Are Anxiety Disorders Associated with Accelerated Aging? A Focus on Neuroprogression by Giampaolo Perna, Giuseppe Iannone, Alessandra Alciati, Daniela Caldirola

“…Potential mechanisms of this association, limitations of the current research, and implications for treatments and future studies are discussed.…”
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Exploring Mitochondrial Evolutionary Pathways: Insights into the Origin of the Endemic Ohrid Trout by Anila Hoda, Chiara Locci, Ilenia Azzena, Noemi Pascale, Ilaria Deplano, Roland Kristo, Arian Demiri, Fabio Scarpa, Marco Casu, Daria Sanna

“…Additionally, our findings suggest that the modern <i>Salmo letnica</i> population likely originated in Lake Ohrid from <i>Salmo farioides</i> founders through evolutionary differentiation, potentially driven by environmental changes. Future studies incorporating a larger number of samples from both <i>Salmo letnica</i> and <i>Salmo farioides</i> are essential to fully understand the evolutionary and ecological dynamics of <i>Salmo letnica</i> morphotypes.…”
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Cytochrome P450 Metabolism of Betel Quid-Derived Compounds: Implications for the Development of Prevention Strategies for Oral and Pharyngeal Cancers by Che-Yi Lin, Tien-Szu Pan, Chun-Chan Ting, Shih-Shin Liang, Shu-Hung Huang, Hsiu-Yueh Liu, Edward Cheng-Chuan Ko, Chung-Wei Wu, Jen-Yang Tang, Ping-Ho Chen

“…Our discussion of CYP polymorphisms provides insight into the importance of screening tests in OPMDs patients for the prevention of oral and pharyngeal cancers. Future studies will establish a strong foundation for the development of chemoprevention strategies, polymorphism-based clinical diagnostic tools (e.g., specific single-nucleotide polymorphism (SNP) “barcodes”), and effective treatments for BQ-related oral disorders.…”
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Racial/Ethnic Differences in Poststroke Rehabilitation Outcomes by Charles Ellis, Hyacinth I. Hyacinth, Jamie Beckett, Wuwei Feng, Marc Chimowitz, Bruce Ovbiagele, Dan Lackland, Robert Adams

“…Black stroke survivors appear to generally achieve poorer functional outcomes than White stroke survivors. Future studies are warranted to evaluate the precise magnitude of these differences, whether they go beyond chance, and the underlying contributory mechanisms.…”
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Investigation of Fluoride Release Patterns of Glass Ionomer Lining Materials: A Comparative Study of Chemical, Resin Modified, and Single-Component Glass Ionomer Cements by Neda Sadeghian Marnani, Mehrdad Kazemian

“…Therefore, any of these materials could be considered for clinical use depending on specific circumstances. Future studies should focus on evaluating the ease of use and other favorable properties of these materials to ensure successful clinical applications.…”
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Detection of Insulin in Insulin-Deficient Islets of Patients with Type 1 Diabetes by Yuliya Krivova, Alexandra Proshchina, Dmitry Otlyga, Anastasia Kharlamova, Sergey Saveliev

“…These results suggest that islet α-cells may contain insulin and/or other insulin-like proteins (proinsulin, C-peptide). Future studies are needed to evaluate the role of α-cells in insulin secretion and diabetes pathogenesis.…”
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Understanding the role of sex on outcomes for the cancer patient undergoing treatment with immune checkpoint inhibitors: a scoping review protocol by Grace Lu-Yao, Jennifer M Johnson, Amy L Shaver, Nikita Nikita, Swapnil Sharma, Daniel S Lefler, Atrayee Basu-Mallick, Meghan L Butryn

“…The results will be used to inform future studies on the potential differential impacts of ICIs. …”
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Smartphone Delivery of Mobile HIV Risk Reduction Education by Karran A. Phillips, David H. Epstein, Mustapha Mezghanni, Massoud Vahabzadeh, David Reamer, Daniel Agage, Kenzie L. Preston

“…We concluded that video-based mHIVRR education delivered via smartphone is acceptable, feasible and may increase HIV/STD risk reduction knowledge. Future studies, with pre-intervention assessments of knowledge and random assignment, are needed to confirm these findings.…”
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Alzheimer’s disease and infectious agents: a comprehensive review of pathogenic mechanisms and microRNA roles by Seyyed Sam Mehdi Hosseininasab, Rasoul Ebrahimi, Shirin Yaghoobpoor, Kiarash Kazemi, Yaser Khakpour, Ramtin Hajibeygi, Ashraf Mohamadkhani, Mobina Fathi, Kimia Vakili, Arian Tavasol, Zohreh Tutunchian, Tara Fazel, Mohammad Fathi, Mohammadreza Hajiesmaeili

“…These findings suggest important areas for further research to be explored in future studies.…”
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New anchovy burgers: a sustainable and nutritious alternative to red meat in fast food by Giovanni Luca Russo, Antonio L. Langellotti, Rossella Di Monaco, Gabriele Buonocunto, Francesca Colonna, Nunzio Velleca, Anna Ilaria Di Paola, Lucia Avella, Silvana Cavella, Paolo Masi

“…The findings lay a foundation for future studies to further explore the interplay of sensory attributes and consumer preferences, potentially guiding the development of innovative and sustainable fast-food products. …”
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SBU-WSD-Corpus: A Sense Annotated Corpus for Persian All-words Word Sense Disambiguation by Hossein Rouhizadeh, Mehrnoush Shamsfard, Vahide Tajalli

“…Providing baselines for future studies on the Persian All-words WSD task, we evaluate several WSD models on SBU-WSD-Corpus. …”
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Changes of Metabolomic Profile in Helianthus annuus under Exposure to Chromium(VI) Studied by capHPLC-ESI-QTOF-MS and MS/MS by Alan Alexander Gonzalez Ibarra, Kazimierz Wrobel, Eunice Yanez Barrientos, Alma Rosa Corrales Escobosa, J. Felix Gutierrez Corona, Israel Enciso Donis, Katarzyna Wrobel

“…To gain further insight on the effect of Cr(VI) in sunflower, isocoumarins and sesquiterpenes were selected as the target compounds for future study.…”
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Systematic analysis of the pharmacogenomics landscape towards clinical implementation of precision therapeutics in Greece by George P. Patrinos, Kariofyllis Karamperis, Margarita-Ioanna Koufaki, Maria Skokou, Zoe Kordou, Eirini Sparaki, Margarita Skaraki, Christina Mitropoulou

“…This study would not only provide the foundations for expediting the adoption of PGx in clinical reality in Greece but can also serve as a paradigm for replicating future studies in other European countries, to expand on previously available pilot studies.…”
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Minimal Impacts of Tyre Particle Exposure on Estuarine Meiofaunal Community Structure, Primary Production, and Nutrient Cycling by Charlotte Woodhouse, Dannielle Senga Green, Andy Foggo, Paul J. Somerfield, Richard C. Thompson, Samantha L. Garrard

“…Leachate dilution will occur naturally in marine systems and should be a consideration in the design of future studies.…”
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Chromosome-level genome assembly and annotation of Barbel chub Squaliobarbus curriculus by Qingmei Zheng, Feng Huang, Haiyan Zheng, Hui Zhang, Rushu Wen, Chao Li

“…Overall, the chromosome-level genome of S. curriculus will provide valuable genomic resources for genetic breeding, population genomics, sex-related marker identifications, and other future studies.…”
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Risk factors for brain metastasis in lung cancer: an umbrella review of systematic reviews and meta-analyses by Sumei Wang, Xinliang Wan, Handan Mo, Jixin Chen, Qichun Zhou, Shenghong Qiu, Yongchun Zou, Wanyin Wu, Qing Tang

“…Prophylactic cranial irradiation and older age were associated with reduced risk.Conclusions This umbrella review suggests that several risk factors may be associated with brain metastasis in lung cancer, but the overall quality of evidence is low. Future studies with improved methodologies are needed to validate these findings.PROSPERO registration number CRD42023484563…”
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Psychosocial and Quality of Life Outcomes of Prosthetic Auricular Rehabilitation with CAD/CAM Technology by Chi Keung Tam, Colman Patrick McGrath, Samuel Mun Yin Ho, Edmond Ho Nang Pow, Henry Wai Kuen Luk, Lim Kwong Cheung

“…Our present findings can inform research design and hypotheses generation of future studies.…”
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Discovery of Novel Leaf Rust Responsive microRNAs in Wheat and Prediction of Their Target Genes by Dhananjay Kumar, Dharmendra Singh, Pulkit Kanodia, Kumble Vinod Prabhu, Manish Kumar, Kunal Mukhopadhyay

“…The present study provides insight into potential miRNAs with probable roles in leaf rust pathogenesis and their target genes in wheat which establish a foundation for future studies.…”
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Information Security Risk Framework for Digital Transformation Technologies by Eduardo Stefani, Ivanir Costa, Marcos Antonio Gaspar, Roberto de Souza Goes, Rogerio Carlos Monteiro, Breno Ribeiro Petrili, Alexandre de Paula Pereira

“…As a contribution to both industry and academia, this work offers a framework that can support companies in their digital transformation journey by helping them to recognize and manage the cybersecurity risks associated with digital technologies. Future studies could expand on this framework by developing a model for risk prioritization and mitigation.…”
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Potential roles for vitamin D in preventing and treating impulse control disorders, behavioral addictions, and substance use disorders: A scoping review by Laya Jalilian-Khave, Razi Kitaneh, Binah Baht Ysrayl, Anna Borelli, Melissa C. Funaro, Marc N. Potenza, Gustavo A. Angarita

“…While data suggest a potential beneficial effect of vitamin D on preventing or treating these conditions, there were significant limitations identified by the JBI and SYRCLE assessments. Future studies should include impulse control disorders and other under-explored conditions, address heterogeneity regarding forms, doses, and duration of exposures to vitamin D, and explore vitamin D's potential therapeutic mechanisms.…”
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