Reverse epidemiology of obesity paradox: Fact or fiction? by Bellamkonda K. Kishore

“…Evidence suggests that the development of obesity and insulin resistance are influenced by genetic (or ethnic) make up and dietary habits (culture) of the individuals. …”
Get full text

Notch/CXCR4 Partnership in Acute Lymphoblastic Leukemia Progression by Georgia Tsaouli, Elisabetta Ferretti, Diana Bellavia, Alessandra Vacca, Maria Pia Felli

“…ALL may affect B-cell or T-cell lineages. Different genetic alterations characterize the two ALL forms. …”
Get full text

L’histoire d’un vrai faux traité philosophique (Ḥatatā Zar’a Yā‘eqob et Ḥatatā Walda Ḥeywat). Épisode 2 : Le temps de la démystification et la traversée du désert (de 1916 aux anné... by Anaïs Wion

“…It provides a new interpretation based on genetic criticism of these texts that tries to see the author, Juste d’Urbin, at work writing the Hatatā Zar’a Yā‘eqob. …”
Get full text

Joint Optimization of Energy Conservation and Migration Cost for Complex Systems in Edge Computing by Xiaolong Xu, Yuan Xue, Mengmeng Cui, Yuan Yuan, Lianyong Qi

“…In addition, nondominated sorting genetic algorithm III (NSGA-III) is adopted to generate optimal resource scheduling strategies. …”
Get full text

Mitochondrial DNA variants and their impact on epigenetic and biological aging in young adulthood by Klara Mareckova, Ana Paula Mendes-Silva, Martin Jáni, Anna Pacinkova, Pavel Piler, Vanessa F. Gonçalves, Yuliya S. Nikolova

“…A total of 81 participants from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) prenatal birth cohort had good quality genetic data as well as blood-based markers to estimate biological aging in the late 20. …”
Get full text

Mycobacterium avium subsp. paratuberculosis in an Italian Cohort of Type 1 Diabetes Pediatric Patients by Maria Luisa Manca Bitti, Speranza Masala, Francesca Capasso, Novella Rapini, Simona Piccinini, Federica Angelini, Andrea Pierantozzi, Roberta Lidano, Silvia Pietrosanti, Daniela Paccagnini, Leonardo A. Sechi

“…These findings taken together support the hypothesis of MAP as an environmental risk factor for the development of T1D in genetically predisposed subjects, probably involving a mechanism of molecular mimicry between MAP antigens and pancreatic islet β-cells.…”
Get full text

Melanoma genomics – will we go beyond BRAF in clinics? by Justyna Mirek, Wiesław Bal, Magdalena Olbryt

“…Abstract In the era of next-generation sequencing, the genetic background of cancer, including melanoma, appears to be thoroughly established. …”
Get full text

Sequence Variants of ADIPOQ and Association with Type 2 Diabetes Mellitus in Taiwan Chinese Han Population by Ming-Kai Tsai, Hui-Min David Wang, Jeng-Chuan Shiang, I-Hung Chen, Chih-Chiang Wang, Ya-Fen Shiao, Wen-Sheng Liu, Tai-Jung Lin, Tsung-Ming Chen, Ya-Huey Chen

“…Large-scale genome-wide association studies identified loci for type 2 diabetes mellitus (T2DM), including adiponectin (ADIPOQ) gene and transcription factor 7-like 2 (TCF7L2), but few studies clarified the effect of genetic polymorphisms of ADIPOQ and TCF7L2 on risk of T2DM. …”
Get full text

Repetitive Noninvasive Monitoring of HSV1-tk-Expressing T Cells Intravenously Infused into Nonhuman Primates Using Positron Emission Tomography and Computed Tomography with F-FEAU by Gianpietro Dotti, Mei Tian, Barbara Savoldo, Amer Najjar, Laurence J.N. Cooper, James Jackson, Amanda Smith, Osama Mawlawi, Rajesh Uthamanthil, Agatha Borne, David Brammer, Vincenzo Paolillo, Mian Alauddin, Carlos Gonzalez, David Steiner, William K. Decker, Frank Marini, Steven Kornblau, Catherine M. Bollard, Elizabeth J. Shpall, Juri G. Gelovani

“…Noninvasive imaging of adoptively transferred CTLs using molecular-genetic reporter imaging with positron emission tomography and computed tomography (PET-CT) represents an innovative approach to understanding the long-term migratory patterns and therapeutic potential of adoptively transferred T cells. …”
Get full text

Faking the News: Intentional Guided Variation Reflects Cognitive Biases in Transmission Chains Without Recall by Stubbersfield Joseph, Tehrani Jamshid, Flynn Emma

“…While copying error is directly analogous to genetic mutation, guided variation is a specifically cultural process that does not have a close parallel in biological evolution. …”
Get full text

Research on the optimization of drum structure based on virtual prototyping technology by Xin Jin, Dongpo Han, Guochao Zhao, Lijuan Zhao, Hongmei Liu

“…By fitting the comprehensive performance evaluation function of the drum, the optimal structural parameters are obtained through the improved Non-Dominated Sorting Genetic Algorithms (NSGA-II). Taking into account both technical and economic factors, the optimal helix angle is ultimately determined to be 18°, the optimal installation angle is 45°, and the optimal cutting distance is 71 mm. …”
Get full text

Structural health evaluation of arch bridge by field test and optimized BPNN algorithm by Zhihua Xiong, Zhuoxi Liang, Xulin Mou, Yu Zhang

“…Back Propagation Neural Network (BPNN), Genetic Algorithm-based BPNN (GA-BPNN), Particle Swarm Optimization Algorithm-based BPNN (PSO-BPNN) approaches and test data analysis are adopted to compare the measured data with the simulated data to quantitatively identify the damage degree of the selected bridge. …”
Get full text

Developmental Programming of Hypertension and Kidney Disease by Euming Chong, Ihor V. Yosypiv

“…The risk of developing late-onset diseases such as hypertension, chronic kidney disease (CKD), obesity or type 2 diabetes is increased in infants born prematurely at <37 weeks of gestation or in low birth weight (LBW) infants weighing <2,500 g at birth. Both genetic and environmental events contribute to the programming of subsequent risks of CKD and hypertension in premature or LBW individuals. …”
Get full text

Genome-Wide Identification of Genes Probably Relevant to the Uniqueness of Tea Plant (Camellia sinensis) and Its Cultivars by Yan Wei, Wang Jing, Zhou Youxiang, Zhao Mingming, Gong Yan, Ding Hua, Peng Lijun, Hu Dingjin

“…Tea (Camellia sinensis) is a popular beverage all over the world and a number of studies have focused on the genetic uniqueness of tea and its cultivars. However, molecular mechanisms underlying these phenomena are largely undefined. …”
Get full text

Ophiocordyceps salganeicola, a parasite of social cockroaches in Japan and insights into the evolution of other closely-related Blattodea-associated lineages by João P. M. Araújo, Mitsuru G. Moriguchi, Shigeru Uchiyama, Noriko Kinjo, Yu Matsuura

“…We found a high degree of genetic similarity between specimens from different islands, infecting these two Salganea species and that this relationship is ancient, likely not originating from a recent host jump. …”
Get full text

Osteogenesis Imperfecta with Celiac Disease and Type II Diabetes Mellitus Associated: Improvement with a Gluten-Free Diet by Luis Rodrigo, Isabel Pérez-Martinez

“…Osteogenesis imperfecta (OI) is a genetic disease, with a connective tissue alteration, consisting in the presence of multiple spontaneous fractures or after minimal traumatism. …”
Get full text

PSO Based PI Controller Design for a Solar Charger System by Her-Terng Yau, Chih-Jer Lin, Qin-Cheng Liang

“…According to the simulation and experimental results, the control parameters resulted from PSO have better performance than genetic algorithms (GAs).…”
Get full text

In Vitro Expansion of Bone Marrow Derived Mesenchymal Stem Cells Alters DNA Double Strand Break Repair of Etoposide Induced DNA Damage by Ian Hare, Marieta Gencheva, Rebecca Evans, James Fortney, Debbie Piktel, Jeffrey A. Vos, David Howell, Laura F. Gibson

“…Previous investigations have identified genetic and phenotypic alterations of MSCs with in vitro passage, but little is known regarding how culturing influences the ability of MSCs to repair double strand DNA breaks (DSBs), the most severe of DNA lesions. …”
Get full text

Facioscapulohumeral muscular dystrophy: a review of pathogenesis, clinical symptoms, and treatment by T. Mikalauskas, B. Burnytė

“…The disease can present in many ways, from an asymptomatic form to a life dependent on a wheelchair, so it is important for doctors to keep up to date with the latest information so they can identify this genetic disorder faster and help the patient live a full life. …”
Get full text

m5C‐TNKmer: Identification of 5‐Methylated Base Cytosine of Ribonucleic Acid Using Supervised Machine Learning Techniques by Shahid Qazi, Dilawar Shah, Mohammad Asmat Ullah Khan, Shujaat Ali, Mohammad Abrar, Asfandyar Khan, Muhammad Tahir

“…This model provides a powerful tool for scientists to accurately identify RNA m5C sites, contributing to a deeper understanding of genetic functions and regulatory mechanisms.…”
Get full text