Systematic identification of secondary bile acid production genes in global microbiome by Yuwei Yang, Wenxing Gao, Ruixin Zhu, Liwen Tao, Wanning Chen, Xinyue Zhu, Mengping Shen, Tingjun Xu, Tingting Zhao, Xiaobai Zhang, Lixin Zhu, Na Jiao

“…This gene catalog provides a comprehensive and reliable foundation for future studies on microbial bile acid metabolism, offering new insights into the microbial contributions to health and disease.IMPORTANCEBile acid metabolism is an important function in both host and environmental microorganisms. …”
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Viral load suppression rate of third-line antiretroviral therapy and its association with gender among HIV patients after second-line treatment failure in Africa: a systematic revi... by Tilahun Degu Tsega, Sintayehu Simie Tsega, Asaye Alamneh Gebeyehu, Getaneh Atikilt Yemata, Rahel Mulatie Anteneh, Almaw Genet Yeshiwas, Getasew Yirdaw, Chalachew Yenew, Anley Shiferaw Enawgaw, Amare Genetu Ejigu, Ahmed Fentaw Ahmed, Zeamanuel Anteneh Yigzaw, Berhanu Abebaw Mekonnen, Meron Asmamaw Alemayehu, Abathun Temesgen, Abebaw Molla, Habitamu Mekonen, Assefa Andargie Kassa, Gashaw Melkie Bayeh

“…Therefore, to maintain and further improve the strong viral load suppression rates of TLARVT in Africa, it is essential to focus on appropriate regimen selection, patient counseling and switching, adherence support, and regular viral load testing. Future studies with larger sample sizes should explore the association between gender and viral load suppression to provide conclusive findings.…”
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Modulation of myeloid and T cells in vivo by Bruton’s tyrosine kinase inhibitor ibrutinib in patients with metastatic pancreatic ductal adenocarcinoma by Li Zhang, Matthew Crocker, Lawrence Fong, Lisa M Coussens, Charles D Lopez, Shamilene Sivagnanam, Meenal Sinha, Brandon Chen, Jaqueline Marquez, Alexander Cheung, Whitney Tamaki, Jacob Stultz, Kendra Todd, Courtney Betts, Madeline J Griffith, Isabelle Solman, Eric Liu, Denise Pener, Anne Fahlman, Erin Taber, Kimberly Lerner, Brindha Rajagopalan, Clarisha Ware, Mark Bridge, Johnson Vo, Hannah Dragomanovich, Julie Sudduth-Klinger, Gina Vaccaro, Margaret Tempero

“…These effects were not observed when combining ibrutinib with standard of care chemotherapy. Future studies may focus on other therapeutic combinations that augment the immunomodulatory effects of ibrutinib in solid tumors.Trial registration number NCT02562898.…”
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Ultrasound and histopathological assessment of benign, borderline, and malignant thyroid tumors in pediatric patients: an illustrative review and literature overview by Dominika Januś, Dominika Januś, Monika Kujdowicz, Monika Kujdowicz, Aleksandra Kiszka-Wiłkojć, Aleksandra Kiszka-Wiłkojć, Konrad Kaleta, Anna Taczanowska-Niemczuk, Anna Taczanowska-Niemczuk, Jan Radliński, Kamil Możdżeń, Zuzanna Nowak, Wojciech Górecki, Wojciech Górecki, Jerzy B. Starzyk, Jerzy B. Starzyk

“…This overlap necessitates referrals for fine-needle aspiration biopsy (FNAB) in children more frequently than in adults. Future studies utilizing artificial intelligence (AI) to predict clinical outcomes in thyroid nodule diagnostics may offer new advancements, particularly given the increasing number of pediatric patients with solid thyroid lesions.…”
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Cancer-related health behaviors during the COVID 19 pandemic in geographically diverse samples across the US by Breanna B. Greteman, Allison Cole, Mary E. Charlton, Jackilen Shannon, Deanna Kepka, Electra D. Paskett, Evelinn A. Borrayo, Jamie L. Studts, Hayley S. Thompson, Isabel Scarinci, Lynn Chollet Hinton, Elizabeth A. Chrischilles, Crystal J. Garcia-Auguste, Kaila Christini, Heather Aker, Jesse J. Plascak, Felicity W. K. Harper, Monica L. Baskin, Sejong Bae, Vishruti Pandya, Young-il Kim, Babalola Faseru, Christie Befort, Hanluen Kuo, Mark Dignan, Juan Canedo, Victoria Champion, Bettina F. Drake, Kia L. Davis, Debra L. Friedman, Mohamed I. Elsaid, Scherezade K. Mama, Wendy F. Cohn

“…Conclusion Our findings suggest that certain demographics and those who adhered to social distancing measures were more likely to self-report unfavorable changes in health behaviors during the pandemic. Future studies should examine if the behaviors returned to baseline following relief from pandemic restrictions, and if these behavior changes are associated with increased cancer incidence and mortality.…”
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Proposal and Strategy for Nursing-Led Research: Protocol for an Unfunded Clinical Trial by Leticia Carmen Simón-López, Ismael Ortuño-Soriano, Raquel Luengo-González, Paloma Posada-Moreno, Ignacio Zaragoza-García, Rubén Sánchez-Gómez

“…This is why initiatives to conduct unfunded clinical trials have been identified as an important issue to pay attention to in future studies. Therefore, we present our initiative through Rogers’ theory, which is highlighted in the literature for diffusing innovative change across organizations. …”
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Unity in diversity: navigating global connections through cultural exchange by Dwi Mariyono, Annis Nur Alifatul Kamila, Akmal Nur Alif Hidayatullah

“…Research limitations/implications – This research is limited by its reliance on secondary data from policy documents and literature, without primary data from affected communities or policymakers. Future studies could incorporate interviews and surveys to gain first-hand perspectives. …”
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Employment status and information needs of patients with breast cancer: a multicentre cross-sectional study of first oncology consultations by Lidia Del Piccolo, Maria Angela Mazzi, Cinzia Perlini, Giuseppe Deledda, Alberto Ghilardi, Chiara Buizza, Alessandro Bottacini, Claudia Goss

“…Patients' characteristics including employment status could be considered in tailoring work and social-related information provided during the first oncological consultation. Future studies could explore potential differences in information needs according to the different kinds of work.…”
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Survival in patients with CKD 3–5 after 12 months of exercise training – a post-hoc analysis of the RENEXC trial by Sara Denguir, Matthias Hellberg, Martin Almquist, Naomi Clyne

“…These factors require elucidation in future studies. Trial registration ClinicalTrials.gov NCT02041156. …”
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Resident-based learning model for sustainable resident participation in municipal solid waste management program by A. Ghazali, J. Tjakraatmadja, . Sunarti, E.Y.D. Pratiwi

“…However, some adjustments may be required for residents with different characteristics. Future studies may focus on testing and refining the model to improve its applicability. …”
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Spatial-Temporal Variation and Driving Forces of Carbon Storage at the County Scale in China Based on a Gray Multi-Objective Optimization-Patch-Level Land Use Simulation-Integrated... by Gui Chen, Qingxia Peng, Qiaohong Fan, Wenxiong Lin, Kai Su

“…However, several limitations remain, as follows: the singularity of carbon density data, and the research scope being confined to small-scale mountainous forest ecosystems. Future studies could consider collecting continuous annual soil carbon density data and employing land-use simulation models (such as PLUS or CLUMondo) appropriate to the study area’s dimensions.…”
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Serial systemic immune inflammation indices: markers of acute migraine events or indicators of persistent inflammatory status? by Tissa Wijeratne, Melanie J. Murphy, Chanith Wijeratne, Paolo Martelletti, Leila Karimi, Vasso Apostolopoulos, Carmela Sales, Nina Riddell, Sheila G. Crewther

“…The control group displayed similar findings to MO inpatients, suggesting persistent systemic inflammation in a subset of migraine patients regardless of in patient or outpatient of presentation and highlighting the need for future studies to more rigorously evaluate the role of systemic inflammation in migraine pathophysiology, chronicity, and progression though the multiple phases of migraine including the interictal phase.…”
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Retrieval and Evaluation of Global Surface Albedo Based on AVHRR GAC Data of the Last 40 Years by Shaopeng Li, Xiongxin Xiao, Christoph Neuhaus, Stefan Wunderle

“…Overall, GAC43 offers a promising long-term and consistent albedo with good accuracy for future studies such as global climate change, energy balance, and land management policy.…”
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Determinants of fertility in timed artificial insemination programs in beef cattle: predictive ability and risk factors from almost 2 million data points by R.E.F. Assis, F. Baldi, L.B. Temp, R. Ungerfeld, M.F. de Sá Filho

“…Despite the influence of each factor, this study demonstrated the usefulness of analyzing big databases, allowing to determine effects that cannot be studied with experimental approaches, providing a complementary approach to decide where to focus future studies to enhance TAI pregnancy rates in beef cattle.…”
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Role of Positron Emission Tomography-Computed Tomography Scan in Reaching Definite Diagnosis in Patients With Fever of Unknown Origin and Inflammation of Unknown Origin in Rheumato... by Koreli UY, Torun ES, Adaş M

“…This is mainly due to the detailed initial evaluations that are performed in internal medicine clinics. Future studies with more patients will better define the role of PET/CT in FUO/IUO patients in rheumatology clinics.Keywords: fever of unknown origin, inflammation of unknown origin, PET/CT, rheumatology…”
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Multicultural values: meeting point of two forces in developing Islamic education by Dwi Mariyono

“…Resource constraints: resource limitations may have impacted the scope and depth of the research. Future studies could seek additional resources to conduct more extensive investigations and analyses. …”
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Translation and Validation of the Italian Version of the Team-Based Learning Student Assessment Instrument (TBL-SAI) in Nursing Students by Valeria Vannini, Rosario Caruso, Sara Alberti, Sergio Rovesti, Paola Ferri

“…<b>Conclusions</b>: This study successfully validated the Italian version of the TBL-SAI, demonstrating its reliability and validity for assessing perceptions of TBL among Italian undergraduate nursing students. However, future studies should employ Confirmatory Factor Analysis to further test the proposed factor structure and explore the instrument’s applicability in various educational settings. …”
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The effects of contralateral limb cross-education training on post-surgical rehabilitation outcomes in patients with anterior cruciate ligament reconstruction: a randomized control... by Chao Liu, ShiJia Li, JianPing Li, HongHao Zhang, GuQiang Li, XiangZhan Jiang

“…Nonetheless, the fundamental mechanics of its effects remain ambiguous, and variables such as individual differences and neuromuscular adaptation processes may affect training results. Future studies should examine its long-term impacts and uncover potential neuromuscular pathways to establish a solid scientific basis for improving postoperative rehabilitation procedures.…”
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Identifying and Ranking the Causes of Delay Based on Production Strategies in Manufacturing Projects by Mohsen Rouzbahani, Mohammad Forozandeh

“…Therefore, more context-specific research is needed to examine the unique aspects of organizational cultures that include social, political, economic, technological, personnel, and personal considerations. Therefore, future studies should provide the analysis and findings in each case because each one will bring distinctive and unique findings in its case. …”
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Efficacy of non-invasive brain stimulation interventions on cognitive impairment: an umbrella review of meta-analyses of randomized controlled trials by Minmin Wu, Wenjing Song, Xue Wang, Lili Teng, Jinting Li, Jiongliang Zhang, Xinyue Li, Donghui Yu, Huanhuan Jia, Binhan Wang, Qiang Tang, Luwen Zhu

“…Despite potential benefits, results should be interpreted cautiously due to study heterogeneity and methodological limitations. Future studies should investigate their long-term effects and applicability across dementia types. …”
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