Single-cell RNA-seq analysis reveals microenvironmental infiltration of myeloid cells and pancreatic prognostic markers in PDAC by Yanying Fan, Lili Wu, Xinyu Qiu, Han Shi, Longhang Wu, Juan Lin, Jie Lin, Tianhong Teng

“…However, understanding the myeloid cell at both a genetic and cellular level remains a significant challenge. …”
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Quantitative proteomic analysis unveils a critical role of VARS1 in hepatocellular carcinoma aggressiveness through the modulation of MAGI1 expression by Natalia Hermán-Sánchez, Mercedes del Rio-Moreno, Rubén Ciria, Marina E. Sánchez-Frias, Maite G. Fernández-Barrena, Iker Uriarte, Eduardo Chicano-Galvez, Ignacio Ortea, Ángela Peralbo-Molina, Javier Briceño, Matías A. Avila, Manuel Rodríguez-Perálvarez, Raúl M. Luque, Juan L. López-Cánovas, Manuel D. Gahete

“…Abstract Background Hepatocellular carcinoma (HCC) genetic/transcriptomic signatures have been widely described. …”
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<i>Ex Vivo</i> Regional Gene Therapy Compared to Recombinant BMP-2 for the Treatment of Critical-Size Bone Defects: An In Vivo Single-Cell RNA-Sequencing Study by Arijita Sarkar, Matthew C. Gallo, Jennifer A. Bell, Cory K. Mayfield, Jacob R. Ball, Mina Ayad, Elizabeth Lechtholz-Zey, Stephanie W. Chang, Osamu Sugiyama, Denis Evseenko, Jay R. Lieberman

“…<i>Ex vivo</i> regional gene therapy is a promising tissue-engineering strategy for bone regeneration: osteogenic mesenchymal stem cells (MSCs) can be genetically modified to express an osteoinductive stimulus (e.g., bone morphogenetic protein-2), seeded onto an osteoconductive scaffold, and then implanted into a bone defect to exert a therapeutic effect. …”
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Influence of Cardiorespiratory Fitness on PPARG mRNA Expression Using Monozygotic Twin Case Control by Marcos Roberto Queiroga, Ricardo Augusto Barbieri, Sandra Aires Ferreira, André Ducati Luchessi, Rosario Dominguez Crespo Hirata, Mario Hiroyuki Hirata, Eduardo Kokubun

“…In conclusion, the cardiorespiratory fitness may modulate PPARG expression in childhood and adolescence, independently of the genetic background.…”
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A mechanistic-statistical approach to infer dispersal and demography from invasion dynamics, applied to a plant pathogen by Saubin, Méline, Coville, Jérome, Xhaard, Constance, Frey, Pascal, Soubeyrand, Samuel, Halkett, Fabien, Fabre, Frédéric

“…Dispersal, and in particular the frequency of long-distance dispersal (LDD) events, has strong implications for population dynamics with possibly the acceleration of the colonisation front, and for evolution with possibly the conservation of genetic diversity along the colonised domain. However, accurately inferring LDD is challenging as it requires both large-scale data and a methodology that encompasses the redistribution of individuals in time and space. …”
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The phytoplasma SAP54 effector acts as a molecular matchmaker for leafhopper vectors by targeting plant MADS-box factor SVP by Zigmunds Orlovskis, Archana Singh, Adi Kliot, Weijie Huang, Saskia A Hogenhout

“…The molecular mechanisms behind these extended phenotypes - where genetic information of one organism is manifested as traits in another - remain largely unclear. …”
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Machine Learning Based on a Multiparametric and Multiregional Radiomics Signature Predicts Radiotherapeutic Response in Patients with Glioblastoma by Zi-Qi Pan, Shu-Jun Zhang, Xiang-Lian Wang, Yu-Xin Jiao, Jian-Jian Qiu

“…Methods. The MRI images, genetic data, and clinical data of 152 patients with GBM were analyzed. 122 patients from the TCIA dataset (training set: n=82; validation set: n=40) and 30 patients from local hospitals were used as an independent test dataset. …”
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Inflammatory adhesion mediates myocardial segmental necroptosis induced by mixed lineage kinase domain-like protein in acute myocardial infarction by Lijiang Wei, Naifu Wan, Wentong Zhu, Chenchen Liu, Zeyu Chen, Wuwei Rong, Lujun Zhang, Meifeng Xie, Yueqi Qin, Ting Sun, Qing Jing, Ankang Lyu

“…Pharmacological depletion of macrophages or genetic knockout of macrophage-specific MLKL (MLKLM−KO) reduced the occurrence of MSN. …”
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Clinical implementation of next-generation sequencing testing and genomically-matched therapy: a real-world data in a tertiary hospital by Jin Won Kim, Hee Young Na, Sejoon Lee, Ji-Won Kim, Koung Jin Suh, Se Hyun Kim, Yu Jung Kim, Keun-Wook Lee, Jong Seok Lee, Jaihwan Kim, Jin-Hyeok Hwang, Kihwan Hwang, Chae-Yong Kim, Yong Beom Kim, Soomin Ahn, Kyu Sang Lee, Hyojin Kim, Hye Seung Lee, So Yeon Park, Gheeyoung Choe, Jee Hyun Kim, Jin-Haeng Chung

“…Using the Association for Molecular Pathology genetic variant classification system, we found that 257 (26.0%) patients harbored tier I variants, and 859 (86.8%) patients carried tier II variants. …”
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Comparative study of the production potential of indigenous poultry breeds of Banat naked neck and Svrljig hen: Reproductive parameters and egg quality by Škrbić Zdenka, Petričević Veselin, Rakonjac Simeon, Dosković Vladimir, Tolimir Nataša, Bogosavljević-Bošković Snežana, Lukić Miloš

“…Under the applied rearing, nutrition and photoperiod conditions, BNN hens achieved production in accordance with their genetic potential defined by the breed standard, while SH layers with 126.43 eggs/housed hen achieved production higher than the breed standard. …”
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Deficiency of the palmitoyl acyltransferase ZDHHC7 modulates depression-like behaviour in female mice after a mild chronic stress paradigm by Christa Hohoff, Nicole Kerkenberg, Mingyue Zhang, Weronika Palkowska, Lydia Wachsmuth, Maja Peng, Lena Stiehl, Christiane Schettler, Johannes C. S. Zang, Andreas Huge, Evgeni Ponimaskin, Cornelius Faber, Bernhard T. Baune, Weiqi Zhang

“…It seemed to be related to a sex-specific stress response and may reveal genetic factors of CS-resilience in female mice.…”
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Comparison of clinical and pharmacodynamic features of proton pump inhibitors efficacy in gastroesophageal reflux disease by O. A. Storonova, A. S. Trukhmanov

“…Intensity of acid-suppressive action of PPI depends on drug metabolic pathways and genetically determined features of cytochrome P450 system. …”
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Expression of Wnt signaling proteins LEF1, β-catenin, GSK3β, DVL1, and N-myc varies across retinoblastoma subtypes and pRb phosphorylation status by Leon Marković, Anja Bukovac, Ana Maria Varošanec, Antonia Jakovčević, Davor Tomas, Zdenko Sonicki, Borna Puljko, Fran Dumančić, Reno Hrašćan, Nives Pećina-Šlaus

“…Retinoblastomas without germline mutations (RB1 +/+) exhibited high pRb, N-myc, and LEF1 levels, while those in genetically predisposed children (RB1 +/- ) showed lower expression of these proteins. …”
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Nerve Enlargement in Patients with INF2 Variants Causing Peripheral Neuropathy and Focal Segmental Glomerulosclerosis by Quynh Tran Thuy Huong, Linh Tran Nguyen Truc, Hiroko Ueda, Kenji Fukui, Koichiro Higasa, Yoshinori Sato, Shinichi Takeda, Motoshi Hattori, Hiroyasu Tsukaguchi

“…<b>Methods</b>: To characterize the peripheral nerve phenotype of INF2-related CMT, we studied the clinical course, imaging, histology, and germline genetic variants in two unrelated CMT-DIE patients. …”
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Examining the progress and implementation of neonatal peritoneal dialysis in the Ningxia autonomous region by Zhen Tian, Xiu Luo, Hua Yang, Zhi-Mei Ma, Juan Yang, Yong-Jia Ji

“…Among the cases, sepsis was the primary cause of AKI in three cases (43%), with preterm infants accounting for 67% of these cases; genetic metabolic disorder in two cases (28.5%), and twin-twin transfusion syndrome in two cases (28.5%), both involving premature infants; and one of these two involving severe asphyxia. …”
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Cellular heterogeneity and cytokine signatures in acute myeloid leukemia: A novel prognostic model by Jinxia Cao, Bin Hu, Tianqi Li, Dan Fang, ling Jiang, Jun Wang

“…Acute Myeloid Leukemia (AML) is a complex hematological malignancy distinguished by its heterogeneity in genetic aberrations, cellular composition, and clinical outcomes. …”
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An investigation of machine learning methods applied to genomic prediction in yellow-feathered broilers by Bogong Liu, Huichao Liu, Junhao Tu, Jian Xiao, Jie Yang, Xi He, Haihan Zhang

“…This work provides valuable insights into genomic prediction, aiding genetic breeding in broilers.…”
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Complex treatment approach to primary open-angle glaucoma: focus on neuroprotection by M. Kh. Khubetsova, V.V. Kadyshev, B.F. Ambalova

“…Fedorov NMRC “MNTK “Eye Microsurgery”, Moscow, Russian Federation</b> </p> <p> <b>²Moscow Genetic Research Center, Moscow, Russian Federation</b> </p> <p> <b>³Right-Shore Central Regional Clinical Hospital, Beslan, Russian Federation</b> </p> <p> <i>According to the WHO, glaucoma is now the second leading cause of blindness globally. …”
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GluN2D-containing NMDA receptors in parvalbumin neurons in the nucleus accumbens regulate nocifensive responses in neuropathic pain by Sukanya G. Gakare, Gajanan P. Shelkar, Dinesh Y. Gawande, Ratnamala Pavuluri, Pauravi J. Gandhi, Shashank M. Dravid

“…Here, we investigated the role of GluN2C- and GluN2D-containing NMDA receptors in the development of neuropathic pain induced by cisplatin, a widely used chemotherapeutic agent. Through genetic and pharmacological strategies, we found that GluN2D-containing NMDA receptors play a targeted role in regulating cisplatin-induced neuropathic pain (CINP), while sparing inflammatory or acute pain responses. …”
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Why is it so difficult to understand why we don’t understand human systemic lupus erythematosus? Contemplating facts, conflicts, and impact of “the causality cascade paradigm”... by Ole Petter Rekvig, Ole Petter Rekvig

“…These data comprise famous descriptions of distinct, dynamically changing DNA structures linked to the genetic machinery. These unique structures have since their discoveries decades ago mostly been ignored in SLE research. …”
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