<i>Klebsiella pneumoniae</i> Phage M198 and Its Therapeutic Potential by Lika Leshkasheli, Ia Kusradze, Darejan Bolkvadze, Lia Askilashvili, Maria Chichashvili, Giorgi Tsertsvadze, Elisabed Zaldastanishvili

“…Here, we characterize phage M198 in terms of its biological and genetic properties. Since in some phage therapy cases, phages are administered in combination with antibiotics, here, we also screen for possible synergistic effects of combining phage M198 with six different antibiotics. …”
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First Description of KPC-2-Producing Klebsiella oxytoca Isolated from a Pediatric Patient with Nosocomial Pneumonia in Venezuela by Indira Labrador, María Araque

“…Although carbapenem resistance in the Enterobacteriaceae is still unusual in Venezuela, KPCs have a great potential to spread due to their localization on mobile genetic elements. Therefore, rapid detection of KPC-carrying bacteria with phenotypic and confirmatory molecular tests is essential to establish therapeutic options and effective control measures.…”
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Optimal Allocation Method of Discrete Manufacturing Resources for Demand Coordination between Suppliers and Customers in a Fuzzy Environment by Wei Xu, Yinyun Yu

“…Next, the bilevel planning model for optimal configuration of manufacturing resources in discrete manufacturing environment is established under the consideration of the respective interests of both the customers and the suppliers, and the fast nondominated sorting genetic algorithm (NSGA-II) is used to solve the model. …”
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Therapeutic Potential of Mesenchymal Stem Cells in Regenerative Medicine by Devang M. Patel, Jainy Shah, Anand S. Srivastava

“…MSCs are currently being tested for their potential use in cell and gene therapy for a number of human debilitating diseases and genetic disorders. This paper summarizes the current clinical and nonclinical data for the use of MSCs in tissue repair and potential therapeutic role in various diseases.…”
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A Hybrid Constraints Handling Strategy for Multiconstrained Multiobjective Optimization Problem of Microgrid Economical/Environmental Dispatch by Xin Li, Jingang Lai, Ruoli Tang

“…Then, a hybrid constraints handling strategy (HCHS) based on nondominated sorting genetic algorithm II (NSGAII) is proposed to deal with the typical constraints, by which the constraints violations can be removed in several steps during the evolutionary process. …”
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Role of Macrophages in the Pathogenesis of Atopic Dermatitis by Sadaf Kasraie, Thomas Werfel

“…Several cofactors, such as an impaired skin barrier function, modifications of the immune system, and a complex genetic background, direct the course of AD. Within this complex network, macrophages play a pivotal role in enhanced susceptibility to cutaneous infections and act as central connecting components in the pathogenesis of AD on the cellular level. …”
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Evidence for the Involvement of Lipid Rafts and Plasma Membrane Sphingolipid Hydrolases in Pseudomonas aeruginosa Infection of Cystic Fibrosis Bronchial Epithelial Cells by Domitilla Schiumarini, Nicoletta Loberto, Giulia Mancini, Rosaria Bassi, Paola Giussani, Elena Chiricozzi, Maura Samarani, Silvia Munari, Anna Tamanini, Giulio Cabrini, Giuseppe Lippi, Maria Cristina Dechecchi, Sandro Sonnino, Massimo Aureli

“…Cystic fibrosis (CF) is the most common autosomal genetic recessive disease caused by mutations of gene encoding for the cystic fibrosis transmembrane conductance regulator. …”
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Multiobjective Optimization Design of Truss Antenna by Di Wu, Xiaofei Ma, Jinbao Chen, Chuanzhi Chen, Jiang Zhao, Kunyang Lin

“…Finally, tolerance optimization is carried out by using the multiobjective genetic algorithm. The results indicate that the Pareto solution is obtained with an error less than 10%. …”
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Development of a Portable Rapid Detection Method for Porcine Epidemic Diarrhea Virus Using Reverse Transcription-Recombinase-Aided Amplification Technology by Yiran Zhao, Weijie Yi, Qicheng Yang, Jiahao Li, Yanke Shan, Fei Liu

“…Its exceptionally high morbidity and mortality rate contributes significantly to the economic losses of the swine industry. The continuous genetic mutations of PEDV have compromised the effectiveness of classical strain vaccines. …”
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Advances in plant male sterility for hybrid seed production: an overview of conditional nuclear male sterile lines and biotechnology-based male sterile systems by Naresh Vasupalli, Naresh Vasupalli, Kanakachari Mogilicherla, Kanakachari Mogilicherla, Vahab Shaik, Vahab Shaik, K. R. S. Sambasiva Rao, Shripad R. Bhat, Xinchun Lin, Xinchun Lin

“…Male sterility forms the foundation of hybrid seed production technology in field crops. A variety of genetically controlled male sterility/fertility systems starting with cytoplasmic male sterility (CMS), genic male sterility (GMS) including conditional male sterility and transgenic-based male sterility have been developed and deployed for heterosis breeding over the past century. …”
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Directed Evolution of Microbial Communities in Fermented Foods: Strategies, Mechanisms, and Challenges by Zihan Yao, Ting Xie, Hongjie Deng, Shuzhi Xiao, Tao Yang

“…While DEMC shows substantial potential for refining fermented food products, it faces challenges such as maintaining genetic diversity and functional stability of the communities. …”
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Assessing spacer acquisition rates in E. coli type I-E CRISPR arrays by Luke J. Peach, Haoyun Zhang, Brian P. Weaver, James Q. Boedicker, James Q. Boedicker

“…CRISPR/Cas is an adaptive defense mechanism protecting prokaryotes from viruses and other potentially harmful genetic elements. Through an adaptation process, short “spacer” sequences, captured from these elements and incorporated into a CRISPR array, provide target specificity for the immune response. …”
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GLBR: A novel global load balancing routing scheme based on intelligent computing in partially disconnected wireless sensor networks by Zeyu Sun, Guisheng Liao, Cao Zeng, Lan Lan, Guozeng Zhao

“…Second, we adopt the genetic algorithm to build extra routing between different segments for intersegment load balancing. …”
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Control of Discrete Event Systems by Means of Discrete Optimization and Disjunctive Colored PNs: Application to Manufacturing Facilities by Juan-Ignacio Latorre-Biel, Emilio Jiménez-Macías, Mercedes Pérez de la Parte, Julio Blanco-Fernández, Eduardo Martínez-Cámara

“…Furthermore, the metaheuristic of genetic algorithms is applied to the search of the best solutions in the solution space. …”
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Pathophysiology and Treatment of Psoriasis: From Clinical Practice to Basic Research by Yujie Gao, Tianqi Xu, Yu Wang, Yanjinhui Hu, Shaoping Yin, Zhiguo Qin, Hua Yu

“…Ongoing research is progressively deciphering its molecular underpinnings; the future of psoriasis diagnostics may involve genetic and immunological profiling to pinpoint biomarkers, enabling more accurate and timely interventions. …”
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Wilson’s Disease: Diagnosis of Wilson’s Disease in Ethiopian Young Sisters by Nebiyu Bekele, Frew Ewnetu, Tigest Hailu, Zerubabel Tegegne, Abilo Tadesse

“…Clinical signs, biochemical parameters, histologic findings, and/or ATP7B genetic testing are required to diagnose Wilson’s disease. …”
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Research on the Effect of DPSO in Team Selection Optimization under the Background of Big Data by Qian Zhao, Lian-ying Zhang

“…By comparing the iterative results of genetic algorithm, ordinary particle swarm algorithm, and discrete particle swarm algorithm, it is found that the DPSO algorithm is effective and preferred in the study of team selection with the background of big data.…”
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Substantiation of application and estimation of efficacy of probiotics at inflammatory bowel diseases by Ye. A. Poluektova, Yu. O. Sidorina, S. Yu. Kuchumova, A. V. Korolev, O. S. Shifrin

“…Microbiome changes result in initiation of cascade of pathological immune reactions of the host in related to presence of genetical defects, that, in turn, promotes development of clinical symptoms and morphological changes in intestinal wall. …”
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Approach for designing and modelling of nanoscale DG MOSFET devices using Kriging metamodelling technique by Toufik Bentrcia, Fayçal Djeffal, Elasaad Chebaki

“…It is also shown that the obtained Kriging interpolation models are precise enough to be used as objective functions in the context of a genetic algorithm optimisation with the aim of improving the device analogue/RF performance in terms of transconductance and cut‐off frequency parameters. …”
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Harnessing artificial intelligence for enhanced nanoparticle design in precision oncology by Mujibullah Sheikh, Pranita S. Jirvankar

“…In the same manner, we focused on the utilization of AI in enhancing patient-centered treatment through the establishment of drug delivery systems that will complement the genetic and molecular makeup of patients. Additionally, we present evidence suggesting that AI-designed nanoparticles have the potential to be environmentally sustainable alternatives in cancer therapy. …”
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