Intraductal Papillary Neoplasms of the Bile Duct by Masayuki Ohtsuka, Hiroaki Shimizu, Atsushi Kato, Hideyuki Yoshitomi, Katsunori Furukawa, Toshio Tsuyuguchi, Yuji Sakai, Osamu Yokosuka, Masaru Miyazaki

“…Although several authors have investigated molecular genetic changes during the development and progression of IPNB, these are still poorly characterized and controversial.…”
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Myasthenia Gravis Development and Crisis Subsequent to Multiple Sclerosis by Kurosh Gharagozli, Maziar Shojaei, Ali Amini Harandi, Nayyereh Akbari, Manouchehr Ilkhani

“…Furthermore, some evidences support the role of systemic immune dysregulation due to a genetic susceptibility that is common to these two diseases. …”
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APOE4 and sedentary lifestyle synergistically impair neurovascular function in the visual cortex of awake mice by Silvia Anderle, Orla Bonnar, Joseph Henderson, Kira Shaw, Andre M. Chagas, Letitia McMullan, Alexandra Webber, Kirsty McGowan, Sarah L. King, Catherine N. Hall

“…Here, we ask whether genetic and lifestyle risk factors for AD—the ε4 allele of the Apolipoprotein (APOE) gene, and physical activity—can together produce this reduction in cerebral blood flow which leads eventually to AD. …”
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Analysis and Dynamic Prediction of Bus Dwell Time Under Rainfall Conditions by Baoyun SUN, Yaping YANG, Lei DONG, Honglin LU, Zimin WANG

“…Support vector machine, k-nearest neighbour and backpropagation (BP) prediction models were established, and the BP neural network model, having the best prediction effect, was optimised using a genetic algorithm (GA). The constructed GA-BP prediction model was more realistic than the BP prediction model and can be used to predict bus dwell times under rainfall conditions. …”
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Research Status on Jumping Function of Quadruped Robots by Hua Congcong, Yang Zihe, Xia Yanting, Yan Jianrong, Gao Guanjian, Luo Fuliang, Ma Wenshuo, Li Zhijie

“…In addition, advanced control methods such as reinforcement learning, neural networks, and genetic algorithms also were explored and applied. …”
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Genomic Copy Number Variation Affecting Genes Involved in the Cell Cycle Pathway: Implications for Somatic Mosaicism by Ivan Y. Iourov, Svetlana G. Vorsanova, Maria A. Zelenova, Sergei A. Korostelev, Yuri B. Yurov

“…Recently, it has been hypothesized that zygotic genomic variation naturally occurring in humans is likely to predispose to nonheritable genetic changes (aneuploidy) acquired during the lifetime through affecting cell cycle regulation, genome stability maintenance, and related pathways. …”
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Heterogeneity in Seed Samples from Vineyards and Natural Habitats Along the Eurasian <i>Vitis vinifera</i> Range: Implications for Domestication and Hybridization by Diego Rivera, Javier Valera, David Maghradze, Maia Kikvadze, Anna Nebish, Rafael Ocete, Carlos Álvar Ocete, Claire Arnold, Emilio Laguna, Francisco Alcaraz, Diego José Rivera-Obón, Gianni Lovicu, Massimino Farci, Concepción Obón

“…The results demonstrate the significance of these mixed populations as repositories of genetic diversity, underscoring their conservation value, particularly considering the negative impact of habitat alterations, especially in riparian forests due to major public works.…”
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Leveraging haplotype information in heritability estimation and polygenic prediction by Jonas Meisner, Michael Eriksen Benros, Simon Rasmussen

“…This may hinder the impact of polygenic risk scores in modern diverse populations due to small differences in genetic architectures. Reference-free estimators of polygenic scores are instead based on genomic best linear unbiased predictions and model the population of interest directly. …”
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The causal relationship between steroid hormones and risk of stroke: evidence from a two-sample Mendelian randomization study by Yang Zhang, Miaowen Jiang, Di Wu, Ming Li, Xunming Ji

“…Through genome-wide association meta-analysis, the genetic variants of steroid hormones, including testosterone/17β-estradiol (T/E2) ratio, aldosterone, androstenedione, progesterone, and hydroxyprogesterone, were acquired as instrumental variables. …”
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Long-read sequencing revealed complex biallelic pentanucleotide repeat expansions in RFC1-related Parkinson’s disease by Peng Liu, Fan Zhang, Xinhui Chen, Xiaosheng Zheng, Miao Chen, Zhiru Lin, Shuqi Chen, Lebo Wang, Xinchen Wang, Nan Jin, Chenxin Ying, Fei Xie, Bo Wang, Sheng Wu, Zhidong Cen, Wei Luo

“…We screened RFC1-repeat expansions in 1445 patients with parkinsonism. Comprehensive genetic and clinical, and pathological assessments were performed. …”
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Short Reads Phasing to Construct Haplotypes in Genomic Regions That Are Associated with Body Mass Index in Korean Individuals by Kichan Lee, Seonggyun Han, Yeonjeong Tark, Sangsoo Kim

“…Genome-wide association (GWA) studies have found many important genetic variants that affect various traits. Since these studies are useful to investigate untyped but causal variants using linkage disequilibrium (LD), it would be useful to explore the haplotypes of single-nucleotide polymorphisms (SNPs) within the same LD block of significant associations based on high-density variants from population references. …”
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Utilization of Cardiac Magnetic Resonance Imaging for Assessing Myocardial Fibrosis in Prognosis Evaluation and Risk Stratification of Patients with Dilated Cardiomyopathy by Xin-Yi Feng, Yu-Cong Zheng, Ying-Xia Yang, Wen-Feng He, Fan Yang, Ling-Li Wang, Han-Feng Yang, Chun-Ping Li, Xiao-Xue Xu, Rui Li

“…Dilated cardiomyopathy (DCM) is the ultimate manifestation of the myocardial response to various genetic and environmental changes and is characterized mainly by impaired left ventricular systolic and diastolic function. …”
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Selective utilization of medicinal polysaccharides by human gut Bacteroides and Parabacteroides species by Zepeng Qu, Hongbin Liu, Ji Yang, Linggang Zheng, Jumin Huang, Ziming Wang, Chun Xie, Wenlong Zuo, Xiong Xia, Lin Sun, Yifa Zhou, Ying Xie, Jingguang Lu, Yizhun Zhu, Lili Yu, Lihua Liu, Hua Zhou, Lei Dai, Elaine Lai-Han Leung

“…Through comparative transcriptomics and genetical manipulation, we validated that the polysaccharide utilization locus PUL34_Bu enabled Bacteroides uniformis to utilize Dendrobium polysaccharides (i.e. glucomannan). …”
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Modeling the effect of extrusion parameters on density of biomass pellet using artificial neural network by Abedin Zafari, Mohammad Hossein Kianmehr, Rahman Abdolahzadeh

“…Shankar and Bandyopadhyay and Shankar et al. successfully used genetic algorithms and artificial neural networks to understand and optimize an extrusion process. …”
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Integrating paleoparasitological, paleogenetic, and archaeological data to understand the paleoecological scenario of pre-Columbian archaeological site Gruta do Gentio II, Brazil by Ludmila Gurjão, Lorrayne Brito, Ondemar Dias, Jandira Neto, Alena Mayo Iñiguez

“…The origin of coprolites was genetically defined as five species of mammals, humans, felines as Panthera onca and Leopardus pardalis, and marsupials as Didelphis albiventris and Philander opossum. …”
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Multi-carrier information hiding algorithm based on three-dimensional model’s concave-convex structure characteristics by Shuai REN, Lei SHI, Binbin WANG, Huirong CHENG, Qianqian ZHANG, Honglin LIU

“…Aiming at the problem that the embedding capacity, invaibility and robustness of a single-carrier information hiding algorithm cannot be further improved due to the limitation of the number of carriers, the voxelization of the carrier and the embedding of secret information were combined with the concave-convex structure characteristics of the three-dimensional model, and a method was proposed.A multi-carrier information hiding algorithm based on the three-dimensional model’s concave-convex structure features.Firstly, the three-dimensional model was voxelized, and the three-dimensional model’s concave-convex structure features were extracted from the data set obtained after voxelization to classify the carrier library, and the concave-convex degree was obtained by conversion after the interval was encoded.Secondly, the secret information was segmented according to the number of carrier classifications and scrambled and optimized, so that the embedding of the carrier and the secret information was effectively connected through its classification and number of segments, and double embedding of secret information by encoding data of concavity intervals and voxelized coordinate points, respectively, to further improve the performance of the algorithm.Finally, the genetic algorithm was applied to optimize the secret information to complete the information hiding.The experiment shows that compared with the high-capacity three-dimensional model steganography algorithm based on a single carrier, the invisibility, robustness and capacity of the algorithm were significantly improved.…”
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Later-Life Mortality and Longevity in Late-18th and 19th-Century Cohorts. Where Are We Now, and Where Are We Heading? by Rick Mourits

“…Yet, later-life mortality and longevity are generally studied from a genetic perspective, while the social dimension has received less attention. …”
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Bacteriophages: Uncharacterized and Dynamic Regulators of the Immune System by Anshul Sinha, Corinne F. Maurice

“…These bacterial viruses are estimated to be as numerous as their bacterial hosts, with tremendous and mostly uncharacterized genetic diversity. In addition, bacteriophages are not passive members of the gut microbiota, as highlighted by the recent evidence for their active involvement in human health. …”
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Integration research of blockchain and social networks in rural management systems under fuzzy cognitive environment by Wencun Wang, Jun Yao, Di Zhao, Can Huang

“…The system automatically invokes the Matlab dynamic link library and employs a hybrid genetic algorithm to plan delivery routes. This study presents key findings on implementing an intelligent rural management system incorporating fuzzy sets, blockchain, and IoT technology. …”
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Piezo1-directed neutrophil extracellular traps regulate macrophage differentiation during influenza virus infection by Yuexin Wang, Qiuli Yang, Yingjie Dong, Likun Wang, Zhiyuan Zhang, Ruiying Niu, Yufei Wang, Yujing Bi, Guangwei Liu

“…Herein, we found that the ion channel Piezo1 directs neutrophil extracellular trap (NET) formation and regulates macrophage functional differentiation in anti-influenza virus immunity. Genetic deletion of Piezo1 in neutrophils inhibited the generation of NETs and M1 macrophage differentiation while driving the development of M2 macrophages during viral infection. …”
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