Optimising (re-)irradiation for locally recurrent head and neck cancer: impact of dose-escalation, salvage surgery, PEG tube and biomarkers on oncological outcomes—a single centre... by Julia Katharina Schleifenbaum, Janis Morgenthaler, Shachi Jenny Sharma, Jens Peter Klußmann, Philipp Linde, Simone Wegen, Johannes Rosenbrock, Christian Baues, Emmanouil Fokas, Richard Khor, Sweet Ping Ng, Simone Marnitz, Maike Trommer

“…Other significant factors for longer OS in univariate analysis included low inflammatory status (Glasgow Prognostic Score 0) and radiation doses ≥ 50 Gy. …”
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Risk factors of aspiration in neurocritical care patients with enteral nutrition (神经重症肠内营养支持患者误吸危险因素分析) by WANG Dan (王丹), KUANG Hongmei (况红梅), LIU Weichen (刘韦辰)

“…The results of logistic regression showed that aspiration history (OR= 28. 122), sedative hypnotics (OR= 3. 188), catheterization depth (OR=0. 853) and Glasgow Scale score (OR= 0. 671) were the influencing factors of aspiration in neurocritical care patients with enteral nutrition. …”
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Multi-Isotope Geochemical Baseline Study of the Carbon Management Canada Research Institutes CCS Field Research Station (Alberta, Canada), Prior to CO2 Injection by Rachel E. Utley, Emma Martin-Roberts, Nicholas Utting, Gareth Johnson, Domokos Györe, Marta Zurakowska, Finlay M. Stuart, Adrian J. Boyce, Thomas H. Darrah, Pauline Gulliver, R. Stuart Haszeldine, Don Lawton, Stuart M. V. Gilfillan

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Using stated-preferences methods to develop a summary metric to determine successful treatment of children with a surgical condition: a study protocol by Nigel Hall, Marian Knight, Nick Lansdale, Lisa Hinton, Charles Opondo, Simon Kenny, Stefano Giuliani, John Buckell, Oliver Rivero-Arias, Kokila Lakhoo, Alexander Macdonald, Crispin Jenkinson, Benjamin Allin, Rema Ramakrishnan, Gregor Walker, Timothy Bradnock, Karolina Kuberska, Benjamin M Craig, Goher Ayman, Anna May Long, Joanne Shepherd

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Ensemble estimates of global wetland methane emissions over 2000–2020 by Z. Zhang, B. Poulter, J. R. Melton, W. J. Riley, G. H. Allen, D. J. Beerling, P. Bousquet, J. G. Canadell, E. Fluet-Chouinard, P. Ciais, N. Gedney, P. O. Hopcroft, A. Ito, R. B. Jackson, A. K. Jain, K. Jensen, F. Joos, T. Kleinen, S. H. Knox, S. H. Knox, T. Li, X. Li, X. Liu, K. McDonald, G. McNicol, P. A. Miller, J. Müller, P. K. Patra, P. K. Patra, C. Peng, S. Peng, Z. Qin, R. M. Riggs, M. Saunois, Q. Sun, H. Tian, X. Xu, Y. Yao, Y. Xi, W. Zhang, W. Zhang, Q. Zhu, Q. Zhu, Q. Zhuang

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A randomised controlled implementation trial of the feasibility and effectiveness of school staff delivery of a selective substance use and mental health program during the COVID-1... by Lucinda Grummitt, Kirsty Rowlinson, Joanne Cassar, Chloe Conroy, Louise Birrell, Lexine Stapinski, Emma Louise Barrett, Julia Macauley, Maree Teesson, Nicola C. Newton, Erin V. Kelly

“…Methods A cluster-randomised controlled implementation trial was conducted in Sydney, Australia and was guided by the RE-AIM framework (Glasgow et al. 1999); which measures reach, effectiveness, adoption, implementation, and maintenance. …”
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Health checks for autistic adults: study protocol for a cluster randomised controlled trial by Jeremy R. Parr, Helen Taylor, Colin Wilson, Clare Scarlett, Sarah Al-Asmori, Carole Buckley, Sally-Ann Cooper, Cristina Fernandez-Garcia, Tracy Finch, Rhianna Lees, Nicholas Lennox, Hannah Merrick, Sebastian Moss, Christina Nicolaidis, Malcolm Osbourne, Dora M. Raymaker, Tomos Robinson, Anna Urbanowicz, James M. S. Wason, Barry Ingham

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Modulation of brain activity in brain-injured patients with a disorder of consciousness in intensive care with repeated 10-Hz transcranial alternating current stimulation (tACS): a... by David Williamson, Francis Bernard, Stefanie Blain-Moraes, Caroline Arbour, Virginie Williams, Louis de Beaumont, Catherine Duclos, Béatrice P De Koninck, Daphnee Brazeau, Amelie A Deshaies, Marie-Michele Briand, Charlotte Maschke

“…Both phases will be conducted in medically stable brain-injured adult patients (traumatic brain injury and hypoxic-ischaemic encephalopathy), with a Glasgow Coma Scale score ≤12 after continuous sedation withdrawal. …”
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ImmunoglobuliN in the Treatment of Encephalitis (IgNiTE): protocol for a multicentre randomised controlled trial by R Kneen, M Lim, A Vincent, A J Pollard, W K Chong, L-M Yu, M A Iro, M Sadarangani, M Absoud, C A Clark, A Easton, V Gray, M Pike, T Solomon, L Willis

“…The primary outcome is ‘good recovery’ (score of 2 or lower on the Glasgow Outcome Score Extended—paediatric version), at 12 months after randomisation. …”
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Development of Space Weather Reasonable Worst‐Case Scenarios for the UK National Risk Assessment by Mike Hapgood, Matthew J. Angling, Gemma Attrill, Mario Bisi, Paul S. Cannon, Clive Dyer, Jonathan P. Eastwood, Sean Elvidge, Mark Gibbs, Richard A. Harrison, Colin Hord, Richard B. Horne, David R. Jackson, Bryn Jones, Simon Machin, Cathryn N. Mitchell, John Preston, John Rees, Neil C. Rogers, Graham Routledge, Keith Ryden, Rick Tanner, Alan W. P. Thomson, James A. Wild, Mike Willis

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Serum neuritin as a predictive biomarker of early neurological deterioration and poor prognosis after spontaneous intracerebral hemorrhage: a prospective cohort study by Yanwen Xu, Hanyu Zhu, Yuqi Su, Zhizhi Chen, Chuanliu Wang, Ming Yang, Feifei Jiang, Yunping Li, Yongming Xu

“…We aimed to explore the prognostic and predictive value of serum neuritin in ICH.MethodsIn this prospective cohort study, serum neuritin levels were measured at admission in 202 patients, on post-ICH days 1, 3, 5, 7, and 10 in 54 of these patients, and at the time of enrollment in 100 healthy controls. The Glasgow Coma Scale (GCS) and hematoma volume were used as severity indicators. …”
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Application of the procedural sedation protocol for patients with traumatic brain injury and related nursing management (颅脑损伤患者实施程序化镇静的效果及护理) by ZHANG Feiting (张飞婷), YANG Zhiying (杨智颖), YANG Ruinan (杨蕊南)

“…Patient in the control group received conventional therapy for sedation, and those in the study group were given a procedural sedation protocol. The Glasgow Coma Scale (GCS), Sedation-agitation Scale(SAS), dosage of sedatives and length of hospital stays were measured and compared between two groups. …”
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Duration of External Neck Stabilisation (DENS) following odontoid fracture in older or frail adults: protocol for a randomised controlled trial of collar versus no collar by John Norrie, Julie Woodfield, David J Lowe, Paul M Brennan, Catriona Keerie, Julia Lawton, Matthew J Reed, Andrew Stoddart, Julia Boyd, Helen Eborall, Gina Cranswick, James Tomlinson, Polly L Black, Sadaquate Khan, Patrick Statham, Ellie Edlmann, Phillip Correia Copley, Angela Niven, Susan Deborah Shenkin

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Applied machine learning for predicting the properties and carbon and phosphorus fate of pristine and engineered hydrochar by Shiyu Xie, Tao Zhang, Siming You, Santanu Mukherjee, Mingjun Pu, Qing Chen, Yaosheng Wang, Esmat F. Ali, Hamada Abdelrahman, Jörg Rinklebe, Sang Soo Lee, Sabry M. Shaheen

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Lymphocyte-C-reactive protein ratio upon admission to predict disease progression and ICU admission in adult patients with diabetic ketoacidosis by Yi-Jia Hu, Shu-Xiao Qiu, Jian-Nan Zhang, Qi-Qi Lai, Yi-Lu Lin, Lin-Qiong Liu, Di Wu, Hui-Ying Liu, Huan Meng, Jia-Xi Xu, Jia-Ning Zhang, Bo-Wen Liu, Yan Gao, Kai Kang, Yang Gao

“…Significant differences in demographic and clinical data were observed among these groups. Glasgow coma scale (GCS) score, LCR, pH, and bicarbonate (HCO3 -) were identified as protective factors for severe DKA. …”
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European standard clinical practice recommendations for paediatric high-grade gliomas by Elwira Szychot, Géraldine Giraud, Darren Hargrave, Dannis van Vuurden, Jacques Grill, Veronica Biassoni, Maura Massimo, André O. Von Büren, Rejin Kebudi, Maria João Gil-da-Costa, Sophie Veldhuijzen van Zanten, Simon Bailey, Michael Karremann, Stephanie Bolle, Thankamma Ajithkumar, Mechthild Krause, Yasmin Lassen-Ramshad, Geert Janssens, Giovanni Morana, Ulrike Löbel, Shivaram Avula, Brigitte Bison, Maarten Lequin, Kristian Aquilina, Ulrich Thomale, Pelle Nilsson, Sami Bui-Quy Abu Hamdeh, Torsten Pietsch, Pascale Varlet, Thomas S. Jacques, Pieter Wesseling, David Jones, Uri Tabori, Anirban Das, David Mulligan, Francesca Kozmann, Christof M. Kramm

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Retrospective analysis of amantadine response and predictive factors in intensive care unit patients with non-traumatic disorders of consciousness by Corinna Blum, Constanze Single, Kornelia Laichinger, Anna Hofmann, Tim W. Rattay, Tim W. Rattay, Kamaldeen Adeyemi, Reimer Riessen, Michael Haap, Helene Häberle, Ulf Ziemann, Annerose Mengel, Katharina Feil

“…Patients were classified as responders if their Glasgow Coma Scale (GCS) improved by ≥3 points within 5 days. …”
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Early systemic insults following severe sepsis-associated encephalopathy of critically ill patients: association with mortality and awakening—an analysis of the OUTCOMEREA database... by Michael Thy, Romain Sonneville, Stéphane Ruckly, Bruno Mourvillier, Carole Schwebel, Yves Cohen, Maité Garrouste-Orgeas, Shidasp Siami, Cédric Bruel, Jean Reignier, Elie Azoulay, Laurent Argaud, Dany Goldgran-Toledano, Virginie Laurent, Claire Dupuis, Julien Poujade, Lila Bouadma, Etienne de Montmollin, Jean-François Timsit, on the behalf of the OUTCOME R. E. A. network

“…We included patients hospitalized in intensive care unit (ICU) for at least 48 h with severe SAE (defined by a score on the Glasgow Coma Scale (GCS) ≤ 13 and severe sepsis or septic shock (SEPSIS 2.0 criteria)) requiring invasive ventilation and who had no primary brain injury. …”
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A machine learning model to predict neurological deterioration after mild traumatic brain injury in older adults by Daisu Abe, Motoki Inaji, Takeshi Hase, Eiichi Suehiro, Naoto Shiomi, Hiroshi Yatsushige, Shin Hirota, Shu Hasegawa, Hiroshi Karibe, Akihiro Miyata, Kenya Kawakita, Kohei Haji, Hideo Aihara, Shoji Yokobori, Takeshi Maeda, Takahiro Onuki, Kotaro Oshio, Nobukazu Komoribayashi, Michiyasu Suzuki, Taketoshi Maehara

“…Patients with an admission Glasgow Coma Scale (GCS) score of 12 or below or who underwent surgical treatment immediately upon admission were excluded. …”
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Influence of Socio-Demographic, Occupational and Lifestyle Variables on Sleep Time by Dutheil F, Saint-Arroman C, Clinchamps M, Flaudias V, Fantini ML, Pereira B, Berthon M, Laporte C, Baker JS, Charkhabi M, Cocco P, Lecca R, Puligheddu M, Figorilli M, Zak M, Ugbolue UC, Ubago-Guisado E, Gracia-Marco L, Bouillon-Minois JB, Vialatte L

“…Frederic Dutheil,1,* Chloé Saint-Arroman,1,* Maëlys Clinchamps,1 Valentin Flaudias,2 Maria Livia Fantini,3 Bruno Pereira,4 Mickael Berthon,5 Catherine Laporte,6 Julien Steven Baker,7 Morteza Charkhabi,8 Pierluigi Cocco,9 Rosamaria Lecca,9 Monica Puligheddu,9 Michela Figorilli,9 Marek Zak,10 Ukadike Chris Ugbolue,11 Esther Ubago-Guisado,12 Luis Gracia-Marco,13 Jean-Baptiste Bouillon-Minois,1 Luc Vialatte14 1Université Clermont Auvergne, CNRS, Physiological and Psychosocial Stress, LaPSCo, Preventive and Occupational Medicine, University Hospital of Clermont-Ferrand, Clermont-Ferrand, F-63000, France; 2Department of Psychiatry, University Hospital of Clermont-Ferrand, University of Clermont Auvergne, Clermont-Ferrand, France; 3NPsy-Sydo, Neurology Department, University Hospital of Clermont-Ferrand, Université Clermont Auvergne, Clermont-Ferrand, France; 4Biostatistics Department, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France; 5Laboratoire de Psychologie Sociale et Cognitive (LAPSCO), Université Clermont Auvergne, CNRS, Clermont-Ferrand, France; 6Clermont Auvergne INP, University Hospital of Clermont-Ferrand, CNRS, Institut Pascal, Université Clermont Auvergne, Clermont-Ferrand, F-63000, France; 7Department of Sport, Physical Education and Health, Centre for Health and Exercise Science Research, Hong Kong Baptist University, Kowloon Tong, Hong Kong; 8Université Clermont Auvergne, CNRS, Physiological and Psychosocial Stress, LaPSCo, Clermont-Ferrand, France; 9Department of Medical Sciences and Public Health, Neurology Unit, University of Cagliari and AOU Cagliari, Monserrato, Cagliari, 09042, Italy; 10Collegium Medicum, Institute of Health Sciences, Jan Kochanowski University of Kielce, Kielce, Poland; 11School of Health and Life Sciences, Institute for Clinical Exercise & Health Science, University of the West of Scotland, Glasgow, UK; 12Epidemiology and Control of Chronic Diseases, CIBER of Epidemiology and Public Health (CIBERESP), Madrid, 28029, Spain; 13Epidemiology, Prevention and Cancer Control, Instituto de Investigación Biosanitaria Ibs. …”
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