Histocompatibility and Hematopoietic Transplantation in the Zebrafish by Jill L. O. de Jong, Leonard I. Zon

“…The zebrafish has proven to be an excellent model for human disease, particularly hematopoietic diseases, since these fish make similar types of blood cells as humans and other mammals. The genetic program that regulates the development and differentiation of hematopoietic cells is highly conserved. …”
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Fuzzy Theory-Based Data Placement for Scientific Workflows in Hybrid Cloud Environments by Zheyi Chen, Xu Zhao, Bing Lin

“…To address this problem, we propose an adaptive discrete particle swarm optimization algorithm based on the fuzzy theory and genetic algorithm operators (DPSO-FGA) to minimize the fuzzy data transmission time of scientific workflows. …”
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COVID-19 and APOL-1 High-Risk Genotype-Associated Collapsing Glomerulonephritis by Sasmit Roy, Srikanth Kunaparaju, Narayana Murty Koduri, Vikram Sangani, Mytri Pokal, Venu Madhav Konala, Mamtha Balla, Sreedhar Adapa

“…Our case highlights a similar case of COVID-19 in a 65-year-old AA descendant with biopsy-proven FSGS and genetically confirmed APOL-1 alleles.…”
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Responsible and safe innovation in education: an iGEM showcase by Britte Bouchaut, Lotte Asveld

“…This paper showcases a project involved in the international Genetically Engineered Machines (iGEM) competition – a competition dedicated to the advancement of synthetic biology – executed at Delft University of Technology, the Netherlands. …”
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Antenna Configuration Method for RF Measurement Based on DOPs in Satellite Formation Flying by Weiqing Mu, Rongke Liu, Zijie Wang, Yukai Liu

“…In order to select the optimal antenna configuration in real time in a scene where the intersatellite position and attitude change dynamically, this study presents an optimal antenna configuration selection strategy and models the antenna configuration selection as a combinatorial optimization problem. Furthermore, the genetic algorithm (GA) with two encoding mechanisms is proposed to solve this problem. …”
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Sailing Speed Optimization Model for Slow Steaming Considering Loss Aversion Mechanism by Yuzhe Zhao, Jingmiao Zhou, Yujun Fan, Haibo Kuang

“…The value functions against the benchmark speed were constructed based on physiological expected utility (PEU) to reveal the features of loss aversion, and the objective function was derived from these value functions with the aim to optimize the sailing speed. After that, a Genetic Algorithm (GA) solution with fitness function and special operators was built to solve the proposed model. …”
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A Therapeutic Challenge: Liddle’s Syndrome Managed with Amiloride during Pregnancy by Amelia Caretto, Liviana Primerano, Francesca Novara, Orsetta Zuffardi, Stefano Genovese, Maurizio Rondinelli

“…Hypertension worsened after the 25th week of gestation and amiloride was safely administered, firstly in combination with hydrochlorothiazide (the only formulation commercially available in Italy) and, thereafter, as a single drug. Genetic testing was performed in the patient’s family in order to support diagnosis and clinical management.…”
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GSK-3β at the Intersection of Neuronal Plasticity and Neurodegeneration by Tomasz Jaworski, Ewa Banach-Kasper, Katarzyna Gralec

“…Equalizing GSK-3β activity in these mouse models by genetic or pharmacological interventions is able to rescue some of these abnormalities. …”
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Joubert Syndrome Presenting with Motor Delay and Oculomotor Apraxia by Harjinder Gill, Brinda Muthusamy, Denize Atan, Cathy Williams, Matthew Ellis

“…MRI of the older sibling demonstrated the characteristic “molar tooth sign” (MTS) of Joubert syndrome which was subsequently confirmed on MRI in the younger sibling. We discuss the genetically heterogeneous ciliopathies now grouped as Joubert syndrome and Related Disorders. …”
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Identification of a binding site for small molecule inhibitors targeting human TRPM4 by Babatunde Ekundayo, Prakash Arullampalam, Christian E. Gerber, Anne-Flore Hämmerli, Sabrina Guichard, Mey Boukenna, Daniela Ross-Kaschitza, Martin Lochner, Jean-Sebastien Rougier, Henning Stahlberg, Hugues Abriel, Dongchun Ni

“…Abstract Transient receptor potential (TRP) melastatin 4 (TRPM4) protein is a calcium-activated monovalent cation channel associated with various genetic and cardiovascular disorders. The anthranilic acid derivative NBA is a potent and specific TRPM4 inhibitor, but its binding site in TRPM4 has been unknown, although this information is crucial for drug development targeting TRPM4. …”
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Recombinant expression systems for production of stabilised virus-like particles as next-generation polio vaccines by Lee Sherry, Mohammad W. Bahar, Claudine Porta, Helen Fox, Keith Grehan, Veronica Nasta, Helen M. E. Duyvesteyn, Luigi De Colibus, Johanna Marsian, Inga Murdoch, Daniel Ponndorf, Seong-Ryong Kim, Sachin Shah, Sarah Carlyle, Jessica J. Swanson, Sue Matthews, Clare Nicol, George P. Lomonossoff, Andrew J. Macadam, Elizabeth E. Fry, David I. Stuart, Nicola J. Stonehouse, David J. Rowlands

“…Using our previously established genetic techniques to stabilize the structural capsid proteins, we demonstrate production of poliovirus VLPs of all three serotypes, from four different recombinant expression systems. …”
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Program for Studying Intergenerational Transmissions in Infant Mortality Using the Intermediate Data Structure (IDS) by Luciana Quaranta

“…Studies conducted in historical populations and developing countries have evidenced the existence of clustering in infant deaths, which could be related to genetic inheritance and/or to social and cultural factors such as education, socioeconomic status or parental care. …”
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Juvenile Hemochromatosis due to a Homozygous Variant in the HJV Gene by María-Belén Moreno-Risco, Manuel Méndez, María-Isabel Moreno-Carralero, Ana-María López-Moreno, José-Manuel Vagace-Valero, María-José Morán-Jiménez

“…The purpose of this study was to identify the gene variant that causes the disease. The genetic study was performed with a targeted gene panel: HFE, HJV, HAMP, TFR2, SLC40A1, FTL, and FTH1. …”
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Multitask Oriented Virtual Resource Integration and Optimal Scheduling in Cloud Manufacturing by Zhen Cheng, Dechen Zhan, Xibin Zhao, Hai Wan

“…According to the correlation model and characteristics of resource sharing, the formulation in which resource time-sharing scheduling strategy is employed is put forward, and then the formulation is simplified to solve the problem easily. The genetic algorithm based on the real number matrix encoding is proposed. …”
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Anderson–Fabry Disease: An Overview of Current Diagnosis, Arrhythmic Risk Stratification, and Therapeutic Strategies by Chiara Tognola, Giacomo Ruzzenenti, Alessandro Maloberti, Marisa Varrenti, Patrizio Mazzone, Cristina Giannattasio, Fabrizio Guarracini

“…Furthermore, we discuss the role of genetic and biochemical markers in predicting arrhythmic risk and the implications for personalized treatment strategies. …”
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Xeroderma Pigmentosum: Man Deprived of His Right to Light by Subhash Mareddy, Jithendra Reddy, Subhas Babu, Preethi Balan

“…T4N5 and photolyase liposomal lotions are innovations in the therapy of XP. Genetic counselling implicating the effect of consanguineous marriages should be considered in the management of XP patients.…”
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Harnessing artificial intelligence for predicting breast cancer recurrence: a systematic review of clinical and imaging data by Jaqueline Alvarenga Silveira, Alexandre Ray da Silva, Mariana Zuliani Theodoro de Lima

“…SVMs are effective with high-dimensional clinical data, while Neural Networks in genetic and molecular analysis. Despite these advancements, limitations such as dataset diversity, sample size, and evaluation standardization persist, emphasizing the need for further research. …”
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Combined Hamartoma of the Retina and Retinal Pigment Epithelium in a Patient with Gorlin Syndrome: Spontaneous Partial Resolution of Traction Caused by Epiretinal Membrane by José L. Sánchez-Vicente, Miguel Contreras-Díaz, Trinidad Rueda, Enrique Rodríguez de la Rúa-Franch, Fredy E. Molina-Socola, Cristina Vital-Berral, Asunción Alfaro-Juárez, Fernando López-Herrero, Ana Muñoz-Morales

“…Epiretinal membrane (EM) was also detected. Genetic study was performed to confirm the diagnosis of GS. …”
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Comprehensive Rehabilitation Therapy for A Child with Reducing Body Myopathy by Xinhong WU, Fan WU, Yun ZHANG, Taibiao LI, Tiebin YAN

“…Objective:To investigate the characteristics and rehabilitation therapy of a case with reducing body myopathy (RBM).Methods:A case of a child with limb weakness due to RBM was admitted, and the clinical features, laboratory tests results, imaging findings, muscle pathology and genetic testing results of the child were analyzed. …”
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AP1 Transcription Factors in Epidermal Differentiation and Skin Cancer by Richard L. Eckert, Gautam Adhikary, Christina A. Young, Ralph Jans, James F. Crish, Wen Xu, Ellen A. Rorke

“…., proliferation, apoptosis, and differentiation). Various in vivo genetic approaches have been used to study these proteins including targeted and conditional knockdown, overexpression, and expression of dominant-negative inactivating AP1 transcription factors in epidermis. …”
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