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Effect of remote ischemic preconditioning on perioperative neurocognitive disorder in elderly patients undergoing major surgery and associated genetic variant analysis: a randomized clinical trial
Published 2025-02-01“…Abstract Objective To investigate whether remote ischemic preconditioning (RIPC) could reduce the incidence of perioperative neurocognitive disorder (PND) in elderly patients undergoing major surgery (> 2 h), to assess the potential of myeloid differentiation factor 2 (MD2) and cystatin C as biomarkers and to identify key genetic variants associated with PND. …”
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Advancing Neuroscience and Therapy: Insights into Genetic and Non-Genetic Neuromodulation Approaches
Published 2025-01-01“…This review highlights significant advancements in applying these techniques to treat neurological and psychiatric disorders. Genetic methods, such as sonogenetics and magnetogenetics, have demonstrated high specificity and temporal precision in targeting neuronal populations, while non-genetic methods, such as transcranial magnetic stimulation and photobiomodulation therapy, offer noninvasive and versatile clinical intervention options. …”
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Genetics of Endometrial Cancers
Published 2010-01-01“…Microsatellite instability is another important genetic event in this type of tumor. In contrast, p53 mutations or Her2/neu overexpression are more frequent in non-endometrioid tumors. …”
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Phenotyping the males of mouse and rat strains with genetically defined behavioral disturbances in a model of sexual activation
Published 2015-12-01“…Noteworthy, highly excitable GC strain animals corresponding to the manic pole of bipolar disorders prevail at the current stage of breeding. …”
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Genetics of Childhood Obesity
Published 2011-01-01“…Besides environmental factors, genetic factors are known to play an important role in the pathogenesis of obesity. …”
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Impact of blastocyst biopsy for preimplantation genetic testing on maternal and neonatal outcomes following single frozen embryo transfer cycles
Published 2025-01-01Subjects: Get full text
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Neurobiology of Major Depressive Disorder
Published 2013-01-01“…We survey studies which relate abnormal neurogenesis to major depressive disorder. Clinically, descriptive gene and protein expression analysis and genetic and functional studies revised here show that individual alterations of a complex signaling network, which includes the hypothalamic-pituitary-adrenal axis; the production of neurotrophins and growth factors; the expression of miRNAs; the production of proinflammatory cytokines; and, even, the abnormal delivery of gastrointestinal signaling peptides, are able to induce major mood alterations. …”
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Associations between physical activities and self-harm behaviour in depression across the genotype: findings from the UK biobank
Published 2025-01-01Subjects: “…Depressive disorders…”
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Classification of schizophrenia, bipolar disorder and major depressive disorder with comorbid traits and deep learning algorithms
Published 2025-02-01“…Abstract Many psychiatric disorders share genetic liabilities, but whether these shared liabilities can be utilized to classify and differentiate psychiatric disorders remains unclear. …”
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Swimming through asymmetry: zebrafish as a model for brain and behavior lateralization
Published 2025-01-01Subjects: Get full text
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Preimplantation Genetic Diagnosis in Marfan Syndrome
Published 2013-01-01“…Marfan syndrome (MFS) is a systemic hereditable disorder of the connective tissue with mainly cardiovascular manifestations, such as aortic dilatation and dissection. …”
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Molecular genetic basis of epidermolysis bullosa
Published 2023-03-01“…Epidermolysis bullosa (EB) is an inherited disorder of skin fragility, caused by mutations in a large number of genes associated with skin integrity and dermal-epidermal adhesion. …”
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A systematic literature review to evaluate the cardiac and cerebrovascular outcomes of patients with Fabry disease treated with agalsidase Beta
Published 2025-01-01Subjects: Get full text
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Longitudinal genetic studies of cognitive characteristics
Published 2020-03-01“…The association between cognitive functioning and genes, which have been previously involved in developing psychiatric disorders (MEF2C, CYP2D6, FAM109B, SEPT3, NAGA, TCF20, NDUFA6 genes), was revealed, thus indicating the role of the similar mechanisms of genetic and neural networks in both normal cognition and cognitive impairment. …”
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Role of Ketamine in the Treatment of Psychiatric Disorders
Published 2021-06-01“…Additional potential off-label uses for ketamine in psychiatric disorders have been studied, including PTSD, anxiety disorders, bipolar depression, and substance use disorders.…”
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