Intravenous esketamine in pediatric Rett syndrome: An open-label, early phase 1 pilot study by Huiping Li, Shu Liu, Caimei Lin, Yuchao Wu, Xiuping Wu, Yukun Huang, Yajun Wu, Xiubin Tong, Xiu Xu

“…The treatment with intravenous esketamine was generally well tolerated and safe, with some patients experiencing mild AEs, including self-alleviating nausea, vomiting, and irritability. …”
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Uniform boundedness of $ (SL_2(\mathbb{C}))^{n} $ and $ (PSL_2(\mathbb{C}))^{n} $ by Fawaz Aseeri

“…. $ We also prove that if $ G_1, \dots, G_n $ be quasisimple groups such that $ G_i $ is uniformly bounded for each $ i\in \{1, \dots, n\}, $ then $ G_1\times\dots \times G_n $ is uniformly bounded. This is also a generalization of some previously known results in the literature.…”
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Deep learning improves physician accuracy in the comprehensive detection of abnormalities on chest X-rays by Pamela G. Anderson, Hannah Tarder-Stoll, Mehmet Alpaslan, Nora Keathley, David L. Levin, Srivas Venkatesh, Elliot Bartel, Serge Sicular, Scott Howell, Robert V. Lindsey, Rebecca M. Jones

“…The AI system accurately detected chest X-ray abnormalities (AUC: 0.976, 95% bootstrap CI: 0.975, 0.976) and generalized to a publicly available dataset (AUC: 0.975, 95% bootstrap CI: 0.971, 0.978). …”
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Educational intervention on oral cancer and its prevention in pre-university students by José Carlos Alvarez Hernández, Eniley Quintana Morales, Ailen Guzmán López, Marino Enrique León Palombí, Marileidi Morales Cabrera, Mara Isabel Morales Pardo

“…Inadequate levels of information were determined in the diagnostic stage in terms of: generalities (96.0%), risk factors (91.2%), oral self-examination (96.0%) and promotion and prevention measures (95.2%). %). …”
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Survey on the presence of floating microplastics, trace metals and metalloids in seawater from Southern Italy to the United States of America by Elisabetta Morici, Gaetano Cammilleri, Sergio Scirè, Francesco Paolo Bonomo, Luigi Tranchina, Francesca Terracina, Paola Galluzzo, Vincenzo Ferrantelli, Vincenzo Paolo Monteverde, Francesco Giuseppe Galluzzo, Sergio Davì, Mariano Licciardi, Salvatore Dara

“…The results reveal the presence of MPs in all the samples analyzed and a broad variation in microplastic concentration (230–3320 MPs/L), with filaments or fibers being the most abundant shape. Coastal waters generally exhibit higher MPs, TM and Ms concentrations than open sea waters. …”
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Analysing the Effects of Atmospheric Teleconnections on Streamflow Regime in the Eastern Black Sea Basin in Türkiye by Cenk Sezen

“…The findings showed that the relationship between raw streamflow data and atmospheric teleconnections is generally more significant and negative in the winter and spring. …”
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Multi-Objective Optimal Design of Dropping Shock of Series Cushioning Packaging System by Yang Xue, Wei-Sheng Song, Hong-Tao Miao, Jing Wang, Yu Li

“…The cushion packaging system generally consists of products, cushioning materials, and an outside packaging carton. …”
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APPLIED IR TRAINING AND AN EFFECTIVE FOREIGN POLICY by A. A. Baykov

“…The author draws on the empirical data, collected by means of analysis, processing and generalization of expert assessments and evaluations of Russian and foreign participants of international faculty and university forums in International Studies in 2015. …”
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Structural and Economic Approach to the Selection of Peak Regulating Capacities at Thermal Power Plants by E. V. Bohdan, M. B. Karnitski

“…The paper proposes an approach to solving the problem of achieving an effective combination of reliability and efficiency of energy systems on the example of gas turbines and CCGT power units. A generalized desirability function has been obtained, which includes a number of parameters for choosing a rational relationship and mutual influence between the reliability and efficiency of electricity production with the participation of thermal power plant equipment in regulating the daily load schedule. …”
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MACEDONIAN NATIONAL INNOVATION SYSTEM – MAIN CHALLENGES by Radmil Polenakovik, Ivana Stankovska, Bojan R. Jovanovski

“… It is generally accepted that the National Innovation Systems (NIS) are one of the most comprehensive systemic approaches that give insight into innovative and economic performance of a country. …”
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Evaluation of the effects of short-term PM2.5 exposure on triglyceride-glucose metrics in a population in eastern China by Zhenpeng Guo, Chenchen Yang, Qiang Zhang, Xinling Shi, Xiaona Li, Qun Zhang, Jianming Wang

“…TyG levels concerning short-term PM2.5 exposure were examined using a generalized additive model. Results In the overall population, at lags of 0–7 and 0–14 days in the single-pollutant model, it was observed that a 10 µg/m3 rise in PM2.5 corresponded to a 0.0021 elevation in TyG levels. …”
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Action plan proposal to obtain triple certification in a natural gas transportation company by Cintia Guerra Bueno, Jorge Lucas Costa Pinheiro, Wagner da Silveira Marques, Telma Fidelis Fragoso da Silva, Alberto Eduardo Besser Freitag

“…Limitations of the investigation: The main one is the generalization limit of the conclusions, models or theories developed from a single case study, used in this work. …”
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3D Numerical Simulation of Landslides for the Full High Waste Dump Using SPH Method by Chunhui Cao, Jili Feng, Zhigang Tao

“…Waste dump that is generally composed of a large number of loose geotechnical materials is prone to landslides under external loads. …”
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Fluid Flow and Heat Transport Computation for Power-Law Scaling Poroperm Media by Peter Leary, Peter Malin, Rami Niemi

“…In applying Darcy’s law to fluid flow in geologic formations, it is generally assumed that flow variations average to an effectively constant formation flow property. …”
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Effect of alloying elements on the stacking fault energies of dilute al-based alloys by Gao Q., Zhang H., Yang R., Fan Z., Liu Y., Wang J., Geng X., Gao Y., Shang S., Du Y., Liu Z.

“…It is also found that the γSF of Al-X generally decreases with the increase of equilibrium volume. …”
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Immunotherapy-associated autoimmune hemolytic anemia by Uqba Khan, Tarik Hadid, Farman Ali, Muhammad Siddique Khurram, Awais Zaka

“…The following case represents an unusual adverse effect of combined treatment with ipilimumab and nivolumab used for treatment of metastatic melanoma.Case presentation A 43-year-old woman with metastatic melanoma presented with severe generalized weakness and fatigue. She has received two cycles of ipilimumab and nivolumab, last administered 3 weeks prior to her presentation. …”
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Association between platelet count and 30-day in-hospital mortality among intensive care unit patients with sepsis: a multicenter retrospective cohort study by Jun Wang, Pan Zhou, Xin Li, Li Zhou, Zhe Deng

“…Analyses were adjusted for demographics, clinical parameters, comorbidities, and treatments. Generalized additive models and two-piecewise linear regression were used to assess the relationship between platelet count and mortality.ResultsA U-shaped relationship was identified with an inflection point at 176 × 10⁹/L. …”
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<i>Bacillus thuringiensis</i> Cry1A Insecticidal Toxins and Their Digests Do Not Stimulate Histamine Release from Cultured Rat Mast Cells by Hisashi Ohto, Mayumi Ohno, Miho Suganuma-Katagiri, Takashi Hara, Yoko Egawa, Kazuya Tomimoto, Kosuke Haginoya, Hidetaka Hori, Yuzuri Iwamoto, Tohru Hayakawa

“…Public acceptance of genetically modified crops engineered with <i>Bacillus thuringiensis</i> (Bt) insecticidal protein genes (BT-GMCs), which confer resistance to various lepidopteran insect pests, is generally lacking. As a major concern over BT-GMCs is the allergenicity of insecticidal proteins, alleviating safety concerns should help increase public acceptance. …”
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Differential Cytotoxicity Responses by Dog and Rat Hepatocytes to Phospholipogenic Treatments by James K. Morelli, Paul J. Ciaccio

“…These data demonstrate that (a) dog hepatocytes were generally less capable of mounting an adaptive, protective phospholipidotic response than rat hepatocytes, (b) effects on mitochondria and survival were preventable by lysosomal protection, and (c) destabilizing changes in both organelles are involved causally in cytotoxicity.…”
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Norcantharidin induces G2/M arrest and apoptosis via activation of ERK and JNK, but not p38 signaling in human renal cell carcinoma ACHN cells by Huang Shuaishuai, Tuergong Gulimire, Zhu Hangjie, Wang Xue, Weng Guobin, Ren Yu

“…Renal cell carcinoma (RCC) is generally acknowledged as the most resistant primary malignancy unresponsive to conventional radiotherapy and chemotherapy treatments. …”
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