Novel banana lectin CAR-T cells to target pancreatic tumors and tumor-associated stroma by Malcolm K Brenner, Challice Bonifant, Norihiro Watanabe, Mary K McKenna, Daniel Brenner, Ada Ozcan, Maureen Legendre, Dafydd G Thomas, Christopher Ashwood, Richard D Cummings, David M Markovitz

“…The incorporation of glycan-targeting lectins within CARs thus extends their activity to include both malignant cells and their supporting stromal cells, disrupting the TME that otherwise diminishes the activity of cellular therapies against solid tumors.…”
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Real-world of Limosilactobacillus reuteri in mitigation of acute experimental colitis by Ningning Yue, Hailan Zhao, Peng Hu, Yuan Zhang, Chengmei Tian, Chen Kong, Zhiliang Mai, Longbin Huang, Qianjun Luo, Daoru Wei, Ruiyue Shi, Shaohui Tang, Yuqiang Nie, Yujie Liang, Jun Yao, Lisheng Wang, Defeng Li

“…First, L. reuteri-CMVs selectively promoted the proliferation of the beneficial bacterium Akkermansia muciniphila (AKK) by upregulating the expression of glycosidases (beta-N-acetylhexosaminidase and alpha-N-acetylglucosaminidase) involved in glycan degradation and metabolic pathways and restored the disrupted gut microbiota balance. …”
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Supplementation with yak (Bos grunniens) bone collagen hydrolysate altered the structure of gut microbiota and elevated short-chain fatty acid production in mice by Zitao Guo, Dalong Yi, Bo Hu, Lingyu Zhu, Ji Zhang, Yuliang Yang, Chunyu Liu, Yi Shi, Zhenghua Gu, Yu Xin, Huaigao Liu, Liang Zhang

“…The predicted functions of gut microbes in the MD group were significantly increased at “lipid metabolism” and “glycan biosynthesis and metabolism”. Moreover, the SCFA production in the YBCH groups was elevated. …”
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Impacts of plant root traits and microbial functional attributes on soil respiration components in the desert-oasis ecotone by Jinlong Wang, Jinlong Wang, Jinlong Wang, Guanghui Lv, Guanghui Lv, Guanghui Lv, Jianjun Yang, Jianjun Yang, Jianjun Yang, Xuemin He, Xuemin He, Xuemin He, Hengfang Wang, Hengfang Wang, Hengfang Wang, Wenjing Li, Wenjing Li, Wenjing Li

“…Notably, both Ra and Rh displayed robust positive correlations with the abundance of phosphatidylinositol glycan A, a key player in microbial carbon metabolism. …”
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Identification of SLC35A1 as an essential host factor for the transduction of multi-serotype recombinant adeno-associated virus (AAV) vectors by Xiujuan Zhang, Siyuan Hao, Zehua Feng, Kang Ning, Cagla Aksu Kuz, Shane McFarlin, Donovan Richart, Fang Cheng, Ander Zhang-Chen, Richenda McFarlane, Ziying Yan, Jianming Qiu

“…The highly selected genes revealed after two rounds of screening included the previously reported KIAA0319L, TM9SF2, and RNF121, along with a cluster of genes involved in glycan biogenesis, Golgi apparatus localization, and endoplasmic reticulum penetration. …”
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Studies on fatty acids and microbiota characterization of the gastrointestinal tract of Tianzhu white yaks by Chen Shaopeng, Cui Changze, Qi Youpeng, Mi Baohong, Zhang Meixian, Jiao Chenyue, Zhu Chune, Wang Xiangyan, Hu Jiang, Hu Jiang, Shi Bingang, Shi Bingang, Ma Xueming, Zhao Zhidong, Zhao Zhidong, Zhang Xiaolan

“…KEGG functional prediction of the microbiota indicated that the dominant functions in the rumen, abomasum, colon, and jejunum were amino acid metabolism, glycan biosynthesis and metabolism, carbohydrate metabolism, and membrane transport, respectively, reflecting the digestive functions of these organs. …”
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A Lectin from Dioclea violacea Interacts with Midgut Surface of Lutzomyia migonei, Unlike Its Homologues, Cratylia floribunda Lectin and Canavalia gladiata Lectin by Juliana Montezuma Barbosa Monteiro Tínel, Melina Fechine Costa Benevides, Mércia Sindeaux Frutuoso, Camila Farias Rocha, Francisco Vassiliepe Sousa Arruda, Mayron Alves Vasconcelos, Francisco Nascimento Pereira-Junior, João Batista Cajazeiras, Kyria Santiago do Nascimento, Jorge Luiz Martins, Edson Holanda Teixeira, Benildo Sousa Cavada, Ricardo Pires dos Santos, Margarida Maria Lima Pompeu

“…Promastigote and gut sand fly surface glycans are important ligands in this attachment. …”
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Expanding the concept of ID conversion in TogoID by introducing multi-semantic and label features by Shuya Ikeda, Kiyoko F. Aoki-Kinoshita, Hirokazu Chiba, Susumu Goto, Masae Hosoda, Shuichi Kawashima, Jin-Dong Kim, Yuki Moriya, Tazro Ohta, Hiromasa Ono, Terue Takatsuki, Yasunori Yamamoto, Toshiaki Katayama

“…This enhancement enables TogoID to distinguish relationships such as "glycans bind to proteins" or "glycans are processed by proteins" between glycans and proteins. …”
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A lectin produced by a Streptomyces species targets mammalian pancreatic acinar cells in mice and humans by Janine C. Quijano, Honoka Natsuyama, Alonso Tapia, Karine Bagramyan, Jose A. Ortiz, Jacob Mares, Markus Kalkum, Yoko Fujita-Yamaguchi, Hsun Teresa Ku

“…Abstract Lectins are produced in almost all life forms, can interact with targets (glycans) in a cross-kingdom manner and have served as valuable tools for studying glycobiology. …”
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The S-Layer Glycome—Adding to the Sugar Coat of Bacteria by Robin Ristl, Kerstin Steiner, Kristof Zarschler, Sonja Zayni, Paul Messner, Christina Schäffer

“…S-layer glycoproteins have the unique feature of self-assembling into 2D lattices providing a display matrix for glycans with periodicity at the nanometer scale. Typically, bacterial S-layer glycans are O-glycosidically linked to serine, threonine, or tyrosine residues, and they rely on a much wider variety of constituents, glycosidic linkage types, and structures than their eukaryotic counterparts. …”
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Synthesis of trehalose-based chemical tools for the study of the mycobacterial membrane by Lesur, Emilie, Rollando, Paulin, Guianvarc’h, Dominique, Bourdreux, Yann

“…Over the last decades, both bioorthogonal chemical reporters and fluorescent probes for the metabolic labeling of bacterial cell glycans were developed including several trehalose-based probes to study the dynamics of mycomembrane components. …”
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AzioInositols in the Treatment of Insulin-Mediated Diseases by Giovanna Muscogiuri, Stefano Palomba, Antonio Simone Laganà, Francesco Orio

“…Finally, molecular insights into inositol insulin-sensitizing effects will be covered focusing on the possible role of inositol glycans as insulin second messengers.…”
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Roles of core fucosylation modification in immune system and diseases by Qiu Pan, Xiao-Lian Zhang

“…Core fucosylation, catalyzed by α1,6-fucosyltransferase (FUT8), is an important N-glycosylation modification process that attaches a fucose residue via an α1,6-linkage to the core N-acetylglucosamine of N-glycans in mammals. Research over the past three decades has revealed the critical role of FUT8-mediated core fucosylation modification in various physiological and pathological processes, including cell growth, adhesion, receptor activation, antibody-dependent cellular cytotoxicity (ADCC), tumor metastasis and infections. …”
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Human Milk Oligosaccharides: The Journey Ahead by Chandan Ray, Joshi A. Kerketta, Subhash Rao, Snehal Patel, Shantanu Dutt, Kamal Arora, Femitha Pournami, Phani Bhushan

“…Human milk oligosaccharides (HMOs) are unconjugated glycans that constitute an important component of the protection conferred by breast milk on the neonate. …”
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Glycosylation Profile of the Transferrin Receptor in Gestational Iron Deficiency and Early-Onset Severe Preeclampsia by Alejandra María Gómez-Gutiérrez, Beatriz Elena Parra-Sosa, Julio Cesar Bueno-Sánchez

“…The increase in Gal-GlcNAc may be due to the increased presence of antennary structures and the mannose glycans of TfR1 may indicate the presence of misfolded or incomplete proteins. …”
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Stereoselective Conversions of Carbohydrate Anomeric Hydroxyl Group in Basic and Neutral Conditions by Monika Khaleri, Qingjiang Li

“…The rapidly growing glycoscience has boosted the research on the synthesis of glycans and their conjugates, which are centered on the stereoselective formation of glycosidic bonds. …”
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Bovine milk-derived sialylglycopeptide concentrate suppresses mumps virus infection by Tadanobu Takahashi, Yuuki Kurebayashi, Shunsuke Suzuki, Kobun Konagaya, Yutaka Narimichi, Eiji Kobatake, Hirofumi Fukudome, Toshiyuki Yamaguchi, Fumihiko Sakai, Toshinobu Arai, Toshihide Kabuki, Akira Minami, Hideyuki Takeuchi

“…This MSGP concentrate was rich in short glycans containing α2–3 linked sialic acids, resembling the MuV binding receptors, which may contribute to inhibiting MuV infection. …”
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N-Acetylglucosamine Functions in Cell Signaling by James B. Konopka

“…GlcNAc also impacts signal transduction by altering the degree of branching of N-linked glycans, which influences cell surface signaling proteins. …”
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High-Titre Neutralizing Antibodies to H1N1 Influenza Virus after Mouse Immunization with Yeast Expressed H1 Antigen: A Promising Influenza Vaccine Candidate by Edyta Kopera, Konrad Zdanowski, Karolina Uranowska, Piotr Kosson, Violetta Sączyńska, Katarzyna Florys, Bogusław Szewczyk

“…Analysis of the N-linked glycans using mass spectrometry revealed that the H1 protein is glycosylated at the same sites as the native HA. …”
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Similarities and Differences in the Glycosylation Mechanisms in Prokaryotes and Eukaryotes by Anne Dell, Alaa Galadari, Federico Sastre, Paul Hitchen

“…Recent years have witnessed a rapid growth in the number and diversity of prokaryotic proteins shown to carry N- and/or O-glycans, with protein glycosylation now considered as fundamental to the biology of these organisms as it is in eukaryotic systems. …”
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