Cytisine compared to combination nicotine replacement therapy to reduce cigarette consumption in relapsed smokers: protocol for a pilot randomized controlled trial by Hassan Mir, Javad Heshmati, Kerri-Anne Mullen, Ashley Baldwin, Evyanne Quirouette, Andrew Pipe, Robert Reid

“…This will inform future studies aimed at recruiting patients who have relapsed to understand how best to support them to quit smoking. …”
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Genes underlying cold acclimation in the tea plant (<i>Camellia sinensis</i> (L.) Kuntze) by L. S. Samarina, L. S. Malyukova, M. V. Gvasaliya, A. M. Efremov, V. I. Malyarovskaya, S. V. Loshkareva, M. T. Tuov

“…The data obtained on different plant species may correlate with the mechanisms of frost tolerance of tea and are the basis for future studies of the signaling pathways of response to cold in the tea plant. …”
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Understanding patients’ emotional well-being, perceptions and concerns during an unprecedented deferment of arthroplasty: an Italian qualitative study by Marina Torre, Iuliia Urakcheeva, Paola Ciccarelli, Michael Tenti, Virgilia Toccaceli

“…Deterioration appeared mitigated by inner resources, favourable living conditions and, in some cases, by the psychosocial phenomenon, not detected in other studies, of the ‘lockdown paradox’ associated with mobility and autonomy restrictions shared by the whole community. Future studies are needed to investigate predictors of negative feelings and deterioration of quality of life in patients experiencing sudden major surgery delays.…”
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Visual and Auditory fMRI Paradigms for Presurgical Language Mapping: Convergent Validity and Relationship to Individual Variables by Antonina Omisade, Christopher B. O’Grady, Matthias H. Schmidt, John D. Fisk

“…It also offers an alternative paradigm to make this procedure more accessible to a broader range of patients. Future studies will replicate results with a sample of patients with epilepsy across a broad range of intellectual abilities.…”
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Deep learning in gonarthrosis classification: a comparative study of model architectures and single vs. multi-model methods by Sahika Betul Yayli, Kutay Kılıç, Salih Beyaz

“…These findings emphasize the importance of task-specific architectures and preprocessing. Future studies should explore ensemble modeling, advanced augmentations, and clinical validation to enhance applicability.…”
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Effects of a 12-week aerobic dance programme on diastolic blood pressure in stage one hypertensive adults by Lucy-joy Wachira, Mshilla Maghanga, Constance Adron Nakayiza Nsibambi, Edwin Kiptolo Boit, Loyce Nahwera

“…This study concluded that participating in an aerobic dance programme at a moderate intensity for 12 weeks did not statistically significantly reduce diastolic blood pressure of adults with stage one hypertension. Future studies on this population should investigate additional influencing factors and varying training intensity to assess any other effects.…”
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The Impact of Electrophysiological Diversity on Pattern Completion in Lithium Nonresponsive Bipolar Disorder: A Computational Modeling Approach by Abraham Nunes, Selena Singh, Anouar Khayachi, Shani Stern, Thomas Trappenberg, Martin Alda

“…These cognitive deficits may not be fully corrected by medications that minimize excitability. Future studies should test our predictions by examining behavioral correlates of pattern completion in lithium‐responsive and ‐nonresponsive BD patients.…”
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Pancreatic exocrine insufficiency after pancreatic resection: a systematic review by Marcello Di Martino, Ángela de la Hoz Rodriguez, Andrea Saibanti, Guillermo Salvador Camarmo, Nico Pagano, Elena Martín-Pérez, Matteo Donadon

“…Additionally, few studies report on micronutrient deficiencies, variations in anthropometric data or PEI-related patient-reported outcomes. Future studies should aim to establish a gold standard for diagnosis and severity assessment of post-pancreatectomy PEI and provide guidance for tailored pancreatic enzyme replacement therapy.…”
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Tumor-derived exosomal lncRNA-MIR193BHG promotes bone metastasis of breast cancer by targeting the miR-489-3p/DNMT3A signaling axis in osteoclasts by Xiaoya Liu, Rui Ma, Feng Wei, Maihuan Wang, Yiwei Jiang, Peng Zheng, Zhen Cao

“…Conclusions These findings suggest that lncRNA-MIR193BHG plays a critical regulatory role in breast cancer bone metastasis, and the lncRNA-MIR193BHG/miR-489-3p/DNMT3A signaling axis could be a potential target for the treatment of breast cancer bone metastasis. Future studies should further explore the broader applicability of this mechanism and its clinical feasibility.…”
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Evaluation of a Novel Water-Based Automated Endoscope Cleaning Process Compared to Conventional Manual Cleaning for Reducing Duodenoscope Contaminatio by Koen van der Ploeg, Juliëtte A. Severin, Margreet C. Vos, Nicole S Erler, Adriana J.C. Bulkmans, Marco Bruno, Bibi C.G.C. Mason-Slingerland

“…These results are promising. However, future studies should confirm these findings in larger samples and explore the other advantages of using the AT in duodenoscope cleaning. …”
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Efficacy and safety of anti-thrombotic therapy after surgical mitral valve repair: a scoping review by Jian Ye, Jenny Chen, Hazal Ece Babadagli, Ricky Turgeon, Erica HZ Wang

“…This scoping review aimed to summarise current evidence on the safety and efficacy of anti-thrombotic therapy after MVr, identify knowledge gaps and propose a future study design.Methods We searched MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Clinicaltrials.gov, the WHO International Clinical Trials Registry Platform and bibliographies of included trials, guidelines and other reviews from inception to 17 September 2024. …”
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Impact of the COVID-19 pandemic on primary care for hypertension in the UK: a population-based cohort study by Christel Renoux, James M. Brophy, Kyle Johnson, Sarah Beradid, Robert W. Platt

“…Blood pressure measurements fell by 69% (95% CI 65% to 72%) in April 2020, recovering in February 2021.Conclusions Hypertension diagnosis and management in UK primary care were significantly disrupted during the COVID-19 pandemic. Future studies should investigate the potential clinical implications for the cardiovascular health of the UK population.…”
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Kruppel-family zinc finger proteins as emerging epigenetic biomarkers in head and neck squamous cell carcinoma by Patrick Pearson, Kendra Smith, Nilita Sood, Elizabeth Chia, Alicia Follett, Michael B. Prystowsky, Simon Kirby, Thomas J. Belbin

“…Conclusions Both ZNF132 and ZNF154 represent novel clinically significant biomarkers in head and neck cancer with potential tumour suppressive properties. Future studies will address the underlying molecular mechanisms by which ZNF154 expression in HNSCC contributes to the control of cell growth and migration. …”
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Assessing psychological health and reproductive function: Depression, anxiety, and stress in infertile men compared to controls: A case-control study by Seyedeh Narjes Roudbaraki, Maryam Ramezani, Bita Saifi, Mostafa Salimi, Massood Issapour Cheshani

“…Limitations included phone-based data collection and the depression, anxiety, and stress scale 21 questionnaire’s screening nature. Future studies should involve larger populations and consider economic status as a variable related to mental health. …”
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Telemedicine for HIV care: a cross-sectional survey of people living with HIV receiving care at two federally qualified health centers in Los Angeles during a mature phase of the C... by Daisy Walker, Corrina Moucheraud, Derrick Butler, Christian Takayama, Steven Shoptaw, Judith S. Currier, Jay Gladstein, Risa Hoffman

“…Conclusions During a mature phase of the COVID-19 pandemic, PLHIV in our study showed high satisfaction with telemedicine, largely conducted as telephone visits, and high interest in telemedicine visits as a component of their future HIV care. Future studies should explore barriers to implementing video telemedicine in FQHCs and determine telemedicine’s impact on clinical outcomes, including engagement and viral suppression.…”
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Presence of distinct operant phenotypes and transient withdrawal-induced escalation of operant ethanol intake in female rats by Joseph R Pitock, Shannon R Wheeler, Arleen Perez Ayala, Shikun Hou, Nathaly M Arce Soto, Elizabeth J Glover

“…Our findings provide new insight into similarities and differences in operant ethanol self-administration between males and females and emphasize the importance of including females in future studies of ethanol drinking and dependence.…”
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Exposure pathways (diet, dissolved or particulate substrate) of rare earth elements to aquatic organisms by Ashlyn Kernaghan, Duc Huy Dang

“…Nevertheless, our results confirming preferential uptake pathways of the six organisms can help select appropriate species in future studies to monitor REE exposure from vaious fractions: dissolved, particulate forms or in the food webs (i.e., diet).…”
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Evaluation of Entomopathogenic Nematode Isolates against Subterranean Termites under Laboratory and Field Conditions [version 3; peer review: 2 approved, 1 approved with reservatio... by Fikremariam Yimer, Teshale Daba Dinka, Tariku Tesfaye Edosa, Belay Feyisa, Belay Abate Gutema, Dawit Melisie Achlehum

“…Conclusions This result showed that the entomopathogenic nematode isolates have the potential to manage subterranean termites in the maize field. Future studies should be based on collection of local isolates and develop a full package for the virulent isolates.…”
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The Association between Ambient Fine Particulate Matter and Oral Neoplasm among Smokers and Betel Quids Chewers by Mei-Sheng Ku, Pallop Siewchaisakul, Amy Ming-Fang Yen, Chen-Yu Liu

“…Subjects from areas of higher PM2.5 levels were found to have greater risk of OPMD/OC in Taiwan. Future studies are warranted to investigate the effect of personal PM2.5 exposure on OPMD/OC risk.…”
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Preoperative Anxiety Management Practices in Pediatric Anesthesia: Comparative Analysis of an Online Survey Presented to Experts and Social Media Users by Armin Sablewski, Christine Eimer, Marcus Nemeth, Clemens Miller

“…Our study highlights the potential for meaningful use of social media but future studies should explore the impact of social media health care professionals’ knowledge in other specific topics. …”
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