Association between the ABCC11 gene polymorphism-determined earwax properties and external auditory canal microbiota in healthy adults by Yasunobu Amari, Masahiro Hosonuma, Takuya Mizukami, Junya Isobe, Yuki Azetsu, Eiji Funayama, Yuki Maruyama, Toshiaki Tsurui, Kohei Tajima, Aya Sasaki, Yoshitaka Yamazaki, Ryota Nakano, Yutaka Sano, Atsushi Ishida, Tatsuya Nakanishi, Seiji Mochizuki, Yuri Yoshizawa, Sumito Kumagai, Sakiko Yasuhara, Kakei Ryu, Tatsunori Oguchi, Atsuo Kuramasu, Kiyoshi Yoshimura, Takehiko Sambe, Sei Kobayashi, Naoki Uchida

“…We determined the presence of genome–microbiome interactions in the resident microbiota of the ear canal. Future studies should focus on ABCC11 gene polymorphisms to elucidate the pathogenesis of ear diseases and develop therapeutic methods.…”
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Disparities in the uptake of HPV-related cancer prevention strategies among women by HIV status in Puerto Rico by Marievelisse Soto-Salgado, Melisa Ramos-Sepúlveda, Jeslie M. Ramos-Cartagena, Maribel Tirado-Gómez, Humberto M. Guiot, Cristina Muñoz-Masso, Lorena González-Sepúlveda, Ana Patricia Ortiz

“…Conclusions: Although we observed high uptake of cervical and anal Pap screening in this clinic-based sample, HPV vaccination was deficient. Future studies should involve developing tailored cancer prevention strategies for WLWH to increase HPV vaccination uptake.…”
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Cross-Cultural Adaptation and Validation of the Hong Kong Version of the Knee Injury and Osteoarthritis Outcome Score (HK-KOOS) for Patients with Knee Osteoarthritis by Andy S. K. Cheng, Ka-chun Chan, Sum-yuet Chan, Miu-kwan Fan, Man-kwan Fung, Oi-yan Lee, Cindy T. T. Kwok, Jackson K. K. Wong

“…Discussion and Conclusions. Future studies should further examine the dimensionality of the KOOS. …”
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Evaluation of Chat Generative Pre-trained Transformer and Microsoft Copilot Performance on the American Society of Surgery of the Hand Self-Assessment Examinations by Taylor R. Rakauskas, BS, Antonio Da Costa, BS, Camberly Moriconi, BS, Gurnoor Gill, BA, Jeffrey W. Kwong, MD MS, Nicolas Lee, MD

“…Clinical Relevance: While holding promise within medical education, caution should be used with large language models as more detailed evaluation of consistency is needed. Future studies should explore how these models perform across multiple trials and contexts to truly assess their reliability.…”
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Synthesizing the impact of armed conflicts on food security, livelihoods and social dynamics in Amhara region, Ethiopia by Jemal Hassen Muhyie, Desalegn Yayeh, Seblewongiel Ayenalem Kidanie, Wubshet Asnake Metekia, Temesgen Tilahun

“…Government, non-governmental organizations, and community-based institutions should play a crucial role in building community resilience and support post-conflict reconstruction efforts. Future studies can capitalize on this qualitative finding and could design a large scale assessment using quantified data to further provide evidence on post-conflict reconstruction efforts.…”
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The Clinical Impact of Tumor Grade Heterogeneity in Nonmuscle- invasive Urothelial Carcinoma of the Bladder by Meftun Culpan, Ferhat Keser, Ayberk İplikci, Gözde Kır, Gökhan Atış, Asif Yıldırım

“…Our results should be verified by future studies.…”
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Effect of conservative treatment on greater trochanteric pain syndrome: a systematic review and network meta-analysis of randomized controlled trials by Si-Qi Wang, Ning-Yi Guo, Wei Liu, Hong-jie Huang, Bing-bing Xu, Jian-quan Wang

“…Owing to the limited number of included studies, comparing the effects of different conservative treatments remains challenging. Future studies should expand the quantity of RCTs to identify the optimal conservative treatment strategy for GTPS. …”
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Weight Change and Predictors of Weight Change Among Patients Initiated on Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide or Bictegravir/Emtricitabine/Tenofovir Alafenamid... by Bruno Emond, Carmine Rossi, Aurélie Côté-Sergent, Keith Dunn, Patrick Lefebvre, Marie-Hélène Lafeuille, Prina Donga

“…Weight gain is an important factor to consider when selecting antiretroviral regimens, since it is associated with long-term health consequences. Future studies with larger sample size and longer follow-up time are warranted.…”
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Prevalence of and factors associated with symptoms consistent with a diagnosis of irritable bowel syndrome among resident physicians in standardised training in China: a cross-sect... by Xin Wang, Ning Li, Xia Li, Zhigang Li, Jun Zhao, Xuefei Wang, Xin Hao, Jiayi Yang, Junjian Tian

“…Depression symptoms were significantly associated with IBS (unadjusted OR 0.498, 95% CI 0.265 to 0.935, p=0.030).Conclusion These findings suggest that IBS is common among resident physicians in standardised training. Future studies should investigate emotional distress, especially stress and depression, in the development of prevention or treatment of IBS.…”
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Genetic variation reveals the therapeutic potential of BRSK2 in idiopathic pulmonary fibrosis by Zhe Chen, Mingyang Tang, Nan Wang, Jiangjiang Liu, Xiaoyan Tan, Haitao Ma, Jing Luo, Kai Xie

“…Conclusions BRSK2 is identified as a critical pathogenic factor in IPF, with strong potential as a therapeutic target. Future studies should focus on its translational implications and the development of targeted therapies to improve patient outcomes.…”
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Identifying Digital Markers of Attention-Deficit/Hyperactivity Disorder (ADHD) in a Remote Monitoring Setting: Prospective Observational Study by Heet Sankesara, Hayley Denyer, Shaoxiong Sun, Qigang Deng, Yatharth Ranjan, Pauline Conde, Zulqarnain Rashid, Philip Asherson, Andrea Bilbow, Madeleine J Groom, Chris Hollis, Richard J B Dobson, Amos Folarin, Jonna Kuntsi

“…The participants with ADHD were (1) slower (PdPdPdPdPdPPdPdPdPdPd ConclusionsIn a novel exploration of digital markers of ADHD, we identified candidate digital signals of restlessness, inconsistent attention, and difficulties completing tasks. Larger future studies are needed to replicate these findings and to assess the potential of such objective digital signals for tracking ADHD severity or predicting outcomes.…”
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Tinnitus Suppression with Electrical Stimulation at the Most Basal Contact of the Cochlear Implant Electrode as a Model for Round Window Stimulation by Kiana Kheirkhah, Valerie Van Kelecom, Marc Leblans, Joost van Dinther, Glynnis De Greve, Erwin Offeciers, Andrzej Zarowsk

“…The long-term effects of this therapy should be confirmed in future studies.…”
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Risk factors for fear of falling in stroke patients: a systematic review and meta-analysis by Li Ma, Qi Xie, Juhong Pei, Ling Gou, Yabin Zhang, Juanping Zhong, Yujie Su, Xinglei Wang, Xinman Dou

“…Sensitivity analysis (leave-one-out method) showed that the pooled estimate was stable.Conclusion This meta-analysis indicated that female population, impaired balance ability, lower mobility, history of falls and walking aid in patients with stroke might be at greater risk for FoF. Future studies are recommended to determine other risk factors specific to patients with stroke.…”
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Asthma and obesity increase inflammatory markers in children by Harshita Shailesh, Safa Noor, Lena Hayati, Antonisamy Belavendra, Nicholas Van Panhuys, Abdul Badi Abou-Samra, Stefan Worgall, Ibrahim Janahi, Ibrahim Janahi

“…These findings challenge the previous view that obesity enhances inflammation in individuals with asthma and highlight the importance of considering both conditions while treating obesity-associated asthma in children. Future studies are necessary to further explore the mechanisms that link obesity and asthma in the pediatric population.…”
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The enlarged perivascular spaces in the hippocampus is associated with memory function in patients with type 2 diabetes mellitus by Peichun Pan, Dongsheng Zhang, Jing Li, Min Tang, Xuejiao Yan, Xin Zhang, Man Wang, Xiaoyan Lei, Xiaoling Zhang, Jie Gao

“…H-EPVS may serve as a potential neuroimaging biomarker for cognitive impairment in patients with T2DM, warranting further investigation and validation in future studies.…”
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Assessing awareness and treatment knowledge of preventable blindness in rural and urban South African communities by Z Kiva, J E Wolvaardt

“…Without this, there will be little demand for any treatment or service. Future studies are needed to understand which health promotion interventions are effective in preventable blindness in rural populations. …”
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Exploring the Prognostic Role of Trop-2, CD47, and CD163 Expression Levels on Survival Outcomes in Patients with Triple-Negative Breast Cancer by Ramazan Oguz Yüceer, Sedanur Aydın, Iclal Gelir, Tulay Koc, Ersin Tuncer, Mahmut Ucar

“…These findings offer promising prospects for future studies on combined antibody–drug conjugates (ADCs), as they may present opportunities to address multiple resistance mechanisms in the management of TNBC and enhance clinical outcomes.…”
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The science and politics of ‘knowledge’ in safe sport research by Benjamin Carr

“…Attempting to unify future studies for comparable results, Parent et al. (2018) introduced and validated the Violence Towards Athletes Questionnaire (VTAQ). …”
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The Association of moisture intake and constipation among us adults: evidence from NHANES 2005–2010 by Deng-Chao Wang, Xue-Feng Peng, Wen-Xing Chen, Miao Yu

“…This emphasizes the importance of considering adequate moisture intake in the prevention and management of constipation. Future studies should adopt a prospective design to further verify the causal relationship between dietary moisture intake and constipation progression.…”
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Prevalence and health consequences of nonmedical use of tramadol in Africa: A systematic scoping review. by Saidou Sabi Boun, Olumuyiwa Omonaiye, Sanni Yaya, Sanni Yaya

“…This highlights the need for targeted interventions to address unique challenges contributing to tramadol misuse. Future studies should focus on the social and economic costs of abuse on households to better understand the impact on well-being. …”
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