Brain-Derived Neurotrophic Factor and Nerve Growth Factor Therapeutics for Brain Injury: The Current Translational Challenges in Preclinical and Clinical Research by Serena-Kaye Sims, Brynna Wilken-Resman, Crystal J. Smith, Ashley Mitchell, Lilly McGonegal, Catrina Sims-Robinson

“…BDNF and NGF have demonstrated the ability to improve functional recovery in preclinical and to a lesser extent clinical studies. …”
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Use of testosterone replacement therapy in the rehabilitation of patients with intensive care unit-associated weakness and hospital-associated deconditioning: the Singapore General... by Geoffrey Sithamparapillai Samuel, Du Soon Swee

“…This was matched with good functional recovery in terms of distance ambulated and less assistance needed for ambulation. …”
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Dialectics and Implications of Natural Neurotropic Autoantibodies in Neurological Disease and Rehabilitation by A. B. Poletaev, A. A. Abrosimova, M. A. Sokolov, A. B. Gekht, V. V. Alferova, E. I. Gusev, T. Ya. Nikolaeva, C. Selmi

“…Among patients with different functional recovery after ischemic stroke, a difference in time-related trends of Id-Abs and AId-Abs was encountered. …”
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Neuroprotective Effects of Bone Marrow Mesenchymal Stem Cells on Bilateral Common Carotid Arteries Occlusion Model of Cerebral Ischemia in Rat by Bagher Pourheydar, Sara Soleimani Asl, Mostafa Azimzadeh, Adel Rezaei Moghadam, Asghar Marzban, Mehdi Mehdizadeh

“…In conclusion, intravenous injection of BMSCs can significantly decrease the number of apoptotic neurons and significantly improve functional recovery, which may be a beneficial treatment method for ischemic injuries.…”
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Limb Muscle Reinnervation with the Nerve-Muscle-Endplate Grafting Technique: An Anatomical Feasibility Study by Liancai Mu, Jingming Chen, Jing Li, Stanislaw Sobotka, Themba Nyirenda

“…As current treatment methods result in poor functional recovery, novel treatment approaches need to be studied. …”
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AAV-KLF7 Promotes Descending Propriospinal Neuron Axonal Plasticity after Spinal Cord Injury by Wen-Yuan Li, Ying Wang, Feng-Guo Zhai, Ping Sun, Yong-Xia Cheng, Ling-Xiao Deng, Zhen-Yu Wang

“…Unsurprisingly, DPSN tracts have been shown to mediate functional recovery following SCI. KLF7 could contribute to CST axon plasticity after spinal cord injury. …”
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The Role of IL-6 and TNF-Alpha Biomarkers in Predicting Disability Outcomes in Acute Ischemic Stroke Patients by Ciprian-Ionuț Băcilă, Maria-Gabriela Vlădoiu, Mădălina Văleanu, Doru-Florian-Cornel Moga, Pia-Manuela Pumnea

“…While numerous studies have suggested a correlation between elevated levels of these cytokines and poor functional recovery, further investigation is needed to understand their prognostic value in acute ischemic stroke. …”
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Dose-Dependent Differential Effect of Neurotrophic Factors on In Vitro and In Vivo Regeneration of Motor and Sensory Neurons by Daniel Santos, Francisco Gonzalez-Perez, Xavier Navarro, Jaume del Valle

“…Although peripheral axons can regenerate after nerve transection and repair, functional recovery is usually poor due to inaccurate reinnervation. …”
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Frailty in Older Adults and Physical Activity by Jorge Luis Abreus Mora, Vivian Bárbara González Curbelo

“…Early interventions, which include exercise and mobilization, help reduce the severity of associated complications and facilitate the functional recovery of this age group. Resistance, flexibility, balance and strength exercises reduce the incidence and risk of falls, morbidity and mortality and prevent functional deterioration.…”
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Surgery for Bacterial Endocarditis Complicated by Diffuse Alveolar Hemorrhage by Kazuhiro Kurisu, Hiroshi Mitsuo, Yasutaka Ueno

“…We believe that the strategy of respiratory functional recovery by aggressive rehabilitation is essential for the achievement of a successful surgical outcome in patients with alveolar hemorrhage.…”
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Comparative analysis of the parapatellar and subpatellar approaches in reducing peripheral knee pain post-intramedullary tibial fracture surgery by Shaoyu Han, Bingjun Cui, Lang Wu, Chuangong Wang, Zhixiang Chen

“…Postoperative knee pain significantly impacts functional recovery; however, studies on this issue are limited. …”
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Short-Term Postoperative Pain and Function of Unilateral Biportal Endoscopic Discectomy versus Percutaneous Endoscopic Lumbar Discectomy for Single-Segment Lumbar Disc Herniation:... by Weihao Zhu, Yu Yao, Jie Hao, Wenbin Li, Feng Zhang

“…Current evidence suggests that both UBE and PELD are effective in relieving short-term postoperative pain and promoting functional recovery, and there is no difference in complications between them; UBE requires longer operation time, and PELD may be superior in relieving immediate postoperative pain. …”
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Strategies for Optimizing Acute Burn Wound Therapy: A Comprehensive Review by Andrei Cretu, Andreea Grosu-Bularda, Eliza-Maria Bordeanu-Diaconescu, Florin-Vlad Hodea, Vladut-Alin Ratoiu, Catalina-Stefania Dumitru, Mihaela-Cristina Andrei, Tiberiu-Paul Neagu, Ioan Lascar, Cristian-Sorin Hariga

“…These strategies aim to optimize both functional recovery and aesthetic outcomes, reducing scarring and improving the quality of life for burn patients. …”
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Plasticity of the Central Nervous System Involving Peripheral Nerve Transfer by Jun Shen

“…The inability of deprived cortical regions representing damaged nerves to overcome corresponding maladaptive plasticity after the reinnervation of muscle fibers and sensory receptors is thought to be correlated with lasting and unfavorable functional recovery. However, the concept of central nervous system plasticity is rarely elucidated in classical textbooks involving peripheral nerve injury, let alone peripheral nerve transfer. …”
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Hypertension and Its Impact on Stroke Recovery: From a Vascular to a Parenchymal Overview by Benjamin Maïer, Nathalie Kubis

“…Finally, we discuss the impact of antihypertensive therapies on cell responses to hypertension and functional recovery. This attractive topic remains a focus of continued investigation and stresses the relevance of including this vascular risk factor in preclinical investigations of stroke outcome.…”
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Can the Spinal Cord Learn and Remember? by Pierre A. Guertin

“…Experiments performed mainly in spinal cord–transected animals have reported that, indeed, spinal-mediated functions, such as the stretch or flexion reflex, pain signaling, micturition, or locomotion, may undergo plasticity changes associated with partial functional recovery that occur spontaneously or conditionally. …”
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An immunoregulation PLGA/Chitosan aligned nanofibers with polydopamine coupling basic fibroblast growth factor and ROS scavenging for peripheral nerve regeneration by Xiaokun Chen, Jihai Xu, Feng Qin, Ziyuan Yang, Xueyuan Li, Miao Yu, Ming Li, Yanhua Wang, Wang Xin

“…The repair and functional recovery of long-segment peripheral nerve injuries are crucial in clinical settings. …”
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Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function by Gustavo Della-Flora Nunes, Lindsay A. Osso, Johana A. Haynes, Lauren Conant, Michael A. Thornton, Michael E. Stockton, Katherine A. Brassell, Amanda Morris, Yessenia I. Mancha Corchado, John A. Gaynes, Anthony R. Chavez, Michaelanne B. Woerner, Deidre A. MacKenna, Aryan Alavi, Anne Danks, Alon Poleg-Polsky, Rohan Gandhi, Jeffrey A. Vivian, Daniel J. Denman, Ethan G. Hughes

“…These findings advance our understanding of remyelination and its impact on functional recovery to inform future therapeutic strategies.…”
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Medial Radial Head Dislocation Associated with a Proximal Olecranon Fracture: A Bado Type V? by Neil Segaren, Hani B. Abdul-Jabar, Nicholas Segaren, Matthew Barry

“…Following surgery, there was evident fracture union, articular congruency, and a full functional recovery. Medial radial head dislocation is not accounted for in the Bado (1967) classification of the Monteggia lesion and hence we propose the addition of a Bado V category.…”
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Immediate Cementless Hemiarthroplasty for Severe Destructive Glenohumeral Tuberculous Arthritis by Suriya Luenam, Arkaphat Kosiyatrakul

“…Postoperatively, the patients were satisfied with the rapid symptomatic relief and significant functional recovery. With the follow-up period of 5 years, the operative results were still satisfactory and the reactivation of the infection was not detected.…”
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