Acute Effects of Ketamine Infusion on Postoperative Mood Scores in Patients Undergoing Dilation and Curettage: A Randomized Double-Blind Controlled Study by Raham Hasan Mostafa, Ahmed Mohamed Khamis, Ashraf Nabil Saleh, Yehia Mamdouh Hassan Mekki, Mohamed Mohamed Kamal, Ismail Mohammed Ibrahim, Mohamed Abdulmohsen Abdulnaiem Ismaiel

“…Observed data here support an acute effect of ketamine on mood but any further claim will be speculative. Further future studies exploring postoperative mood scores after 24 hours post-infusion are needed. …”
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Quantifying research hotspots and trends in brucella spondylitis: a bibliometric analysis by Zhangui Gu, Zhangui Gu, Zongqiang Yang, Zongqiang Yang, Le Fei, Le Fei, Daihao Wei, Daihao Wei, Long Ma, Qiang Liu, Jiandang Shi

“…Current research focuses on diagnosis and complications, while future studies may explore management and instrumentation. …”
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Development of Speech and Communication in Polish Children with 22q11.2 Deletion Syndrome: A Cross-Sectional Study by Natalia Moćko, Marcin Rudzki, Zuzanna Miodońska, Julia Olesiak, Katarzyna Jochymczyk-Woźniak, Michał Kręcichwost

“…These preliminary observations point to the need for future studies and increased awareness efforts in this area.…”
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Evaluating cardiac performance in beagle dogs: Transesophageal echocardiography and myocardial work assessment by Beibei Ge, Changqing Miao, Di Xu, Mingxia Li, Fang Xu, Xiaoxian Wang, Fen Chen, Yan Li, Yan Chen, Chanjuan Gong, Peng Li, Fang Wang, Jing Yao

“…Conclusions: TEE provides detail morphological and functional assessments of the Beagle hearts, offering reference data for future studies. Myocardial work analysis presents a novel method for evaluate myocardial contractility and mechanical properties, with promising applicatons in veterinary medicine.…”
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Basic research for ultrasound-guided injection into skeletal muscle lesions in an experimental animal model by KiyomitsuFujimoto, TakashiKanamoto, ShunyaOtani, RyoMiyazaki, KosukeEbina, KenNakata

“…It also showed that ultrasound-guided injections allowed for highly accurate distribution of solution and cells in abnormal muscle tissue, but the patterns of solution and cell distribution were markedly different. Although future studies using a more clinically relevant model are necessary, these results are important findings when considering biological therapies for skeletal muscle injuries and disorders. …”
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Novel insights into palatal shelf elevation dynamics in normal mouse embryos by Jeremy P. Goering, Michael Moedritzer, Marta Stetsiv, Dona Greta Isai, Brittany M. Hufft-Martinez, An J. Tran, Zaid Umar, Madison K. Rickabaugh, Paul Keselman, Munish Chauhan, Pamela V. Tran, William M. Brooks, William M. Brooks, Kenneth J. Fischer, Andras Czirok, Andras Czirok, Irfan Saadi, Irfan Saadi

“…Thus, our data reveal novel insights into rapid dynamic changes during PS elevation, and lay the foundation for future studies of normal and abnormal palatogenesis.…”
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CRISPR/Cas9-editing of PRNP in Alpine goats by Aurélie Allais-Bonnet, Christophe Richard, Marjolaine André, Valérie Gelin, Marie-Christine Deloche, Aurore Lamadon, Gwendoline Morin, Béatrice Mandon-Pépin, Eugénie Canon, Dominique Thépot, Johann Laubier, Katayoun Moazami-Goudarzi, Ludivine Laffont, Olivier Dubois, Thierry Fassier, Patrice Congar, Olivier Lasserre, Tiphaine Aguirre-Lavin, Jean-Luc Vilotte, Eric Pailhoux

“…This new variant will be tested for its potential properties with respect to prion disease. Future studies will also evaluate the effects of genetic background on other characters associated with PRNP KO, as previously described in the Norwegian breed or other species.…”
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Does a Provider Contact Wristband Reduce Emergency Department Visit Rates Following Hip or Knee Arthroplasty? by David C. Hein, MD, Ajay K. Srivastava, MD, Seann E. Willson, MD, Paul M. Telehowski, MD, Patrick J. Atkinson, PhD, Theresa S. Atkinson, PhD

“…Conclusions: Patients utilized the wristband number, but this did not significantly reduce the number of ED visits within 3 years. Future studies should track ED visits and identify decision-making factors behind ED use in order to find ways to improve the intervention.…”
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Development and validation of a model to identify polycystic ovary syndrome in the French national administrative health database by Eugénie Micolon, Sandrine Loubiere, Appoline Zimmermann, Julie Berbis, Pascal Auquier, Blandine Courbiere

“…Our findings may be useful for future studies on PCOS using administrative data on a national scale, or even on an international scale given the similarity of coding in this field.…”
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Thioredoxin‐interacting protein (TXNIP) is a substrate of the NEDD4‐like E3 ubiquitin‐protein ligase WWP1 in cellular redox state regulation of acute myeloid leukemia cells by Sara Giovannini, Yanan Li, Rosalba Pecorari, Claudia Fierro, Claudia Fiorilli, Federica Corigliano, Valeria Moriconi, Ji Zhou, Anna De Antoni, Artem Smirnov, Sara Rinalducci, Anna Maria Timperio, Massimiliano Agostini, Jinping Zhang, Yufang Shi, Eleonora Candi, Gerry Melino, Francesca Bernassola

“…Hence, a contribution to the increased cell death observed in WWP1‐depleted cells also possibly arises from the attenuation of glucose up‐take and glycolytic flux resulting from TXNIP accumulation. Future studies are needed to establish whether TXNIP‐dependent deregulation of redox homeostasis in WWP1‐overexpressing blasts may affect the response of leukemic cells to chemotherapeutic drugs.…”
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Plant Growth and Nutritional Quality Attributes of Basella alba Applied with Variable Rates of Nitrogen Fertilizer at Different Planting Dates under Canadian Maritime Climatic Cond... by Nishchitha Hemmige Natesh, Mercy O. Ijenyo, Samuel Kwaku Asiedu, H. P. Vasantha Rupasinghe, Lord Abbey

“…However, it is recommended to reduce the rate of N fertilizer application during high-temperature conditions. Future studies are required to investigate phosphorus and potassium fertilization and nitrate accumulation in B. alba and potential health risks.…”
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Symptoms indicative of early knee osteoarthritis after ACL reconstruction: descriptive analysis of the SHIELD cohort by Anna Cronström, May Arna Risberg, Martin Englund, Dorthe B. Strauss, Paul Neuman, Carl Johan Tiderius, Eva Ageberg

“…Conclusion: The proportion of participants fulfilling existing classification criteria for symptoms indicative of early OA after ACLR is highly dependent on the criteria applied and different criteria seem to capture varying aspects of early OA symptoms. Future studies will reveal if these symptoms will persist long-term or just reflect more transient issues.…”
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Association Between SHBG Levels and Hypertensive Disorders of Pregnancy: A Systematic Review and Meta‐Analysis by Ajay Malvi, Muhammed Shabil, Mahalaqua Nazli Khatib, Roopashree R, Mandeep Kaur, Manish Srivastava, Amit Barwal, G. V. Siva Prasad, Pranchal Rajput, Rukshar Syed, Kamal Kundra, Vinamra Mittal, Amit Kumar, Pancham Cajla, Ganesh Bushi, Rachana Mehta, Zaid Khan, Prakasini Satapathy, Shilpa Gaidhane, Renu Sah

“…Further high‐quality research is required to better understand the role of SHBG in pregnancy‐related hypertensive disorders. Future studies should consider larger sample sizes, more precise measurement techniques, and explore potential confounding factors to clarify the potential utility of SHBG as a biomarker for predicting GH and PE.…”
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Protective effect of resveratrol on retinal damage in glaucoma: a systematic review and meta-analysis of preclinical studies by Feng Zhang, Feng Zhang, Tao Li, Junli Wan, Junli Wan, Lu Wang, Lu Wang, Wenmei Guo, Wenmei Guo, Yue Hu, Yue Hu, Hao Wang, Hao Wang, Wei Bian, Wei Bian

“…However, given that the animal research models utilized in the study may not fully reflect the intricate scenarios of multiple coexisting diseases in clinical settings, and the administration methods in animal models may differ from those in clinical practice, future studies should aim to provide higher levels of evidence to facilitate the clinical translation of these findings.Systematic Review Registration:identifier [CRD42024535673].…”
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PD-1/PD-L1 inhibitors related adverse events: A bibliometric analysis from 2014 to 2024 by Qingya Song, Zongliang Yu, Wenping Lu, Zhili Zhuo, Lei Chang, Heting Mei, Yongjia Cui, Dongni Zhang

“…Biomarker research and multi-phase clinical trials are likely to be key areas of focus in future studies.…”
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Android to gynoid fat ratio and its association with functional capacity in male patients with heart failure by Marcelo Rodrigues Dos Santos, Guilherme Wesley Peixoto daFonseca, Letícia Pironato Sherveninas, Francis Ribeiro deSouza, Antônio Carlos Battaglia Filho, Caio Eduardo Novaes, Rosa Maria Rodrigues Pereira, Carlos Eduardo Negrão, Antônio Carlos Pereira Barretto, Maria‐Janieire de Nazaré Nunes Alves

“…Conclusions Body fat distribution, particularly android and gynoid fat composition, together with other cofactors, might have an important adverse role on functional capacity in male patients with HFrEF. Future studies are needed to address possible mechanisms involved in this relationship.…”
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High Glucose Level Disturbs the Resveratrol-Evoked Curtailment of CX3CL1/CX3CR1 Signaling in Human Placental Circulation by Dariusz Szukiewicz, Michal Pyzlak, Grzegorz Szewczyk, Aleksandra Stangret, Seweryn Trojanowski, Michal Bachanek, Wojciech Braksator, Jaroslaw Wejman

“…In conclusion, euglycemia assures optimal effects of resveratrol pertaining to CX3CL1/CX3CR1 signaling in the placenta. Future studies on resveratrol are needed, especially those including maternal-fetal risk assessments.…”
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To Hemoadsorb or Not to Hemoadsorb—Do We Have the Answer Yet? An Updated Meta-Analysis on the Use of CytoSorb in Sepsis and Septic Shock by Carmen Orban, Angelica Bratu, Mihaela Agapie, Tudor Borjog, Mugurel Jafal, Romina-Marina Sima, Oana Clementina Dumitrașcu, Mihai Popescu

“…The addition of CytoSorb to CRRT may be associated with decreased survival as compared to CRRT alone, but future studies are needed to draw a definitive conclusion.…”
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Phytomedicinal armamentarium: A review of inula racemosa-derived alantolactones and isoalantolactones in anticancer therapy by Joshi Gaurav Santoshrao, Smriti Jamwal, Rakesh Kumar, Ekta Bisht, Bisen Harsh Krishnakumar, Shreya Katoch, R.K. Asrani

“…Their diverse mechanisms of action and minimal side effects position them as candidates for further research and development. Future studies should focus on clinical trials to establish their efficacy and safety in humans, paving the way for new cancer therapies.…”
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Does Differential Habitat Selection Facilitate Coexistence Between Badgers and Hedgehogs? by Katie A. Lee, Antonio Uzal, Louise K. Gentle, Philip J. Baker, Richard J. Delahay, Anthony Sévêque, Robert S. Davis, Richard W. Yarnell

“…Although these findings are consistent with hedgehogs avoiding badgers via a landscape of fear, they are also indicative of differential habitat use, highlighting the need for more holistic studies considering variation in habitat selection and food availability when investigating intraguild relationships. Future studies exploring alternative hypotheses for urban habitat selection by hedgehogs are needed to better understand how possible spatial niche partitioning may support their coexistence with badgers in some areas.…”
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