Combining Genetic Variants to Improve Risk Prediction for NAFLD and Its Progression to Cirrhosis: A Proof of Concept Study by Umberto Vespasiani-Gentilucci, Chiara Dell’Unto, Antonio De Vincentis, Andrea Baiocchini, Marco Delle Monache, Roberto Cecere, Adriano Maria Pellicelli, Valerio Giannelli, Simone Carotti, Giovanni Galati, Paolo Gallo, Francesco Valentini, Franca Del Nonno, Davide Rosati, Sergio Morini, Raffaele Antonelli-Incalzi, Antonio Picardi

“…Combining different disease-associated variants may represent the way for genetics to keep strength in NAFLD diagnostics.…”
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Healthy individuals genetically at-risk for the development of Pemphigus vulgaris or Alopecia areata share disease-like cytokine dysregulation by Rebekah R. Schwartz, Kristina Seiffert-Sinha, Animesh A. Sinha

“…Thus, in both AA and PV, we reveal cytokine dysregulations that are linked to genetic background. The presence of disease promoting pathways in not only patients, but also genetically related, but healthy control individuals further evokes the novel hypothesis that there may be co-existing disease counteracting immune protective mechanisms at play in thwarting the threat of disease in genetically predisposed individuals who, despite harboring disease associated immune imbalances, remain healthy. …”
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Genetic variability in the cholecystokinin A receptor affects lipid profile and glucose tolerance in patients with polycystic ovary syndrome by Eva Drnovsek, Mojca Jensterle, Katja Goričar, Sara Redenšek, Andrej Janež, Irina Milisav, Vita Dolžan

“…Introduction Cholecystokinin (CCK) is involved in several metabolic pathways, and CCK agonists are considered as a potential novel treatment option in populations with increased metabolic risk, including polycystic ovary syndrome (PCOS). As genetic variability of cholecystokinin A and B receptor genes (CCKAR and CCKBR, respectively) may modify their biological actions, we investigated the impact of CCKAR and CCKBR genetic variability on anthropometric and metabolic parameters in patients with PCOS. …”
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Stress-sensitive neurosignalling in depression: an integrated network biology approach to candidate gene selection for genetic association analysis by J. Anke M. van Eekelen, Justine A. Ellis, Craig A. Olsson, Craig E. Pennell, Jeff Craig, Richard Saffery, Eugen Mattes

“…Genetic risk for depressive disorders is poorly understood despite consistent suggestions of a high heritable component. …”
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An Optimization Model for Shell Plate Seam Landing Using Minimum Manufacturing Cost and a Solution by Genetic Algorithm by Ho Rim Pae, Min Hyok Jon, Chol Jun Pak

“…We consider a shape optimization problem that the optimal solution is searched among the possible alternatives when the position and shape of the seams are changed and apply the genetic algorithm to the solution of this shape optimization problem. …”
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A Case Report and Genetic Characterization of a Massive Acinic Cell Carcinoma of the Parotid with Delayed Distant Metastases by Anthony C. Nichols, Michelle Chan-Seng-Yue, John Yoo, Sumit K. Agrawal, Maud H. W. Starmans, Daryl Waggott, Nicholas J. Harding, Samuel A. Dowthwaite, David A. Palma, Kevin Fung, Bret Wehrli, S. Danielle MacNeil, Philippe Lambin, Eric Winquist, James Koropatnick, Joe S. Mymryk, Paul C. Boutros, John W. Barrett

“…This study provides the first insights into the genetic underpinnings of this cancer. Future large-scale efforts will be necessary to define the mutational landscape of salivary gland malignancies to identify therapeutic targets and biomarkers of treatment failure.…”
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Genetic and biochemical analysis of severe hypertriglyceridemia complicated with acute pancreatitis or with low post-heparin lipoprotein lipase mass by Takashi Suzuki, Makoto Kurano, Akari Isono, Takuya Uchino, Yohei Sayama, Honami Tomomitsu, Daiki Mayumi, Ruriko Shibayama, Toru Sekiguchi, Naoki Edo, Kiyoko Uno-Eder, Kenji Uno, Koji Morita, Toshio Ishikawa, Kazuhisa Tsukamoto

“…Severe hypertriglyceridemia is a pathological condition caused by genetic factors alone or in combination with environmental factors, sometimes leading to acute pancreatitis (AP). …”
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Integrated healthy lifestyle even in late-life mitigates cognitive decline risk across varied genetic susceptibility by Jun Wang, Chen Chen, Jinhui Zhou, Zinan Xu, Lanjing Xu, Xinwei Li, Zhuchun Zhong, Yuebin Lv, Xiaoming Shi

“…Abstract It remains unclear whether the benefits of adhering to a healthy lifestyle outweigh the effects of high genetic risk on cognitive decline. We examined the association of combined lifestyle factors and genetic risk with changes in cognitive function and six specific dimensions of cognition among older adults from the Chinese Longitudinal Healthy Longevity Survey (1998–2018, n = 18,811, a subset of 6301 participants with genetic information). …”
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Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis by Jiaqi Yao, Yuhong Jiang, Pengcheng Zhang, Yifan Miao, Xiajia Wu, Hang Lei, Zhijun Xie, Yong Tian, Xianlin Zhao, Juan Li, Lv Zhu, Meihua Wan, Wenfu Tang

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Molecular-genetic approaches to species identification of platyhelminthes of the genus <i>Ligophorus</i> (Monogenea) parasitising flathead mullet by E. A. Vodiasova, E. S. Chelebieva, O. V. Shikhat, D. M. Atopkin, E. V. Dmitrieva

“…A fragment of the 28S ribosomal gene, which includes conserved and variable sites, was chosen as a genetic marker. Three approaches were used as follows: amplified fragment length analysis, allelespecific PCR with endpoint detection and allele-specific real-time PCR using SYBR Green intercalating dye. …”
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NEK4: prediction of available drug targets and common genetic linkages in bipolar disorder and major depressive disorder by Bin Gong, Chenxu Xiao, Yu Feng, Yu Feng, Jing Shen

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Statistical Method Based on Bayes-Type Empirical Score Test for Assessing Genetic Association with Multilocus Genotype Data by Yi Tian, Li Ma, Xiaohong Cai, Jiayan Zhu

“…Simultaneous testing of multiple genetic variants for association is widely recognized as a valuable complementary approach to single-marker tests. …”
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Another Report of Acalculous Cholecystitis in a Greek Patient with Infectious Mononucleosis: A Matter of Luck or Genetic Predisposition? by Theocharis Koufakis, Ioannis Gabranis

“…More studies are required in order to clarify the pathophysiological and genetic backgrounds that connect acalculous cholecystitis and EBV infection.…”
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Genetic structure of the collection of ryegrass (<i>Lolium</i>) cultivars: a study based on SSR and SCoT markers by Yu. M. Mavlyutov, E. A. Vertikova, A. O. Shamustakimova, I. A. Klimenko

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Ultrasound, Echocardiography, MRI, and Genetic Analysis of a Fetus with Congenital Diaphragmatic Hernia and Partial 11q Trisomy by Yolanda Fernández-Perea, Lutgardo García-Díaz, Javier Sánchez, Guillermo Antiñolo, Salud Borrego

“…We report the case of a fetus with isolated CDH diagnosed at 21 weeks of gestation by ultrasound and confirmed by RMI, whose genetic analysis of amniotic fluid cells identified a de novo partial trisomy of the long arm of chromosome 11. …”
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Genetic and epigenetic characterization of sarcoma stem cells across subtypes identifies EZH2 as a therapeutic target by Edmond O’Donnell, Maria Muñoz, Ryan Davis, Jessica Bergonio, R. Lor Randall, Clifford Tepper, Janai Carr-Ascher

“…Utilizing patient-derived samples from five sarcoma subtypes we investigated if a common genetic signature across STS-CSCs could be targeted. …”
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Leveraging Radiomics and Genetic Algorithms to Improve Lung Infection Diagnosis in X-Ray Images Using Machine Learning by A. Beena Godbin, S. Graceline Jasmine

“…To optimize the performance of machine learning models, the paper incorporates genetic algorithms for hyperparameter optimization. …”
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Genetic Diversity Analysis of Mulberry Silkworm (Bombyx Mori L.) Hybrids and Breeds in Azerbaijan Using RAPD Markers by Mammadov Ayaz, Aghayeva Saltanat, Bakırov Guduret, Gulubeyova Mahpuba, Ismayılova Gular

“…In order to study the genetic diversity of silkworms (Bombyx mori L.) breeding in Azerbaijan, the following breeds and hybrids were analyzed: SHZEM 4 x GE 143, Chingiz x Yagub, Yagub x Chingiz, GE 143, Yagub, SHZEM 4 belted, Chingiz, GE 143 x SHZEM 4 using RAPD molecular markers. …”
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Prevalence and genetic diversity of tick-borne encephalitis virus in ixodid ticks from specific regions of northwestern Russia. by Alena A Sharova, Nikolay K Tokarevich, Regina R Baimova, Olga A Freylikhman, Islam A Karmokov, Ekaterina G Riabiko, Gelena A Lunina, Roman V Buzinov, Olga V Sokolova, Lidia V Buts, Lubov A Bespyatova, Liliya A Bubnova, Olga S Safonova, Elena L Kalinina, Andrey I Stankevich, Rose Vikse, Ashild K Andreassen, Anna S Gladkikh, Majid Forghani, Anastasia S Gritseva, Margarita R Popova, Edward S Ramsay, Vladimir G Dedkov

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HCNetlas: A reference database of human cell type-specific gene networks to aid disease genetic analyses. by Jiwon Yu, Junha Cha, Geon Koh, Insuk Lee

“…Cell type-specific actions of disease genes add a significant layer of complexity to the genetic architecture underlying diseases, obscuring our understanding of disease mechanisms. …”
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