Dual use and gain-of-function research: a significant endeavor with biosecurity imperatives by James Giordano, Diane DiEuliis

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The dangerous biology of pathogenic germs by Berche, Patrick

Subjects: “…Gain-of-function…”
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Selective metabolic regulations by p53 mutant variants in pancreatic cancer by Sabrina Caporali, Alessio Butera, Alessia Ruzza, Carlotta Zampieri, Marina Bantula’, Sandra Scharsich, Anna-Katerina Ückert, Ivana Celardo, Ian U. Kouzel, Luigi Leanza, Andreas Gruber, Joan Montero, Angelo D’Alessandro, Thomas Brunner, Marcel Leist, Ivano Amelio

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Aux/IAAs: specificity and redundancy by Qiming Wen, Qian Gong, Huaying Yu, Panyu Yang

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Allelic effects on uromodulin aggregates drive autosomal dominant tubulointerstitial kidney disease by Guglielmo Schiano, Jennifer Lake, Marta Mariniello, Céline Schaeffer, Marianne Harvent, Luca Rampoldi, Eric Olinger, Olivier Devuyst

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Characterization of a pathogenic gain-of-function mutation in the N-terminal domain of STAT1 which is reported to be associated with eosinophilic esophagitis by Kristin Annawald, Anke Gregus, Oliver Wirths, Thomas Meyer

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Successful anti-IL-6 treatment for interstitial lung disease associated with STAT3 gain-of-function: a case report and literature review by Peng Zhou, Meifang Zhu, Yuting Pan, Jing Jin, Zhidan Fan, Haiguo Yu

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Gain-of-Function and Loss-of-Function Mutations in the RyR2-Expressing Gene Are Responsible for the CPVT1-Related Arrhythmogenic Activities in the Heart by Roshan Paudel, Mohsin Saleet Jafri, Aman Ullah

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Heterogeneous phenotype of a Chinese Familial WHIM syndrome with CXCR4V340fs gain-of-function mutation by Yu Huang, Yu Huang, Yu Huang, Lu Li, Lu Li, Ran Chen, Ran Chen, Lang Yu, Lang Yu, Shunkai Zhao, Yanjun Jia, Yanjun Jia, Ying Dou, Ying Dou, Ying Dou, Zhiyong Zhang, Zhiyong Zhang, Yunfei An, Yunfei An, Xuemei Tang, Xuemei Tang, Xiaodong Zhao, Xiaodong Zhao, Lina Zhou

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SCN1A gain of function effects in Dravet syndrome: Insights into clinical phenotypes and therapeutic implications by Yoko Kobayashi Takahashi, Kenshiro Tabata, Shimpei Baba, Eri Takeshita, Noriko Sumitomo, Yuko Shimizu‐Motohashi, Takashi Saito, Eiji Nakagawa, Atsushi Ishii, Shinichi Hirose, Mitsuhiro Kato, Naomichi Matsumoto, Hirofumi Komaki, Ken Inoue

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Mitogen-Activated Protein Kinase Kinase Kinase 1 Overexpression Disrupts Development of the Ocular Surface Epithelium by Maureen Mongan, Bo Xiao, Antonius Christianto, Yueh-Chiang Hu, Ying Xia

Subjects: “…MAP3K1 gain-of-function…”
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Natural Antioxidants Reduce Oxidative Stress and the Toxic Effects of RNA-CUG_(exp) in an Inducible Glial Myotonic Dystrophy Type 1 Cell Model by Fernando Morales, Dayana Vargas, Melissa Palma-Jiménez, Esteban J. Rodríguez, Gabriela Azofeifa, Oscar Hernández-Hernández

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STAT6 gain-of-function disease: p.D519N is a new disease-causing variant that responds well to dupilumab treatment by Simran Samra, MSc, Eleanor Cook, MBBS, Jessica Wilson, APRN, Mehul Sharma, PhD, Liam Golding, MSc, David T. Yao, BSc, Rebecca A. Marsh, MD, Stuart E. Turvey, MBBS, DPhil

Subjects: “…STAT6 gain-of-function disease…”
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Research Progress in Diseases Caused by STAT1 Gain-of-Function Mutations by LI Linpeng, MA Jing, GU Hao, SHU Zhou, MAO Huawei

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Design of Quality Gain-Loss Function with the Cubic Term Consideration for Larger-the-Better Characteristic and Smaller-the-Better Characteristic by Bo Wang, Ruiyu Yang, Pengyuan Li, Qikai Li, Hui Yu, Zhiyong Li

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Large-Scale Rice Mutant Establishment and High-Throughput Mutant Manipulation Help Advance Rice Functional Genomics by Eyob Kassaye Wolella, Zhen Cheng, Mengyuan Li, Dandan Xia, Jianwei Zhang, Liu Duan, Li Liu, Zhiyong Li, Jian Zhang

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Oncogenic and teratogenic effects of Trp53Y217C, an inflammation-prone mouse model of the human hotspot mutant TP53Y220C by Sara Jaber, Eliana Eldawra, Jeanne Rakotopare, Iva Simeonova, Vincent Lejour, Marc Gabriel, Tatiana Cañeque, Vitalina Volochtchouk, Monika Licaj, Anne Fajac, Raphaël Rodriguez, Antonin Morillon, Boris Bardot, Franck Toledo

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Nav1.8 and Chronic Pain: From Laboratory Animals to Clinical Patients by Yu-Feng Xie

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