Repeated Long-Term DT Application in the DEREG Mouse Induces a Neutralizing Anti-DT Antibody Response by Junhua Wang, Myriam Siffert, Markus Spiliotis, Bruno Gottstein

“…Regulatory T (Tregs) cells play an important role in mediating tolerance to self-antigens but can also mediate detrimental tolerance to tumours and pathogens in a Foxp3-dependent manner. Genetic tools exploiting the foxp3 locus including bacterial artificial chromosome- (BAC-) transgenic DEpletion of REGulatory T cells (DEREG) mice have provided essential information on Treg biology and the potential therapeutic modulation of tolerance. …”
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THERAPY-RELATED MYELOID NEOPLASMS: CONSIDERATIONS FOR PATIENTS’ CLINICAL EVALUATION. by Raffaele Palmieri, Ilaria Del Principe, Luca Maurillo, Adriano Venditti, Francesco Buccisano

“…Such malignancies present unique features, including advanced age, high comorbidities burden, and unfavorable genetic profiles. All these features justify the need for a specific diagnostic work-up and dedicated treatment algorithms. …”
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Two-Echelon Location-Routing Problem with Fuzzy Demand of Rural E-Commerce Logistics by Xiaojuan LU, Jianjun WANG, Shuai WU, Shiyu ZHENG, Qian LIU

“…Additionally, we present a two-stage Improved Non-Dominated Sorting Genetic Algorithm II (INSGA-II) that integrates stochastic simulation and a K-means clustering algorithm to effectively solve the problem. …”
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Stage-specific modulation of Drosophila gene expression with muscle GAL4 promoters by Ziwei Zhao, Erika R Geisbrecht

“…The bipartite GAL4/UAS system is the most widely used method for targeted gene expression in Drosophila melanogaster and facilitates rapid in vivo genetic experimentation. Defining precise gene expression patterns for tissues and/or cell types under GAL4 control will continue to evolve to suit experimental needs. …”
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Prenatal Diagnosis and Management of a Fetal Goiter Hypothyroidism due to Dyshormonogenesis by Catarina Matos Figueiredo, Inês Falcão, Joana Vilaverde, Joana Freitas, Maria João Oliveira, Cristina Godinho, Jorge Dores, Maria Céu Rodrigues, Carmen Carvalho, Teresa Borges

“…Currently, he is 6 years old with adequate growth and normal psychomotor development. Genetic study found a heterozygous mutation in the TPO gene.…”
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Oncolytic Viruses: The Power of Directed Evolution by Maxine Bauzon, Terry W. Hermiston

“…Using ColoAd1, an oncolytic virus derived by this approach as a prototype, we highlight the benefits of directed evolution, discuss methods to “arm” these novel viruses, and introduce techniques for their genetic modulation and control.…”
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Molecular characterization of the sea lamprey retina illuminates the evolutionary origin of retinal cell types by Junqiang Wang, Lin Zhang, Martina Cavallini, Ali Pahlevan, Junwei Sun, Ala Morshedian, Gordon L. Fain, Alapakkam P. Sampath, Yi-Rong Peng

“…The diversification of amacrine and some ganglion cell types appears, however, to be distinct in the lamprey. We further infer genetic regulators in specifying retinal cell classes and identify ancestral regulatory elements across species, noting decreased conservation in specifying amacrine cells. …”
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Dendritic Cell-Based Approaches for Therapeutic Immune Regulation in Solid-Organ Transplantation by Giuseppe Vassalli

“…Recent data suggest that injected immunosuppressive DCs may inhibit allograft rejection, not by themselves, but through conventional DCs of the host. Genetically engineered DCs have also been tested. Two clinical trials in type-1 diabetes and rheumatoid arthritis have been carried out, and other trials, including one trial in kidney transplantation, are in progress or are imminent.…”
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An optimized approach for container deployment driven by a two-stage load balancing mechanism. by Chaoze Lu, Jianchao Zhou, Qifeng Zou

“…The subsequent stage utilizes a genetic algorithm for fine-grained resource allocation, ensuring an equitable distribution of resources to each container service on a single virtual machine. …”
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Bibliometric mapping of mesenchymal stem cell therapy for bone regeneration from 2013 to 2023 by Qianqian Chen, Qianqian Chen, Yiqi Su, Zhen Yang, Qiyuan Lin, Yan Ke, Yan Ke, Dan Xing, Dan Xing, Dan Xing, Dan Xing, Hui Li, Hui Li

“…With the advancement of tissue engineering, MSCs have been increasingly applied in bone repair and regeneration, and their clinical application potential has grown through interdisciplinary approaches involving biomaterials and genetic engineering. However, there is a lack of systematic reviews summarizing their applications in bone regeneration. …”
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Kin Competition Drives the Evolution of Earlier Metamorphosis by Bing Dong, Andy Gardner

“…Here we develop a mathematical model to investigate how kin selection shapes the optimal timing of metamorphosis from foraging, non‐reproductive larva to reproductive adult, when larvae tend to cluster with their genetic relatives. We consider the full range of larval competition intensities—from no competition to full competition—and the full range of relatedness coefficients—from unrelated to clonality. …”
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Multicompare Tests of the Performance of Different Metaheuristics in EEG Dipole Source Localization by Diana Irazú Escalona-Vargas, Ivan Lopez-Arevalo, David Gutiérrez

“…We study the use of nonparametric multicompare statistical tests on the performance of simulated annealing (SA), genetic algorithm (GA), particle swarm optimization (PSO), and differential evolution (DE), when used for electroencephalographic (EEG) source localization. …”
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Mechanisms of oxidative stress-induced sperm dysfunction by Yutao Wang, Xun Fu, Hongjun Li

“…ROS-induced DNA fragmentation compromises genetic integrity, potentially leading to infertility and adverse offspring outcomes. …”
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Impact of population screening for Lynch syndrome insights from the All of Us data by Jiheum Park, Hemanth Karnati, Sheila D. Rustgi, Chin Hur, Xiao-Fei Kong, Fay Kastrinos

“…Abstract Lynch Syndrome (LS) is a common genetic cancer condition that allows for personalized cancer prevention and early cancer detection in identified gene carriers. …”
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Advancements in Cardiac Amyloidosis Treatment by Tarek Ziad Arabi, Abdullah Shaik, Ahmed El-Shaer, Omar Al Tamimi, Eman Nayaz Ahmed, Mohamad S. Alabdaljabar, Ahmad Safdar, Ali Mushtaq

“…However, barriers such as high costs, limited availability of genetic testing, and inadequate multidisciplinary care continue to impede comprehensive management. …”
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Despicable role of epithelial–mesenchymal transition in breast cancer metastasis: Exhibiting de novo restorative regimens by Paras Famta, Saurabh Shah, Biswajit Dey, Kondasingh Charan Kumar, Deepkumar Bagasariya, Ganesh Vambhurkar, Giriraj Pandey, Anamika Sharma, Dadi A. Srinivasarao, Rahul Kumar, Santosh Kumar Guru, Rajeev Singh Raghuvanshi, Saurabh Srivastava

“…This highly regulated event causes phenotypic, genetic, and epigenetic changes in the tumor microenvironment (TME). …”
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Urban Rail Transit Scheduling under Time-Varying Passenger Demand by Xing Zhao, Zhongyan Hou, Jihuai Chen, Yin Zhang, Junying Sun

“…A hybrid algorithm which consists of the main algorithm based on genetic algorithm and the nested algorithm based on train traction calculation and safety distance requirement is designed to solve the model. …”
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Optimal Trajectory Planning and Linear Velocity Feedback Control of a Flexible Piezoelectric Manipulator for Vibration Suppression by Junqiang Lou, Yanding Wei, Guoping Li, Yiling Yang, Fengran Xie

“…And the sum of the link vibration energy is chosen as the objective function. Then, genetic algorithm is used to determine the optimal trajectory. …”
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Effect of cutting position in the mother plant and use of auxin on the rooting efficiency of cuttings in four varieties of Cannabis sp. by Axel Voisin, Sebastián Gómez, Esteban Colmann Lerner, Oswaldo Aranda Mosquera, Blanca Villarreal, Sandra Sharry, Christian Weber

“…This work addresses the importance of producing genetically stable plant material, especially in medicinal production where cloning plants with known characteristics is essential for large-scale production. …”
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Exercise-Induced Rhabdomyolysis and Stress-Induced Malignant Hyperthermia Events, Association with Malignant Hyperthermia Susceptibility, and RYR1 Gene Sequence Variations by Antonella Carsana

“…MH is an autosomal dominant hypermetabolic condition that occurs in genetically predisposed subjects during general anesthesia, induced by commonly used volatile anesthetics and/or the neuromuscular blocking agent succinylcholine. …”
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