A Study of Epstein-Barr Virus BRLF1 Activity in a Drosophila Model System by Amy Adamson, Dennis LaJeunesse

“…Through an additional genetic screen, we have identified several Drosophila genes, with human homologs, that may offer further insights into the pathways that BRLF1 interacts with in order to promote EBV replication.…”
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OPTIMIZATION OF FATIGUE LIFE OF TRANSMISSION SHAFT BASED ON RESPONSE SURFACE METHOD by LIU LongJie, ZHAO LiHui, SHI ChengMiao, ZHENG SongLin, WENG Shuo, LIU XiangZhen, DAI Lei

“…The response surface method and genetic algorithm are used to optimize the structural parameters of the transmission shaft（tooth root fillet, spline transition arc, and arc groove depth）. …”
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Transcriptional Regulators of Claudins in Epithelial Tight Junctions by Niamat Khan, Abdul R. Asif

“…Based on their significant role in the molecular architecture of TJ, diversity, and disease association, further understanding about claudin family proteins and their genetic/epigenetic regulators is indispensable.…”
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Epitope-Driven Vaccine Development for Zika Virus: A Bioinformatics Approach by Riska Ayu Sutriyansyah, Muhamad Hilmi Ihsanul Iman, Cahya Ajeng Valenta Tresna Sulung, Nelly Indira Kusuma Wardani, Arif Nur Muhammad Ansori

“…ZIKV is a member of the Flaviviridae family, which can spread through Aedes mosquitoes, sexual intercourse, from mother to fetus, and blood transfusions. The genetic material is single-stranded RNA with positive polarity. …”
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Probiotic Bacteria Influence the Composition and Function of the Intestinal Microbiota by Paul W. O'Toole, Jakki C. Cooney

“…We now have the microbial inventories and genetic blueprints to begin tackling intestinal microbial ecology at an unprecedented level of detail, aided by the understanding that dietary components may be utilized differentially by individual phylotypes. …”
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Development of a Nonlinear Integer Optimization Model for Tenant Mix Layout in a Shopping Centre by Hongyue Lv, Ting-Kwei Wang

“…To solve this problem, a nonlinear integer optimization model with defined characteristics was proposed and solved using a genetic algorithm. A shopping centre case study is also presented to verify the performance of the model.…”
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Rolling Bearing Degradation State Identification Based on LPP Optimized by GA by He Yu, Hong-ru Li, Zai-ke Tian, Wei-guo Wang

“…And then, locally preserving projection (LPP) is utilized to reduce dimension of original fusion feature set and genetic algorithm is applied to optimize the process of feature fusion. …”
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Physiological premature aging of ovarian blood vessels leads to decline in fertility in middle-aged mice by Lu Mu, Ge Wang, Xuebing Yang, Jing Liang, Huan Tong, Lingyu Li, Kaiying Geng, Yingnan Bo, Xindi Hu, Ruobing Yang, Xueqiang Xu, Yan Zhang, Hua Zhang

“…This leads to a diminished blood supply to the ovaries, resulting in inadequate development and maturation of ovarian follicles. Utilizing genetic-modified mouse models, we demonstrate that granulosa cell secreted VEGFA governs ovarian angiogenesis, but the physiological decline in oBV is not attributed to VEGFA insufficiency. …”
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Predicting cell morphological responses to perturbations using generative modeling by Alessandro Palma, Fabian J. Theis, Mohammad Lotfollahi

“…To tackle these shortcomings, we present IMage Perturbation Autoencoder (IMPA), a generative style-transfer model predicting morphological changes of perturbations across genetic and chemical interventions. We show that IMPA accurately captures morphological and population-level changes of both seen and unseen perturbations on breast cancer and osteosarcoma cells. …”
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Evolution of tick vaccinology by José de la Fuente, Srikant Ghosh, Ala Tabor

“…The evolution of tick vaccinology has been driven by multiple challenges such as (1) Ticks are difficult to control, (2) Vaccines control tick infestations by reducing ectoparasite fitness and reproduction, (3) Vaccine efficacy against multiple tick species, (4) Impact of tick strain genetic diversity on vaccine efficacy, (5) Antigen combination to improve vaccine efficacy, (6) Vaccine formulations and delivery platforms and (7) Combination of vaccines with transgenesis and paratransgenesis. …”
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A Case of Thanatophoric Dysplasia Type I with Fetal Hydrops in the First Trimester by Giannina Calongos, Masateru Hori, Mai Ogino, Hideaki Sawai

“…With the strong suspicion of a fetal skeletal disease, specifically thanatophoric dysplasia (TD), and after extensive genetic counseling, termination of the pregnancy was performed per the parents’ wishes with mechanical cervical dilation and gemeprost (PGE1) administration. …”
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Characterization of the Complete Mitochondrial Genome of Kaloula mediolineata (Microhylidae, Anura) and Its Phylogenetic Analysis by Thu-Thao Thi Huynh, Minh Trong Quang, Hoang Danh Nguyen

“…Conclusions: This study provides valuable genetic information about the molecular characteristics and evolutionary relationships of Kaloula species, which can inform future research and conservation efforts for this threatened frog species.…”
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Models for the marrow: A comprehensive review of AI‐based cell classification methods and malignancy detection in bone marrow aspirate smears by Tabita Ghete, Farina Kock, Martina Pontones, David Pfrang, Max Westphal, Henning Höfener, Markus Metzler

“…Moreover, AI is capable of identifying genetic mutations phenotypically. This pipeline has the potential to offer an accurate and rapid preliminary analysis of the bone marrow in the clinical routine. …”
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Roles of the Oxidative Stress and ADMA in the Development of Deep Venous Thrombosis by Meral Ekim, M. Ramazan Sekeroglu, Ragıp Balahoroglu, Halil Ozkol, Hasan Ekim

“…Venous thromboembolism has multifactorial origin and occurs in the context of complex interactions between environmental and genetic predisposing factors. Oxidative stress plays an important role in the physiopathology of venous thrombosis. …”
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Estrous Synchronization and Fixed-Time Artificial Insemination by Vitor R. G. Mercadante, Darren D. Henry, Francine M. Ciriaco, Pedro L. P. Fontes, Nicky Oosthuizen, G. Cliff Lamb

“…Over the last four decades, several advances in reproductive biotechnologies, such as artificial insemination (AI), synchronization of estrus, and fixed-time AI (TAI), have allowed producers to improve the genetic traits of their cattle and shorten the lengths of both the breeding season and subsequent calving season, which can lead to increased overall profitability of cow-calf production systems. …”
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Discontiguous recurrences of IDH-wildtype glioblastoma share a common origin with the initial tumor and are frequently hypermutated by Malcolm F. McDonald, Sricharan Gopakumar, Tareq A. Juratli, Ilker Y. Eyüpoglu, Ganesh Rao, Jacob J. Mandel, Ali Jalali

“…Little is currently known about the genetic profile of discontiguous recurrences. In our institutional database, we identified 22 patients with targeted exome sequencing of pairs of initial and recurrent IDH-wildtype glioblastoma. …”
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Advances in Knowledge Regarding Arterial Curvature and its Relationship to Ischemic Stroke: A Narrative Review by Lin-Han Zhang, Fei Cao

“…Arterial curvature is primarily influenced by genetic factors, hypertension, sex, and age, and it may indicate weakened arterial walls. …”
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Incidental imaging detection of Kartagener syndrome in a female: A case report by Natasha Dhakal, MBBS, Prajwal Dahal, MD

“…Kartagener syndrome is a rare ciliopathic genetic disorder characterized by a triad of chronic sinusitis, situs inversus, and bronchiectasis. …”
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Transitioning from NAFLD to MAFLD and MASLD: the toxic relationship with alcohol consumption by Mubin Ozercan, Ahmed Tawheed, Mohamed El-Kassas

“…Metabolic substrates of alcohol (especially acetaldehyde) have a major responsibility and genetic susceptibility, alterations in microbiota and immune system are important co-factors for this injury. …”
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Beyond Benign: A Case of Subependymal Giant Cell Astrocytomas Provoking Hydrocephalus in Tuberous Sclerosis Complex by Antonio Navarro-Ballester, Rosa Álvaro-Ballester, Miguel Ángel Lara-Martínez

“… 22-year-old male diagnosed with Tuberous Sclerosis Complex (TSC), a genetic disorder characterized by benign tumors in various organs, with a focus on neurological implications. …”
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