Systematic protein–protein interaction mapping for clinically relevant human GPCRs by Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar

Subjects: “…G‐protein‐coupled receptors…”
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Expression and correlation of endoglin, sEndoglin, and MMP-14 on preeclampsia placenta by Febriana Catur Iswanti, Ninik Mudjihartini, Reni Paramita, Yuditiya Purwosunu, Ani Retno Prijanti

“…In contrast, sEndoglin (0.05 [0.0–0.01] ng/μg protein vs. 0.02 [0.0–0.3] ng/μg protein) and MMP-14 (0.14 [0.1–0.6] ng/μg protein vs. 0.11 [0.1–1.3] ng/μg protein) concentrations were significantly higher in preeclampsia placentas compared to normal placentas. …”
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The Quantitative Analysis of bFGF and VEGF by ELISA in Human Meningiomas by Yves Denizot, Rafael De Armas, François Caire, Jean Jacques Moreau, Isabelle Pommepuy, Véronique Truffinet, François Labrousse

“…The quantitative analysis of VEGF using ELISA in various subtypes of grade I meningiomas reported higher VEGF contents in meningothelial (2.38±0.62 pg/μg protein, n=7), transitional (1.08±0.21 pg/μg protein, n=13), and microcystic meningiomas (1.98±0.87 pg/μg protein, n=5) as compared with fibrous ones (0.36±0.09 pg/μg protein, n=5). …”
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Plasma macrophage colony-stimulating factor levels during cardiopulmonary bypass with extracorporeal circulation by Y. Denizot, P. Fixe, E. Cornu, N. Nathan

“…Plasma M-CSF concentrations were stable during ECC and increased at the 6th (7.3 ± 0.7 IU/μg protein) and 24th (8.6 ± 0.8 IU/μg protein) postoperative hour compared with pre-ECC values (4.9 ± 0.5 IU/μg protein). …”
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Testicular Nitric Oxide and Thiobarbituric Acid Reactive Substances Levels in Obstructive Azoospermia: A Possible Role in Pathophysiology of Infertility

“…Testicular tissue nitrate/nitrite and TBARS levels were <mml:math alttext="$35.7pm 3.1$"><mml:mrow><mml:mn>35.7</mml:mn><mml:mo>&#x00B1;</mml:mo><mml:mn>3.1</mml:mn></mml:mrow></mml:math><mml:math alttext="$mu$"><mml:mi>&#x03BC;</mml:mi> </mml:math>mol/g protein and <mml:math alttext="$3.7pm 0.1$"><mml:mrow> <mml:mn>3.7</mml:mn><mml:mo>&#x00B1;</mml:mo><mml:mn>0.1</mml:mn> </mml:mrow></mml:math> nmol/g protein in Group-1, and <mml:math alttext="$19.3pm 0.7$"> <mml:mrow><mml:mn>19.3</mml:mn><mml:mo>&#x00B1;</mml:mo><mml:mn>0.7</mml:mn> </mml:mrow></mml:math><mml:math alttext="$mu$"><mml:mi>&#x03BC;</mml:mi> </mml:math>mol/g protein and <mml:math alttext="$3.1pm 0.1$"><mml:mrow><mml:mn>3.1</mml:mn><mml:mo>&#x00B1;</mml:mo><mml:mn>0.1</mml:mn></mml:mrow></mml:math> nmol/g protein in Group-2, respectively. …”
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Comparison of sialic acid content in bovine and buffalo milk and meat by Michela Contò, Simona Rinaldi, Sebastiana Failla

“…Neu5Ac content was significantly higher in buffalo milk than in cow milk (1045 vs. 906 μg/g protein). In contrast, Neu5Gc content was significantly lower in buffalo milk than in cow milk (58 vs. 106 μg/g protein). …”
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Supplementation of Arjun (Terminalia arjuna) bark powder prevented oxidative stress and enhanced antioxidants in kidneys on isoproterenol-treated Swiss albino mice model by Rashedul Haque, Sajib Paul, Md. Tipu Sultan, Faizul Islam Chowdhury, Md. Kawser, Shariful Islam Nayan, S.M. Hafiz Hassan, Afsana Kabir Chowdhury, Raiyana Huda, Sauda Sumaya Dina, Sheikh Zahir Raihan

“…Catalase plasma (ISO- 15.90 U/min, ISO + Arjun 2.5%- 19.75 U/min, P = 0.0070) and in catalase kidney (ISO- 381.6 U/min/g protein, ISO + Arjun 2.5%- 581.9 U/min/g protein, P = 0.0082). …”
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Therapeutic Strategies for Neuropathic Pain: Potential Application of Pharmacosynthetics and Optogenetics by Gum Hwa Lee, Sang Seong Kim

“…Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) facilitate the artificial manipulation of intracellular signaling through excitatory or inhibitory G protein subunits activated by biologically inert synthetic ligands. …”
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Structure and function of a near fully-activated intermediate GPCR-Gαβγ complex by Maxine Bi, Xudong Wang, Jinan Wang, Jun Xu, Wenkai Sun, Victor Ayo Adediwura, Yinglong Miao, Yifan Cheng, Libin Ye

“…Abstract Unraveling the signaling roles of intermediate complexes is pivotal for G protein-coupled receptor (GPCR) drug development. …”
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Dexmedetomidine Inhibits Voltage-Gated Sodium Channels via α2-Adrenoceptors in Trigeminal Ganglion Neurons by Sang-Taek Im, Youn Yi Jo, Gayoung Han, Hyun Jung Jo, Yong Ho Kim, Chul-Kyu Park

“…Dexmedetomidine-induced inhibition of INa was mediated by G protein-coupled receptors (GPCRs) as this effect was blocked by intracellular perfusion with the G protein inhibitor GDPβ-S. …”
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Metabolite-Sensing Receptors: Emerging Targets for Modulating Chronic Pain Pathways by Ciprian Pușcașu, Corina Andrei, Octavian Tudorel Olaru, Anca Zanfirescu

“…Recent advances highlight the critical role of metabolite-sensing G protein-coupled receptors (GPCRs) in various chronic pain types. …”
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Differential proteome analysis of pea roots at the early stages of symbiosis with nodule bacteria by I. V. Leppyanen, A. N. Kirienko, A. A. Lobov, E. A. Dolgikh

“…This indicates that G-proteins and phospholipases can play a key role in the development of early stages of symbiosis in peas. …”
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Conformational diversity in class C GPCR positive allosteric modulation by Giuseppe Cannone, Ludovic Berto, Fanny Malhaire, Gavin Ferguson, Aurelien Fouillen, Stéphanie Balor, Joan Font-Ingles, Amadeu Llebaria, Cyril Goudet, Abhay Kotecha, Vinothkumar K.R., Guillaume Lebon

“…Abstract The metabotropic glutamate receptors (mGlus) are class C G protein-coupled receptors (GPCR) that form obligate dimers activated by the major excitatory neurotransmitter L-glutamate. …”
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Dietary Phosphorus Requirement of Giant Gouramy (Osphronemus gouramy Lac.) by M. Agus Suprayudi, Mia Setiawati

“…Four semipurified diet containing isoprotein (41,0%) and isoenergy (10.0 kcal/g protein) but different in phosphorus content were prepared. …”
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Investigating Whether Consuming Meals in a Dining Room Impacts Patients’ Mood, Level of Interaction, and Subsequent Nutrient Intake in a Stroke Rehabilitation Ward. by Sali Abouhajar, Grace Bennett, Linda Dooley, Tracy Waldron, Katie Walsh, Sile Murphy, Aoibheann McMorrow, Joseph Harbison, Suzanne L Doyle

“…Results:There was no significant difference in protein and energy consumption in the dining room (16.4g protein and 379.2kcal) compared to at the bedside (13.2g protein and 333.8kcal), p=0.160 and p=0.110 respectively. …”
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Treatment of a mutant KRAS lung cancer cell line with polyisoprenylated cysteinyl amide inhibitors activates the MAPK pathway, inhibits cell migration and induces apoptosis. by Matthew D Gregory, Kweku Ofosu-Asante, Jassy Mary S Lazarte, Pablo E Puente, Nada Tawfeeq, Nadine Belony, Yong Huang, Ite A Offringa, Nazarius S Lamango

“…Furthermore, 5 μM of NSL-YHJ-2-27 depleted the singly polyisoprenylated monomeric G-proteins RAC 1/2/3 and CDC42 by 77 and 76%, respectively. …”
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Nuciferine relieves type 2 diabetes mellitus via enhancing GLUT4 expression and translocation by Tongxi Zhou, Guanjun Song, Di Tian, Qinghua Liu, Jinhua Shen, Xinzhou Yang, Ping Zhao

“…In this study, the in vitro studies indicated that nuciferine-induced GLUT4 translocation was regulated by G protein-PLC-PKC and AMPK pathways and nuciferine-enhanced intracellular Ca2+ was mediated by G protein-PLC-IP3-IP3R pathway, the increase in intracellular Ca2+ caused by nuciferine was not directly related to GLUT4 translocation, but both promote glucose uptake. …”
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Gαs Protein Expression Is an Independent Predictor of Recurrence in Prostate Cancer by Lijuan Wang, Guihua Jin, Chenchen He, Xijing Guo, Xia Zhou, Meng Li, Xia Ying, Le Wang, Huili Wu, Qing Zhu

“…T393C polymorphism in the gene GNAS1, which encodes the G-protein alpha s subunit (Gαs) of heterotrimeric G protein, is significantly associated with the clinical outcome of patients suffering from several cancers. …”
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Re-annotation of SARS-CoV-2 proteins using an HHpred-based approach opens new opportunities for a better understanding of this virus by Brézellec, Pierre

“…Equally interestingly, Lutropin-choriogonadotropic hormone receptor showed similarities with 23 viral G-protein coupled receptors, particularly from Herpesvirales. …”
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Recovery of Proteins from Sweet Potato Cell Liquid by Acidification via Inoculation-Enhanced Fermentation and Determination of Functional Properties of Protein Products by Qingshuai Li, Liping Liu, Yanlei Han, Xiangying Zhao, Mingjing Yao, Jing Ma, Mo Han, Jiaxiang Zhang

“…The results indicated that the pH of SPCL could be reduced to approximately 4.0 within 6 h of fermentation with inoculation, resulting in an SPP extraction yield of 55.45% and purity of 66.23 g protein/100 g. With the addition of heating treatment, the extraction yield of SPP increased to 76.97–95.34%, while it maintained the purity of 66.36–70.12 g protein/100 g. …”
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