From heparan glycobiology to stem cell therapy: a historical perspective by Victor Nurcombe

“…If the important progress in the past 40 years is any guide, the field of glycobiology is about to enter a golden era, with realistic prospects for glycotherapies that encompass a range of clinical disorders.…”
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Responsive nanomaterials in biomedicine, patent path and prospect analysis by Xinrui Liu, Hongmei Yuan

“…For complex diseases such as cancer, chronic inflammation, and genetic disorders, traditional treatment methods are often limited by insufficient targeting and significant side effects. …”
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Osteopetrosis and Hip Fracture. Case Report and Literature Review by Liyanira Alonso Leiva, José Julio Requeiro Molina, Ana María Machado Consuegra

“…Osteopetrosis constitutes a group of genetic disorders that determine skeletal sclerosis. …”
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The Impact of Farnesoid X Receptor Activation on Intestinal Permeability in Inflammatory Bowel Disease by Maja Stojancevic, Karmen Stankov, Momir Mikov

“…Defects in the intestinal epithelial barrier have been observed in several intestinal disorders such as inflammatory bowel disease (IBD). …”
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Protein C Deficiency Caused by a Novel Mutation in the PROC Gene in an Infant with Delayed Onset Purpura Fulminans by Mariam S. Al Harbi, Ayman W. El-Hattab

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Whole-Genome Duplication and Purifying Selection Contributes to the Functional Redundancy of Auxin Response Factor (ARF) Genes in Foxtail Millet (Setaria italica L.) by You Chen, Bin Liu, Yujun Zhao, Wenzhe Yu, Weina Si

“…Auxin response factors (ARFs) play crucial roles in auxin-mediated response, whereas molecular genetics of ARF genes was seldom investigated in Setaria italica, an important crop and C4 model plant. …”
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Computational model for mammalian circadian oscillator: interacting with NAD+/SIRT1 pathway and age-related changes in gene expression of circadian oscillator by N. L. Podkolodnyy, N. N. Tverdokhleb, O. A. Podkolodnaya

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A Girl with Autoimmune Cytopenias, Nonmalignant Lymphadenopathy, and Recurrent Infections by Marjolein A. C. Mattheij, Ellen J. H. Schatorjé, Eugenie F. A. Gemen, Lisette van de Corput, Peet T. G. A. Nooijen, Mirjam van der Burg, Esther de Vries

“…Her symptoms partly fit the definitions of both autoimmune lymphoproliferative syndrome (ALPS) and common variable immunodeficiency disorders (CVIDs). Genetic analysis showed no abnormalities in the ALPS-genes FAS, FASLG, and CASP10. …”
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The DNA Replication Stress Hypothesis of Alzheimer’s Disease by Yuri B. Yurov, Svetlana G. Vorsanova, Ivan Y. Iourov

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Mitochondrial trifunctional protein deficiency caused by a deep intronic deletion leading to aberrant splicing by Thomas Cassini, Sarah Silverstein, Molly Behan, Cynthia J. Tifft, May Christine Malicdan, David R. Adams, Undiagnosed Diseases Network, Sun‐Young Ahn, Debra S. Regier

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Quantification of Free Circulating DNA and Differential Methylation Profiling of Selected Genes as Novel Non-Invasive Biomarkers for Endometriosis Diagnosis by Moncef Benkhalifa, Pierre Alain Menoud, David Piquemal, Jack Y. Hazout, Sami Mahjoub, Mohammed Zarquaoui, Noureddine Louanjli, Rosalie Cabry, Andre Hazout

“…Quantifying peripheral Cf-DNA and the specific differential methylation of a group of genes have been proposed as potential non-invasive diagnostic biomarkers for somatic and constitutional genetics and for various other pathological disorders. …”
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Multiple Pulp Stones in Primary and Developing Permanent Dentition: A Report of 4 Cases by Mohita Marwaha, Radhika Chopra, Payal Chaudhuri, Atul Gupta, Jayna Sachdev

“…Metabolic evaluation of patients through liver function test, kidney function test, and blood investigation did not show any metabolic disorders. Patients were also evaluated for any systemic, syndromic, or genetic involvement, but this was also noncontributing. …”
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A modern approach to the treatment of plaque psoriasis by Drvar Daniela Ledić, Vlahinić Tomislav, Maleš Željan, Turčić Petra, Čeović Romana

“…The etiopathogenesis of the disease is multifactorial, the key factors being genetic predisposition combined with immunological disorders, environmental factors and skin barrier damage. …”
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Peripheral nerve injury induces dystonia-like movements and dysregulation in the energy metabolism: A multi-omics descriptive study in Thap1+/− mice by Colette Reinhold, Susanne Knorr, Rhonda L. McFleder, Lisa Harder-Rauschenberger, Tom Gräfenhan, Andreas Schlosser, Michael Sendtner, Jens Volkmann, Chi Wang Ip

“…DYT-THAP1 dystonia is a monogenetic form of dystonia, a movement disorder characterized by the involuntary co-contraction of agonistic and antagonistic muscles. …”
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A Dutch Fanconi Anemia FANCC Founder Mutation in Canadian Manitoba Mennonites by Yne de Vries, Nikki Lwiwski, Marieke Levitus, Bertus Kuyt, Sara J. Israels, Fré Arwert, Michel Zwaan, Cheryl R. Greenberg, Blanche P. Alter, Hans Joenje, Hanne Meijers-Heijboer

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Dopamine receptors and key elements of the neurotrophins (BDNF, CDNF) expression patterns during critical periods of ontogenesis in the brain structures of mice with autism-like be... by P. D. Pravikova, M. A. Arssan, E. A. Zalivina, E. M. Kondaurova, E. A. Kulikova, I. I. Belokopytova, V. S. Naumenko

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Alterations in the social-conditioned place preference and density of dopaminergic neurons in the ventral tegmental area in Clsnt2-KO mice by I. N. Rozhkova, S. V. Okotrub, E. Yu. Brusentsev, K. E. Uldanova, E. A. Chuyko, V. A. Naprimerov, T. V. Lipina, T. G. Amstislavskaya, S. Ya. Amstislavsky

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Choice of Unmanipulated T Cell Replete Graft for Haploidentical Stem Cell Transplant and Posttransplant Cyclophosphamide in Hematologic Malignancies in Adults: Peripheral Blood or... by Shatha Farhan, Edward Peres, Nalini Janakiraman

“…Allogeneic hematopoietic stem cell transplantation (SCT) is often the only curative option for many patients with malignant and benign hematological stem cell disorders. However, some issues are still of concern regarding finding a donor like shrinking family sizes in many societies, underrepresentation of the ethnic minorities in the registries, genetic variability for some races, and significant delays in obtaining stem cells after starting the search. …”
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The Application of Convolutional Neural Network Combined with Fuzzy Algorithm in Colorectal Endoscopy for Tumor Assessment by Te-Jen Su, Feng-Chun Lee, Cheuk-Kwan Sun, Fu-Xiang Ke, Shih-Ming Wang, Ming-Chih Huang

“…In addition to uncontrollable factors such as family genetic disorders, diet, and bad habits, life stress may lead to an unhealthy body mass index (BMI), which, together with aging, increases the incidence of colorectal cancer. …”
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Therapeutic Potential of Mesenchymal Stem Cells in Regenerative Medicine by Devang M. Patel, Jainy Shah, Anand S. Srivastava

“…MSCs are currently being tested for their potential use in cell and gene therapy for a number of human debilitating diseases and genetic disorders. This paper summarizes the current clinical and nonclinical data for the use of MSCs in tissue repair and potential therapeutic role in various diseases.…”
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