INTESTINAL MICROBIOME - A LEADING FACTOR IN HUMAN HEALTH AND DISEASES by E. Blum Hubert

“…Based on modern molecular, genetic, epigenetic microbiologic and biochemical studies it is, on the one hand, possible to identify disease-related point mutations and single nucleotide polymorphisms within genome-wide association analyses (GWAS). …”
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Modeling of Chronic Myeloid Leukemia: An Overview of In Vivo Murine and Human Xenograft Models by Pallavi Sontakke, Jenny Jaques, Edo Vellenga, Jan Jacob Schuringa

“…With the availability of iPSC technology, it has become feasible to derive, maintain, and expand CML subclones that are at least genetically identical to those in patients. The following review provides an overview of all murine as well as human xenograft models for CML established till date.…”
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The ABC transporter Opp imports reduced glutathione, while Gsi imports glutathione disulfide in Escherichia coli by Lisa R. Knoke, Maik Muskietorz, Lena Kühn, Lars I. Leichert

“…Glutathione transport out of and into cellular compartments and the extracellular space is a determinant of the thiol-disulfide redox state of the organelles and bodily fluids in question, but is currently not well understood. Here we use the genetically-encoded, glutathione-measuring redox probe Grx1-roGFP2 to comprehensively elucidate the import of extracellular glutathione into the cytoplasm of the model organism Escherichia coli. …”
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Control of virulence by small RNAs in Streptococcus pneumoniae. by Beth Mann, Tim van Opijnen, Jianmin Wang, Caroline Obert, Yong-Dong Wang, Robert Carter, Daniel J McGoldrick, Granger Ridout, Andrew Camilli, Elaine I Tuomanen, Jason W Rosch

“…Furthermore, using targeted genetic approaches and Tn-seq transposon screening, we demonstrate that many of the identified sRNAs have important global and niche-specific roles in virulence. …”
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CDK4 inactivation inhibits apoptosis via mitochondria-ER contact remodeling in triple-negative breast cancer by Dorian V. Ziegler, Kanishka Parashar, Lucia Leal-Esteban, Jaime López-Alcalá, Wilson Castro, Nadège Zanou, Laia Martinez-Carreres, Katharina Huber, Xavier Pascal Berney, María M. Malagón, Catherine Roger, Marie-Agnès Berger, Yves Gouriou, Giulia Paone, Hector Gallart-Ayala, George Sflomos, Carlos Ronchi, Julijana Ivanisevic, Cathrin Brisken, Jennifer Rieusset, Melita Irving, Lluis Fajas

“…While CDK4 is known for its role in cell proliferation, its metabolic function in cancer, particularly in triple-negative breast cancer (TNBC), remains unclear. Our study, using genetic and pharmacological approaches, reveals that CDK4 inactivation only modestly impacts TNBC cell proliferation and tumor formation. …”
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Age-related features of alpha rhythm dynamics: a brief review by I.S. Polikanova, I.N. Mikheev, S.V. Leonov, O.V. Martynova

“…Parameters of the alpha rhythm, such as individual stability, genetic predisposition, and age-related characteristics, make it a promising marker for both normative development and brain aging in determining cognitive and biological age.…”
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Endometriosis Gene Expression Heterogeneity and Biosignature: A Phylogenetic Analysis by Mones Abu-Asab, Ming Zhang, Dennis Amini, Nihad Abu-Asab, Hakima Amri

“…Endometriosis is a multifactorial disease with poorly understood etiology, and reflecting an evolutionary nature where genetic alterations accumulate throughout pathogenesis. …”
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Autism common variants associated with white matter alterations at birth: cross-sectional fixel-based analyses of 221 European term-born neonates from the developing human connecto... by Hai Le, Alexandra F. Bonthrone, Alena Uus, Daphna Fenchel, Alexandra Lautarescu, Konstantina Dimitrakopoulou, A. David Edwards, Joseph V. Hajnal, Serena J. Counsell, Lucilio Cordero-Grande, Daan Christiaens, Dafnis Batalle, Maximilian Pietsch, Anthony N. Price, Hamel Patel, Charles Curtis, Harriet Cullen, Maria Deprez, Jacques-Donald Tournier

“…Despite the condition having high heritability, the relationship between autism common genetic variants and WM changes during this period remains unclear. …”
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RESEARCH ON PARAMETRIC ANALYSIS AND MULTI-OBJECTIVE OPTIMIZATION OF CYLINDRICAL PRESSURE STRUCTURE by LIU Feng, TU ChaoHua, ZHAO YanKai

“…In order to improve the design efficiency and performance of the cylindrical pressure structure,strength and stability analysis methods were determined,the initial scheme was analyzed. the second development of Abaqus software was carried out by using Python language,Abaqus was integrated with i Sight software,the parametric analysis flow of pressure structure was designed,could realize automatic modeling and analysis of cylindrical pressure structure. the most Latin hypercube method was used to selectting the sample points,the sensitivity analysis of the design variables were carried out,The comparison of the fitting accuracy shown that the response surface model had the highest accuracy,the approximate model of the cylindrical pressure structure based on the fourth-order response surface was obtained. the multi-objective optimization model was established,The second generation of non dominated sorting genetic algorithm was used to solving the multi-objective optimization problem,the results shown that the weight of the optimization scheme was reduced,while the ultimate strength was greatly improved,improved the performance of the cylindrical pressure structure.…”
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An Improved NSGA-II Algorithm for Transit Network Design and Frequency Setting Problem by Shushan Chai, Qinghuai Liang

“…In order to obtain the better network schemes, a multi-population genetic algorithm is proposed based on NSGA-II framework. …”
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Histone deacetylase inhibition with givinostat: a multi-targeted mode of action with the potential to halt the pathological cascade of Duchenne muscular dystrophy by A. Aartsma-Rus

“…HDAC inhibition has consequently been investigated as a therapeutic approach for muscular dystrophies that, significantly, works independently from specific genetic mutations, making it potentially suitable for all patients with DMD. …”
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Lightweight Design and Dynamics Analysis of ZYL-15000D Directional Drill Reducer by Xiaohong Zhao, Xianguo Yan, Zhi Chen, Hang Su

“…This paper selects the method of reducing the transmission ratio to optimize the size parameters of the reducer. MATLAB genetic algorithm is used in the optimization design, and the minimum volume of the rotary part reducer is taken as the objective of optimization design, while the design variables and constraints are determined. …”
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An efficient spectrum sensing of mixed kernel SVM based on sampling covariance matrix by Jianyuan NIE, Jianrong BAO, Bin JIANG, Chao LIU, Fang ZHU, Jianhai HE

“…In recent years,with the blind detection algorithms were proposed,more and more blind algorithms based on sampling covariance matrix were applied to spectrum sensing.The detection threshold was an approximation,and the detection performance would be affected for this algorithms.Thus,the mixed kernel function support vector machine (SVM) efficient spectrum sensing based on sampling covariance matrix was proposed.The statistics which were maximum minimum eigenvalue (MME) and covariance absolute value (CAV) of sensing signal sampling covariance matrices were used as the feature vectors of SVM and were trained to generate a spectrum sensing classifier.The advantage of this algorithm was that it needn’t calculate the detection threshold and the extraction of features reduces size of the sample set.The genetic algorithm (GA) was used to optimize the parameters of mixed kernel function SVM algorithm.The experimental results show that the proposed method has higher detection probability than MME and CAV algorithms,and has less sensing time than SVM,which has good practicability.…”
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Program for Studying Intergenerational Transmissions in Infant Mortality Using the Intermediate Data Structure (IDS) by Luciana Quaranta

“…Studies conducted in historical populations and developing countries have evidenced the existence of clustering in infant deaths, which could be related to genetic inheritance and/or to social and cultural factors such as education, socioeconomic status or parental care. …”
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Diagnosis and genomic characterization of the largest western equine encephalitis virus outbreak in Uruguay during 2023–2024 by Gonzalo Tomás, Ana Marandino, Sirley Rodríguez, Gabriel Luz Wallau, Filipe Zimmer Dezordi, André Luiz Sá de Oliveira, Claudia Techera, Lucía Calleros, Sofía Grecco, Joaquín Williman, Ramiro Pérez, Lucía Bassetti, Raúl Negro, Lucía Moreira Marrero, Adriana Delfraro, Roberto Vidal, Yanina Panzera, Ruben Pérez

“…The most recent large outbreak occurred in South America from November 2023 to April 2024. We identified and genetically characterized Uruguayan strains during this outbreak to understand their evolutionary trends and rapid expansion. …”
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Effect of Larval Density on Development of the Coconut Hispine Beetle, Brontispa longissima (Gestro) (Coleoptera: Chrysomelidae) by Mika Murata, Dang Thi Dung, Shun-ichiro Takano, Ryoko Tabata Ichiki, Satoshi Nakamura

“…Recently we found that B. longissima was divided into two monophyletic clades by genetic analysis. Therefore, we also compared the results between two populations, from Ishigaki, Japan (ISH) and Papua New Guinea (PNG), which were representative of the two monophyletic clades of B. longissima. …”
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Chromosome-level genome assembly of Triplophysa bombifrons using PacBio HiFi sequencing and Hi-C technologies by Chengxin Wang, Site Luo, Yong Song, Liting Yang, Xinyue Wang, Shengao Chen

“…Abstract Triplophysa bombifrons, a species of bony fish localized in China, has largely been understudied genetically, with limited data available beyond its mitochondrial genome. …”
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Optimal Design of the Sealing Structure of a Hydraulic Cylinder on the Basis of a Surrogate Model by Hong Zhang, Yu Sun, Chenchen Li, Haoran Wang

“…Then, a surrogate model was fitted and optimised through a constrained Latin hypercube method, an interpolating recmultiquadric radial basis function method, and the genetic algorithm. The results indicate that the seal and seal groove structures obtained through optimisation with the surrogate model provide a superior sealing effect to unoptimised structures. …”
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Ficolins and the Recognition of Pathogenic Microorganisms: An Overview of the Innate Immune Response and Contribution of Single Nucleotide Polymorphisms by Stefan Bidula, Darren W. Sexton, Silke Schelenz

“…Additionally, we will explore the various genetic susceptibility factors that predispose individuals to infection.…”
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The evolution of personalized medicine: literature review by I. S. Dolgopolov, M. Yu. Rykov

“…It can be assumed that the individualization of medical practice will develop, especially in the case of rare genetic diseases. Moreover, an individual approach to the patient is more effective and rentable.…”
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