Predicting Disease Onset from Mutation Status Using Proband and Relative Data with Applications to Huntington's Disease by Tianle Chen, Yuanjia Wang, Yanyuan Ma, Karen Marder, Douglas R. Langbehn

“…Accurate estimation of the AAO distribution based on CAG repeat length is important for genetic counseling and the design of clinical trials. …”
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Size, shape, and dose — three crucial determinants for applying nanoparticles in sustainable plant biology by Anindita Dey, Papiya Nandy

“…More research is needed on many fronts regarding the interaction of NPs with plants, including the absorption capacity of diverse plant species, methods of uptake and translocation, and interactions between the NPs and plant tissues at cellular and genetic levels. However, the effects of these tiny particles after entering the plant body will be influenced directly or indirectly by the three most critical factors: the shape, size, and dose of NPs used during applications. …”
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Immunocompatibility of Bacteriophages as Nanomedicines by Tranum Kaur, Nafiseh Nafissi, Olla Wasfi, Katlyn Sheldon, Shawn Wettig, Roderick Slavcev

“…Recently, phages have been employed as gene-delivery vectors (phage nanomedicine), for nearly half a century as tools in genetic research, for about two decades as tools for the discovery of specific target-binding proteins and peptides, and for almost a decade as tools for vaccine development. …”
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Ornamental Exterior versus Therapeutic Interior of Madagascar Periwinkle (Catharanthus roseus): The Two Faces of a Versatile Herb by Naghmeh Nejat, Alireza Valdiani, David Cahill, Yee-How Tan, Mahmood Maziah, Rambod Abiri

“…The correlation between genetic diversity, variants, and TIA production exists. …”
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Molecular profiling and detection methods of microRNA in cancer research by Nurul-Syakima Ab Mutalib, Imilia Ismail, Hooi-Leng Ser

“…However, with more researchers dwelling into the world of these mysterious genetic codes, a group of non-protein coding RNA (ncRNA) known as microRNAs (miRNAs) is now being recognized to play important roles than they were thought to be. …”
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Neuronal Ceroid Lipofuscinosis in Border Collie Dogs in Japan: Clinical and Molecular Epidemiological Study (2000–2011) by Keijiro Mizukami, Takuji Kawamichi, Hiroshi Koie, Shinji Tamura, Satoru Matsunaga, Shigeki Imamoto, Miyoko Saito, Daisuke Hasegawa, Naoaki Matsuki, Satoshi Tamahara, Shigenobu Sato, Akira Yabuki, Hye-Sook Chang, Osamu Yamato

“…In 4 kennels with affected dogs, the dogs were genotyped. The genetic relationships of all affected dogs and carriers identified were analyzed. …”
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Feature Selection and Parameter Optimization of Support Vector Machines Based on Modified Cat Swarm Optimization by Kuan-Cheng Lin, Yi-Hung Huang, Jason C. Hung, Yung-Tso Lin

“…Previous studies have indicated that CSO algorithms outperform other well-known metaheuristics, such as genetic algorithms and particle swarm optimization. …”
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Transposon mediated functional genomic screening for BRAF inhibitor resistance reveals convergent Hippo and MAPK pathway activation events by Li Chen, Iulian Pruteanu-Malinici, Anahita Dastur, Xunqin Yin, Dennie Frederick, Ruslan I. Sadreyev, Cyril H. Benes

“…Although several forward genetic screens performed in the same context have identified a broad range of resistance genes that poorly overlap, an integrative analysis revealed a much smaller functional diversity of resistance mechanisms, including reactivation of the MAPK pathway, PI3K-AKT pathway, and Hippo pathway, suggesting that a relatively small number of therapeutic strategies might overcome resistance manifested by a large gene set. …”
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Animal models in biomedical research: Relevance of Drosophila melanogaster by Olabisi Tajudeen Obafemi, Ademola Olabode Ayeleso, Olusola Bolaji Adewale, Jeremiah Unuofin, Bidemi Emmanuel Ekundayo, Monde Ntwasa, Sogolo Lucky Lebelo

“…Apart from its relatively short lifespan, high fecundity and ease of rearing, the simplicity of its genome and lower redundancy of its genes when compared with vertebrate models, as well as availability of genetic tool kit for easy manipulation of its genome, have all contributed to its emergence as a valid animal model of human diseases. …”
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Molecular logic for cellular specializations that initiate the auditory parallel processing pathways by Junzhan Jing, Ming Hu, Tenzin Ngodup, Qianqian Ma, Shu-Ning Natalie Lau, M. Cecilia Ljungberg, Matthew J. McGinley, Laurence O. Trussell, Xiaolong Jiang

“…This high-resolution account of cellular heterogeneity from the molecular to the circuit level reveals the molecular logic driving cellular specializations, thus enabling the genetic dissection of auditory processing and hearing disorders with a high specificity.…”
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A plasmid-chromosome crosstalk in multidrug resistant enterobacteria by Laura Toribio-Celestino, Alicia Calvo-Villamañán, Cristina Herencias, Aida Alonso-del Valle, Jorge Sastre-Dominguez, Susana Quesada, Didier Mazel, Eduardo P. C. Rocha, Ariadna Fernández-Calvet, Alvaro San Millan

“…This operon includes two genes coding for a pirin and an isochorismatase family proteins (pfp and ifp), and shows evidence of horizontal mobilization across Proteobacteria species. Combining genetic engineering, transcriptomics, and CRISPRi gene silencing, we show that a pOXA-48-encoded LysR regulator is responsible for the plasmid-chromosome crosstalk. …”
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CoTF-reg reveals cooperative transcription factors in oligodendrocyte gene regulation using single-cell multi-omics by Jerome J. Choi, John Svaren, Daifeng Wang

“…Validation using oligodendrocyte eQTLs and their eGenes that are regulated by these cooperative TFs show potential regulatory roles for genetic variants. Experimental validation using ChIP-seq data confirms some cooperative TF pairs, such as SOX10-OLIG2. …”
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An overview of hereditary spherocytosis and the curative effects of splenectomy by Kyril Turpaev, Elizaveta Bovt, Elizaveta Bovt, Soslan Shakhidzhanov, Soslan Shakhidzhanov, Elena Sinauridze, Elena Sinauridze, Nataliya Smetanina, Larisa Koleva, Larisa Koleva, Nikita Kushnir, Nikita Kushnir, Anna Suvorova, Fazoil Ataullakhanov, Fazoil Ataullakhanov, Fazoil Ataullakhanov

“…Splenectomy does not correct most genetically determined membrane abnormalities in erythrocytes in patients with hereditary spherocytosis. …”
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Geometry optimization on the cross section of adhesively bonded thin-walled composite beam subjected to axial crushing load by Xiao Han, Jingru Ye, Shaoqiang Hou, Wenbin Hou

“…The non-dominated sorting genetic algorithm II (NSGA-II) was introduced to search for global optimum solution, and radial basis function (RBF) approximations for the objective functions were applied to reduce the computational cost. …”
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Clinical Isolates of Mycobacterium tuberculosis Differ in Their Ability to Induce Respiratory Burst and Apoptosis in Neutrophils as a Possible Mechanism of Immune Escape by María M. Romero, Luciana Balboa, Juan I. Basile, Beatriz López, Viviana Ritacco, Silvia S. de la Barrera, María C. Sasiain, Lucía Barrera, Mercedes Alemán

“…Tuberculosis pathogenesis was earlier thought to be mainly related to the host but now it appears to be clear that bacterial factors are also involved. Genetic variability of Mycobacterium tuberculosis (Mtb) could be slight but it may lead to sharp phenotypic differences. …”
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Orthopedic Manifestations of Bruck Syndrome: A Case Series with Intermediate to Long-term Follow-Up by Adolfredo Santana, Geovanny Oleas-Santillán, Jeanne M. Franzone, L. Reid Nichols, J. Richard Bowen, Richard W. Kruse

“…Data were collected from medical records, radiographs, dual-energy X-ray absorptiometry (DEXA) scans, genetic tests, and gait analysis. All had contractures at birth and genotypic findings including mutations in PLOD2 or FPKB10. …”
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A germline FLT3 variant in aplastic anemia by Lemchukwu C. Amaeshi, Amalia A. Sofianidi, Aditi Shastri, Mendel Goldfinger, Marina Konopleva, Amit K. Verma, Mark Chaitowitz, Ioannis Mantzaris

“…Abstract FMS-like tyrosine kinase 3 (FLT3) genetic variants are commonly seen in high-grade myeloid neoplasms and are typically gain-of-function mutations associated with a proliferative disease phenotype. …”
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Impairments in Activities of Daily Living in Older Japanese Men in Hawaii and Japan by Robert D. Abbott, Aya Kadota, Katsuyuki Miura, Takehito Hayakawa, Takashi Kadowaki, Tomonori Okamura, Akira Okayama, Kamal H. Masaki, Hirotsugu Ueshima

“…In this comparison of genetically similar samples, findings suggest that different strengths in risk factor associations with cardiovascular disease in Japan and westernized countries may also include different strengths in associations with impaired ADL.…”
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Karyotype Patterns of Hypsolebias antenori (Cyprinodontiformes: Rivulidae): An Endangered Killifish of the Semiarid Region of Brazil by Wallace Silva do Nascimento, Juliana Galvão Bezerra, Paulo Augusto Lima-Filho, Maria Emília Yamamoto, Sathyabama Chellappa, Wagner Franco Molina

“…Annual fish which belong to the order Cyprinodontiformes constitute an excellent model for evolutionary studies. their short life cycle, distribution in ecologically dynamic environments, and low agility make them favorable for genetic analyses. The species Hypsolebias antenori (Rivulidae), encountered in seasonal pools located in the semiarid region of Northeastern Brazil, has been the object of surveys with a view to study its ecological and behavioral aspects. …”
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Genome assembly of the grassland caterpillar Gynaephora qinghaiensis by Youpeng Lai, Shan Xiao, Minggang Qin, Xinhai Ye, Fang Wang, Qi Fang

“…The availability of the reference genome could provide genetic resources to uncover adaptive evolutionary mechanisms of grassland caterpillars to high-altitude environments and contributes to the development of integrated pest management strategies.…”
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