An Efficient Genome Fragment Assembling Using GA with Neighborhood Aware Fitness Function by Satoko Kikuchi, Goutam Chakraborty

“…In this work, we have shown how our modified genetic algorithm (GA) could solve this problem efficiently. …”
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Human ACE2 transgenic pigs are susceptible to SARS-CoV-2 and develop COVID-19-like disease by Long Fung Chau, Simon Lillico, Tanja Opriessnig, Rosemary Blake, Luc Tardy, Chen-Hsuin Lee, Scott Maxwell, Claire Warren, Elizabeth Thornton, Catherine L. Mclaughlin, Gerry McLachlan, Christine Tait-Burkard, Sarah Fletcher, Stephen Anderson, Sharon Brown, Louise Gibbard, Thomas Tzelos, Dawn MacMillan-Christensen, J. Kenneth Baillie, David A. Dorward, David J. Griffiths, Finn Grey

“…Pigs are increasingly recognized as valuable models for human disease due to their genetic, anatomical, physiological, and immunological similarities to humans, and they present a more ethically viable alternative to non-human primates. …”
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Diagnosis and Management of Freeman-Burian Syndrome: A Case Report by Aidin Arabzadeh, Hossein Azaditalab, Hesam Alitaleshi, Mohammad Reza Abbaszadeh

“…   Abstract: Introduction: Freeman Sheldon syndrome is a rare genetic disease of varying severity with craniocarpotarsal manifestations, which has many difficulties in orthopedic management also anaesthetic concerns about intubation difficulties and malignant hyperthermia and mutch tendency of deformities for recurrence. …”
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Potential Mechanisms of Exercise in Gestational Diabetes by Saeid Golbidi, Ismail Laher

“…This condition shares same array of underlying abnormalities as occurs in diabetes outside of pregnancy, for example, genetic and environmental causes. However, the role of a sedentary lifestyle and/or excess energy intake is more prominent in GDM. …”
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Sensory experience controls dendritic structure and behavior by distinct pathways involving degenerins by Sharon Inberg, Yael Iosilevskii, Alba Calatayud-Sanchez, Hagar Setty, Meital Oren-Suissa, Michael Krieg, Benjamin Podbilewicz

“…Calcium imaging of the PVD neurons in a micromechanical device revealed that controlled mechanical stimulation of the body wall produces similar calcium dynamics in both isolated and crowded animals. Our genetic results, supported by optogenetic, behavioral, and pharmacological evidence, suggest an activity-dependent homeostatic mechanism for dendritic structural plasticity, that in parallel controls escape response to noxious mechanosensory stimuli.…”
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Recurrence of acne after treatment with systemic isotretinoin: causes and methods of prevention by Marina M. Tlish, Marina E. Shavilova

“…The article focuses on the fact that the effectiveness of isotretinoin in patients with acne depends both on a competent treatment strategy and on the characteristics of the course of the disease (genetic burden, comorbid pathology), which are individual for each patient. …”
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Analysis of the Modification Sensitivity of Herringbone Gear by Yong Zhao, Yajun Huang, Bin Yan, Yong Guo, Yuanyuan Zhang, Wei Cao

“…Using Romax software， genetic algorithm is used to carry out the optimal modification of tooth profile， drum shape and topology， and the modification deformation momentum is superimposed on the optimal modification. …”
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Synergistic Optimization Method for URT Network Train Connection Scheme in Peak and Off-Peak Periods by Ruihua Xu, Xuyang Song, Feng Zhou, Fangsheng Wang

“…Subsequently, a corresponding solution method based on a genetic algorithm and simulation was designed. Finally, the Suzhou URT network was used as a case study, and the passenger flow of the transfer station was simulated and calculated using relevant automatic fare collection (AFC) data. …”
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Enabling next-generation engineered TCR-T therapies based on high-throughput TCR discovery from diagnostic tumor biopsies by Thomas Kuilman, Deborah S. Schrikkema, Jules Gadiot, Raquel Gomez-Eerland, Laura Bies, Julia Walker, Robbert M. Spaapen, Hanna Kok, Demi Houg, Milena Viyacheva, Yvonne B. Claassen, Manuel Saornil, Oscar Krijgsman, Bas Stringer, Huiwen Ding, Anou Geleijnse, Anne C. Meinema, Bianca Weissbrich, Melissa Lancee, Carmen G. Engele, Marianna Sabatino, Pei-Ling Chen, Kenneth Y. Tsai, James J. Mulé, Vernon K. Sondak, Jitske van den Bulk, Noel F. de Miranda, Inge Jedema, John G. Haanen, Jeroen W. J. van Heijst, Ton N. Schumacher, Carsten Linnemann, Gavin M. Bendle

“…Here, we develop a platform for the efficient identification of tumor-specific TCR genes from diagnostic tumor biopsies, including core-needle biopsies frozen in a non-viable format, to enable engineered T cell therapy. Using a genetic screening approach that detects antigen-reactive TCRs with high sensitivity and specificity based on T cell activation, we show that high complexity TCR libraries can be efficiently screened against multiplexed antigen libraries to identify both HLA class I and II restricted TCRs. …”
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Hereditary Hyperferritinemia-Cataract Syndrome in 3 Generations of a Family in East Tennessee by Heidi A. Worth, Zachary Marlette, David Aljadir, Ronald Lands

“…While investigators have dissected the gene where several responsible mutations reside, it remains a relatively unknown genetic disorder to clinicians. The result is often an expensive, invasive evaluation for iron overload, followed by a well-intended prescription for a series of phlebotomies that delivers morbidity instead of benefit. …”
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Intergenerational Transfers in Infant Mortality in Southern Sweden, 1740-1968 by Luciana Quaranta

“… Studies conducted in historical populations and developing countries have evidenced the existence of clustering in infant deaths, which could be related to genetic inheritance, early life exposures, and/or to social and cultural factors such as education, socioeconomic status or parental care. …”
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A Trajectory Planning Method for Optimal Energy Consumption of the Hydraulic Excavator by Zhang Yunyue, Sun Zhiyi, Sun Qianlai, Wang Yin, Yang Jiangtao

“…Under the constraint conditions of the joint angle, angular velocity, and angular acceleration, the improved adaptive genetic algorithm is used to optimize the uniform acceleration (deceleration) and constant velocity motion time of each joint, obtain the optimal motion curve of each joint, and realize the optimal energy consumption trajectory planning of the hydraulic excavator. …”
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Vitamin D Binding Protein and Bone Health by Ishir Bhan

“…Vitamin D binding protein (DBP) is the major carrier protein of 25-hydroxyvitamin D (25(OH) D) in the circulation, where it may serve roles in maintaining stable levels during times of decreased 25(OH) availability and in regulating delivery of 25(OH) D to target tissues. Several genetic polymorphisms of DBP have been described that lead to phenotypic changes in the protein that may affect affinity, activity, and concentration. …”
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New perspectives on DNA methylation modifications in ocular diseases by Fei-Fei Zong, Da-Dong Jia, Guang-Kun Huang, Meng Pan, Hao Hu, Shi-Yi Song, Liang Xiao, Ru-Weng Wang, Liang Liang

“…Ophthalmic diseases are a kind of complex diseases, and their pathogenesis involves many factors such as genetic, environmental and individual differences. …”
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Exome sequencing of 18,994 ethnically diverse patients with suspected rare Mendelian disorders by Heonjong Han, Go Hun Seo, Seong-In Hyun, Kisang Kwon, Seung Woo Ryu, Rin Khang, Eugene Lee, JiHye Kim, Yongjun Song, Won Chan Jeong, Joohyun Han, Dong-wook Kim, Soyeon Yang, Sohyun Lee, Sohyun Jang, Jungsul Lee, Hane Lee

“…Abstract We investigated the effectiveness of exome sequencing (ES) in diagnosing ethnically diverse patients with rare genetic disorders. A total of 18,994 patients referred to a single reference laboratory for ES between 2020 and 2022 were studied for the diagnostic rate and factors influencing the diagnostic rate. …”
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Modeling and Dynamical Analysis of the Water Resources Supply-Demand System: A Case Study in Haihe River Basin by Chongli Di, Xiaohua Yang

“…Then, the gray code hybrid accelerating genetic algorithm (GHAGA) is adopted to identify the unknown parameters of the system based on the statistic data (1998–2009). …”
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Chromosome-level genome assembly of black carp Mylopharyngodon piceus using Nanopore and Hi-C technologies by Yuxuan Zhang, Yanwen Shao, Xudong Liu, Liang Zhong, Zhaoyan Zhong, Weiwei Zeng, Jiping Zhang, Wenlong Cai, Runsheng Li

“…Taken together, our study provides a chromosome-level genome assembly, which can serve as a valuable genetic resource to support further biological studies and breeding efforts of black carp.…”
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Potential Mechanisms for Racial and Ethnic Differences in Antimüllerian Hormone and Ovarian Reserve by Reshef Tal, David B. Seifer

“…However, the mechanisms which may underlie such racial differences in ovarian reserve are unclear. Various genetic factors and environmental factors such as obesity, smoking, and vitamin D deficiency which have been shown to correlate with serum AMH levels and also display significant racial/ethnic variations are discussed in this review. …”
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A Girl with PRRT2 Mutation Presenting with Benign Familial Infantile Seizures Followed by Autistic Regression by Li Zhang, Zhen-Xia Wan, Jin-Yi Zhu, Hui-Juan Liu, Jin Sun, Xiao-Hui Zou, Ting Zhang, Yan Li

“…In this report, we present a rare case of a girl with a confirmed clinical and genetic diagnosis of BFIS due to a frameshift heterozygous mutation in PRRT2 (c.649dupC). …”
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Therapeutics of bitter plants from Northeast region of India and their pharmacological and phytochemical perspectives by Bhaskar Das, Bharat Gopalrao Somkuwar, Sushil Kumar Chaudhary, Evanylla Kharlyngdoh, Careen Liza Pakyntein, Kishor Basor, Jitendra Kumar Shukla, Pardeep Kumar Bhardwaj, Pulok Kumar Mukherjee

“…Marginality, fragility, inaccessibility, ethnicity, and cultural diversity thrived in the region, resulting in the richest reservoir of genetic variation of bioresources. Several bitter plants are used by the locals as both food and medicine to treat a variety of diseases. …”
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