QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP AND MOLECULAR DOCKING STUDIES OF HYDROXAMIC ACID DERIVATIVES AS NOVEL CLASS INHIBITORS AGAINST HELICOBACTER PYLORI UREASE by Ibrahim Tijjani Ibrahim, Adamu Uzairu, Balarabe Sagagi

“…Relevant molecular descriptors were selected by Genetic Function Algorithms (GFA). The best model obtained was given a distinct validated, good and robust statistical parameters which include; square correlation coefficient R2 value of (0.9989), adjusted determination coefficient, R2adj value of (0.9984), Leave one out cross validation determination coefficient Q2 value of (0.9948) and external validation as predicted determination coefficient R2 value of(0.8409). …”
Get full text

Evaluation of Genotype Diversity in Oat Germplasm and Definition of Ideotypes Adapted to the Mediterranean Environment by Anna Iannucci, Pasquale Codianni, Luigi Cattivelli

“…A germplasm evaluation was carried out to determine the genetic diversity, using univariate and multivariate analyses, and to define an oat ideotype for grain and fodder production adapted to the Mediterranean environment. …”
Get full text

A Modified Asymmetric Bouc–Wen Model-Based Decoupling Control of an XY Piezoactuated Compliant Platform with Coupled Hysteresis Characteristics by Xubin Zhou, Weidong Chen, Qing Xiao, Xiangsen Kong, Xingtian Liu, Liping Zhou, Yichong Dong, Quan Zhang

“…To establish the hysteresis characteristics of the piezo-driven manipulator, a modified Bouc–Wen model has been proposed, and a Genetic Algorithm-based Particle Swarm Optimization (GA-PSO) was adopted to recognize the parameters of the model. …”
Get full text

Successful Traceability of Wildlife Samples Contributes to Wildlife Conservation: A Case Study of Tracing the Snub-Nosed Monkey (<i>Rhinopithecus</i> spp.) by Xibo Wang, Ying Shen, Yang Teng, Ruifeng Wu, Shuhao Liu, Jilai Zhao, Can Hu, Ming Li, Huijuan Pan, Jiwei Qi

“…Additionally, we found that relying only on mitochondrial genetic information is insufficient for rapid and accurate traceability to subspecies-level geographic populations. …”
Get full text

Defining the Optimal Level of Pressure Fluctuations at Pressure Control Management Strategy for Reducing Water Losses in Water Networks by Talha İbrahim Arduçoğlu, Furkan Boztaş, Mahmut Fırat

“…In the next stage, the operating scenario for the flow-sensitive advanced pressure management was started to be created. Genetic algorithm was used in the MATLAB environment to create the most suitable scenario. …”
Get full text

Curing simulation and data-driven curing curve prediction of thermoset composites by Chenchen Wu, Ruming Zhang, Pengyuan Zhao, Liang Li, Dingguo Zhang

“…Then, the temperature–time and the resulting degree-of-cure-time curves obtained from finite element simulations were created for training the prediction models using machine learning approaches of support vector regression (SVR), back propagation (BP) neural network and BP neural network optimized by genetic algorithm (GA-BP). The validation and evaluation indices illustrate that the degree-of-cure curve prediction model trained by the GA-BP neural network yields the highest accuracy.…”
Get full text

Animal Models for Human-Pathogenic Coronavirus and Animal Coronavirus Research by Fenglian Xiao, Jincheng Hu, Minsheng Xu, Di Wang, Xiaoyan Shen, Hua Zhang, Jie Miao, Haodong Cai, Jihui Wang, Yaqing Liu, Shan Xiao, Longchao Zhu

“…These approaches include using viral delivery methods to induce the expression of viral receptors in mouse tissues and employing gene-editing techniques to create genetically modified mice. This has led to the successful establishment of infection models for multiple coronaviruses, significantly advancing related research. …”
Get full text

WeiFu: A Novel Pan-Cancer Driver Gene Identification Method Using Incidence-Weighted Mutation Scores by Yanjie Ren, Azlan Mohd Zain, Yan Zhang, Rozita Abdul Jalil, Mahadi Bahari, Norfadzlan Bin Yusup, Mazlina Abdul Majid, Azurah A. Samah, Didik Dwi Prasetya, Nurhafizah Moziyana Mohd Yusop

“…Genetic and genomic variations are primary drivers of tumor development. …”
Get full text

Updates in Biliary Atresia: Aetiology, Diagnosis and Surgery by Mark Davenport

“…Facts about its aetiology are hard to encounter but might include genetic, developmental, exposure to an environmental toxin, or perinatal virus infection. …”
Get full text

Plotting of Ethylene Glycol Blood Concentrations Using Linear Regression before and during Hemodialysis in a Case of Intoxication and Pharmacokinetic Review by Youngho Kim

“…Pharmacokinetic review revealed minimal elimination of EG by alcohol dehydrogenase (ADH) which could be related to genetic predisposition for ADH activity and home medications as well as presence of propylene glycol. …”
Get full text

Regional anesthesia and muscle-wasting diseases in pediatrics: A focused educational review by Amr Elhamrawy, Islam Elmitwalli, Candice Burrier, Giorgio Veneziano, Joseph D. Tobias

“…The muscular dystrophies or muscle-wasting diseases include a diverse group of genetic disorders, which result in progressive degeneration of skeletal muscles, progressive muscle weakness, and comorbid multi-system involvement. …”
Get full text

Parathyroid carcinoma and pheochromocytoma in a patient with neurofibromatosis type 1: a rare association by Jardelina Brena Rocha Leite, Nicole Ramalho De Freitas, Rafaella Nelice de Holanda Cardoso, Erik Trovão Diniz, Gabriel Rodrigues de Assis Ferreira, Fernão Henrique Costa e Alvim, Camila Ribeiro Coutinho Madruga, Ana Carolina Thé Garrido, Luciano Albuquerque, Patricia Sampaio Gadelha, Ruy Lyra, Lucio Vilar

“…Surgical intervention confirmed the presence of pheochromocytoma and parathyroid carcinoma. Genetic analysis corroborated NF1 with a pathogenic variant in the NF1 gene. …”
Get full text

Optimal compensation method for centrifugal impeller considering aerodynamic performance and dimensional accuracy by Tao Zhou, Sitong Xiang, Hainan Zhang, Jianguo Yang

“…Finally, based on the mapping model, the second-generation non-dominated sorting genetic algorithm was used to optimize the control points of the mirror compensation surface, and thereby obtain the optimal compensation surface. …”
Get full text

Later-Life Mortality and Longevity in Late-18th and 19th-Century Cohorts. Where Are We Now, and Where Are We Heading? by Rich J. Mourits

“…Yet, later-life mortality and longevity are generally studied from a genetic perspective, while the social dimension has received less attention. …”
Get full text

Association between TLR4 and TLR9 Gene Polymorphisms with Development of Pulmonary Tuberculosis in Zahedan, Southeastern Iran by Danial Jahantigh, Saeedeh Salimi, Roya Alavi-Naini, Abolfazl Emamdadi, Hamid Owaysee Osquee, Farzaneh Farajian Mashhadi

“…Some evidence suggests that a variety of genetic factors contribute to development of the tuberculosis (TB). …”
Get full text

Optimized Skip-Stop Metro Line Operation Using Smart Card Data by Peitong Zhang, Zhanbo Sun, Xiaobo Liu

“…Different from the conventional “A/B” scheme, the proposed Flexible Skip-Stop Scheme (FSSS) can better accommodate spatially and temporally varied passenger demand. A genetic algorithm (GA) based approach is then developed to efficiently search for the optimal solution. …”
Get full text

Stock Price Change Rate Prediction by Utilizing Social Network Activities by Shangkun Deng, Takashi Mitsubuchi, Akito Sakurai

“…In this paper, we propose a hybrid model that combines multiple kernel learning (MKL) and genetic algorithm (GA). MKL is adopted to optimize the stock price change rate prediction models that are expressed in a multiple kernel linear function of different types of features extracted from different sources. …”
Get full text

Facultative parthenogenesis: a transient state in transitions between sex and obligate asexuality in stick insects? by Larose, Chloé, Lavanchy, Guillaume, Freitas, Susana, Parker, Darren J., Schwander, Tanja

“…These populations comprised three genetic lineages. Females from all lineages were capable of parthenogenesis (with variable efficiency) but their propensity to reproduce sexually after mating varied extensively. …”
Get full text

Case Report: A rare presentation of rapidly progressive moyamoya disease refractory to unilateral surgical revascularization by Daniel Friel Leach, Srivikram Margam S, Aaron Gustin, Paul J. Gustin, Mohamad N. Jajeh, Yhana C. Chavis, Kristin V. Walker, Joshua S. Bentley

“…While the pathophysiology of MMD is unknown, there remain numerous clinical associations including radiation therapy to the brain, inherited genetic syndromes, hematologic disorders, and autoimmune conditions. …”
Get full text

Effect of Recombinant Human Growth Hormone Treatment in a Patient with Short Stature Associated with the Ring Chromosome 17 Syndrome by Gustavo Tempone Cardoso Penna, Gabriela de Rezende Lelot, Ana Luiza de Rezende Lelot, Juliana Greghi Hernandez, Carolina Costa Figueiredo, Nara Michelle de Araujo Evangelista, Vania de Fatima Tonetto Fernandes, Guido de Paula Colares Neto

“…The patient’s severe short stature may be related to genetic, environmental, and hormonal factors and the positive response to rhGH may indicate abnormalities in the somatotropic axis that were mitigated with the treatment. …”
Get full text