Heterochrony in orthodenticle expression is associated with ommatidial size variation between Drosophila species by Montserrat Torres-Oliva, Elisa Buchberger, Alexandra D. Buffry, Maike Kittelmann, Genoveva Guerrero, Lauren Sumner-Rooney, Pedro Gaspar, Georg C. Bullinger, Javier Figueras Jimenez, Fernando Casares, Saad Arif, Nico Posnien, Maria D. S. Nunes, Alistair P. McGregor, Isabel Almudi

“…We previously showed that the larger eyes of Drosophila mauritiana compared to D. simulans are generally caused by differences in ommatidia size rather than number. …”
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Metabarcoding the night sky: Monitoring landscape-scale insect diversity through bat diet by Cynthia Tobisch, Svenja Dege, Bernd Panassiti, Julian Treffler, Christoph Moning

“…We explored spatial and temporal variation in the diet of P. pipistrellus and quantified effects of landscape composition and configuration on insect species richness and composition using generalized linear models and non-metric multidimensional scaling. …”
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Stability and changes in meaning in life profiles and their impact on mental health among chinese university students: a latent transition analysis by Sylvia Y. C. L. Kwok, Siqi Fang, Bella Meici Huang, Alebel Addis Tesfaw, Xi Deng

“…The few person-centered studies conducted were generally cross-sectional in nature and have failed to address changes in MIL. …”
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Quo vadis autoimmune hepatitis? - Summary of the 5th international autoimmune hepatitis group research workshop 2024Keypoints by Bastian Engel, David N. Assis, Mamatha Bhat, Jan Clusmann, Joost PH. Drenth, Alessio Gerussi, María-Carlota Londoño, Ye Htun Oo, Ida Schregel, Marcial Sebode, Richard Taubert

“…Although standard treatment with corticosteroids and thiopurines improves the life expectancy of patients with AIH, remission rates and tolerability are generally overestimated and the development of alternative first-line and salvage therapies has been disappointingly slow compared to in rheumatological diseases or inflammatory bowel disease. …”
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Multi-dimensional evidence from the UK Biobank shows the impact of diet and macronutrient intake on aging by Chen Zhu, Youfa Wang, Xiaosong Yang, Qiran Zhao, Wenyan Xu, Xiaolu Wang, Yanjun Liang, Qihui Chen, Shenggen Fan

“…Results Our results show that healthier diets are generally associated with improved aging outcomes from HDFE analyses. …”
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Inflamed immune phenotype predicts favorable clinical outcomes of immune checkpoint inhibitor therapy across multiple cancer types by Jeanne Shen, Sergio Pereira, Chan-Young Ock, Yung-Jue Bang, Seulki Kim, Sehhoon Park, Se-Hoon Lee, George A Fisher, Young Kwang Chae, Yoon-La Choi, Jin-Haeng Chung, Tony S K Mok, Leeseul Kim, Jun-Eul Hwang, Gahee Park, Sanghoon Song, Seunghwan Shin, Yoojoo Lim, Wonkyung Jung, Heon Song, Hyojin Kim, Taebum Lee, Sukjun Kim, Chang Ho Ahn, Seokhwi Kim, Ben W Dulken, Stephanie Bogdan, Maggie Huang, Chiyoon Oum, Siraj M. Ali

“…On subgroup analysis, the IIP was generally prognostic of favorable PFS across major patient subgroups, with the exception of the microsatellite unstable/mismatch repair deficient subgroup.Conclusion The AI-based IIP may represent a practical, affordable, clinically actionable, and tumor-agnostic biomarker prognostic of ICI therapy response across diverse tumor types.…”
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Newly isolated halotolerant Gordonia terrae S-LD serves as a microbial cell factory for the bioconversion of used soybean oil into polyhydroxybutyrate by Song Xu, Ruiqin Han, Lidan Tao, Zhipeng Zhang, Junfei Gao, Xinyuan Wang, Wei Zhao, Xiaoxia Zhang, Zhiyong Huang

“…Abstract Polyhydroxybutyrate (PHB) is a class of biodegradable polymers generally used by prokaryotes as carbon sources and for energy storage. …”
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Adverse drug events (ADEs) risk signal mining related to eculizumab based on the FARES database by Xi-Feng Wang, Lu-Ri Bao, Ta-La Hu, Rui-Feng Xu, Wu-Niri Gao, Jing-Yuan Wang, Jian-Rong Zhao, Zhen-Li Fu, Shu-Fang Wang, Yan Meng

“…IntroductionEculizumab is a C5 complement inhibitor approved by the FDA for the targeted treatment of four rare diseases, paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), generalized myasthenia gravis (gMG), and aquaporin-4 immunoglobulin G-positive optic neuromyelitis optica spectrum disorders (AQP4-IgG+NMOSD). …”
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tDCS cranial nerve Co-stimulation: Unveiling brainstem pathways involved in trigeminal nerve direct current stimulation in rats by Alireza Majdi, Liyi Chen, Lars E. Larsen, Robrecht Raedt, Myles Mc Laughlin

“…Background: The effects of transcranial direct current stimulation (tDCS) are generally thought to result from the polarization of cortical neurons by the weak electric fields it creates. …”
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Land use intensity differently influences soil communities across a range of arable fields and grasslands by Chenguang Gao, Johanna E.M. Schild, Gabriel Y.K. Moinet, T. Martijn Bezemer, Franciska T. de Vries, Jan Hassink, Nick van Eekeren, Kevin Beentjes, Peter M. van Bodegom

“…A key strength of this study is that these patterns can be generalized because the samples were collected from 87 farmlands where multiple agricultural practices were implemented simultaneously. …”
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Life cycle greenhouse gas emissions of hydrogen imported by maritime transportation: A South Korean case study by Gyuna Kwak, Juha Lee, Yujin Jung, Wonjae Choi

“…Importing ammonia is generally more advantageous than liquid hydrogen, unless the grid electricity emissions are exceptionally low, specifically below 332.1 g-CO2-eq.…”
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Contemporary Management of Patients With Chagas Cardiomyopathy in Bolivia by Evan Czulada, BS, Sascha Bercovitch, BA, Yazan Alshawkani, MD, Natalia Noya Weise, MD, Adriana E. Hernani Rodrigo, BS, Ronald Gustavo Durán Saucedo, MD, Marcelo Buhezo Chamón, MD, Robert H. Gilman, MD, David T. Martin, MD

“…While pacemaker therapy was generally available to cardiologists (66%), patients received devices only through private insurance or philanthropy, with few physicians (28%) offering implantable cardioverter-defibrillators regularly. …”
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Effect of custom-designed transfection buffer on delivery of genome modification components into primary cells of buffalo, cattle, goats, and sheep by Shreya Malhotra, Priyanka Singh, Aseem Tara, Bosco Jose, Devika Gautam, Ram Prasad, Gaurav Tripathi, Sacchinandan De, Naresh L. Selokar

“…Electroporation efficiency depends on various physical parameters, of which cell type is considered a major factor for transfection efficiency. Primary cells are generally less susceptible to transfection than other cell types due to their finite lifespan and limited expansion capacity. …”
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Hooks, Lines, and Sinkers: How Active Galactic Nucleus Feedback and Cosmic-Ray Transport Shape the Far-infrared–Radio Correlation of Galaxies by Sam B. Ponnada, Rachel K. Cochrane, Philip F. Hopkins, Iryna S. Butsky, Sarah Wellons, N. Nicole Sanchez, Cameron Hummels, Yue Samuel Lu, Dušan Kereš, Christopher C. Hayward

“…We present the first reproduction of the z  ∼ 0 FRC using detailed synthetic observations of state-of-the-art cosmological zoom-in simulations from the Feedback in Realistic Environments (FIRE-3) suite with explicitly evolved CR proton and electron (CRe) spectra, for three models for CR transport and multichannel active galactic nucleus (AGN) feedback. In doing so, we generally verify the predictions of “calorimeter” theories at high FIR luminosities ( L _60 _μ _m  ≳ 10 ^9.5 L _⊙ ) and at low FIR luminosities ( L _60 _μ _m ≲ 10 ^9.5 L _⊙ ), the so-called “conspiracy” of increasing UV radiation escape in tandem with increasing CRe escape, and find that the global FRC is insensitive to orders-of-magnitude locally variable CR transport coefficients. …”
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Improving drug repositioning with negative data labeling using large language models by Milan Picard, Mickael Leclercq, Antoine Bodein, Marie Pier Scott-Boyer, Olivier Perin, Arnaud Droit

“…Supervised machine learning is commonly used to score drug candidates but is hindered by the lack of reliable negative data—drugs that fail due to inefficacy or toxicity— which is difficult to access, lowering their prediction accuracy and generalization. Positive-Unlabeled (PU) learning has been used to overcome this issue by either randomly sampling unlabeled drugs or identifying probable negatives but still suffers from misclassification or oversimplified decision boundaries. …”
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Implementing a rapid geographic range expansion - the role of behavior changes by Logan, Corina, McCune, Kelsey, LeGrande-Rolls, Christa, Marfori, Zara, Hubbard, Josephine, Lukas, Dieter

“…It is generally thought that behavioral flexibility, the ability to change behavior when circumstances change, plays an important role in the ability of species to rapidly expand their geographic range. …”
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Impact of the Timing of Enzyme Replacement Therapy Initiation and Cognitive Impairment Status on Outcomes for Patients with Mucopolysaccharidosis II (MPS II) in the United States:... by Karen S. Yee, David Alexanderian, Yidie Feng, Xiaowei Ren, Bernd Schweikert, Olulade Ayodele

“…Evaluation of developmental and behavioral signs and symptoms in the full study population showed that communication delay (70.0% of patients), cognitive delay (62.1%), behavioral problems (52.9%), and toileting delay (50.0%) were particularly common; earliest documented signs and symptoms were motor delay (median [range] age at first documentation: 4.2 [0.9-18.7] years) and behavioral problems (4.4 [0.6-13.7] years). Patients with CI generally experienced greater symptom burden and higher HRU than those without CI, with the most notable differences documented for communication and toileting delays. …”
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An automated adaptive trading system for enhanced performance of emerging market portfolios by Cristiana Tudor, Robert Sova

“…The system incorporates an Autoregressive Moving Average-Generalized AutoRegressive Conditional Heteroskedasticity model that offers an interpretability advantage over machine-learning methods. …”
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The effect of R&D capitalization on revenue-expense matching: Focusing on the bio-pharmaceutical industries in South Korea by Dongjoon Choi, Inkyung Yoon, Hansol Lee

“…The results indicate that R&D capitalization generally weakens revenue-expense matching in these industries. …”
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Viviendas en renta en ciudades mexicanas by Jaime Sobrino

“…La pregunta que guía al artículo es la siguiente:¿cuál ha sido la importancia de la vivienda en renta en la demanda habitacional del país en el periodo 1950-2015, y cómo se ha relacionado la vivienda en renta con los procesos más generales de la ciudad, como la pobreza, la desigualdad y la segregación? …”
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