Role of Interleukin- (IL-) 17 in the Pathogenesis and Targeted Therapies in Spondyloarthropathies by I-Tsu Chyuan, Ji-Yih Chen

“…Spondyloarthropathy (SpA) is a unique type of joint inflammation characterized by coexisting erosive bone damage and pathological new bone formation. Previous genetic association studies have demonstrated that several cytokine pathways play a critical role in the pathogenesis of ankylosing spondylitis (AS), psoriatic arthritis (PsA), and other types of SpA. …”
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Non-B DNA Secondary Structures and Their Resolution by RecQ Helicases by Sudha Sharma

“…Such secondary structures have a range of biological functions but also induce genetic instability. Increasing evidence suggests that genomic instabilities induced by non-B DNA secondary structures result in predisposition to diseases. …”
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Personality traits of women with hereditary risk for breast/ovarian cancer versus obstetric history and cancer preventive behaviors by Joanna Żurawska, Beata Pięta, Maciej Wilczak, Małgorzata Wojciechowska, Paweł Rzymski, Agnieszka Pieczykolan, Justyna Krysa, Agnieszka Bień

“…A total of 357 women, participants of ‘The National Program for Families With Genetic/Familial High Risk for Cancer’, were included in the study. …”
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Smoking and Pulmonary Fibrosis: Novel Insights by Katerina D. Samara, George Margaritopoulos, Athol U. Wells, Nikolaos M. Siafakas, Katerina M. Antoniou

“…Rheumatoid arthritis results from the interaction between genetic and environmental factors, while the best established environmental factor is tobacco smoking. …”
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CD133+PD-L1+ cancer cells confer resistance to adoptively transferred engineered macrophage-based therapy in melanoma by Jiaojiao Xu, Zhe Li, Qinli Tong, Sihang Zhang, Jianchen Fang, Aihua Wu, Guoguang Wei, Chen Zhang, Sheng Yu, Binbin Zheng, Hongzheng Lin, Xueling Liao, Zeyu Xiao, Wei Lu

“…Abstract Adoptive transfer of genetically or nanoparticle-engineered macrophages represents a promising cell therapy modality for treatment of solid tumor. …”
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Gene Mutation and Its Association with Clinicopathological Features in Young Patients with Non-Small-Cell Lung Cancer by Wencui Kong, Zongyang Yu, Wenwu Wang, Jingrong Yang, Jingfang Wang, Zhongquan Zhao

“…We investigated the correlation between genetic mutations and clinical-pathological features in young patients with NSCLC. …”
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GGE biplot for stability and adaptability in cashew tree clones by Gilberto Ken Iti Yokomizo, Francisco das Chagas Vidal Neto, Kuang Hongyu, Levi de Moura Barros

“…The interaction genotype versus environment makes it difficult the genetic improvement of the species for the selection of more adapted and stable genotypes. …”
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Risk-Based Multiobjective Optimal Seismic Design for RC Piers Using the Response Surface Method and NSGA-II by Sicong Hu, Yixuan Zou, Yufeng Gai, Zheng Huang, Guquan Song

“…The Pareto optimal solutions of piers are determined by applying an improved version of the nondominated sorting genetic algorithm (NSGA-II). As a case study, the proposed optimal seismic design method is applied to a continuous concrete box girder bridge. …”
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Melanonychia Secondary to Long-Term Treatment with Hydroxycarbamide: An Essential Thrombocytosis Case by Umit Yavuz Malkan, Gursel Gunes, Eylem Eliacik, Okan Yayar, Ibrahim Celalettin Haznedaroglu

“…Some investigators suggested that genetic factors, induction of melanocytes, and some changes in nail matrix could be the reason of hydroxycarbamide related melanonychia. …”
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Neurophysiology of Drosophila Models of Parkinson’s Disease by Ryan J. H. West, Rebecca Furmston, Charles A. C. Williams, Christopher J. H. Elliott

“…While the structure-function relationship is complex, the genetic tractability of Drosophila offers the chance to separate fundamental changes from downstream consequences. …”
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Predictive Biomarkers of Bacillus Calmette-Guérin Immunotherapy Response in Bladder Cancer: Where Are We Now? by Luís Lima, Mário Dinis-Ribeiro, Adhemar Longatto-Filho, Lúcio Santos

“…Several molecules, including CD68 and genetic polymorphisms, have been identified as promising surrogate biomarkers. …”
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Evaluation of novel NaOH/activated carbon/zeolite biocomposite as an efficient adsorbent for oilfield produced water treatment by Eghe Amenze Oyedoh, Onyedikachi Praise Igbokwe

“…The adsorption process was optimized using Response Surface Methodology (RSM) and Artificial Neural Networks (ANN) integrated with genetic algorithms. The results indicated a hydrocarbon removal efficiency of 99.86 % with RSM and 99.99 % with ANN under optimal conditions. …”
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Herbal medicine and leptospirosis in Southeast Asia: A comprehensive bibliometric analysis (1973-2023) by Shah Putri Ade Dian, Stefani Widodo, Putri Damayanti Irma, Halim Shariff, Abidah Safithri, Muhammad Almanfaluthi

“…Keyword analysis highlights “leptospirosis,” “leptospira,” and “DNA extraction” as central themes, demonstrating a focus on the genetic and diagnostic aspects of the disease alongside the exploration of plant-based treatments. …”
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Pleiotrophin deletion prevents high-fat diet-induced cognitive impairment, glial responses, and alterations of the perineuronal nets in the hippocampus by Héctor Cañeque-Rufo, Teresa Fontán-Baselga, Milagros Galán-Llario, Agata Zuccaro, María Gracia Sánchez-Alonso, Esther Gramage, María del Pilar Ramos-Álvarez, Gonzalo Herradón

“…To test this hypothesis, we used an HFD-induced obesity model in Ptn genetically deficient mice (Ptn−/−). First, we confirmed that Ptn deletion prevents HFD-induced obesity. …”
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Characterization and phylogenetic analysis of the chloroplast genome of endangered Impatiens chishuiensis by LAN Wenxiang, MO Qing, HUANG Haiquan, HUANG Meijuan

“…[Objective] The chloroplast genome structure and phylogenetic location of Impatiens chishuiensis were studied in order to provide scientific basis for the conservation of plant germplasm resources, genetic diversity, and phylogeny of I. chishuiensis. …”
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Autoimmune Hepatitis: Progress from Global Immunosuppression to Personalised Regulatory T Cell Therapy by Nwe Ni Than, Hannah C. Jeffery, Ye H. Oo

“…The precise aetiology of AIH is still unknown but current evidence suggests both genetic and environmental factors are involved. Breakdown in peripheral self-tolerance, and impaired functions of FOXP3+ regulatory T cell along with effector cell resistance to suppression at the tissue level seem to play an important role in AIH immunopathogenesis. …”
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The intestinal microbiome as a separate organ by Yu. O. Shulpekova

“…Intestinal microbiome encompasses about 1014 microorganisms, over 99% of microbiome genetic material belong to bacteria. In healthy people three basic enterotypes (according to the type of dominating species) are defined. …”
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A human pathogenic hantavirus circulates and is shed in taxonomically diverse rodent reservoirs. by Samuel M Goodfellow, Robert A Nofchissey, Chunyan Ye, Jaecy K Banther-McConnell, Thanchira Suriyamongkol, Joseph A Cook, Jonathan L Dunnum, Ivana Mali, Steven B Bradfute

“…<h4>Results</h4>We conducted an extensive survey of SNV genetic prevalence in wild-caught small mammal communities throughout New Mexico and observed that 27% of all animals were positive for SNV. …”
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A Variant in Is Associated with the Risk of Ankylosing Spondylitis in Koreans by Sung-Min Cho, Seung-Hyun Jung, Yeun-Jun Chung

“…Regarding its etiology, although HLA-B27 is known to be the strongest genetic factor of AS, much evidence suggests the potential contribution of non-MHC genes to the susceptibility to AS. …”
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Qualitative Parameters of the Colonic Flora in Patients with HNF1A-MODY Are Different from Those Observed in Type 2 Diabetes Mellitus by Sandra Mrozinska, Piotr Radkowski, Tomasz Gosiewski, Magdalena Szopa, Malgorzata Bulanda, Agnieszka H. Ludwig-Galezowska, Iwona Morawska, Agnieszka Sroka-Oleksiak, Bartlomiej Matejko, Przemyslaw Kapusta, Dominika Salamon, Maciej T. Malecki, Pawel Wolkow, Tomasz Klupa

“…Type 2 diabetes mellitus (T2DM) is determined by genetic and environmental factors. There have been many studies on the relationship between the composition of the gastrointestinal bacterial flora, T2DM, and obesity. …”
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