Oral Health Impact Profile in Celiac Patients: Analysis of Recent Findings in a Literature Review by Gabriele Cervino, Luca Fiorillo, Luigi Laino, Alan Scott Herford, Floriana Lauritano, Giuseppe Lo Giudice, Fausto Famà, Rossella Santoro, Giuseppe Troiano, Gaetano Iannello, Marco Cicciù

“…The celiac disease (CD) is a chronic immune-mediated disorder triggered by the ingestion of gluten that appears in genetically predisposed patients. …”
Get full text

Understanding the Spectrum of Mild Clinical Outcomes and Novel Findings in Arterial Tortuosity Syndrome Among Qatari Patients: Implications of SLC2A10 Mutation by Muhammed Riyas K. Rahmath, Haytham Ibrahim, Muhammad Faiyaz-Ul-Haque, Zafar Nawaz, Ahmad Zitoun, Ahmed Hussein, Ahmed Sadek, Ayman El-Menyar, Reema Kamal, Hassan Al-Thani, Gulab Sher

“…The cohort study included 21 patients who were genetically confirmed by mutations in the SLC2A10 gene. …”
Get full text

Cytochrome P450 Metabolism of Betel Quid-Derived Compounds: Implications for the Development of Prevention Strategies for Oral and Pharyngeal Cancers by Che-Yi Lin, Tien-Szu Pan, Chun-Chan Ting, Shih-Shin Liang, Shu-Hung Huang, Hsiu-Yueh Liu, Edward Cheng-Chuan Ko, Chung-Wei Wu, Jen-Yang Tang, Ping-Ho Chen

“…In this review, we summarize the current knowledge base regarding CYP genetic variants and related oral disorders. In clinical applications, we focus on cancers of the oral cavity and pharynx and OPMDs associated with CYP gene polymorphisms, including CYP1A1, CYP2A6, CYP2E1, and CYP26B1. …”
Get full text

Metabolic Context Regulates Distinct Hypothalamic Transcriptional Responses to Antiaging Interventions by Alexis M. Stranahan, Bronwen Martin, Wayne Chadwick, Sung-Soo Park, Liyun Wang, Kevin G. Becker, William H. WoodIII, Yongqing Zhang, Stuart Maudsley

“…A greater understanding of how genetic background contributes to hypothalamic response mechanisms could pave the way for the development of more nuanced therapeutics for the treatment of metabolic disorders that occur in diverse physiological backgrounds.…”
Get full text

The Gut Microbiome Profile in Obesity: A Systematic Review by Olga Castaner, Albert Goday, Yong-Moon Park, Seung-Hwan Lee, Faidon Magkos, Sue-Anne Toh Ee Shiow, Helmut Schröder

“…Among the vast quantity of factors attributed to obesity, environmental, dietary, lifestyle, genetic, and others, the microbiome has aroused curiosity, and the scientific community has published many original articles. …”
Get full text

Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences by Gloria Ortiz-Guerrero, Diana Amador-Muñoz, Carlos Alberto Calderón-Ospina, Daniel López-Fuentes, Mauricio Orlando Nava Mesa

“…PPIs are a widely indicated class of drugs for gastric acid-related disorders, although most older adult users are not treated for the correct indication. …”
Get full text

Development and validation of a prognostic model for critically ill type 2 diabetes patients in ICU based on composite inflammatory indicators by Lin Liu, Yan-Bo Zhao, Zhuo-Ting Cheng, Ya-Hui Li, Yang Liu

Get full text

Clinical and endoscopical and morphofunctional scores in evaluation of development of gastroesophageal reflux disease in various age groups by M. A. Osadchuk, A. M. Zolotovitskaya, N. V. Kireyeva, S. N. Nikolenko, I. M. Kvetnoy

“…Thus in age aspect these disorders aggravate and total disturbance of neurohumoral regulation of the upper parts of the gut that determines extraesophageal manifestations of GERD is observed. …”
Get full text

Bovine mycoplasmosis occurrence on livestock farms in the Russian Federation for 2015–2018 by Mohammad Abed Alhussen, A. A. Nesterov, V. V. Kirpichenko, S. P. Yatsentyuk, A. V. Sprygin, O. P. Byadovskaya, A. V. Kononov

“…All of these highlight the need for control of semen products as a source for mycoplasmosis spread as well as insufficiency of single testing of semen for granting the disease-free status to the breeding farm for genetic material marketing.…”
Get full text

Multidisciplinary approach to functional somatic syndromes: study protocol for a population-based prospective cohort study by Hamidreza Roohafza, Harold Snieder, Fatemeh Hadizadeh, Peyman Adibi, Alireza Ani, Ahmad Vaez

“…Introduction Isfahan functional disorders (ISFUN) cohort study aims to describe the interplay of genetic and environmental factors in shaping the characteristics of functional somatic syndromes (FSS). …”
Get full text

A Case of Atypical Neurofibromatous Neoplasm of Uncertain Biologic Potential: Unravelling the Enigma by Apoorva Pande, Samarth Shukla, Sourya Acharya, Pravin Gadkari, Milind Pande

“…Neurofibromatoses are a group of genetic disorders that cause tumours to form on the nerve tissue. …”
Get full text

Testing of chickens experimentally infected with A/H9N2 avian influenza virus isolates for their immune responses by O. S. Osipova, M. A. Volkova, S. V. Frolov, D. B. Andreychuk, I. A. Chvala

“…Data on tests of chickens for their immune responses to infection with low pathogenic А/Н9N2 avian influenza virus isolates belonging to Y-280 and G1 genetic lines are presented in the paper. CD4⁺/CD8⁺ ratios were determined with flow cytometry for initial immune status examination and for detection of apparent immune system disorders. …”
Get full text

Methods of massive parallel reporter assays for investigation of enhancers by S. E. Romanov, D. A. Kalashnikova, P. P. Laktionov

“…The correct deployment of genetic programs for development and differentiation relies on finely coordinated regulation of specific gene sets. …”
Get full text

Diagnosis and management of superficial arteriovenous malformations: French healthcare network’s recommendations by Olivia Boccara, Didier Salvan, Claude Laurian, Caroline Degrugillier-Chopinet, Nathalie Degardin, Jean-Guillaume Dillinger, Julie Malloizel-Delaunay, Stéphane Mouton, Stéphane Munck, Annabel Maruani, Annouk Bisdorff-Bresson

Get full text

Candidate antirheumatic genotherapeutic plasmid constructions have low immunogenicity by T. S. Nepomnyashchikh, T. V. Tregubchak, S. N. Yakubitskiy, O. S. Taranov, R. A. Maksyutov, S. N. Shchelkunov

“…These drawbacks are in general associated with repeated systemic injections of large amounts of recombinant protein required to achieve the therapeutic efficacy. Genetic therapy might provide a good and effective solution. …”
Get full text

Identifying novel heterozygous PI4KA variants in fetal abnormalities by Chen Cheng, Fan Yang, Xinlin Chen, Sheng Zhao

“…Abstract Background The clinical manifestations of PI4KA-related disorders are characterized by considerable variability, predominantly featuring neurological impairments, gastrointestinal symptoms, and a combined immunodeficiency. …”
Get full text

Siglec-E augments adipose tissue inflammation by modulating TRAF3 signaling and monocytic myeloid-derived suppressor cells during obesity by Ahmed Rakib, Mousumi Mandal, Md Abdullah Al Mamun, Sonia Kiran, Nelufar Yasmen, Lexiao Li, Daniel M. Collier, Jianxiong Jiang, Frank Park, Udai P. Singh

“…Taken together, these results suggest that a genetic deficiency of siglec-E plays a key role in inducing AT inflammation by differentially altering M-MDSCs and CD8+CXCR3+ T cell function and adipogenesis by TRAF3 and Akt signaling in AT.ConclusionOur findings strongly suggest that modulation of siglec-E pathways might have a protective effect at least in part against AT inflammation and metabolic disorders.…”
Get full text

Transcriptomic data reveals MYC as an upstream regulator in laying hen follicular recruitment by Ashley E Kramer, Kathryn M Ellwood, Nicole Guarino, Cong-Jun Li, Aditya Dutta

Get full text

A Newborn with Genital Ambiguity, 45,X/46,XY Mosaicism, a Jumping Chromosome Y, and Congenital Adrenal Hyperplasia by Lei Zhang, Linda D. Cooley, Sonal R. Chandratre, Atif Ahmed, Jill D. Jacobson

“…Disorders of sex development (DSD), formerly termed “intersex” conditions, arise from numerous causes. …”
Get full text

Integrating MAPK pathway inhibition into standard-of-care therapy for pediatric low-grade glioma by Erin E. Crotty, Aimee A. Sato, Aimee A. Sato, Mohamed S. Abdelbaki

Get full text