Delta opioid receptors engage multiple signaling cascades to differentially modulate prefrontal GABA release with input and target specificity by Ryan P.D. Alexander, Kevin J. Bender

“…We found that DORs regulate inhibition from these interneuron classes using different G-protein signaling pathways that both converge on presynaptic calcium channels but regulate distinct aspects of calcium channel function. …”
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Interleukin-1β Expression Is Required for Lysophosphatidic Acid-Induced Lymphangiogenesis in Human Umbilical Vein Endothelial Cells by Chih-Hsin Lin, JenHer Lu, Hsinyu Lee

“…Lysophosphatidic acid (LPA) is a lipid mediator which binds to G-protein-coupled receptors and regulates various cellular responses, including inflammation of endothelial cells. …”
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Ion Channel Activities in Neural Stem Cells of the Neuroepithelium by Masayuki Yamashita

“…The neuroepithelial cell shows robust increases in the nucleoplasmic [Ca2+] in response to G protein-coupled receptor activation in S-phase, during which the nucleus is located in the basal region of the neuroepithelial cell. …”
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Analysis of Signals Leading to Differentiation of Immature HL-60 after Administration of IL-4 by Simon Vassiliadis

“…Based on previous reports that HLA-DR induction by IL-4 in the HL-60 system is mediated via the G-protein system (p21ras), this study was undertaken in order to define the intermediate signalling steps followed by this agent from the moment it is added to cultures to the differentiated cellular form obtained. …”
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The Role of CXCR3 in Nervous System-Related Diseases by Fangyuan Wang, Bing Guo, Ziyang Jia, Zhou Jing, Qingyi Wang, Minghe Li, Bingqi Lu, Wulong Liang, Weihua Hu, Xudong Fu

“…Inflammatory chemokines are a group of G-protein receptor ligands characterized by conserved cysteine residues, which can be divided into four main subfamilies: CC, CXC, XC, and CX3C. …”
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Expression of GPR43 in Brown Adipogenesis Is Enhanced by Rosiglitazone and Controlled by PPARγ/RXR Heterodimerization by Jiamiao Hu, Arong Zhou, Peter C. K. Cheung, Baodong Zheng, Shaoxiao Zeng, Shaoling Lin

“…GPR43, a G-protein coupled receptor recognizing short-chain fatty acids, has been reported to participate in many biological functions of white adipocytes, such as adipogenesis and lipolysis. …”
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The Reporter System for GPCR Assay with the Fission Yeast Schizosaccharomyces pombe by Shintaro Sasuga, Toshiya Osada

“…G protein-coupled receptors (GPCRs) are associated with a great variety of biological activities. …”
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Anticonvulsant valproic acid and other short-chain fatty acids as novel anticancer therapeutics: Possibilities and challenges by Lipska Katarzyna, Gumieniczek Anna, Filip Agata A.

“…Moreover, it up-regulates the expression of certain G protein-coupled receptors (GPCRs), which are involved in various signaling pathways associated with cancer. …”
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Differentiation between some Ulva spp. by morphological, genetic and biochemical analyses by M. M. Ismail, E. S. Mohamed

“…The biochemical composition (e.g. protein, carbohydrate, lipid and pigment composition) of the collected Ulva spp. grouped the collected Ulva spp. into two groups (U. fasciata and U. lactuca) and other (U. compressa and U. linzea).…”
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Influence of AGTR1 and ABCB1 Gene Polymorphism on the Curative Effect of Irbesartan by Qiao Wang, Lingsen You, Zeyu Li, Leiyi Zhang, Xueqi Li, Xuesong Yang

“…Eventually, we assumed that the different drug responses of irbesartan among various AGTR1 genotypes were due to the diversity of the irbesartan-conjugated protein, which is responsible for crossing-coupled intracellular G-protein-coupled receptors (GPCRs).…”
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CXCR2 Is Essential for Radiation-Induced Intestinal Injury by Initiating Neutrophil Infiltration by Jing Hu, Qian Ji, Fei Chen, Xiaoqin Gong, Chuansheng Chen, Kaijun Zhang, Ye Hua, Jinlei Wang, Rongkun Li, Xu Wang, Chunhua Dai, Ye Tian

“…By clearing neutrophils with an anti-Ly6G antibody, we found that neutrophil infiltration is critical for irradiation-induced intestinal injury. CXCR2 is a G-protein-coupled receptor that mediates the migration of neutrophils by combining with its ligands. …”
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Therapeutic Potential of 5-HT2C Receptor Ligands by Nanna H. Jensen, Thomas I. Cremers, Florence Sotty

“…Serotonin 2C receptors are G protein-coupled receptors expressed by GABAergic, glutamatergic, and dopaminergic neurons. …”
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Green Synthesis of New Pyrrolo [1,2-a] quinoxalines as Antiproliferative Agents in GPER-expressing Breast Cancer Cells by Gabriele Carullo, Sarah Mazzotta, Francesca Giordano, Francesca Aiello

“…4,5-Dihydropyrrolo [1,2-a]quinoxalines are interesting druggable scaffolds, with multifaceted biological properties, including anticancer properties targeting the G protein-coupled estrogen receptor 1 (GPER). In this work, the synthesis and preliminary antiproliferative activity of a small set of new 4,5-dihydropyrrolo[1,2-a]quinoxalines (18-20) and pyrrolo[1,2-a]quinoxalines (21, 22) has been reported, inspired by known antiproliferative agents (G-1, G-15, and G-36). …”
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Impact of the crosstalk between the PTEN and PAFR as well as PAFR and EGFR pathways in cancer by Anita Thyagarajan, Zaid Sirhan, Ravi P. Sahu

“…Importantly, high tumor expression of a G-protein coupled platelet-activating factor-receptor (PAFR) is associated with increased tumor progression as well as decreased overall survival and poor prognosis in malignancies such as non-small cell lung cancer (NSCLC). …”
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Identification of key regulators in pancreatic ductal adenocarcinoma using network theoretical approach. by Kankana Bhattacharjee, Aryya Ghosh

“…Our analysis revealed 33 key regulators were predominantly enriched in neuroactive ligand-receptor interaction, Cell adhesion molecules, Leukocyte transendothelial migration pathways; positive regulation of cell proliferation, positive regulation of protein kinase B signaling biological functions; G-protein beta-subunit binding, receptor binding molecular functions etc. …”
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Interaction of GPER-1 with the endocrine signaling axis in breast cancer by Luis Molina Calistro, Yennyfer Arancibia, Marcela Alejandra Olivera, Sigrid Domke, Rodrigo Flavio Torres

“…G Protein-Coupled Estrogen Receptor 1 (GPER-1) is a membrane estrogen receptor that has emerged as a key player in breast cancer development and progression. …”
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Effect of Microbial Transglutaminase on Ice Cream Heat Resistance Properties – a Short Report by Kasprzyk Iwona, Markowska Joanna, Polak Elżbieta

“…TG was added at a concentration of 2 U/g protein. We studied the effect of transglutaminase on fresh and 3-month-stored at -25°C ice cream. …”
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Evaluation of Genotype Diversity in Oat Germplasm and Definition of Ideotypes Adapted to the Mediterranean Environment by Anna Iannucci, Pasquale Codianni, Luigi Cattivelli

“…It is rich in primary metabolites (e.g., protein, carbohydrate, and fibre) as well as in many secondary compounds (e.g., fructo-oligosaccharides). …”
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Anti-Inflammatory Effects of Epoxyeicosatrienoic Acids by Scott J. Thomson, Ara Askari, David Bishop-Bailey

“…The mechanisms by which EETs mediate their effects are largely unknown but may include direct binding to peroxisome proliferator-activated receptors (PPARs), G-protein coupled receptors (GPCRs), or transient receptor potential (TRP) channels, which initiate anti-inflammatory signalling cascades.…”
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Apelin Protects Primary Rat Retinal Pericytes from Chemical Hypoxia-Induced Apoptosis by Li Chen, Yong Tao, Jing Feng, Yan Rong Jiang

“…Apelin, as the endogenous ligand of G protein-coupled receptor APJ, participates in a number of physiological and pathological processes. …”
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