a cardiac chamber or great vessel. Clinical manifestations can include heart failure, myocardial ischemia due to coronary steal, arrhythmias, or infective endocarditis. …”
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7623
Abrasion resistant characteristics of UHPC based on high-speed underwater method: Efficiency, process, evaluation, and mechanisms
Published 2025-01-01“…Ultra-High-Performance Concrete (UHPC) exhibits excellent abrasion resistance and has great potential for application in hydraulic engineering. …”
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7624
A thermo-responsive chitosan-based injectable hydrogel for delivery of curcumin-loaded polycaprolactone microspheres to articular cartilage: in-vitro and in-vivo assessments
Published 2025-03-01“…The hydrogel exhibited great porosity (∼57.96 %) with a mean pore diameter of ∼104.30 µm, and a compressive modulus of ∼4.65 kPa, offering an encouraging micro-environment for cell proliferation and tissue regeneration. …”
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7625
Toward Sustainable Biocultural Ecotourism: An Integrated Spatial Analysis of Cultural and Biodiversity Richness in Colombia
Published 2025-01-01“…While biocultural richness is high in the Amazon, Pacific and Caribbean regions, we found that there are no win‐win‐win locations where culture, species richness and accessibility are all high. Areas with great potential for biocultural ecotourism development largely coincide with designated Indigenous Reserves and Afro‐Colombian Territories. …”
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7626
Effect of Kinases in Extracellular Vesicles from HIV-1-Infected Cells on Bystander Cells
Published 2025-01-01“…As of 2023, there were 39.9 million people living with Human Immunodeficiency Virus type 1 (HIV-1). Although great strides have been made in treatment options for HIV-1, and our understanding of the HIV-1 life cycle has vastly improved since the start of this global health crisis, a functional cure remains elusive. …”
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7627
Spatial Characterization of Woody Species Diversity in Tropical Savannas Using GEDI and Optical Data
Published 2025-01-01“…Developing the capacity to monitor species diversity worldwide is of great importance in halting biodiversity loss. To this end, remote sensing plays a unique role. …”
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7628
Molecular Mechanisms Underlying Substance Transport, Signal Transduction, and Anti-Stress Regulation, as Well as Anti-Alkaline Regulation via <i>Bursicon</i> in the Cerebral Gangli...
Published 2025-01-01“…(1) Background: Global climate change is intensifying, and the vigorous development and utilization of saline–alkali land is of great significance. As an important economic aquatic species in the context of saline–alkali aquaculture, it is highly significant to explore the regulatory mechanisms of <i>Eriocheir sinensis</i> under alkaline conditions. …”
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7629
An Optimized NGS Workflow Defines Genetically Based Prognostic Categories for Patients with Uveal Melanoma
Published 2025-01-01“…Results: Employing commercial gene panels, reference mutated DNAs and Sanger sequencing, we performed a comparative analysis and found that our methodological approach successfully predicted survival with great specificity and sensitivity compared to the TCGA-UM cohort that was used as a validation group. …”
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7630
Analysis and Verification of a Slope Steering Model of TRVs in Hilly and Mountainous Environments
Published 2025-01-01“…Therefore, analyzing and researching the steering performance of a tracked robotic vehicle under sloped conditions is of great significance. This study establishes a slope steering model for tracked robotic vehicles based on a ground pressure model of the multi-peak varying amplitude cosine distribution and the shearing displacement relationship between the track and the ground, and analyzes the impact of vehicle structural parameters, road surface parameters, and steering parameters on steering performance. …”
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7631
Detection of β-Lactamases and Outer Membrane Porins among Klebsiella pneumoniae Strains Isolated in Iran
Published 2014-01-01“…The high prevalence of β-lactamase-producing K. pneumoniae detected in this study is of great concern, which requires infection control measures including antibacterial management and identification of β-lactamases-producing isolates.…”
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7632
Comparative evaluation of cell-based assay technologies for scoring drug-induced condensation of SARS-CoV-2 nucleocapsid protein
Published 2025-03-01“…Protein-nucleic acid phase separation has been implicated in many diseases such as viral infections, neurodegeneration, and cancer. There is great interest in identifying condensate modulators (CMODs), which are small molecules that alter the dynamics and functions of phase-separated condensates, as a potential therapeutic modality. …”
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7633
Wheat Leaf Rust Effector Pt48115 Localized in the Chloroplasts and Suppressed Wheat Immunity
Published 2025-01-01“…The study of effector proteins is of great significance for clarifying the pathogenic mechanisms of <i>Pt</i> and effective control of leaf rust. …”
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7634
Analysis of the focal relationship of level five leadership with school organizational excellence
Published 2024-05-01“…The level five leader is in the highest hierarchy of executive abilities and has all the conditions of the competency pyramid and creates lasting greatness by combining humility and professional will. …”
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7635
Boron isotopes fractionation and its application progress in groundwater research
Published 2024-11-01“…The composition and variation of B isotope in groundwater are of great significance to understanding hydrogeochemical processes and the rational development of groundwater resources. …”
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7636
Impact of UV-C irradiance and wavelength on the photodegradation of dibromoacetonitrile
Published 2025-04-01“…A significant finding is that incident irradiance greatly impacted the degradation kinetics even when normalized by fluence. …”
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7637
Embryonic, Larval, and Early Juvenile Development of the Tropical Sea Urchin, Salmacis sphaeroides (Echinodermata: Echinoidea)
Published 2012-01-01“…This study represents the first successful investigation on embryonic, larval, and early juvenile development of S. sphaeroides. The findings would greatly be helpful towards the understanding of ontogeny and life-history strategies, which will facilitate us to develop the breeding, seed production, and culture techniques of sea urchins in captive condition.…”
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7638
Detecting tropical freshly-opened swidden fields using a combined algorithm of continuous change detection and support vector machine
Published 2025-02-01“…Features inclusion of terrain and fire greatly improves classification accuracy. Additionally, over 60% of Laotian swiddens cross-validated by the 375-meter Visible Infrared Imaging Radiometer Suite active fires demonstrate CCD-SVM’s reliability and fidelity. …”
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7639
Care burden and quality of life among family caregivers of children with cerebral palsy in China: the mediating roles of social support and coping styles
Published 2025-02-01“…Abstract Background Children with cerebral palsy have substantial caregiving demands, and the overall health of their caregivers is greatly affected. The contributing variables to caregivers’ quality of life must be identified. …”
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7640
The a criminal’s identity as an element of forensic characteristics of causing negligent serious or moderate bodily harm
Published 2022-12-01“…It has been established that the criminal’s lifestyle, propensity to abuse alcoholic beverages or the use of narcotic drugs are of great importance, which can affect the psychological state of a person and his reactions to events. …”
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