Diverse Linguistic Development in Prelingually Deaf Children with Cochlear Implants by Pia De Stefano, Francesco Pisani, Giuseppe Cossu

“…We report 4 prelingually deaf children (mean age=10.5; SD=1.08), affected by a genetically determined bilateral deafness, due to GJB2 gene mutation Cx26. …”
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Expanding the Phenotype of Congenital Glucocorticoid Deficiency: An Iranian Patient with Cholestasis due to Pathogenic Variants in the MC2R Gene by Shohreh Maleknejad, Setila Dalili, Ameneh Sharifi, Afagh Hassanzadeh Rad, Reza Bayat, Bahareh Rabbani, Nejat Mahdieh

“…Next-generation sequencing identified the genetic causes of the disease, and Sanger sequencing confirmed the variants through segregation analysis. …”
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Insights from a Genome-Wide Study of <i>Pantoea agglomerans</i> UADEC20: A Promising Strain for Phosphate Solubilization and Exopolysaccharides Production by Edith Elizondo-Reyna, Humberto Martínez-Montoya, Yahaira Tamayo-Ordoñez, María Antonia Cruz-Hernández, Mauricio Carrillo-Tripp, María Concepción Tamayo-Ordoñez, Gerardo de Jesús Sosa-Santillán, José Antonio Rodríguez-de la Garza, Mario Hernández-Guzmán, Virgilio Bocanegra-García, Erika Acosta-Cruz

“…These findings suggest a unique genetic background in the <i>P</i>. <i>agglomerans</i> UADEC20 strain.…”
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In Silico Genome Comparison and Distribution Analysis of Simple Sequences Repeats in Cassava by Andrea Vásquez, Camilo López

“…The identified SSRs here may be a valuable addition for genetic mapping and future studies in phylogenetic analyses and genomic evolution.…”
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Pontocerebellar hypoplasia: clinical case and literature review by L. Anužis, E. Buivydas, D. Petrova, M. Šukys, R. Gleiznienė

“…To confirm the diagnosis of PCH2A, genetic analysis is required detecting homozygous missense mutation in the TSEN54 gene. …”
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The OAuth 2.0 Web Authorization Protocol for the Internet Addiction Bioinformatics (IABio) Database by Jeongseok Choi, Jaekwon Kim, Dong Kyun Lee, Kwang Soo Jang, Dai-Jin Kim, In Young Choi

“…In addition, bioinformatics databases, especially genetic databases, require a high level of security and should be designed based on medical information standards. …”
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Rational engineering of minimally immunogenic nucleases for gene therapy by Rumya Raghavan, Mirco J. Friedrich, Indigo King, Samuel Chau-Duy-Tam Vo, Daniel Strebinger, Blake Lash, Michael Kilian, Michael Platten, Rhiannon K. Macrae, Yifan Song, Lucas Nivon, Feng Zhang

“…Abstract Genome editing using CRISPR-Cas systems is a promising avenue for the treatment of genetic diseases. However, cellular and humoral immunogenicity of genome editing tools, which originate from bacteria, complicates their clinical use. …”
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AMPK regulates the maintenance and remodelling of the neuromuscular junction by Sean Y. Ng, Andrew I. Mikhail, Stephanie R. Mattina, Salah A. Mohammed, Shahzeb K. Khan, Eric M. Desjardins, Changhyun Lim, Stuart M. Phillips, Gregory R. Steinberg, Vladimir Ljubicic

“…Method: A comprehensive, multifaceted approach was employed, integrating genetic, physiological, and pharmacological methodologies to elucidate the role of skeletal muscle AMPK in modulating the neuromuscular synapse. …”
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Collagenous Sprue by Hugh James Freeman

“…Future studies are needed to more precisely define molecular and genetic biomarkers that identify homogeneous groups and permit the development of improved treatment strategies for this increasingly recognized disorder.…”
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SAA3 deficiency exacerbates intestinal fibrosis in DSS-induced IBD mouse model by Xiaodong Zou, Tong Wu, Jianjiao Lin, Tao Su, Hui Xiao, Chuyan Ni, Lijuan Hu, Wenchu Lin, Weilin Chen, Richard D. Ye, Li Xiang

“…Our results further indicated that SAA3 genetic disruption in fibroblasts enhanced cell activation to myofibroblasts through HSPB1/NF-κB/TGF-β1/Smads signaling cascade, exacerbating the pathological phenotype of intestinal fibrosis. …”
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Comparative Study of Dual-Rotor Permanent Magnet Machines with Series and Parallel Magnetic Circuits by Zhitong Ran, Zi-Qiang Zhu, Dawei Liang

“…The machines are optimized using the finite element analysis (FEA) based on the genetic algorithm. It shows that the PDRPM machine with the tooth coil (TC) configuration has the highest permanent magnet (PM) utilisation compared to the PDRPM with toroidal winding (TW) configuration and the SDRPM machine with the TC configuration under different slot/pole number combinations. …”
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Oligonucleotides as a Novel Therapeutic Approach: An Innovative Area for Drug Delivery in Neurological Disorders by Yasir Qasim Almajidi, Rana Kadum Muslim, Yaseen T. khalf

“…Ongoing preclinical and clinical studies are assessing the safety and efficacy of Antisense Oligonucleotide) ASOs (in multiple genetic and acquired neurological conditions. The current review provides an update on novel approaches, preclinical, clinical evidence, and delivery route of ASOs. …”
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Risk factors in pediatric asthmatic patients. Cases and control studies. by Rafael Alejandro Gómez Baute, Yaney Gonzalez Iglesias

“…<strong><br />Conclusions: </strong>It is conclusive that the exposure to home allergen plus a genetic favorable factor, the prematurity, and brochiolitis constituted the most outstanding elements to suffer from asthma in the population studied.…”
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The Impact of Farnesoid X Receptor Activation on Intestinal Permeability in Inflammatory Bowel Disease by Maja Stojancevic, Karmen Stankov, Momir Mikov

“…Recent studies have identified a number of factors that contribute to development of IBD including environmental triggers, genetic factors, immunoregulatory defects and microbial exposure. …”
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An Improved Multiobjective Algorithm: DNSGA2-PSA by Dan Qu, Xianfeng Ding, Hongmei Wang

“…To improve the diversity and decrease execution time of the nondominated sorting genetic algorithm II (NSGA-II), an improved algorithm is presented in this paper, which adopts a new vector ranking scheme to decrease the whole runtime and utilize Part and Select Algorithm (PSA) to maintain the diversity. …”
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Cellular Harmony Search for Optimization Problems by Mohammed Azmi Al-Betar, Ahamad Tajudin Khader, Mohammed A. Awadallah, Mahmmoud Hafsaldin Alawan, Belal Zaqaibeh

“…The main rationale behind this is to provide a high level of diversity to overcome the genetic drift. Cellular automata concepts have been embedded to the process of EA in order to provide a decentralized method in order to preserve the population structure. …”
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Variation of the seed and foliar phenolic contents of five wild forms of common bean (Phaseolus vulgaris L.) by Shaila Nayeli Pérez-Salinas, Rene Torres Ricario, Nancy Nohemí Rodarte Rodríguez, Heberto Iván Salas Ayala, Liliana Wallander Compeán

“…Wild species are important for the conservation of biodiversity, and for the genetic improvement of new varieties. Likewise, they could be used as forage, food or medicine, due to the high content of phytochemicals in seeds and leaf tissue, therefore, the information generated is relevant to knowledge about the characterization and diversity of wild Phaseolus species. …”
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Defective homologous recombination and genomic instability predict increased responsiveness to carbon ion radiotherapy in pancreatic cancer by Brock J. Sishc, Janapriya Saha, Elizabeth M. Alves, Lianghao Ding, Huiming Lu, Shih-Ya Wang, Katy L. Swancutt, James H. Nicholson, Angelica Facoetti, Arnold Pompos, Mario Ciocca, Todd A. Aguilera, Michael D. Story, Anthony J. Davis

“…We utilized a panel of human PDAC cell lines with diverse genetic profiles to determine their sensitivity to CIRT compared to γ-rays, assessing relative biological effectiveness (RBE) at 10% survival, which ranged from 1.96 to 3.04. …”
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Progress in immune microenvironment, immunotherapy and prognostic biomarkers in pediatric osteosarcoma by Lin Zhang, Haoming Jiang, Haichao Ma

“…It examines the impact of immune checkpoints, genetic mutations, and inflammatory pathways on osteosarcoma progression, highlighting their contribution to tumor immune evasion and disease advancement. …”
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Multiobjective Multistate System Preventive Maintenance Model with Human Reliability by Chao-Hui Huang, Chun-Ho Wang, Guan-Liang Chen

“…A customised version of the nondominated sorting genetic algorithm III is employed to ensure efficient solution of the PM model with human reliability—which is considered a constrained multiobjective combinatorial optimisation problem. …”
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