MUC5B modulation of early oral biofilm glucose metabolism by Carolina Robertsson, Carolina Robertsson, Julia Davies, Gunnel Svensäter, Anders Bay Nord, Niclas Norrström, Claes Wickström

“…Such core metabolomes can be used to detect deviations in future studies. Significant differences in metabolite abundance elicited by the presence of MUC5B were also detected. …”
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Short-Term Activation of Peroxisome Proliferator-Activated Receptors α and γ Induces Tissue-Specific Effects on Lipid Metabolism and Fatty Acid Composition in Male Wistar Rats by Elin Strand, Vegard Lysne, Mari Lausund Grinna, Pavol Bohov, Asbjørn Svardal, Ottar Nygård, Rolf K. Berge, Bodil Bjørndal

“…Moreover, both PPARα and PPARγ activation lowered plasma TAG and phospholipids, most likely through effects on liver and adipose tissue, respectively. In future studies we aim to reveal whether similar patterns can be found through diet-induced activation of specific pathways.…”
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Subcutaneous sarilumab for the treatment of hospitalized patients with moderate to severe COVID19 disease: A pragmatic, embedded randomized clinical trial. by Westyn Branch-Elliman, Ryan Ferguson, Gheorghe Doros, Patricia Woods, Sarah Leatherman, Judith Strymish, Rupak Datta, Rekha Goswami, Matthew D Jankowich, Nishant R Shah, Thomas H Taylor, Sarah T Page, Sara J Schiller, Colleen Shannon, Cynthia Hau, Maura Flynn, Erika Holmberg, Karen Visnaw, Rupali Dhond, Mary Brophy, Paul A Monach

“…Methods developed and piloted during this trial will be useful in conducting future studies more efficiently.<h4>Trial registration</h4>Clinicaltrials.gov-NCT04359901; https://clinicaltrials.gov/ct2/show/NCT04359901?…”
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Does diabetes modify the triglyceride–glucose index associated with cardiovascular events and mortality? A meta-analysis of 50 cohorts involving 7,239,790 participants by Jun Zhang, Qiye Zhan, Zhihao Deng, Ling Lin, Zhaolan Feng, Huabin He, Deju Zhang, Huilei Zhao, Xiang Gu, Xiaoping Yin, Peng Yu, Xiao Liu

“…The associations for IHD and all-cause death were stronger in diabetic patients than in individuals without diabetes. Future studies should explore the role of diabetes in the TyG index-associated CVD outcomes and mortality. …”
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Researcher views on returning results from multi-omics data to research participants: insights from The Molecular Transducers of Physical Activity Consortium (MoTrPAC) Study by Kelly E. Ormond, Caroline Stanclift, Chloe M. Reuter, Jennefer N. Carter, Kathleen E. Murphy, Malene E. Lindholm, Matthew T. Wheeler

“…However, competing ethical considerations, logistical constraints, and need for more external guidance were raised as key implementation concerns. Future studies should consider views and experiences of other relevant stakeholders, specifically clinical genomics professionals and study participants, regarding the clinical utility of multi-omics information and multi-omics results return.…”
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Digital Information Exchange Between the Public and Researchers in Health Studies: Scoping Review by Nazli Soltani, Thilo Dietz, Doris Ochterbeck, Jens Dierkes, Katja Restel, Lara Christianson, Karina Karolina De Santis, Hajo Zeeb

“…Digital information exchange was associated with more barriers than facilitators, suggesting that more effort is required to improve such an exchange between the public and researchers. Future studies should investigate interactive digital methods and the receiver preferences and needs required for such an exchange.…”
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Cost-utility and cost–benefit analysis of a multi-component intervention (NEXpro) for neck-related symptoms in Swiss office workers by Beatrice Brunner, Andrea Martina Aegerter, Venerina Johnston, Thomas Volken, Manja Deforth, Gisela Sjøgaard, Achim Elfering, Markus Melloh, the NEXpro Collaboration Group

“…As there is still a large research gap in this area, future studies are needed. Trial registration ClinicalTrials.gov, NCT04169646 . …”
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Design and psychometric testing of a moral intelligence instrument for pre-hospital emergency medical services personnel: a sequential-exploratory mixed-method study by Fateme Mohammadi, Rasoul Salimi, Salman Khazaei, Mostafa Bijani

“…Thus, it is suggested that future studies explore the psychometric properties of this tool with a larger sample size and in different cultures.…”
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Global trends and research frontiers on machine learning in sustainable animal production in times of climate change: Bibliometric analysis aimed at insights and orientations for t... by Robson Mateus Freitas Silveira, Concepta Mcmanus, Iran José Oliveira da Siva

“…The main insights generated in the bibliometric analysis were (i) sustainable animal production changed from unidisciplinary science to multidisciplinary science linked to agricultural, environmental and engineering sciences, mainly to genetics and computing; (ii) the concept of sustainable animal production emerged from animal welfare and climate change concepts found in UN's 2030 Agenda; (iii) omics sciences, greenhouse gases, energy efficiency and animal welfare are the main keywords for bibliometric analyses in future studies related to sustainable animal production in the coming centuries; (iii) prediction and classification analyses, i.e., supervised machine learning models used as main tools in animal production; (iv) residual feed intake applied to measure sustainable feed efficiency in animal farming in the past and nowadays; and (v) The United States, China, Brazil and Australia are the main countries publishing studies on sustainability in animal production, but only China has been gaining prominence in publications in this field, in recent years, and it will turn this country into an emerging leader in future publications on this topic. …”
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Composite cardiac computed tomography angiography score for improved risk assessment in chronic coronary syndromes by Subin Lee, Alexander Giesen, Dimitrios Mouselimis, Loris Weichsel, Andreas A. Giannopoulos, Max Nunninger, Matthias Renker, Florian André, Norbert Frey, Grigorios Korosoglou

“…A composite CCTA score, derived by these imaging markers may identify high-risk individuals, who may benefit from more intensified treatment and clinical follow-up in future studies.…”
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Human–nature connectedness and sustainability across lifetimes: A comparative cross‐sectional study in France and Colombia by Gladys Barragan‐Jason, Maxime Cauchoix, Paula A. Diaz‐Valencia, Arielle Syssau‐Vaccarella, Solène Hemet, Camilo Cardozo, Suzanne M. Skevington, Philipp Heeb, Camille Parmesan

“…Our study also suggests that increasing contact with nature during formative teenage years could mitigate the observed decline in human–nature connectedness. Future studies are warranted combining qualitative and quantitative measures related to human–nature connectedness, nature experiences, values and practices in relation to nature, in multiple countries from the global South. …”
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Impact of Lower-Volume Training on Physical Fitness Adaptations in Team Sports Players: A Systematic Review and Meta-analysis by Filipe Manuel Clemente, Rodrigo Ramirez-Campillo, Jason Moran, Piotr Zmijewski, Rui Miguel Silva, Morten Bredsgaard Randers

“…The main contribution of this review is mapping current research, providing a foundation for future studies and training optimization.…”
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Exploring the upper ocean characteristics of a bay using coastal and regional ocean community model by D. Jaishree, P.T. Ravichandran

“…Overall, this study contributes to advancing our understanding of the ocean dynamics of the region and underscores the importance of considering seasonal variations for comprehensive oceanographic research, coastal management, climate modeling, and future studies in the Bay of Bengal.…”
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Remote Continuous Microinjury-Triggered Cytokines Facilitate Severe Diabetic Foot Ulcer Healing via the Ras/Raf/MEK/ERK Pathway by Huang X, Liu J, Wu X, Mo Y, Luo X, Yang Y, Yang C, Liang X, Liang R, Chen Y, Fan Z, Lu W, Chen Y, Hua Q

“…Based on these findings, we proposed a theory that remote continuous microinjuries can trigger the repair of target tissues (ie, microinjury-induced remote repair, MIRR). Future studies are needed to validate this theory.Keywords: microinjury, bone transport, tibial cortex transverse transport, diabetic foot ulcer, endothelial progenitor cells, Ras/Raf/MEK/ERK signaling pathway…”
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Digital Health Technology Interventions for Improving Medication Safety: Systematic Review of Economic Evaluations by Widya Norma Insani, Neily Zakiyah, Irma Melyani Puspitasari, Muhammad Yorga Permana, Kankan Parmikanti, Endang Rusyaman, Auliya Abdurrohim Suwantika

“…ConclusionsDHT interventions are economically viable to improve medication safety, with a substantial reduction in ADEs and medication errors. Future studies should prioritize incorporating alert compliance tracking, ADE and error severity classification, and evaluation of indirect costs, thereby increasing clinical benefits and economic viability.…”
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Integrating urban building information modeling and circular economy framework for green sustainability by N. Andriyani, P. Suprobo, T.J.W. Adi, W.A.N. Aspar, A.D. Jatmiko, A.D. Santoso

“…The government should consider the green demolition framework when refining regulations to include Information Communication Technologies and circular economy concepts. Future studies have the potential to improve the green demolition framework by prioritizing environmentally conscious strategies and ensuring effective coordination among all stakeholders involved to achieve the best possible outcomes in demolition projects.…”
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Changes in Uterine Cancer Incidence Rates in Egypt by Saad Alshahrani, Amr S. Soliman, Ahmed Hablas, Mohamed Ramadan, Jane L. Meza, Steven Remmenga, Ibrahim A. Seifeldein, Robert M. Chamberlain

“…The study confirmed the low incidence rate of uterine cancer in the Gharbiah province of Egypt and significant increase in incidence in recent years. Future studies should focus on verifying the possible effect of hysterectomy on lowering the incidence, the factors related to the changes in rates between rural and urban areas, and the possible impact of nutritional and epidemiologic transitions on the increasing rates.…”
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The association between 24-h movement behaviours and adiposity among Australian preschoolers: a compositional data analysis by Marga Decraene, Kar Hau Chong, Ty Stanford, Dorothea Dumuid, Penny Cross, Greet Cardon, Vera Verbestel, Marieke De Craemer, Anthony Okely

“…Conclusion Despite the association between more time spent in MVPA and higher BMI z-scores, promoting a balanced amount of time in each 24-h movement behaviour—more MVPA, less sedentary time, and sufficient sleep—remains important for overall health. Future studies should address methodological challenges (e.g. recruitment bias that may exist in the parents/children willing to participate versus the general population, recall bias in parent reported sleep duration, or other confounding variables such as diet), use larger and more diverse samples, and consider longitudinal designs. …”
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Industry of employment and occupational class in relation to cardiovascular health by race/ethnicity, sex/gender, age and income among adults in the USA: a cross-sectional study by Symielle A Gaston, Chandra L Jackson, Jamie A Murkey, Dana M Alhasan, W Braxton Jackson

“…Given the higher likelihood of labourer occupations and lower prevalence of mICVH among minoritised racial/ethnic groups, social determinants related to occupational class should be considered in future studies of racial and ethnic disparities in CVH.…”
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Web-based interventions for fear of cancer recurrence: A scoping review with a focus on suggestions for the development and evaluation of future interventions. by Solveiga Zibaite, Sheela Tripathee, Helen Moffat, Beatrix Elsberger, Sara Maclennan

“…Fourth, while web-based interventions do not involve the costs of transportation, traveling time, space, equipment, cleaning, and other expenses, further cost utility analyses should be performed. Finally, future studies should assess how intervention accessibility, adherence, and effectiveness can be improved across different intervention designs, varying from intensive synchronous individual therapist-assisted web-based programme to blended designs combining the advantages of face-to-face and internet-based elements, to entirely self-managed programmes.…”
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