Utility of 5-ALA for resection of CNS tumours other than high-grade gliomas: a protocol for a systematic review by Michael D Jenkinson, Ashwin Venkatesh, Colin Watts, Michael T C Poon, Victoria Wykes, Stephen John Price, Puneet Plaha, Georgios Solomou, Melissa Gough, Conor S Gillespie, Aref-Ali Gharooni, Waqqas Patel

“…We sought to conduct a systematic review of the literature summarising surgical outcomes, evaluate the quality of diagnostic accuracy reported in the literature and qualitatively assess the evidence to inform future studies.Methods and analysis We will search electronic databases (Medline, Embase) with subsequent interrogation of references lists of articles reporting the use of 5-ALA for brain tumours other than high-grade glioma adult patients, which also report the extent of resection and/or survival. …”
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The Association Between Serum Gamma‐Glutamyl Transferase and Gastrointestinal Cancer Risk: A Systematic Review and Meta‐Analysis by Alireza Ramandi, Jacob George, Amir Hossein Behnoush, Alireza Delavari, Zahra Mohammadi, Hossein Poustchi, Reza Malekzadeh

“…Conclusion Higher GGT levels correlate with higher rates of GI cancer incidence, especially in colorectal and hepatic cancers. Future studies should investigate this biomarker's potential role in risk assessment for digestive cancers.…”
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Adrenal (Pro)renin Receptor Expression and Serum Soluble (Pro)renin Receptor Concentration in Primary Aldosteronism by Daisuke Watanabe, Satoshi Morimoto, Noriko Morishima, Yoichiro Kato, Yoji Nagashima, Noriyuki Shibata, Atsuhiro Ichihara

“…Adrenal (P)RR activity might offer a therapeutic target in the treatment of PA, although this issue needs to be investigated in future studies.…”
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Prognostic Factors for Clinical Response in Systemic Lupus Erythematosus Patients Treated by Allogeneic Mesenchymal Stem Cells by Lihui Wen, Myriam Labopin, Manuela Badoglio, Dandan Wang, Lingyun Sun, Dominique Farge-Bancel

“…Achieving CR was associated with older age (p=0.033), no arthralgia/arthritis at baseline (p=0.001), and no prior use of cyclophosphamide (p=0.003) or hydroxychloroquine (p=0.016). Future studies using unique immunosuppressive regimens and allogeneic MSC sources will further elucidate determinants of clinical response to MSC transplant in SLE.…”
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Research trends in glioma chemoradiotherapy resistance: a bibliometric analysis (2003–2023) by Shishi Yu, Jinya Wu, Yuan Jing, Ping Lin, Lang Lang, Yifan Xiong, Wangzhong Chen, Wenhua Liu, Changpeng Sun, Yuntao Lu

“…This study represents the first comprehensive bibliometric analysis of this field, providing a detailed overview of research trends and potential directions for future studies. The findings highlight the need for strengthened international collaboration and multidisciplinary approaches to address the challenges of therapeutic resistance in glioma.…”
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Biological subphenotypes in patients hospitalized with suspected infection in Thailand: a secondary analysis of a prospective observational studyResearch in context by Prapassorn Poolchanuan, Taylor D. Coston, Viriya Hantrakun, Parinya Chamnan, Gumphol Wongsuvan, Pavan K. Bhatraju, Narisara Chantratita, Direk Limmathurotsakul, T. Eoin West, Shelton W. Wright

“…Patient subphenotype assignment was characterized by distinct clinical outcomes and biological profiles which could inform contextualized future study design. Funding: The US National Institutes of Health, the Wellcome Trust, and the Firland Foundation.…”
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Evaluating Explainable AI Methods in Deep Learning Models for Early Detection of Cerebral Palsy by Kimji N. Pellano, Inga Strumke, Daniel Groos, Lars Adde, Espen F. Alexander Ihlen

“…Our work demonstrates that XAI methods can offer reliable and stable explanations for CP prediction models. Future studies should further investigate how the explanations can enhance our understanding of specific movement patterns characterizing healthy and pathological development.…”
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Assessing alcohol industry penetration and government safeguards: the International Alcohol Control Study by Sarah Callinan, Gopalkrishna Gururaj, Shiwei Liu, Sally Casswell, Thomas Karlsson, Jintana Jankhotkaew, Surasak Chaiyasong, Pranil Man Singh Pradhan, Gillian Shorter, Timothy Naimi, Ingeborg Rossow, Keitseope Nthomang, June Yue Yan Leung, Mindaugas Štelemėkas, Mom Kong, Khem Karki, Steve Randerson, Lathika Athauda, Arvind Banavaram, Orfhlaith Campbell, Song Dearak, Emeka W Dumbili, Laura Romero-García, Romtawan Kalapat, Norman Danilo Maldonado Vargas, Juan Felipe Gonzalez-Mejía, Opeyemi Oladunni, Kwame Owino, Juan Camilo Herrera Palacio, Phasith Phatchana, Vanlounny Sibounheuang, Dao The Son, Kate Vallance, Wim van Dalen, Ashley Wettlaufer, Arianne Zamora

“…Data collection can be improved by measuring these government safeguards in future studies.…”
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Pharmacological action of Angelica sinensis polysaccharides: a review by Chunzhen Ren, Chunzhen Ren, Chunzhen Ren, Yali Luo, Xiaojuan Li, Like Ma, Chunling Wang, Chunling Wang, Chunling Wang, Xiaodong Zhi, Xiaodong Zhi, Xinke Zhao, Xinke Zhao, Xinke Zhao, Yingdong Li, Yingdong Li, Yingdong Li

“…This review establishes a theoretical foundation for future studies on the structure, mechanism, and clinical use of ASP.…”
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The causal relationship of cigarette smoking to metabolic disease risk and the possible mediating role of gut microbiota by Jingda Zhang, Lin Hou, Shanxiang Lei, Yan Li, Guogang Xu

“…Conclusion: This work offered genetic evidence linking cigarette smoke to metabolic diseases, suggesting that the gut microbiota, particularly paraprevotella_clara, might be a crucial mediator in the development of type 2 diabetes caused by cigarette smoke. Our future studies should consider conducting other ethnic groups MR analyses, particularly with larger sample sizes. …”
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Multi-thermal recovery layout for a sustainable power and cooling production by biomass-based multi-generation system: Techno-economic-environmental analysis and ANN-GA optimizatio... by Ma Zihao, Naeim Farouk, Pradeep Kumar Singh, Azher M. Abed, Sarminah Samad, Samah G. Babiker, Iskandar Shernazarov, Ahmed Hendy, Ahmad Almadhor, Belgacem Bouallegue, Abdul Rahman Afzal

“…It also provides a model for future studies on carbon emission reduction and improved efficiency. …”
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The effect of Ocimum basilicum on the prevention of postpartum depression symptoms and sleep quality: A triple-blind randomized controlled clinical trial by Monireh Abdi, Elham Rezaei, Mojgan Mirghafourvand, Fatemeh Ebrahimi, Laleh Payahoo, Alireza Shafiei-Kandjani, Solmaz Ghanbari-Homaie

“…Conclusion: The results show that basil does not prevent postpartum depression or improve sleep quality. Future studies should investigate the effects of basil at higher doses and in extract form.…”
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Predictors and Outcomes of Hematoma Expansion and Neurological Decline in Intracerebral Hemorrhage: A Multisite Mobile Stroke Unit Study by Asish K. Gulati, Tianwen Ma, Isaiah Rolle, Ryan Peterson, Bianca Pirlog, Justine Chen, Megan Heckathorn, Jonathan Ratcliff, Nicolas Bianchi, Carol Fleming, Michael Frankel, James Grotta, Ritvij Bowry, Stephanie Parker, William Hicks, Digvijaya Navalkele

“…Interventions to prevent HE and ND should be tested on the MSU in future studies.…”
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Association between the ABCC11 gene polymorphism-determined earwax properties and external auditory canal microbiota in healthy adults by Yasunobu Amari, Masahiro Hosonuma, Takuya Mizukami, Junya Isobe, Yuki Azetsu, Eiji Funayama, Yuki Maruyama, Toshiaki Tsurui, Kohei Tajima, Aya Sasaki, Yoshitaka Yamazaki, Ryota Nakano, Yutaka Sano, Atsushi Ishida, Tatsuya Nakanishi, Seiji Mochizuki, Yuri Yoshizawa, Sumito Kumagai, Sakiko Yasuhara, Kakei Ryu, Tatsunori Oguchi, Atsuo Kuramasu, Kiyoshi Yoshimura, Takehiko Sambe, Sei Kobayashi, Naoki Uchida

“…We determined the presence of genome–microbiome interactions in the resident microbiota of the ear canal. Future studies should focus on ABCC11 gene polymorphisms to elucidate the pathogenesis of ear diseases and develop therapeutic methods.…”
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Disparities in the uptake of HPV-related cancer prevention strategies among women by HIV status in Puerto Rico by Marievelisse Soto-Salgado, Melisa Ramos-Sepúlveda, Jeslie M. Ramos-Cartagena, Maribel Tirado-Gómez, Humberto M. Guiot, Cristina Muñoz-Masso, Lorena González-Sepúlveda, Ana Patricia Ortiz

“…Conclusions: Although we observed high uptake of cervical and anal Pap screening in this clinic-based sample, HPV vaccination was deficient. Future studies should involve developing tailored cancer prevention strategies for WLWH to increase HPV vaccination uptake.…”
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Study for Improving Maternal Pregnancy And Child ouTcomes (IMPACT): a study protocol for a Swedish prospective multicentre cohort study by Anders Larsson, Henrik Imberg, Marius Kublickas, Anna-Karin Wikström, Peter Lindgren, Lina Bergman, Bo Jacobsson, Anna Sandström, Stefan Hansson, Peter Conner, Ylva Carlsson

“…Results from the current as well as future studies using information from the IMPACT database will be published in peer-reviewed journals.Trial registration number NCT03831490.…”
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Cross-Cultural Adaptation and Validation of the Hong Kong Version of the Knee Injury and Osteoarthritis Outcome Score (HK-KOOS) for Patients with Knee Osteoarthritis by Andy S. K. Cheng, Ka-chun Chan, Sum-yuet Chan, Miu-kwan Fan, Man-kwan Fung, Oi-yan Lee, Cindy T. T. Kwok, Jackson K. K. Wong

“…Discussion and Conclusions. Future studies should further examine the dimensionality of the KOOS. …”
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Epigenetic Inhibitors Differentially Impact TGF-β1 Signaling Cascades in COPD Airway Smooth Muscle Cells by Karosham Diren Reddy, Dikaia Xenaki, Ian M. Adcock, Brian G. G. Oliver, Razia Zakarya

“…<b>Conclusions:</b> Our findings offer insight into differential epigenetics in controlling COPD ASM cells and provide a foundation warranting future studies on epigenetic differences associated with COPD diagnosis. …”
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Evaluation of Chat Generative Pre-trained Transformer and Microsoft Copilot Performance on the American Society of Surgery of the Hand Self-Assessment Examinations by Taylor R. Rakauskas, BS, Antonio Da Costa, BS, Camberly Moriconi, BS, Gurnoor Gill, BA, Jeffrey W. Kwong, MD MS, Nicolas Lee, MD

“…Clinical Relevance: While holding promise within medical education, caution should be used with large language models as more detailed evaluation of consistency is needed. Future studies should explore how these models perform across multiple trials and contexts to truly assess their reliability.…”
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Synthesizing the impact of armed conflicts on food security, livelihoods and social dynamics in Amhara region, Ethiopia by Jemal Hassen Muhyie, Desalegn Yayeh, Seblewongiel Ayenalem Kidanie, Wubshet Asnake Metekia, Temesgen Tilahun

“…Government, non-governmental organizations, and community-based institutions should play a crucial role in building community resilience and support post-conflict reconstruction efforts. Future studies can capitalize on this qualitative finding and could design a large scale assessment using quantified data to further provide evidence on post-conflict reconstruction efforts.…”
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