Do serial troponins predict the need for cardiac evaluation in trauma patients after ground-level fall? by Rachael A Callcut, Alyssa R Bellini, James T Ross, Madelyn Larson, Skyler Pearson, Anamaria J Robles

“…The cohort included 560 patients evaluated for a possible syncopal fall, hemodynamically stable, Glasgow Coma Scale score of 15, and with a troponin drawn at presentation. …”
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Standardized Outcomes for Randomized Controlled Trials Targeting Early Interventions in Patients With Moderate-to-Severe Traumatic Brain Injury: Protocol for the Development of a C... by Raphael Cinotti, Yvan Derouin, Amandine Chenet, Lydia Oujamaa, Bertrand Glize, Yoann Launey, Claire Dahyot-Fizelier, Emmanuelle Cartron, Melodie Renvoise, Benedicte Sautenet, Veronique Sebille

“…The evaluation of neurological outcomes, predominantly as primary outcomes, using clinical scales (Glasgow Outcome Scale) has limitations that could explain these results. …”
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Nanosurface‐Reconstructed Fuel Electrode by Selective Etching for Highly Efficient and Stable Solid Oxide Cells by Yueyue Sun, Jun Zhou, Jiaming Yang, Dragos Neagu, Zhengrong Liu, Chaofan Yin, Zixuan Xue, Zilin Zhou, Jiajia Cui, Kai Wu

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Norepinephrine titration in patients with sepsis-induced encephalopathy: cerebral pulsatility index compared to mean arterial pressure guided protocol: randomized controlled trial by Mai Salah Salem, Motaz Amr Abosabaa, Mohamed Samir Abd El Ghafar, Hala Mohey EI-Deen Mohamed EI-Gendy, Salah El-din Ibrahim Alsherif

“…The primary outcome was intensive care unit (ICU) mortality and the secondary outcomes were; MAP that was measured invasively and values were recorded; daily in the morning, at the end of NE infusion and the end of ICU stay, duration of ICU stay, cerebral perfusion pressure (CPP), sequential organ failure assessment (SOFA) score, norepinephrine titration and Glasgow coma scale (GCS) score at discharge. Results ICU mortality percentage wasn`t significantly different between the two groups (p value 0.174). …”
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Quantifying the tumour vasculature environment from CD-31 immunohistochemistry images of breast cancer using deep learning based semantic segmentation by Tristan Whitmarsh, Wei Cope, Julia Carmona-Bozo, Roido Manavaki, Stephen-John Sammut, Ramona Woitek, Elena Provenzano, Emma L. Brown, Sarah E. Bohndiek, Ferdia A. Gallagher, Carlos Caldas, Fiona J. Gilbert, Florian Markowetz

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Potential Risk Factors for In-Hospital Mortality in Patients with Moderate-to-Severe Blunt Multiple Trauma Who Survive Initial Resuscitation by Neslihan Yucel, Tuba Ozturk Demir, Serdar Derya, Hakan Oguzturk, Murat Bicakcioglu, Funda Yetkin

“…High ISS (OR 1.047, 95% CI 1.02-1.08), TBI (OR 8.922, 95% CI 2.57-31.00), sepsis (OR 4.956, 95% CI 1.99-12.36), acute respiratory distress syndrome (ARDS) (OR 8.036, 95% CI 1.85-34.84), respiratory failure (OR 9.630, 95% CI 2.64-35.14), renal failure (OR 74.803, 95% CI 11.34-493.43), and multiple organ failure [MOF] (OR 10.415, 95% CI 4.48-24.24) were risk factors for late in-hospital mortality. High Glasgow Coma Scale (GCS) was a good predictor for survival at 2, 7, and 28 or more days of hospitalization (OR 0.708 and 95% CI 0.56-0.09; OR 0.835 and 95% CI 0.73-0.95; OR 0.798 and 95% CI 0.71-0.90, resp.). …”
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Associated Factors of the Need for Mechanical Ventilation Following Traumatic Injuries; a Registry-Based Study on 2,708 Cases in Iran by Zahra Ramezani, Vali Baigi, Mohammadreza Zafarghandi, Vafa Rahimi-Movaghar, Reza Farahmand-Rad, Akram Zolfaghari Sadrabad, Seyed-Mohammad Piri, Mahgol Sadat Hassan Zadeh Tabatabaei, Khatereh Naghdi, Payman Salamati

“…The significant associated factors of need for MV based on the univariable analysis were age ≥ 65 years (p <0.001); penetrating trauma (p < 0.001) and falling (p = 0.01); private mode of transportation to ED (p < 0.001); site of injury (p < 0.001); heart rate ≥ 100/ minutes (p = 0.04); O2 saturation < 90 % on room air (p < 0.01); Glasgow Coma Scale (GCS) < 13 (p< 0.001); and injury Severity Score (ISS) ≥ 9 (p< 0.001). …”
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Systemic Inflammatory Markers for Predicting Overall Survival in Patients with Osteosarcoma: A Systematic Review and Meta-Analysis by Xiaotong Song, Hao Zhang, Fanxing Yin, Panpan Guo, Xiaocheng Yang, Jinzhu Liu, Yanshuo Han, Zhaozhou Ren

“…These inflammatory markers include C-reactive protein (CRP), neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), platelet to lymphocyte ratio (PLR), and Glasgow prognostic score (GPS). Methods. The Chinese National Knowledge Infrastructure (CNKI), Wanfang, Chinese Scientific Journals (VIP), PubMed, Embase, and Cochrane libraries were searched. …”
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Development and external validation of a dynamic nomogram for predicting the risk of functional outcome after 90 days in patients with acute intracerebral hemorrhage by Shaojie Li, Hongjian Li, Jiani Chen, Baofang Wu, Jiayin Wang, Chaocan Hong, Changhu Yan, Weizhi Qiu, Yasong Li, Hongzhi Gao

“…Through variable screening, this study identified age, Glasgow Coma Scale (GCS), blood glucose, uric acid, hemoglobin, and hematoma location as independent predictors of poor prognosis in intracerebral hemorrhage. …”
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Influence of High-Frequency Repetitive Transcranial Magnetic Stimulation on Neurobehavioral and Electrophysiology in Patients with Disorders of Consciousness by Jian-Min Chen, Qing-Fa Chen, Zhi-Yong Wang, Yang-Jia Chen, Nan-Nan Zhang, Jian-Wen Xu, Jun Ni

“…The outcome measures of performed pre- and postintervention included the latencies of the N20 and N20-P25 amplitudes of SEP, brainstem auditory-evoked potential (BAEP) grade, JFK Coma Recovery Scale-Revised (CRS-R) score, and Glasgow Coma Scale (GCS) score; any adverse events were recorded at any time during the intervention. …”
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Predicting abatacept retention using machine learning by Rieke Alten, Claire Behar, Pierre Merckaert, Ebenezer Afari, Virginie Vannier-Moreau, Anael Ohayon, Sean E. Connolly, Aurélie Najm, Pierre-Antoine Juge, Gengyuan Liu, Angshu Rai, Yedid Elbez, Karissa Lozenski

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The efficacy of open transanal drainage tube against anastomotic leakage in left-sided colorectal cancer surgery: a propensity score matching study by Gen Tsujio, Tatsunari Fukuoka, Atsushi Sugimoto, Ken Yonemitsu, Yuki Seki, Hiroaki Kasashima, Yuichiro Miki, Mami Yoshii, Tatsuro Tamura, Masatsune Shibutani, Takahiro Toyokawa, Shigeru Lee, Kiyoshi Maeda

“…PSM was performed between the OPEN and CLOSED groups on the basis of the following 13 factors: age, sex, BMI, diabetes mellitus (DM), smoking history, modified Glasgow prognostic score (mGPS), ASA-PS, location of distal tumor edge, operative procedure, surgical approach, operative time, intraoperative blood loss, and pathological stage. …”
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Characterisation of HBV and co-infection with HDV and HIV through spatial transcriptomics by Upkar S Gill, Patrick T F Kennedy, Andrew Hall, Rageshri Dhairyawan, Alberto Quaglia, James M Harris, Colin Nixon, Fadi Issa, Amy Cross, Edward Arbe-Barnes, Jane A McKeating, Dimitra Peppa

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Simultaneous Debridement and Titanium Mesh Reconstruction in Patients with Compound Depressed Skull Fracture: A Retrospective Descriptive Study by Srikant Das, Acharya Suryakant Pattajoshi, Mahesh Kumar Kusta, Dibakar Sarkar

“…The frequency of skull fractures was significantly higher in men 91 (92.8%) patients compared to women 7 (7.2%) patients. The mean Glasgow Coma Scale (GCS) score was 13.35 at admission, while it was 14.90 at discharge. …”
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The azimuthal correlation between the leading jet and the scattered lepton in deep inelastic scattering at HERA by ZEUS Collaboration, I. Abt, R. Aggarwal, V. Aushev, O. Behnke, A. Bertolin, I. Bloch, I. Brock, N. H. Brook, R. Brugnera, A. Bruni, P. J. Bussey, A. Caldwell, C. D. Catterall, J. Chwastowski, J. Ciborowski, R. Ciesielski, A. M. Cooper-Sarkar, M. Corradi, R. K. Dementiev, S. Dusini, J. Ferrando, B. Foster, E. Gallo, D. Gangadharan, A. Garfagnini, A. Geiser, G. Grzelak, C. Gwenlan, D. Hochman, N. Z. Jomhari, I. Kadenko, U. Karshon, P. Kaur, R. Klanner, U. Klein, I. A. Korzhavina, N. Kovalchuk, M. Kuze, B. B. Levchenko, A. Levy, B. Löhr, E. Lohrmann, A. Longhin, F. Lorkowski, E. Lunghi, I. Makarenko, J. Malka, S. Masciocchi, K. Nagano, J. D. Nam, Yu. Onishchuk, E. Paul, I. Pidhurskyi, A. Polini, M. Przybycień, A. Quintero, M. Ruspa, U. Schneekloth, T. Schörner-Sadenius, I. Selyuzhenkov, M. Shchedrolosiev, L. M. Shcheglova, N. Sherrill, I. O. Skillicorn, W. Słomiński, A. Solano, L. Stanco, N. Stefaniuk, B. Surrow, K. Tokushuku, O. Turkot, T. Tymieniecka, A. Verbytskyi, W. A. T. Wan Abdullah, K. Wichmann, M. Wing, S. Yamada, Y. Yamazaki, A. F. Żarnecki, O. Zenaiev

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Study protocol: multi-centre, randomised controlled clinical trial exploring stromal targeting in locally advanced pancreatic cancer; STARPAC2 by Hemant M. Kocher, BCI-STARPAC2 team, BPTB team, Precision-Panc team, Peter Sasieni, Pippa Corrie, Mairéad G. McNamara, Debashis Sarker, Fieke E. M. Froeling, Alan Christie, Roopinder Gillmore, Khurum Khan, David Propper

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Predictive value of the systemic immune–inflammation index for outcomes in large artery occlusion treated with mechanical thrombectomy—a single-center study by Ao Qian, Longyi Zheng, Hui He, Jia Duan, Shuang Tang, Wenli Xing

“…Multivariate analysis demonstrated that heightened SII was significantly related to HT (odds ratio [OR]: 1.061, 95% confidence interval [CI]: 1.035–1.086, p &lt; 0.001), MBE (OR: 1.074, 95% CI: 1.045–1.103, p &lt; 0.001), adverse function (OR: 1.061, 95% CI: 1.031–1.092, p &lt; 0.001), and mortality (OR: 1.044, 95% CI: 1.018–1.070, p = 0.001), after adjusting sex, age, Glasgow Coma Scale (GCS) score at admission, initial National Institutes of Health Stroke Scale (NIHSS) score, baseline Alberta Stroke Program Early Computed Tomography Score (ASPECTS), present HMCAS, occluded vessel region, collateral score and successful revascularization. …”
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Coronil effectively inhibits the interaction of clinically relevant Omicron mutants of SARS-CoV-2 spike proteins with human ACE2 receptor by Acharya Balkrishna, Rishabh Dev, Sandeep Kumar, Anurag Varshney

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Characteristics and outcomes of out-of-hospital cardiac arrest among students under school supervision in Japan: a descriptive epidemiological study (2008–2021) by Kosuke Kiyohara, Mamoru Ayusawa, Masahiko Nitta, Takeichiro Sudo, Taku Iwami, Ken Nakata, Yuri Kitamura, Tetsuhisa Kitamura

“…The primary outcome was one-month survival with favorable neurological outcomes, defined as a Glasgow–Pittsburgh cerebral performance category of 1 or 2. …”
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Healthcare provision for displaced people in transit: Analyses of routinely collected data from INTERSOS clinics at the Ukrainian border with Moldova and Poland by Saleh Aljadeeah, Seyed-Moeen Hosseinalipour, Nataliia Khanyk, Eszter Szocs, Aliki Traianou, Ana Tomas, Chrysanthi Tatsi, Elżbieta Czapka, Alessandro Verona, Tessa van Boekholt, Ion Chesov, Apostolos Veizis

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