Safety evaluation of the food enzyme protein‐glutamine γ‐glutamyltransferase from the non‐genetically modified Streptomyces mobaraensis strain AE‐BTG by EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Monika Sramkova, Henk Van Loveren, Laurence Vernis, Jaime Aguilera, Magdalena Andryszkiewicz, Natalia Kovalkovicova, Giulio diPiazza, Yi Liu

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Safety evaluation of the food enzyme α‐amylase from the non‐genetically modified Aspergillus sp. strain FUA by EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Monika Sramkova, Henk Van Loveren, Laurence Vernis, Cristina Fernàndez‐Fraguas, Magdalena Andryszkiewicz, Natalia Kovalkovicova, Eleonora Marini, Yi Liu

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Revised safety evaluation of the food enzyme endo‐1,4‐β‐xylanase from the genetically modified Bacillus subtilis strain LMG S‐24584 produced by a modified process by EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Monika Sramkova, Henk Van Loveren, Laurence Vernis, Silvia Peluso, Magdalena Andryszkiewicz, Daniele Cavanna, Ana Gomes, Natalia Kovalkovicova, Yi Liu

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Factors predicting early discontinuation of methotrexate as a first-line treatment for rheumatoid arthritis in Italy: Results from the GISEA registry by Andreina Manfredi, Marco Sebastiani, Florenzo Iannone, Elisa Gremese, Alessandra Bortoluzzi, Ennio Favalli, Roberto Gorla, Fausto Salaffi, Enrico Fusaro, Rosario Foti, Luca Cantarini, Roberto Caporali, Alberto Cauli, Stefano Alivernini, Francesco Paolo Cantatore, Antonio Carletto, Fabrizio Conti, Salvatore D'Angelo1, Oscar Epis, Roberta Ramonda, Antonio Marchesoni, Gianfranco Ferraccioli, Giovanni Lapadula

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New findings into the genetic population structure of two commercially valuable and threatened sharks, Mustelus mustelus (Linnaeus, 1758) and M. punctulatus (Risso, 1827), allow re... by Matteo Barbato, Matteo Barbato, Matteo Barbato, Sara Bonanomi, Sara Bonanomi, Diego Borme, Ilija Ćetković, Francesco Colloca, Manfredi Di Lorenzo, Manfredi Di Lorenzo, Ilaria A. M. Marino, Ilaria A. M. Marino, Carlotta Mazzoldi, Carlotta Mazzoldi, Carlotta Mazzoldi, Ana Pešić, Antonello Sala, Lorenzo Zane, Lorenzo Zane, Lorenzo Zane, Massimo Mezzavilla

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Post-myocardial infarction ventricular septal defects: incidence and treatment trends during and after the COVID-19 pandemic by Giuseppe Nasso, Ignazio Condello, Walter Vignaroli, Andrea Antonazzo, Francesco Bartolomucci, Barbara Pala, Claudio Larosa, Annachiara Pingitore, Vincenzo Amodeo, Vincenzo Montemurro, Mizar D’Abramo, Roberto Ceravolo, Domenica Donato, Pasquale Fratto, Maria Grazia De Rosis, Giuseppe Diaferia, Rita Torraco, Gaetano Contegiacomo, Guido Lembo, Mario Siro Brigiani, Giuseppe Santarpino, Giuseppe Speziale

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Rapid climate action is needed: comparing heat vs. COVID-19-related mortality by Fulden Batibeniz, Sonia I. Seneviratne, Srinidhi Jha, Andreia Ribeiro, Laura Suarez Gutierrez, Christoph C. Raible, Avni Malhotra, Ben Armstrong, Michelle L. Bell, Eric Lavigne, Antonio Gasparrini, Yuming Guo, Masahiro Hashizume, Pierre Masselot, Susana Pereira da Silva, Dominic Royé, Francesco Sera, Shilu Tong, Aleš Urban, Ana M. Vicedo-Cabrera

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Safety evaluation of the food enzyme fructan β‐fructosidase from the genetically modified Trichoderma reesei strain AR‐577 by EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Monika Sramkova, Henk Van Loveren, Laurence Vernis, Andrew Chesson, Lieve Herman, Natália Kovalkovičová, Jaime Aguilera, Magdalena Andryszkiewicz, Daniele Cavanna, Yi Liu

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Roadmap on specialty optical fibers by Mário F S Ferreira, Mohd Rehan, Vishwatosh Mishra, Shailendra Kumar Varshney, Francesco Poletti, Nguyen Phuoc Trung Hoa, Weichao Wang, Qinyuan Zhang, Wenyu Du, Benli Yu, Zhijia Hu, Xian Feng, Jindan Shi, Anjali, Sunil Kumar, Michal Kamrádek, Mukul Chandra Paul, Kazi Abedin, Bertrand Kibler, Frédéric Smektala, Xiushan Zhu, Andrey Pryamikov, Stephan Reitzenstein

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Blood-based prognostic scores and early dynamics under immunotherapy to select patients with metastatic solid tumors for continuing immune check-point inhibition: a prospective lon... by Javier García-Corbacho, Alberto Indacochea, Iván Victoria, Débora Moreno, Laura Angelats, Azucena E. González Navarro, Laura Mezquita, Fara Brasó-Maristany, Patricia Galván, Begoña Mellado, Nuria Viñolas, Tamara Sauri, Miquel Nogué, Barbara Adamo, Joan Maurel, Estela Pineda, Lydia Gaba, Oscar Reig, Neus Basté, Esther Sanfeliu, Manel Juan, Aleix Prat, Francesco Schettini

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Differential Production of Midkine and Pleiotrophin by Innate APCs upon Stimulation through Nucleic Acid-Sensing TLRs by Elias A. Said, Sumaya Al-Dughaishi, Wadha Al-Hatmi, Iman Al-Reesi, Mohammed S. Al-Balushi, Atika Al-Bimani, Juma Z. Al-Busaidi, Marwa Al-Riyami, Murtadha Al-Khabori, Salam Al-Kindi, Francesco A. Procopio, Shadia Al-Sinawi, Aliyaa Al-Ansari, Crystal Y. Koh, Khalid Al-Naamani, Ali A. Al-Jabri

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Advances in the understanding and therapeutic manipulation of cancer immune responsiveness: a Society for Immunotherapy of Cancer (SITC) review by Francesco M Marincola, Alessandra Cesano, Yana G Najjar, Davide Bedognetti, Marco Ruella, Sarah Warren, Christine Spencer, Elad Ziv, Tomas Kirchhoff, Jennifer McQuade, Tullia C Bruno, Jakob Nikolas Kather, Allison Betof Warner, Christian Hammer, Alberto Carturan, Ryan Augustin, Rhine Shen, Winson S Ho, Rongze O Lu, Luigi Barrea, Violena Pietrobon, Laura Soldati

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ACUTE LEUKEMIA AND LATENT TUBERCULOSIS INFECTION IN ITALY: QUANTIFERON-TB TEST SCREENING IN A LOW TUBERCULOSIS INCIDENCE COUNTRY by Andrea Nunzi, Luigi Della Valle, Elisa Linnea Lindfors Rossi, Giorgia Ranucci, Flavia Mallegni, Federico Moretti, Elisa Meddi, Luca Guarnera, Ilaria Tiravanti, Kristian Taka, Elisa Buzzatti, Fabiana Esposito, Roberto Secchi, Francesca Di Giuliano, Flavia Chirico, Raffaele Palmieri, Luca Maurillo, Francesco Buccisano, Carmelo Gurnari, Giovangiacinto Paterno, Adriano Venditti, Maria Ilaria Del Principe

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Safety evaluation of the food enzyme β‐fructofuranosidase from the non‐genetically modified Saccharomyces cerevisiae strain CNCM I‐3399 by EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Monika Sramkova, Henk Van Loveren, Laurence Vernis, Andrew Chesson, Lieve Herman, Jaime Aguilera, Magdalena Andryszkiewicz, Daniele Cavanna, Giulio diPiazza, Yi Liu

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Use of inpatient palliative care in metastatic testicular cancer patients undergoing critical care therapy: insights from the national inpatient sample by Cristina Cano Garcia, Reha-Baris Incesu, Francesco Barletta, Simone Morra, Lukas Scheipner, Andrea Baudo, Stefano Tappero, Mattia Luca Piccinelli, Zhe Tian, Fred Saad, Shahrokh F. Shariat, Carlo Terrone, Ottavio De Cobelli, Luca Carmignani, Sascha Ahyai, Nicola Longo, Derya Tilki, Alberto Briganti, Severine Banek, Luis A. Kluth, Felix K. H. Chun, Pierre I. Karakiewicz

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PretoxTM: a text mining system for extracting treatment-related findings from preclinical toxicology reports by Javier Corvi, Nicolás Díaz-Roussel, José M. Fernández, Francesco Ronzano, Emilio Centeno, Pablo Accuosto, Celine Ibrahim, Shoji Asakura, Frank Bringezu, Mirjam Fröhlicher, Annika Kreuchwig, Yoko Nogami, Jeong Rih, Raul Rodriguez-Esteban, Nicolas Sajot, Joerg Wichard, Heng-Yi Michael Wu, Philip Drew, Thomas Steger-Hartmann, Alfonso Valencia, Laura I. Furlong, Salvador Capella-Gutierrez

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Superior Mesenteric Artery Syndrome: Clinical, Endoscopic, and Radiological Findings by Emanuele Sinagra, Dario Raimondo, Domenico Albano, Valentina Guarnotta, Melania Blasco, Sergio Testai, Marta Marasà, Vincenzo Mastrella, Valerio Alaimo, Valentina Bova, Giovanni Albano, Dario Sorrentino, Giovanni Tomasello, Francesco Cappello, Angelo Leone, Francesca Rossi, Massimo Galia, Roberto Lagalla, Federico Midiri, Gaetano Cristian Morreale, Georgios Amvrosiadis, Guido Martorana, Marcello Giuseppe Spampinato, Vittorio Virgilio, Massimo Midiri

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A pan-European perspective of third space professionals located in learning and teaching centres by Graham William Scott, Manuel Joao Costa, Mike Ewen, Catherine Lillie, Helene Peterbauer, Oliver Vettori, Carina Weiß, Johanna Warm, Aune Valk, Mari Karm, Hanna-Britt Soots, Guðrún Geirsdóttir, Francesco Magni, Laura Sara Agrati, Nikos Basbas, Daniela Căprioară, Mihai Girtu, Gunvor Larsson Torstensdotter, Peter Dalenius, Josefine Kilborn, Berrin Yanıkkaya, Mehmet Korman, Denizalp Şimşek, Toprak Cem Savaş

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Impact of antiparasitic therapy on cardiovascular outcomes in chronic Chagas disease. A systematic review and meta-analysisResearch in context by Anis Rassi, Jr, Alyssa Grimshaw, Ashwin Sarwal, Ranjit Sah, Sangam Shah, Nelson I. Agudelo Higuita, Fabio Mahamed Rassi, Michaele Francesco Corbisiero, Hannah M. Kyllo, Jordan Stellern, Samantha Kaplan, Luis A. Marcos, Edgar A. Ramírez-García, Martin Casapia, Peter Hotez, Maria Elena Bottazzi, Shital Patel, Carlos Franco-Paredes, José Antonio Marin-Neto, Andrés F. Henao-Martínez

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Determinants of 5-year survival in patients with advanced NSCLC with PD-L1≥50% treated with first-line pembrolizumab outside of clinical trials: results from the Pembro-real 5Y glo... by Mieke Van Hemelrijck, Salvatore Grisanti, Avinash Aujayeb, Martin Forster, Giannis Mountzios, Andrea Napolitano, Bruno Vincenzi, Joachim G J V Aerts, Marina Garassino, Valter Torri, Solange Peters, Alex Friedlaender, Alfredo Addeo, Giuseppe Lo Russo, Roberto Ferrara, Diego Signorelli, Alessandro Russo, So Yeon Kim, Jarushka Naidoo, Scott Gettinger, Heather Wakelee, Martin Sebastian, Mark Awad, Abdul Rafeh Naqash, Alessio Cortellini, Raffaele Giusti, Michele De Tursi, Federica Zoratto, Marco Russano, Rita Chiari, Biagio Ricciuti, Andrea De Giglio, Alain Gelibter, Giuseppe Tonini, Amin H Nassar, Alessandra Curioni-Fontecedro, Eleni Karapanagiotou, Emilio Bria, Jack Bell, Paolo Bironzo, Joao V Alessi, Alessandro Morabito, David J Pinato, Francesco Passiglia, Carlo Genova, Francesca Mazzoni, Alessandro Inno, Francesco Grossi, Luca Cantini, Lorenza Landi, Luigi Della Gravara, Margarita Majem, Uma Mukherjee, Federica Biello, Alessandro Leonetti, Annalisa Guida, Marianna Macerelli, Gabriele Minuti, Giulio Metro, Thomas Newsom-Davis, Eleni Josephides, Andrea Camerini, Elisa Roca, David O’Reilly, Mingjia Li, Laura Mezquita, Teresa Gorría, Claudia A M Fulgenzi, Lauren Young, Joel W Neal, Javier Baena, Francesco Pantano, Jacobo Rogado, Mary Jo Fidler, Teresa Beninato, Federica Pecci, Alessandro Di Federico, Kazuki Takada, Leonardo Brunetti, Talal El Zarif, Laura Moliner, Alberto Servetto, Sukumar Kalvapudi, Sai Yendamuri, Edoardo Garbo, Giuseppina Rita Di Fazio, Monica Loza, Ritujith Jayakrishnan, Michele Montrone, Nichola O Awosika, Bartlomiej Tomasik, Maximilian Rost, Isabelle Monnet, Francesco Agustoni, Artur Katz, Dwight Hall Owen, Michele Ghidini, Armida D’Incecco, Gianpaolo Spinelli, Monica Verrico, Manuel Dupont, Rafael Di Marco Barros, Diego Luigi Cortinovis, Chiara Bennati, Frank Aboubakar Nana, Anne-Marie Dingemans, Taher Abu Hejleh

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