Advancements in the Treatment of Mucopolysaccharidoses: From Established Therapies to Gene Therapy by Joanna Wanat, Wojciech Homa, Aleksandra Warunek, Gabriela Gronowicz, Izabela Dzikowska, Agata Siejka, Daria Stefaniak, Weronika Zielińska, Michał Chról

“… Introduction and purpose Mucopolysaccharidoses (MPS), a subset of inborn errors of metabolism (IEM), are genetic disorders requiring pediatricians to recognize non-specific symptoms and carefully monitor newborns. …”
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Valorization of <i>Cynara cardunculus</i> L. var. <i>scolymus</i> Processing By-Products of Typical Landrace “Carciofo Di Montelupone” from Marche Region (Italy) by Laura Alessandroni, Lorenzo Bellabarba, Samanta Corsetti, Gianni Sagratini

“…This study aims to valorize the by-product in order to promote its cultivation and help producers to create a new supply chain of this cultivar, typical of the Marche region in Italy, which is subject to the potential risk of genetic erosion. Several bioactive substances were monitored and quantified, including inulin, an important D-fructose polymer widely used for its physical–chemical and functional properties and prebiotic activity. …”
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Cryptococcus gattii: Emergence in Western North America: Exploitation of a Novel Ecological Niche by Kausik Datta, Karen H. Bartlett, Kieren A. Marr

“…The relatively uncommon fungal pathogen Cryptococcus gattii recently emerged as a significant cause of cryptococcal disease in human and animals in the Pacific Northwest of North America. Although genetic studies indicated its possible presence in the Pacific Northwest for more than 30 years, C. gattii as an etiological agent was largely unknown in this region prior to 1999. …”
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Eye development under the control of SRp55/B52-mediated alternative splicing of eyeless. by Weronika Fic, François Juge, Johann Soret, Jamal Tazi

“…The genetic programs specifying eye development are highly conserved during evolution and involve the vertebrate Pax-6 gene and its Drosophila melanogaster homolog eyeless (ey). …”
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Design and Application of Automatic Control System for Fully Mechanized Mining Face in Coal Mine by Zhi Yuan, Huanlei Chi, Yan Cao

“…In addition, this paper uses the genetic algorithm to calculate and eliminate the loading phase of the sixth-order input-output equal-length cavity filter and the sixth-order input-output unequal-length cavity filter. …”
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Toxicity and Bioremediation of Heavy Metals Contaminated Ecosystem from Tannery Wastewater: A Review by Bernard E. Igiri, Stanley I. R. Okoduwa, Grace O. Idoko, Ebere P. Akabuogu, Abraham O. Adeyi, Ibe K. Ejiogu

“…Furthermore, this article discussed the biosorption capacity with respect to the use of bacteria, fungi, biofilm, algae, genetically engineered microbes, and immobilized microbial cell for the removal of heavy metals. …”
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FMD molecular epizootology in Russia (phylogenetic analysis *^ß of Russian FMDV isolates) by A. V. Scherbakov

“…It was demonstrated that in different years FMDV of different genetic lineages/ strains was introduced into Russia, i.e. 1995 - O/CATHAY, 2000 and 2004 - O/ME-SA/PanAsia, 2005-2006 - Asial, 2010-2011 - O/SEA/Mea-98,2012 - O/ME-SA/PanAsia, 2013 - A/ASIA/lran-05 and A/ASIA/Sea-97, 2014 - A/ASIA/Sea-97, O/ME-SA/PanAsia and O/SEA/Mea-98. …”
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Finding p-Hub Median Locations: An Empirical Study on Problems and Solution Techniques by Xiaoqian Sun, Weibin Dai, Yu Zhang, Sebastian Wandelt

“…Classical problems in small networks can be solved efficiently using CPLEX because of their low complexity. Genetic algorithms perform well for solving three types of single allocation problems, since the problem formulations can be neatly encoded with chromosomes of reasonable size. …”
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Assessment of Hair Aluminum, Lead, and Mercury in a Sample of Autistic Egyptian Children: Environmental Risk Factors of Heavy Metals in Autism by Farida El Baz Mohamed, Eman Ahmed Zaky, Adel Bassuoni El-Sayed, Reham Mohammed Elhossieny, Sally Soliman Zahra, Waleed Salah Eldin, Walaa Yousef Youssef, Rania Abdelmgeed Khaled, Azza Mohamed Youssef

“…The etiological factors involved in the etiology of autism remain elusive and controversial, but both genetic and environmental factors have been implicated. …”
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PROTAC technology for prostate cancer treatment by Zhen Wang, Dingpeng Zhang, Hiroyuki Inuzuka, Wenyi Wei

“…Key contributors to PrCa progression include genetic mutations, elevated androgen receptor expression, gene amplification, and the rise of androgen receptor splice variants. …”
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Genomic evolution of SARS-CoV-2 in Morocco: Insights from whole genome sequences collected from 2020 to 2024 by Hamza GHAMMAZ, Marouane MELLOUL, Ahlam MBARKI, Mouhssine HEMLALI, Taha CHOUATI, Hicham EL ANNAZ, Nadia TOUIL, Mostafa ELOUENNASS, Khalid ENNIBI, Elmostafa EL FAHIME

“…This study investigates the evolution and genetic diversity of SARS-CoV-2 strains circulating in Morocco to track the spread, clade distributions and mutations of the virus across various regions from February 2020 to June 2024. …”
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Emerging technologies of single-cell multi-omics by Yi June Kim, Koichi Takahashi

“…These technologies have uncovered the intricate landscape of genetic clonality and transcriptional heterogeneity in both normal and malignant hematopoietic systems, highlighting their roles in differentiation, disease progression, and therapy resistance. …”
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Evolution Balancing of the Small-Sized Wheel Loader Assembly Line by Rongshen Lai, Liang Hou, Yongming Wu

“…Then, with minimizing the number of workstations, the in-station and between-station load indexes and adjustment costs, and maximizing relevancy between activities as optimization objectives, meanwhile regarding product platform planning, modularity design and the critical chain technology in concurrent engineering as constraint conditions, the evolution balancing problem of PFAL is optimized using improved genetic algorithm (IGA). Finally, the whole analysis procedure is demonstrated by the small-sized wheel loader PFAL case study and the effectiveness of the proposed method is verified.…”
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OPTIMIZATION DESIGN OF CABIN STRUT BASED ON ISIGHT AND PYTHON FOR CIVIL AIRCRAFT by FANG Yang, ZHANG WeiWen, ZHANG YangYang

“…It utilizes multi-island genetic algorithm for optimization analysis,and an iterative optimization process for the follow-up strut analysis is established. …”
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Predicting immunotherapy efficacy in endometrial cancer: focus on the tumor microenvironment by Liubov A. Tashireva, Irina V. Larionova, Irina V. Larionova, Nikita A. Ermak, Anastasia A. Maltseva, Ekaterina I. Livanos, Anna Yu. Kalinchuk, Marina N. Stakheyeva, Larisa A. Kolomiets

“…The resistance to immunotherapy is multifactorial mechanism, encompassed genetic and epigenetic alterations in tumor cells modulating immune checkpoint molecules, resulted in escaping immune surveillance. …”
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Stability Optimization of a Disc Brake System with Hybrid Uncertainties for Squeal Reduction by Hui Lü, Dejie Yu

“…The combinational algorithm of Genetic Algorithm and Monte-Carlo method is employed to perform the optimization. …”
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An Optimal Design of Multiple Antenna Positions on Mobile Devices Based on Mutual Coupling Analysis by Peerapong Uthansakul, Danai Assanuk, Monthippa Uthansakul

“…Due to the area constraint on a mobile device, the problem of how to design such a system in order to achieve the best benefit is still a huge challenge. In this paper, genetic algorithm (GA) is used to find the optimal antenna positions on a mobile device. …”
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Cotrimoxazole-Resistant Escherichia coli Bacteremia in Neutropenic Patients at a Regional Oncology Hospital by Daniel B Gregson, Anne G Matlow, Andrew E Simor, Peter G Tuffnell, Donald E Low, Ronald Feld, James E Brunton

“…Failure of cotrimoxazole prophylaxis was initially due to the clonal dissemination of a single strain of E coli within the institution, with the subsequent appearance of multiple E coli strains with probable differing genetic bases for their resistance.…”
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MSCs: Delivery Routes and Engraftment, Cell-Targeting Strategies, and Immune Modulation by Thomas J. Kean, Paul Lin, Arnold I. Caplan, James E. Dennis

“…These cell targeting methodologies focus on the modification of cell surface molecules through chemical, genetic, and coating techniques to promote selective adherence to particular organs or tissues. …”
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Developing a framework for tracking antimicrobial resistance gene movement in a persistent environmental reservoir by Amy J. Mathers, Thomas J. X. Li, Qijun He, Sharvari Narendra, Nicole Stoesser, David W. Eyre, A. Sarah Walker, Katie E. Barry, Salvador Castañeda-Barba, Fenix W. Huang, Hardik Parikh, Shireen Kotay, Derrick W. Crook, Christian Reidys

“…Abstract Mobile genetic elements are key to the global emergence of antibiotic resistance. …”
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