A Cell Model for Conditional Profiling of Androgen-Receptor-Interacting Proteins by K. A. Mooslehner, J. D. Davies, I. A. Hughes

“…For this purpose, male genital development relevant mouse cell lines were genetically modified to express a tagged version of wild-type AR, allowing copurification of multiprotein complexes under native conditions followed by mass spectrometry. …”
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True familial aggregation of recurrent furunculosis in families from the Province of Villa Clara by Vicente José Hernández Moreno, Manuela Herrera Martínez

“…Objective: to identify genetic susceptibility in individuals affected by recurrent furunculosis according to the true familial aggregation of the disease in a group of families with affected individuals. …”
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The Interplay between Defensins and Microbiota in Crohn’s Disease by Lorena Coretti, Alessandro Natale, Mariella Cuomo, Ermanno Florio, Simona Keller, Francesca Lembo, Lorenzo Chiariotti, Raffaela Pero

“…In addition to an immunological basis, the disease is frequently associated with genetic alterations including mutations of NOD2 gene. …”
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Case Report: Diagnosis and treatment of incontinentia pigmenti with central nervous system anomalies in one patient by Yun Li, Junbin Hong, Shangge Xu, Tong Zhou, Xiaolan Xiao, Jinghua Yang, Yiting Chen

“…Skin biopsy pathology indicated pigmentation disorder. Molecular genetic testing was conducted to identify IKBKG mutations, and the case was finally diagnosed with incontinentia pigmenti complicated by central nervous system anomalies. …”
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IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis. by Antonella De Luca, Agostinho Carvalho, Cristina Cunha, Rossana G Iannitti, Lucia Pitzurra, Gloria Giovannini, Antonella Mencacci, Lorenzo Bartolommei, Silvia Moretti, Cristina Massi-Benedetti, Dietmar Fuchs, Flavia De Bernardis, Paolo Puccetti, Luigina Romani

“…In humans, two functional genetic variants in IL22 and IDO1 genes were found to be associated with heightened resistance to RVVC, and they correlated with increased local expression of IL-22, IDO1 and kynurenines. …”
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A Group Feature Screening Procedure Based on Pearson Chi-Square Statistic for Biology Data with Categorical Response by Hanji He, Jianfeng He, Guangming Deng

“…However, this is not a simple task as biogenetic data have challenges such as ultra-high dimensionality of potential features, imbalance of response variables, and genetic associations. This study focuses on the group structure in feature screening with biogenetic data. …”
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Cigarette-Smoke-Induced Dysregulation of MicroRNA Expression and Its Role in Lung Carcinogenesis by Rebecca Russ, Frank J. Slack

“…Cigarette smoke may lead to genetic or epigenetic damage to miRNAs, many of which map to fragile sites and some of which contain single nucleotide polymorphisms. …”
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Small molecule APOL1 inhibitors as a precision medicine approach for APOL1-mediated kidney disease by Brandon Zimmerman, Leslie A. Dakin, Anne Fortier, Evanthia Nanou, Angelo Blasio, James Mann, Howard Miller, Marissa Fletcher, Tiansheng Wang, Suganthini Nanthakumar, Gizelle McCarthy, Caline Matar, Prachi Matsye, Guanyu Wang, Phillip Snyder, Kevin Daniel, Harsha Swamy, Kelly Sullivan, Franklin Bright, Audrey Powers, Kevin J. Gagnon, Fan Lu, Steven Paula, Suvarna Khare-Pandit, Larry Henry, Martine Hamel, Francois Denis, Olivier Nicolas, Niresh Hariparsad, Shyamesh Kumar, Jennifer Proctor, Timothy Senter, Brinley Furey, Mark E. Bunnage

“…We hypothesized that inhibition of APOL1 could have therapeutic potential for this genetically-defined form of kidney disease. Here we describe the development of preclinical assays and the discovery of potent and specific APOL1 inhibitors with drug-like properties. …”
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Invasion and ecological impact of the biofouling tube worm Hydroides elegans (Polychaeta: Serpulidae) in Korean coastal waters by Sang Lyeol Kim, Ok Hwan Yu

“…In 2019, H. elegans was found attached to the research vessel ISABU in Korea, and a phylogenetic analysis was conducted to identify the species and determine its genetic characteristics. Following its detection, mesocosm experiments with plastic panels (PP, PE, PET, and EPS) were undertaken to investigate its recruitment and adaptation processes within new ecosystems. …”
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Uncovering the role of microRNAs in esophageal cancer: from pathogenesis to clinical applications by Zhenglin He, Yishuo Ji, Yutong Yuan, Tianfang Liang, Chenglin Liu, Yiping Jiao, Yimeng Chen, Yiming Yang, Liang Han, Liang Han, Yue Hu, Yue Hu, Xianling Cong, Xianling Cong, Xianling Cong

“…By integrating insights from genetic sequencing and molecular biology, we identify key miRNAs that promote or inhibit EC progression and treatment resistance. …”
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Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3 by Peipei Li, Zhini Zhu, Yong Wang, Xuyuan Zhang, Chuanhui Yang, Yalan Zhu, Zixuan Zhou, Yulin Chao, Yonghui Long, Yina Gao, Songqing Liu, Liguo Zhang, Pu Gao, Qianhui Qu

“…In humans, thiamine transporters SLC19A2 and SLC19A3 primarily regulate cellular uptake of both vitamins. Genetic mutations in these transporters, which cause thiamine and pyridoxine deficiency, have been implicated in severe neurometabolic diseases. …”
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Lipedema: Clinical Features, Diagnosis, and Management by Hatan Hisham Mortada, Abdulmalek W. Alhithlool, Nouf Z. AlBattal, Rashika K. Shetty, Ghaleb A. AL-Mekhlafi, Joon Pio Hong, Feras Alshomer

“…The current research indicates that lipedema appears to be a clinical entity related to genetic factors and fat distribution, although distinct from lymphedema and obesity. …”
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An Improved Grasshopper Optimizer for Global Tasks by Hanfeng Zhou, Zewei Ding, Hongxin Peng, Zitao Tang, Guoxi Liang, Huiling Chen, Chao Ma, Mingjing Wang

“…Firstly, a probabilistic mutation mechanism is introduced into the basic GOA, which makes full use of the strong searchability of Cauchy mutation and the diversity of genetic mutation. Then, the effective factors of grasshopper swarm are strengthened by an orthogonal learning mechanism to improve the convergence speed of the algorithm. …”
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Optimal Planning of Distributed Sensor Layouts for Collaborative Surveillance by Thomas A. Wettergren, Russell Costa

“…In particular, we develop a genetic algorithm solution to find spatial sensor density functions that maximize effectiveness against moving targets, where the surveillance performance of individual sensors is dependent on their absolute position in the region as well as their relative position to both the expected target(s) and any asset that is being protected. …”
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Th1 Cytokine-Secreting Recombinant Mycobacterium bovis Bacillus Calmette-Guérin and Prospective Use in Immunotherapy of Bladder Cancer by Yi Luo, Jonathan Henning, Michael A. O'Donnell

“…., interferon-α) has demonstrated improved efficacy, combination therapy requires multiple applications and a large quantity of cytokines. On the other hand, genetic manipulation of BCG to secrete Th1 cytokines continues to be pursued with considerable interest. …”
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Global dynamics of a simple model for wild and sterile mosquitoes by Yu Ichida, Yukihiko Nakata

“…There are known methods to manage the population dynamics of wild and sterile mosquitoes by releasing genetically engineered sterile mosquitoes. Even if a two-dimensional system of ordinary differential equations is considered as a simple mathematical model for developing release strategies, fully understanding the global behavior of the solutions is challenging, due to the fact that the probability of mating is ratio-dependent. …”
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Oxidative Stress and DNA Methylation in Prostate Cancer by Krishna Vanaja Donkena, Charles Y. F. Young, Donald J. Tindall

“…Oxygen radicals are associated with different steps of carcinogenesis, including structural DNA damage, epigenetic changes, and protein and lipid alterations. Epigenetics affects genetic regulation, cellular differentiation, embryology, aging, cancer, and other diseases. …”
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Widespread innervation of motoneurons by spinal V3 neurons globally amplifies locomotor output in mice by Han Zhang, Dylan Deska-Gauthier, Colin S. MacKay, Krishnapriya Hari, Ana M. Lucas-Osma, Joanna Borowska-Fielding, Reese L. Letawsky, Vladimir Rancic, Turgay Akay, Keith K. Fenrich, David J. Bennett, Ying Zhang

“…Despite similar innervation from V3 neurons to flexor and extensor motoneuron pools, V3 neurons preferentially activate extensor muscles. Genetically or optogenetically silencing V3 neurons leads to slower and weaker mice with a reduced ability to adjust extensor muscle force. …”
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A comprehensive review on elucidating the host disease resistance mechanism from the perspective of the interaction between cotton and Verticillium dahliae by Yalin Zhang, Lihong Zhao, Dongpo Li, Ziming Li, Hongjie Feng, Zili Feng, Feng Wei, Jinglong Zhou, Zhiying Ma, Jun Yang, Heqin Zhu

“…In this review, we comprehensively discuss genetic inheritance associated with Verticillium wilt resistance in cotton, the advancements in molecular markers for disease resistance, the functional investigation of resistance genes in cotton, the analysis of pathogenicity genes in V. dahliae, as well as the intricate interplay between cotton and this fungus. …”
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Hemophagocytic Lymphohistiocytosis Associated with Respiratory Syncytial Virus Infection in an Immunocompetent Elderly Patient by Ralph Kamel, Rubal Sharma, Divya Asti, Arshpal Gill, Yevgeniy Skaradinskiy

“…The spectrum comprises hereditary or “primary” HLH that comprises genetically heterogeneous conditions, occurring during childhood. …”
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