Epiregulon: Single-cell transcription factor activity inference to predict drug response and drivers of cell states by Tomasz Włodarczyk, Aaron Lun, Diana Wu, Minyi Shi, Xiaofen Ye, Shreya Menon, Shushan Toneyan, Kerstin Seidel, Liang Wang, Jenille Tan, Shang-Yang Chen, Timothy Keyes, Aleksander Chlebowski, Adrian Waddell, Wei Zhou, Yangmeng Wang, Qiuyue Yuan, Yu Guo, Liang-Fu Chen, Bence Daniel, Antonina Hafner, Meng He, Alejandro Chibly, Yuxin Liang, Zhana Duren, Ciara Metcalfe, Marc Hafner, Christian W. Siebel, M. Ryan Corces, Robert Yauch, Shiqi Xie, Xiaosai Yao

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Leveraging neonatal Fc receptor (FcRn) to enhance antibody transport across the blood brain barrier by Julien Lafrance-Vanasse, Shraddha S. Sadekar, Yanli Yang, Daniela Bumbaca Yadav, William J. Meilandt, Monica K. Wetzel-Smith, Hao Cai, Susan R. Crowell, Van Nguyen, Vivian Lee, Ben Chih, Mandy Kwong, Pamela Chan, Sara Santagostino, Donna Lee, Shan Chung, Greg A. Lazar, James A. Ernst, Jasvinder K. Atwal

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Towards designing improved cancer immunotherapy targets with a peptide-MHC-I presentation model, HLApollo by William John Thrift, Nicolas W. Lounsbury, Quade Broadwell, Amy Heidersbach, Emily Freund, Yassan Abdolazimi, Qui T. Phung, Jieming Chen, Aude-Hélène Capietto, Ann-Jay Tong, Christopher M. Rose, Craig Blanchette, Jennie R. Lill, Benjamin Haley, Lélia Delamarre, Richard Bourgon, Kai Liu, Suchit Jhunjhunwala

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Induction of a distinct macrophage population and protection from lung injury and fibrosis by Notch2 blockade by Mayra Cruz Tleugabulova, Sandra P. Melo, Aaron Wong, Alexander Arlantico, Meizi Liu, Joshua D. Webster, Julia Lau, Antonie Lechner, Basak Corak, Jonathan J. Hodgins, Venkata S. Garlapati, Marco De Simone, Ben Korin, Shimrit Avraham, Jessica Lund, Surinder Jeet, Alexander Reiss, Hannah Bender, Cary D. Austin, Spyros Darmanis, Zora Modrusan, Hans Brightbill, Steffen Durinck, Michael S. Diamond, Christoph Schneider, Andrey S. Shaw, Maximilian Nitschké

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Effectorless Fc-fusion improves FLT3L drug-like properties for cancer immunotherapy combinationsResearch in context by Jérémie Decalf, Evangeline Toy, Dongping He, Radhika Kenkre, Amy M. Berkley, Devon Wong, Mandy Kwong, Yee-Seir Kee, Yue Sun, Srividya Myneni, Xiangdan Wang, Ahmad Ebtikar, Anthony Ancheta, Yanli Yang, Hok Seon Kim, Nga Tang, Debarko Banerji, Elaine Mai, Pranay Dogra, Meredith McLerie, Alan G. Gutierrez, Geraldine Strasser, Gautham K. Rao, Matt Betzenhauser, Wilson Phung, Peter Day, Wendy Sandoval, Ayse Meric Ovacik, Pamela Chan, Shomyseh Sanjabi, Laetitia Comps-Agrar, Sivan Cohen, James A. Ernst, Greg A. Lazar, Christopher C. Kemball, Iraj Hosseini, Yichin Liu, Jill M. Schartner, Travis W. Bainbridge, Christine Moussion

“…Funding: This work was performed at, and funded by Genentech Inc. South San Francisco, CA 94080, USA.…”
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Systemic cytokines drive conserved severity-associated myeloid responses across bacterial and viral infections by Kimberly Kajihara, Donghong Yan, Gretchen L. Seim, Hannah Little-Hooy, Jing Kang, Cynthia Chen, Marco De Simone, Tim Delemarre, Spyros Darmanis, Haridha Shivram, Rebecca N. Bauer, Carrie M. Rosenberger, Sharookh B. Kapadia, Min Xu, Miguel Reyes

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Engineered IL-18 variants with half-life extension and improved stability for cancer immunotherapy by Yue Zhao, Yan Qu, Marina Moskalenko, Dawei Sun, Travis W Bainbridge, Matthieu Masureel, Lifen Wang, Robert Herrera, Maciej T Paluch, Kazi Tasneem, Harpinder Saini, Manal Sadek, Mandy Kwong, Yoon Min Kim, Jay M Bhatt, Christine Tam, Pamela Pui Fung Chan, Ayse Meric Ovacik, Jonathan T Sockolosky, Nathaniel R West, Beyza Bulutoglu

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Characterization of free light chain impurity in a bispecific antibody by Monica Sadek, Neelima Mantha, Steffen Lippold, Delia Li, Kyle Spitler, Ran Li, Phillip Spinosa, Bob Liu, Steven Luu, Nicholas Woon, Yeying Zhang, Jia Guo, Renee Yang, Jonathan Zarzar, Yi Yang

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COP1 Deficiency in BRAF^V600E Melanomas Confers Resistance to Inhibitors of the MAPK Pathway by Ada Ndoja, Christopher M. Rose, Eva Lin, Rohit Reja, Jelena Petrovic, Sarah Kummerfeld, Andrew Blair, Helen Rizos, Zora Modrusan, Scott Martin, Donald S. Kirkpatrick, Amy Heidersbach, Tao Sun, Benjamin Haley, Ozge Karayel, Kim Newton, Vishva M. Dixit

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Nonclinical immunogenicity risk assessment for knobs-into-holes bispecific IgG1 antibodies by Wen-Ting K. Tsai, Yinyin Li, Zhaojun Yin, Peter Tran, Qui Phung, Zhenru Zhou, Kun Peng, Dan Qin, Sien Tam, Christoph Spiess, Jochen Brumm, Manda Wong, Zhengmao Ye, Patrick Wu, Sivan Cohen, Paul J. Carter

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Secreted neurofilament light chain after neuronal damage induces myeloid cell activation and neuroinflammation by Olga I. Kahn, Sara L. Dominguez, Caspar Glock, Margaret Hayne, Steve Vito, Arundhati Sengupta Ghosh, Max Adrian, Braydon L. Burgess, William J. Meilandt, Brad A. Friedman, Casper C. Hoogenraad

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Ligand-activated EGFR/MAPK signaling but not PI3K, are key resistance mechanisms to EGFR-therapy in colorectal cancer by Xueping Qu, Habib Hamidi, Radia M. Johnson, Ethan S. Sokol, Eva Lin, Cathy Eng, Tae Won Kim, Johanna Bendell, Smruthy Sivakumar, Benjamin Kaplan, Felipe de Sousa e Melo, Andrew Mancini, Matthew Wongchenko, Yi Shi, David Shames, Yibing Yan, Fortunato Ciardiello, Carlos Bais

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Author Correction: Proteomics approach identifies aqueous humor biomarkers in retinal diseases by Kevin Huang, Cheryl Schofield, Trung Nguy, Randall Dere, Vincent Wolowski, Juliane Siebourg-Polster, Andreas Dieckmann, Justus G. Garweg, Michael Chang, Lee Honigberg, Jason Hackney, Vahan B. Indjeian

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Membrane display and functional analysis of juxtacrine ligand-receptor signaling by Pradeep M. Nair, Hai Ngu, Eric Torres, Scot Marsters, David A. Lawrence, Jean-Philippe Stephan, Laszlo Komuves, Avi Ashkenazi

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Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability by Wei-Ching Liang, Hongkang Xi, Dawei Sun, Luigi D’Ascenzo, Jonathan Zarzar, Nicole Stephens, Ryan Cook, Yinyin Li, Zhengmao Ye, Marissa Matsumoto, Jian Payandeh, Matthieu Masureel, Yan Wu

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Mass spectrometry-based multi-attribute method in protein therapeutics product quality monitoring and quality control by Feng Yang, Jennifer Zhang, Alexander Buettner, Eva Vosika, Monica Sadek, Zhiqi Hao, Dietmar Reusch, Maximiliane Koenig, Wayman Chan, Anja Bathke, Hilary Pallat, Victor Lundin, Jochen Felix Kepert, Patrick Bulau, Galahad Deperalta, Christopher Yu, Richard Beardsley, Tura Camilli, Reed Harris, John Stults

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Atezolizumab neutralizing assay development: a novel way of evaluating assay cutpoint after sample pretreatment by Rachel Melendez, Jane Ruppel, Cecilia Leddy, Jenny Yang, Ann Brady, Yenny Webb-Vargas, Jochen Brumm, Lynn Kamen, Yuan Song

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MHC2-SCALE enhances identification of immunogenic neoantigens by Joshua G. Gober, Aude-Hélène Capietto, Reyhane Hoshyar, Martine Darwish, Richard Vandlen, Jonathan L. Linehan, Lélia Delamarre, Adel M. ElSohly

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YAP/TAZ activity in PDGFRα-expressing alveolar fibroblasts modulates AT2 proliferation through Wnt4 by Jane Y. Song, Fabien Wehbe, Aaron K. Wong, Ben M. Hall, Jason A. Vander Heiden, Hans D. Brightbill, Joseph R. Arron, David A. Garfield, Anwesha Dey, Jason R. Rock

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Combining Fundamental Kinetics and Standard Alkylation Assays to Prioritize Lead-Like KRAS G12C Inhibitors by Alexandra Frommlet, Lan K. Nguyen, Matt Saabye, Nicholas F. Endres, Melinda M. Mulvihill, John G. Quinn

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