Implementing genomic selection in the IMB: challenges and opportunities by Stefano Biffani, Mayra Gómez, Roberta Cimmino, Dario Rossi, Gianluigi Zullo, Riccardo Negrini, Alberto Cesarani, Giuseppe Campanile, Gianluca Neglia

“…Its inclusion in the genetic evaluation system could increase both the accuracy and genetic progress of the traits of interest of the breed. …”
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Detection of Antimicrobial Resistance Genes Associated with Carbapenem Resistance from the Whole-Genome Sequence of Acinetobacter baumannii Isolates from Malaysia by Mohan Rao, Fairuz A. Rashid, Surianti Shukor, Rohaidah Hashim, Norazah Ahmad

“…The aim of this study was to analyze β-lactamase genetic compositions of CrAb in Malaysia. Methods. …”
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Phase Behavior Identification and Formation Mechanisms of the BZ19-6 Condensate Gas Reservoir in the Deep Bozhong Sag, Bohai Bay Basin, Eastern China by Zhenliang Wang, Shengdong Xiao, Feilong Wang, Guomin Tang, Liwen Zhu, Zilong Zhao

“…However, the phase behavior and genetic mechanisms of hydrocarbon fluids are still unclear. …”
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The mcpC mutant of Salmonella enteritidis exhibits attenuation and confers both immunogenicity and protective efficacy in mice by Lu Zhang, Li Chen, Xuqiang Zhang, Yang Li, Qingfeng Zheng, Yun Li, Ning Li, Qiumei Shi, Yanying Zhang, Tonglei Wu

“…The ΔmcpC offers strong immune protection in mice, providing a solid foundation for the development of genetically engineered attenuated live vaccines against SE.…”
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Assessing the Causal Relationship Between Various Immune Cells and Attention Deficit Hyperactivity Disorder: Mendelian Randomization Study by Qian Ge, Zhongyan Li, Weijing Meng, Chen Cai, Mengdi Qiu, Yafei Liu, Haibo Zhu

“…Conclusions This study provides a broad theoretical foundation for the development of immune‐oriented therapeutic strategies in future clinical practice by demonstrating a potential genetic relationship between immune cells and ADHD. …”
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Identification of HOXA9 methylation as an epigenetic biomarker predicting prognosis and guiding treatment choice in acute myeloid leukemia by Fei Xie, Ting-juan Zhang, Xin-long Zhang, Zi-jun Xu, Liang Qiao, Yun Wang, Yang-jing Zhao, Jun Qian, Jing-dong Zhou

“…HOXA overexpression caused by genetic alterations, such as KMT2A rearrangements, NUP98- fusions and FLT3-ITD mutations, is frequently identified in AML. …”
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PCSK9-antibodies fail to block PCSK9-induced inflammation in macrophages and cannot recapitulate protective effects of PCSK9-deficiency in experimental myocardial infarction by Simon Rauterberg, Simon Rauterberg, Carmen Härdtner, Jennifer Hein, Paola Schrepf, Remi Peyronnet, Christoph Koentges, Tamara A. Vico, Carolin Ehlert, Bianca Dufner, Diana Lindner, Constantin von zur Mühlen, Dennis Wolf, Dirk Westermann, Ingo Hilgendorf, Alexander von Ehr

“…These findings highlight the complex role of PCSK9 in cardiac pathology and caution against the assumption that PCSK9 inhibitors will necessarily yield cardiovascular benefits similar to genetic PCSK9 deficiency.…”
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First detection and molecular characterization of porcine epidemic diarrhea virus (PEDV) in India: evidence of a new variant in Karnataka by Jagadish B. Hiremath, M. Swathi, R. Ramamoorthy, M. Shijili, Damini Sharma, Divakar Hemadri, H. B. Chethankumar, K. P. Suresh, Sharanagouda S. Patil, Shivasharanappa Nayakvadi, S. P. Satheesha, B. R. Shome, Baldev Raj Gulati

“…This study reports the first clinical outbreak of PED in India, followed by the detection and genetic characterization of PED virus (PEDV) during 2022-23. …”
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Multi-Objective Optimal Trajectory Planning for Woodworking Manipulator and Worktable Based on the INSGA-II Algorithm by Jiaping Yi, Changqing Zhang, Sihan Chen, Qinglong Dai, Hang Yu, Guang Yang, Leyuan Yu

“…An improved non-dominated sorting genetic algorithm (INSGA-II) is proposed to achieve a time–jerk multi-objective trajectory planning that can meet the dual requirements of minimal processing time and reduced motion impact. …”
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Dual role of ramR mutation in enhancing immune activation and elevating eravacycline resistance in Klebsiella pneumoniae by Wei Yu, Peiyao Jia, Xiaobing Chu, Shengjie Li, Xinmiao Jia, Ying Zhu, Xiaoyu Liu, Yingchun Xu, Qiwen Yang

“…To determine how specific mutations in ramR influence eravacycline (ERV) resistance and their impact on the immune activation capabilities of K. pneumoniae, thereby highlighting potential targets for therapeutic intervention, we performed genetic sequencing to identify mutations in ramR. …”
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Gastrointestinal complications of hepatic glycogen storage disease: a national survey questionnaire study in China by Xiaoyan Zhang, Zexiong Su, Jiaxing Wu, Hanshi Zeng, Xun Jiang, Ying Wang, Huiqing Shen, Xiaoli Xie, Yuan Xiao, Qing Tang, Xiaoping Luo, Xuemei Zhong, Huan Chen, Jiaoli Lan, Yongxin Chen, Xiaolu Zeng, Huiqiong Zhang, Zhiling Li, Yuxin Zhang, Min Yang

“…Abstract Background Hepatic glycogen storage diseases (GSD) are inborn errors of metabolism with abnormal storage or utilization of glycogen, a complex disease with significant genetic heterogeneity and similar clinical manifestations. …”
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Whole-genome analysis of a ST45-SCCmec IVa (2B)-t116 methicillin-resistant Staphylococcus aureus strain isolated from the sputum of a 5-year-old child with pneumonia by Lin Huang, Rui Guo, Jingxian Lin, Xiaowei Li, Zhicong Li, Limei Zhang, Wenting Li, Rui Xue, Cheng Zhang, Xiaosan Feng, Xiaobin Li, Xiaobin Li

“…The carriage of antibiotic resistance genes, virulence genes, and mobile genetic elements were identified using bioinformatics tools. …”
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Tissue Inhibitor of Metalloproteinase-2 Polymorphisms and Risk for HIV-Associated Neurocognitive Disorder by HariOm Singh, Sushma Jadhav, Dharmesh Samani, Sumitra Nain

“…Hence, we evaluated the genetic variants of TIMP-2 (-418G/C, 303G/A) gene with the risk of HAND. …”
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Patient-derived response estimates from zero-passage organoids of luminal breast cancer by Róża K. Przanowska, Najwa Labban, Piotr Przanowski, Russell B. Hawes, Kristen A. Atkins, Shayna L. Showalter, Kevin A. Janes

“…Downstream mechanisms were tested genetically by lentiviral transduction of two complementary sgRNAs and Cas9 stabilization for the first week of organoid culture. …”
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Risk factors for ocular biological parameters in Chinese preschool children: a cohort study from the Beijing whole childhood eye study by Xi Qin, Yunyun Sun, Yunyun Sun, Shana Wang, Xiaolan Xie, Lei Gao, Huijian Li, Huijian Li, Ruihua Wei, Jing Fu, Jing Fu, Bidan Zhu

“…However, the influence of genetic, growth and development, and environmental factors on these metrics in Chinese preschool children remains unclear. …”
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First microscopic and molecular identification of Cryptosporidium spp. in fat sand rats (Psammomys obesus) in Egypt and their potential zoonotic implications by Sara Abdel-Aal Mohamed, Fatma A. S. Anwar, Ahmed Gareh, Marwa M. I. Ghallab, Remigio Martínez, Asmaa Aboelabbas Gouda, Fatemah Enad Alajmi, Hind Alzaylaee, Ignacio García-Bocanegra, Ignacio García-Bocanegra, Ehab Kotb Elmahallawy, Ehab Kotb Elmahallawy

“…These identified species have been deposited in GenBank™ under the accession numbers OM817461 (C. parvum FSA-1), OM817462 (C. parvum FSA-2), and OM817463 (C. parvum FSA-3) and revealed closed genetic identity with those species reported from human and other animal species in the same geographic location.ConclusionOverall, this study represents the first morphological and genetic identification of C. parvum isolated from fecal samples of fat sand rats trapped from periurban areas in Egypt. …”
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Neurodevelopmental Disorders and Connective Tissue-Related Symptoms: An Exploratory Case-Control Study in Children by Leonardo Zoccante, Gianfranco Di Gennaro, Erika Rigotti, Marco Luigi Ciceri, Andrea Sbarbati, Marco Zaffanello

“…The familial prevalence of these symptoms suggests a potential genetic underpinning, further supporting the hypothesis of shared aetiological pathways. …”
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Near telomere-to-telomere genome assemblies of Silkie Gallus gallus and Mallard Anas platyrhynchos restored the structure of chromosomes and “missing” genes in birds by Qiangsen Zhao, Zhongtao Yin, Zhuocheng Hou

“…Recent pangenome studies suggest that a single genome is insufficient to represent the genetic information of a species, highlighting the need for more comprehensive genomes. …”
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Study of the association of polymorphisms of the folate cycle enzyme gene with the degree of cognitive and affective disorders in patients in the post-covid period by A.A. Shuprovych, O.V. Zinych, N.M. Kushnareva, O.M. Trofymenko, K.P. Komisarenko

“…Recently, molecular genetic studies have become widespread, and demonstrated the importance of DNA and histone methylation processes in the epigenetic regulation of gene expression. …”
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Navegando la transición: desafíos y oportunidades en la atención de los pacientes con errores innatos de la inmunidad by Andrés Felipe Zea-Vera, Lina María Castaño-Jaramillo

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